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Nathan Goodyear

Potential Prostate Cancer Drug Target: Bioactivation of Androstanediol by Conversion to Dihydrotestosterone - 0 views

clincancerres.aacrjournals.org/...5844.full

prostate cancer DHT metabolite metabolites men male hormone hormones 3-alpha-diol 3-alpha androstanediol

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    Article discusses the the conversion of 3-alpha-diol back to DHT and this role in prostate cancer in androgen deprivation therapy.  What we now know is that this metabolite interacts with ER alpha receptor to promote proliferation.  Carcinogenesis appears to be primarily an estrogen driven process and her in prostate cancer, the androgen metabolites are promoting proliferation through estrogen receptors.
Nathan Goodyear

Estrogen receptor beta in the prostate - 0 views

www.sciencedirect.com/...S0303720702000898

3-beta androstanediol ER-beta ER beta DHT metabolite ER estrogen receptor receptors prostate cancer male hormone hormones men

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • Nathan Goodyear on 27 Jan 14
     
    ER beta plays an important role in the prostate.  Loss of ER beta expression in the prostate has been shown to promote carcinogenesis.  In addition, 3-beta androstanediol, a DHT metabolite has been shown to signal through ER beta.
Nathan Goodyear

Genotoxic metabolites of estradio... [J Steroid Biochem Mol Biol. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...14623547

ER estrogen receptor metabolite metabolites breast cancer 3 4 quinones quinones

shared by Nathan Goodyear on 30 Jan 14 - No Cached
  • Nathan Goodyear on 30 Jan 14
     
    study finds estrogen metabolites are involved in carcinogenesis through the production of toxic metabolites 3,4 quinones.  The presence of Estrogen receptors were associated with increased tumor growth. ER was in fact ER alpha.  What is interesting is that ER beta is not expressed these ERKO animals.  This again points to ER beta's anti proliferative action.
Nathan Goodyear

Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydroxysteroid oxidoreductase and 3α(β)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells - 0 views

www.ncbi.nlm.nih.gov/...PMC154104

progesterone metabolites breast cancer 5alpha-reductase 5-alpha pregnene 5-alpha pregnenes 4-pregnene 4-pregnenes

shared by Nathan Goodyear on 30 Jan 14 - No Cached
  • Exposure of human breast cell lines (MCF-7, MCF-10A, and ZR-75-1) to 5α-pregnanes results in changes associated with neoplasia, including increased proliferation and decreased attachment [1], depolymerization of F-actin [2] and decreases in adhesion plaque-associated vinculin
  • Exposure to 4-pregnenes results, in general, in opposite (anti-cancer-like) effects
  • 5αR1 has been detected in various androgen-independent organs, such as the liver and brain
  • ...10 more annotations...
  • 5αR2 has been found predominantly in androgen-dependent organs, such as epididymis and prostate
  • The 5α-pregnanes:4-pregnenes ratio was about 8-fold higher in tumorous than in nontumorous breast tissue after an 8-hour incubation with [14C]progesterone
  • Studies with breast cell lines, showing that 5α-pregnanes stimulate proliferation and decrease attachment of cells
  • both tissue and breast cell line studies suggest that an elevated level of progesterone 5α-reductase activity may be an indicator of breast tumorigenesis, regardless of presence or absence of ER and/or PR
  • 5αR1 is the main isoform expressed in human breast carcinomas [29] and that 5αR2 may not be associated with risk of breast cancer
  • the differences in 5α-pregnane production between the cells is due primarily to a difference in 5αR1 expression
  • As in the case of 5α-reductase activity, the presence or absence of ER and PR do not appear to be related to 5α-reductase expression.
  • the conversion of progesterone to the cancer promoting 5α-pregnanes is significantly higher in the human tumorigenic breast cell lines
  • lthough both 5αR1 and 5αR2 are expressed by these cells, the elevated 5α-reductase activity appears to be the result of significantly greater expression of 5αR1
  • Changes in progesterone metabolizing enzyme expression (resulting in enzyme activity changes) may be responsible for promoting breast cancer progression due to increased production of tumor-promoting 5α-pregnanes and decreased production of anti-cancer 20α – and 3α-4-pregnenes
  • Nathan Goodyear on 30 Jan 14
     
    balance of enzyme production between 5alpha-reductase and 20alpha-hydroxysteroid oxidoreductase and 3alpha(beta)-hydroxysteroid oxidoreductase play role in carcinogenesis and proliferation in the balance of production of progesterone metabolites. The 5alpha pregnenes are pro carcinogenic  and the 4-pregnenes are anti carcinogenic.
Nathan Goodyear

Immunohistochemical Expression of Estrogen and Progesterone Receptors in Human Colorectal Adenoma and Carcinoma Using Specified Automated Cellular Image Analysis System: A Clinicopathological Study - 0 views

www.omjournal.org/fultext_PDF.aspx

estrogen progesterone receptors colon cancer

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    ER and PR are suggested to play role in colon cancer.  The question is do they play a role in carcinogenesis or does the expression of the receptors indicate something else i.e. attempt at differentiation through progesterone.  Also, what receptors are involver here: ER alpha or beta.  Likewise for the progesterone receptors
Nathan Goodyear

Estrogen receptor ß genes associated with colorectal cancer mortality - 0 views

www.fhcrc.org/...ith-colorectal-cancer-mor.html

colon cancer ER beta ER-beta

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    Additional support for ER beta role in protection in colon cancer.  This study found that SNPs in ER beta transcription resulted in reduced ER beta expression and a resultant increase in carcinogenesis.
Nathan Goodyear

Duration of gluten exposure in adult coeliac disease doe... [Gut. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11559646

gluten autoimmune disease autoimmune disease

shared by Nathan Goodyear on 24 Sep 13 - No Cached
  • Nathan Goodyear on 24 Sep 13
     
    study finds that exposure to gluten in "late" celiac disease does not correlate to increased risk of autoimmune disease.  Maybe the timing is important as in hormones and carcinogenesis.
Nathan Goodyear

Taylor & Francis Online :: Effects of Dietary Apigenin on Tumor Latency, Incidence and Multiplicity in a Medroxyprogesterone Acetate- Accelerated 7,12-Dimethylbenz(a)anthracene- Induced Breast Cancer Model - Nutrition and Cancer - Volume 65, Issue 8 - 0 views

www.tandfonline.com/...01635581.2013.833637

breast cancer progestin apigenin medroxyprogesterone acetate

shared by Nathan Goodyear on 26 Nov 13 - No Cached
  • Nathan Goodyear on 26 Nov 13
     
    There is absolutely no reason for women to take medroxyprogesterone acetate.  Whether the author realizes it or not, he states a truth that progestin is a "trigger" in carcinogenesis of the breast.  This study was designed to look at high dose apigenin, which the study found increased risk.
Nathan Goodyear

Loss of expression of oestrogen receptor beta in c... [Oncol Rep. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15944762

ER beta ER-beta colon cancer estrogen receptor estrogen receptors estrogen receptor beta colorectal

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    Loss of ER beta associated with higher risk of colon cancer.  ER beta has been shown to be highly expressed in health colons.  It has been proposed that loss of this ER beta expression is associated with carcinogenesis.
Nathan Goodyear

Opposing actions of the progester... [J Steroid Biochem Mol Biol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19931389

progesterone metabolite progesterone metabolites metabolites 3-alpha pregnene 5-alpha pregnene breast cancer hormone hormones 5-alpha pregnenes 3-alpha pregnenes

shared by Nathan Goodyear on 28 Jan 14 - No Cached
  • Nathan Goodyear on 28 Jan 14
     
    New understanding in progesterone metabolites.  These are not waste products, but are indeed active. This in vitro study found the balance of 5 alpha pregnenes and 3 alpha pregnenes, particularly 3 alpha HP promotes carcinogenesis or inhibits.  These receptors were found in all 4 breast cell lines evaluated.  
Nathan Goodyear

Catechol estrogen metabolites and conjugates in different regions of the prostate of Noble rats treated with 4-hydroxyestradiol: implications for estrogen-induced initiation of prostate cancer - 1 views

carcin.oxfordjournals.org/...329.long

estrogen metabolites prostate cancer COMT GSH estrogen 4-hydroxyestradiol

shared by Nathan Goodyear on 17 Jul 15 - No Cached
  • Nathan Goodyear on 17 Jul 15
     
    loss of ability to handle estrogen quinone metabolites is due to decreased detoxification capacity i.e.COMT, GSH...is associated with prostate carcinogenesis in rats.
Nathan Goodyear

Estrogens and epithelial ovarian cancer - 0 views

www.sciencedirect.com/...S0090825804001994

cancer ovarian cancer ER alpha ER beta ER-alpha ER-beta estrogen hormones

shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • Nathan Goodyear on 11 Sep 15
     
    ER-alpha >ER-beta expression appears to play role in ovarian carcinogenesis.
Nathan Goodyear

Frequent Loss of Estrogen Receptor-β Expression in Prostate Cancer - 0 views

cancerres.aacrjournals.org/...5331.full

ER beta ER-beta prostate cancer prostate cancer estrogen hormones

shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • Nathan Goodyear on 11 Sep 15
     
    loss of ER-beta expression in the prostate is associated with increased prostate carcinogenesis.
Nathan Goodyear

Folate: effects on carcinogenesis and the potentia... [Oncology (Williston Park). 1996] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...8953590

folate folic acid cancer risk

shared by Nathan Goodyear on 15 Feb 11 - No Cached
  • Diminished folate status appears to promote carcinogenesis.
  • Nathan Goodyear on 15 Feb 11
     
    folate deficiency linked to increase cancer risk
Nathan Goodyear

Access : Inflammation and Cancer: Causes and Consequences : Clinical Pharmacology & Therapeutics - 0 views

www.nature.com/...clpt2009254a.html

inflammation cancer

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • Nathan Goodyear on 27 Aug 14
     
    Not only is inflammation a key in carcinogenesis, but cancer plays a role in progression and prognosis.
Nathan Goodyear

The safety of testosterone supplementation ther... [Nat Rev Urol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25069737

prostate cancer testosterone men male hormone hormones

shared by Nathan Goodyear on 30 Jul 14 - No Cached
  • Nathan Goodyear on 30 Jul 14
     
    Review, only abstract available--Testosterone therapy does not affect prostate size, intraprostatic Testosterone levels, or prostate cancer progression.  Carcinogenesis of the prostate is not a androgen driven process.  It is an aromatase process.  DHT metabolites can promote tumor growth via Estrogen receptors later, but initiation, via all accounts, occurs through aromatase expression and production of estrogen in the prostate.
Nathan Goodyear

A new era of testosterone and prostate cancer: from... [Eur Urol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24011426

Testosterone prostate cancer men male hormone hormones

shared by Nathan Goodyear on 06 Aug 14 - No Cached
  • Nathan Goodyear on 06 Aug 14
     
    The tide is beginning to shift on testosterone and Prostate Cancer.  A literature review finds no support for Testosterone and Prostate carcinogenesis or low Testosterone providing any protection against prostate cancer.  
  • Blu Electronic Cigarettes on 07 Aug 14
     
    a good read!
Nathan Goodyear

IJMS | Free Full-Text | mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy | HTML - 0 views

www.mdpi.com/...htm

amino acids hypoxia mTOR protein cancer

shared by Nathan Goodyear on 27 Mar 19 - No Cached
hoangkimchi liked it
  • Nathan Goodyear on 27 Mar 19
     
    Incredible review on mTOR and carcinogenesis and promotion of cancer proliferation
Nathan Goodyear

<i>Artesunate</i> Suppresses the Growth of Prostatic Cancer Cells through Inhibiting Androgen Receptor - 0 views

www.jstage.jst.go.jp/...en

artesunate prostate cancer

shared by Nathan Goodyear on 03 Jun 19 - No Cached
  • Nathan Goodyear on 03 Jun 19
     
    Artesunate found to have broad range of anti-cancer activity, such as pro-apoptosis attenuation of tumor growth, metastasis, and angiogenesis. This study primarily looked at the effect in a prostate cancer mouse model. It found that the artesunate down regulated androgen receptors. Now, there is debate about how and when AR and androgens play a role in prostate cancer as studies have also pointed to estrogen and ER in carcinogenesis of the prostate.
Nathan Goodyear

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade - 0 views

www.ncbi.nlm.nih.gov/...PMC6324991

cancer immune system immune-oncology obesity

shared by Nathan Goodyear on 09 Jun 19 - No Cached
  • Nathan Goodyear on 09 Jun 19
     
    Obesity is not the immune systems friend when it comes to cancer. Why does conventional medicine always look at things through the prism of the effects for drugs and not on the patient, carcinogenesis...
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