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Nathan Goodyear

Therapeutic effects of progesterone and its metabolites in traumatic brain injury may involve non-classical signaling mechanisms - 0 views

www.ncbi.nlm.nih.gov/...PMC3680782

progesterone non-genomic signaling head progesterone metabolites TBI brain injury trauma allopregnanolone traumatic brain injury

shared by Nathan Goodyear on 17 Mar 14 - No Cached
  • Nathan Goodyear on 17 Mar 14
     
    Progesterone and its metabolite allopregnanolone show promise in protecting the brain in TBI.
Nathan Goodyear

Progesterone induces the growth and infiltrat... [Biomed Res Int. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24982875

Progesterone cancer astrocytes brain hormone hormones metabolites

shared by Nathan Goodyear on 07 Jul 14 - No Cached
  • Nathan Goodyear on 07 Jul 14
     
    Progesterone shown to stimulate growth and migration of astrocytes in the brain.  The has both implications in cancer, such as in astrocytomas, but also in TBI.  The study also found that the Progesterone antagonist RU486 inhibited this effect.  A more thorough evaluation would have included the pregnane metabolites.
Nathan Goodyear

Plasma Membrane Receptors for the Cancer-Regulating Progesterone Metabolites, 5α-Pregnane-3,20-dione and 3α-Hydroxy-4-pregnen-20-one in MCF-7 Breast Cancer Cells - 0 views

www.sciencedirect.com/...S0006291X0092847X

Hormones progesterone metabolites receptors progesterone cancer breast cancer 5alpha-pregnane estradiol

shared by Nathan Goodyear on 07 Oct 16 - No Cached
  • Nathan Goodyear on 07 Oct 16
     
    The receptor for the progesterone 5alpha pregnane, 5alpha-P, is unregulated in breast cancer cell line MCF-7.  Estradiol increases the receptor expression.  Not only is there an enzymatic effect in these progesterone pathways, but the receptor is equally unregulated.
Nathan Goodyear

Membrane 5α-pregnane-3,20-dione (5αP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5αP and down-regulated by the progesterone metabolites, 3α-dihydroprogesterone and 20α-dihydroprogesterone, with associated changes - 0 views

www.sciencedirect.com/...S0960076005003420

breast cancer progesterone metabolites progesterone metabolites hormone hormones

shared by Nathan Goodyear on 18 Jun 14 - No Cached
  • Nathan Goodyear on 18 Jun 14
     
    Very interesting study.  In ER/PR + breast cancer cells, Estradiol and 5alpha-dihydroprogestorone increase the membrane expression of 5alpha-dihydroprogesterone receptors.  This has a pro-growth, pro-metastatic potential.  In contrast, the metabolites 3alpha-dihdroprogesterone and 20alpha-HP inhibit the same membrane receptor expression thus giving an antigrowth, anti-metastatic potential.
Nathan Goodyear

Progesterone Metabolites in breast Cancer - 0 views

erc.endocrinology-journals.org/...717.full.pdf

breast cancer CA progesterone metabolites

shared by Nathan Goodyear on 13 Mar 12 - No Cached
  • Nathan Goodyear on 13 Mar 12
     
    Very technical read: but progesterone metabolites play an important role in the development of breast cancer.
Nathan Goodyear

Studies on the Progesterone Receptor Content and Steroid Metabolism in Normal and Pathological Human Breast Tissues: The Journal of Clinical Endocrinology & Metabolism: Vol 48, No 4 - 0 views

press.endocrine.org/...jcem-48-4-585

progesterone metabolite metabolites 5-alpha pregnenes hormone hormones metabolism women 4-pregnene 5-alpha pregnene 4-pregnenes breast cancer

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • Nathan Goodyear on 27 Jan 14
     
    One of the first studies to document progesterone metabolites in breast tissue.
Nathan Goodyear

The dialectic role of progesterone. [Maturitas. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19171445

progesterone metabolite metabolites. hormone hormones receptor PR-A PR-B

shared by Nathan Goodyear on 30 Jan 14 - No Cached
  • Nathan Goodyear on 30 Jan 14
     
    knowledge of progesterone and its metabolites are important in the use of hormones.  As the authors concluded here: "natural steroids should not be disparaged...an update on endocrinological knowledge and experience is rather mandatory for gynecologists".  There in lies the problem.  The IOM has shown that the average physician practices at a level of 17 years behind the current scientific knowledge and the environment created by medical governing bodies discourages questions, so as to protect the system.
Nathan Goodyear

Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride - ScienceDirect - 0 views

www.sciencedirect.com/...S0960076015000060

5 alpha reductase inhibitors 5 alpha reductase progesterone 5alpha-pregnane breast cancer

shared by Nathan Goodyear on 07 Jul 20 - No Cached
  • Nathan Goodyear on 07 Jul 20
     
    5 alpha reductase inhibitor, finasteride inhibits pro-tumor progesterone metabolite pathway.
Nathan Goodyear

Membrane 5alpha-pregnane-3,20-dio... [J Steroid Biochem Mol Biol. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16154741

progesterone metabolite metabolites 3-alpha pregnene 3-alpha pregnenes 5-alpha pregnene 5-alpha pregnenes estradiol hormone hormones breast cancer

shared by Nathan Goodyear on 28 Jan 14 - No Cached
  • Nathan Goodyear on 28 Jan 14
     
    Progesterone metabolites are present on the membrane of ER/PR + as well as ER/PR - breast cancer cell lines.  The balance of 5 alpha pregnane:3 alpha pregnane regulates tumor genesis.  Estradiol increased 5 alpha pregnane receptors as well as 5 alpha pregnane unregulated itself via autocrine activity.  The 3 alpha pregnenes, 3 alpha hydroxyprogesterone and 20 alpha-dihydroprogesterone, decrease the 5 alpha pregnane receptors via paracrine activity.
Nathan Goodyear

Allopregnanolone and mood disorders. [Prog Neurobiol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23978486

allopregnanolone progesterone metabolite metabolites hormone hormones GABA PMDD women mood disorders

shared by Nathan Goodyear on 28 Jan 14 - No Cached
  • Nathan Goodyear on 28 Jan 14
     
    The progesterone metabolite allopregnanolone is shown to play a significant role in the PMDD symptoms.  The mechanism is via a paradoxical GABA-A effect.
Nathan Goodyear

Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydroxysteroid oxidoreductase and 3α(β)-hydroxysteroid oxidoreductases in tumorigenic (MCF7, MDA-MB-231, T-47D) and nontumorigenic (MCF10A) human breast cancer cells - ResearchGate - 0 views

www.researchgate.net/...10A)_human_breast_cancer_cells

progesterone metabolites breast cancer 5-alpha-pregnanediol 4-pregnenediol

shared by Nathan Goodyear on 23 Jan 14 - No Cached
  • Nathan Goodyear on 23 Jan 14
     
    Intra mammary progesterone metabolism and its associated metabolites found to be associated with tumorigenic activity in cell lines.  This was independent from ER PR status.  5 alpha-pregnanes were found to be pro-tumor and 4-pregnanes were anti-tumor.
Nathan Goodyear

BMC Cancer | Full text | Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydroxysteroid oxidoreductase and 3α(β)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast canc - 0 views

www.biomedcentral.com/...9

breast cancer progesterone metabolites progesterone metabolites hormone hormones

shared by Nathan Goodyear on 18 Jun 14 - No Cached
  • Nathan Goodyear on 18 Jun 14
     
    Might the enzymes be more important than the hormones themselves?  The number is important i.e. progesterone, but how the number came to be is more important as it points to the underlying etiology.  Here, the balance of enzymes are found to direct cell line tumor potential.  The enzyme 5alpha-reductase increased production of the 5alpha-pregnanes which increased tumor potential.  In contrast, the enzymes 20alpha-hydrosteroid oxidoreductase and 3alpha-hydroxysteroid oxidoreductase increase production of the 4alpha-pregnanes, which decreased tumor potential.
Nathan Goodyear

The role of progesterone metabolites in breast cancer: Potential for new diagnostics and therapeutics - 0 views

www.sciencedirect.com/...S0960076004004224

progesterone progesterone metabolites cancer breast cancer hormones

shared by Nathan Goodyear on 07 Oct 16 - No Cached
  • Nathan Goodyear on 07 Oct 16
     
    changes in progesterone metabolism associated with breast cancer i.e. 5alpha-pregnanes are associated with proliferation in breast cancer and the 4-pregnenes inhibit proliferation and cellular detachment.
Nathan Goodyear

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma | BMC Cancer | Full Text - 0 views

bmccancer.biomedcentral.com/...1471-2407-4-27

breast cancer cancer progesterone metabolites progesterone hormones 5alpha reductase 5alpha-pregnane 5 alpha reductase 4-pregnenes

shared by Nathan Goodyear on 07 Oct 16 - No Cached
  • Nathan Goodyear on 07 Oct 16
     
    Breast cell culture study finds increase 5alpha-reductase 1/2 activity and decreased 3alpha HSO.  This fits previous previous studies that show that increased 5alpha pregnanes is associated with increased proliferation and increased detachment; in contrast to decreased 4-pregnene metabolites.
Nathan Goodyear

http://ar.iiarjournals.org/content/28/4B/2129.full.pdf - 0 views

ar.iiarjournals.org/...2129.full.pdf

breast cancer progesterone metabolite metabolites 4-pregnene aromatase

shared by Nathan Goodyear on 23 Jan 14 - No Cached
  • Nathan Goodyear on 23 Jan 14
     
    20alpha dihydroprogesterone, a 4 pregnene, has been shown to inhibit breast cancer cell proliferation, decrease mets through increased cell adhesion, and increased apoptosis.  Here, it has been shown to inhibit aromatase activity.  No longer are hormone metabolites to be viewed as waste.  They are biological as active if not more so in many cases.
Nathan Goodyear

Metabolism of pregnenolone by human breast cancer. Evidence for 17α-hydroxylase and 17,20-lyase - 0 views

www.sciencedirect.com/...0039128X79900941

progesterone breast cancer metabolite metabolites pregnenolone

shared by Nathan Goodyear on 28 Jan 14 - No Cached
  • Nathan Goodyear on 28 Jan 14
     
    Study finds that breast cancer cells can make progesterone endogenously from pregnenolone.  
Nathan Goodyear

The dialectic role of progesterone - 0 views

www.sciencedirect.com/...S0378512208003927

progesterone metabolites metabolism progesterone metabolites hormone hormones breast cancer

shared by Nathan Goodyear on 18 Jun 14 - No Cached
  • Nathan Goodyear on 18 Jun 14
     
    Just the abstract available here.  Article states the complexity of hormones found in hormone metabolism.  I love the authors quote, "As steroid hormones are known to be converted to many other steroids occupying different receptors and thereby exerting various different effects..."  Doesn't fit into the "know your numbers" marketing deception does it?
Nathan Goodyear

Allopregnanolone, a progesterone metabolite, i... [Ann Emerg Med. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16546625

progesterone allopregnanolone hormone hormones brain neurology stroke

shared by Nathan Goodyear on 10 Jul 12 - No Cached
  • Nathan Goodyear on 10 Jul 12
     
    again an animal model; but progesterone and allopregnanolone shown to reduce brain damage.  Allopregnanolone was more effective in this animal model.
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