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Nathan Goodyear

Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery - NEJM - 0 views

www.nejm.org/...NEJMoa012908

diet weight loss overweight weight-loss surgery ghrelin bypass

shared by Nathan Goodyear on 26 Oct 11 - No Cached
  • Nathan Goodyear on 26 Oct 11
     
    "diets" and weight-loss surgery effect ghrelin diferently
Nathan Goodyear

Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers - 0 views

www.ncbi.nlm.nih.gov/...PMC1242151

cancer BRCA BRCA 1 BRCA 2 weight loss weight obesity women breast cancer

shared by Nathan Goodyear on 18 Sep 17 - No Cached
  • Nathan Goodyear on 18 Sep 17
     
    normal weight and weight loss in women 18-30 with BRCA1 decrease risk penetrance.
Nathan Goodyear

Subclinical Hypothyroidism, Weight Change, and Body Composition in the Elderly: The Car... - 0 views

press.endocrine.org/...jc.2013-3591

subclinical hypothyroidism weight elderly cardiovascular health

shared by Nathan Goodyear on 16 Apr 14 - No Cached
  • Nathan Goodyear on 16 Apr 14
     
    Study found no significant effect of subclinical hypothyroidism on weight in the elderly.  However, higher free T4 levels were associated with lower baseline weight and weight loss in women. TSH and free T3 were not. associated.
Nathan Goodyear

Bone Loss in Adolescents After Bariatric Surgery -- , 10.1542/peds.2010-0785d -- Pediat... - 0 views

pediatrics.aappublications.org/...peds.2010-0785dv1

weight loss surgery obesity bone

shared by Nathan Goodyear on 15 Apr 11 - No Cached
  • Nathan Goodyear on 15 Apr 11
     
    Weight loss surgery in teens results in bone loss; long-term implications is very poor
Nathan Goodyear

L-Arginine Potentiates Fat Loss ( May 2011) Townsend Letter for Doctors & Patients - 0 views

www.townsendletter.com/...exercise0511.html

L-Arginine fat loss weight obesity obese overweight

shared by Nathan Goodyear on 09 Jul 11 - No Cached
  • Nathan Goodyear on 09 Jul 11
     
    L-Arginine helps preserve muscle mass and increase fat loss.  This has enormous implications in maintaining weight loss long-term
Nathan Goodyear

Obesity - Abstract of article: Body Weight Loss and Weight Maintenance in Relation to H... - 0 views

www.nature.com/...oby2005142a.html

obesity weight-loss overweight oolong green tea fat oxidation

shared by Nathan Goodyear on 25 Nov 11 - No Cached
  • Nathan Goodyear on 25 Nov 11
     
    oolong green tea shown to work synergistically with caffeine to increase thermogenesis and fat oxidation resulting in weight loss.  Nature always seems to provide the right balance of chemicals to give the best results. 
Nathan Goodyear

Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian f... - 0 views

www.mendeley.com/...n-metabolic-factors-women-pcos

myo-inositol weight loss leptin insulin overweight

shared by Nathan Goodyear on 01 Jun 11 - No Cached
  • significant weight loss (and leptin reduction) (P < 0.01) was recorded in the myo-inositol group, whereas the placebo group actually increased weight
  • hese data support a beneficial effect of myo-inositol in women with oligomenorrhea and polycystic ovaries in improving ovarian function.
  • Nathan Goodyear on 01 Jun 11
     
    myo-inositol improves weight loss and leptin resistance through insulin secondary messenger
Nathan Goodyear

Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects - 0 views

www.amjmed.com/...abstract

alpha lipoic acid weight loss obesity

shared by Nathan Goodyear on 05 Apr 11 - No Cached
  • Alpha-lipoic acid 1800 mg/d led to a modest weight loss in obese subjects. Alpha-lipoic acid may be considered as adjunctive therapy for obesity.
  • Nathan Goodyear on 05 Apr 11
     
    alpha lipoic acid leads to weight loss in obese
Nathan Goodyear

ScienceDirect - American Psychologist : Medicare's Search for Effective Obesity Treatme... - 0 views

www.sciencedirect.com/...S0003066X07678289

Diet weight loss overweight health benefits

shared by Nathan Goodyear on 09 Jul 11 - No Cached
  • These studies show that one third to two thirds of dieters regain more weight than they lost on their diets, and these studies likely underestimate the extent to which dieting is counterproductive because of several methodological problems,
  • there is little support for the notion that diets lead to lasting weight loss or health benefits.
  • Nathan Goodyear on 09 Jul 11
     
    "diet' show no lasting benefit in weight loss and health benefits.  In fact, 66% of individuals weigh more than they started after 2 years.
Edgar Anderson

Successful Weight Loss Programme - 1 views

www.menuconcepts.com.au/dietitian.htm

shared by Edgar Anderson on 26 Mar 13 - No Cached
  • Edgar Anderson on 26 Mar 13
     
    Since I gained weight after I gave birth to my second baby, I started following some weight loss programmes and I even went to different gyms. But none of these really helped me. Good thing that I have learned about Menu Concepts. I then went to see one of their expert dieticians for a consultation and guidance in weight loss. And yes! The programme they gave me worked wonders. Now, I am enjoying my ideal weight. Thank you so much Menu Concepts! Succeed in getting your ideal weight! Call 08 8375 7040 Or visit http://www.menuconcepts.com.au/dietitian.htm
Nathan Goodyear

Testosterone and glucose metabolism in men: current concepts and controversies - 0 views

joe.endocrinology-journals.org/...R37.full

Low T Testosterone metabolic syndrome MetS Diabetes men male glucose hormone hormones g

shared by Nathan Goodyear on 04 Feb 14 - No Cached
  • Around 50% of ageing, obese men presenting to the diabetes clinic have lowered testosterone levels relative to reference ranges based on healthy young men
  • The absence of high-level evidence in this area is illustrated by the Endocrine Society testosterone therapy in men with androgen deficiency clinical practice guidelines (Bhasin et al. 2010), which are appropriate for, but not specific to men with metabolic disorders. All 32 recommendations made in these guidelines are based on either very low or low quality evidence.
  • A key concept relates to making a distinction between replacement and pharmacological testosterone therapy
  • ...59 more annotations...
  • The presence of symptoms was more closely linked to increasing age than to testosterone levels
  • Findings similar to type 2 diabetes were reported for men with the metabolic syndrome, which were associated with reductions in total testosterone of −2.2 nmol/l (95% CI −2.41 to 1.94) and in free testosterone
  • low testosterone is more predictive of the metabolic syndrome in lean men
  • Cross-sectional studies uniformly show that 30–50% of men with type 2 diabetes have lowered circulating testosterone levels, relative to references based on healthy young men
  • In a recent cross-sectional study of 240 middle-aged men (mean age 54 years) with either type 2 diabetes, type 1 diabetes or without diabetes (Ng Tang Fui et al. 2013b), increasing BMI and age were dominant drivers of low total and free testosterone respectively.
  • both diabetes and the metabolic syndrome are associated with a modest reduction in testosterone, in magnitude comparable with the effect of 10 years of ageing
  • In a cross-sectional study of 490 men with type 2 diabetes, there was a strong independent association of low testosterone with anaemia
  • In men, low testosterone is a marker of poor health, and may improve our ability to predict risk
    • Nathan Goodyear
      Nathan Goodyear on 04 Feb 14
       
      probably the most important point made in this article
  • low testosterone identifies men with an adverse metabolic phenotype
  • Diabetic men with low testosterone are significantly more likely to be obese or insulin resistant
  • increased inflammation, evidenced by higher CRP levels
  • Bioavailable but not free testosterone was independently predictive of mortality
  • It remains possible that low testosterone is a consequence of insulin resistance, or simply a biomarker, co-existing because of in-common risk factors.
  • In prospective studies, reviewed in detail elsewhere (Grossmann et al. 2010) the inverse association of low testosterone with metabolic syndrome or diabetes is less consistent for free testosterone compared with total testosterone
  • In a study from the Framingham cohort, SHBG but not testosterone was prospectively and independently associated with incident metabolic syndrome
  • low SHBG (Ding et al. 2009) but not testosterone (Haring et al. 2013) with an increased risk of future diabetes
  • In cross-sectional studies of men with (Grossmann et al. 2008) and without (Bonnet et al. 2013) diabetes, SHBG but not testosterone was inversely associated with worse glycaemic control
  • SHBG may have biological actions beyond serving as a carrier protein for and regulator of circulating sex steroids
  • In men with diabetes, free testosterone, if measured by gold standard equilibrium dialysis (Dhindsa et al. 2004), is reduced
    • Nathan Goodyear
      Nathan Goodyear on 04 Feb 14
       
      expensive, laborious process filled with variables
  • Low free testosterone remains inversely associated with insulin resistance, independent of SHBG (Grossmann et al. 2008). This suggests that the low testosterone–dysglycaemia association is not solely a consequence of low SHBG.
  • Experimental evidence reviewed below suggests that visceral adipose tissue is an important intermediate (rather than a confounder) in the inverse association of testosterone with insulin resistance and metabolic disorders.
  • testosterone promotes the commitment of pluripotent stem cells into the myogenic lineage and inhibits their differentiation into adipocytes
  • testosterone regulates the metabolic functions of mature adipocytes (Xu et al. 1991, Marin et al. 1995) and myocytes (Pitteloud et al. 2005) in ways that reduce insulin resistance.
  • Pre-clinical evidence (reviewed in Rao et al. (2013)) suggests that at the cellular level, testosterone may improve glucose metabolism by modulating the expression of the glucose-transported Glut4 and the insulin receptor, as well as by regulating key enzymes involved in glycolysis.
  • More recently testosterone has been shown to protect murine pancreatic β cells against glucotoxicity-induced apoptosis
  • Interestingly, a reciprocal feedback also appears to exist, given that not only chronic (Cameron et al. 1990, Allan 2013) but also, as shown more recently (Iranmanesh et al. 2012, Caronia et al. 2013), acute hyperglycaemia can lower testosterone levels.
  • There is also evidence that testosterone regulates insulin sensitivity directly and acutely
  • In men with prostate cancer commencing androgen deprivation therapy, both total as well as, although not in all studies (Smith 2004), visceral fat mass increases (Hamilton et al. 2011) within 3 months
  • More prolonged (>12 months) androgen deprivation therapy has been associated with increased risk of diabetes in several large observational registry studies
  • Testosterone has also been shown to reduce the concentration of pro-inflammatory cytokines in some, but not all studies, reviewed recently in Kelly & Jones (2013). It is not know whether this effect is independent of testosterone-induced changes in body composition.
  • the observations discussed in this section suggest that it is the decrease in testosterone that causes insulin resistance and diabetes. One important caveat remains: the strongest evidence that low testosterone is the cause rather than consequence of insulin resistance comes from men with prostate cancer (Grossmann & Zajac 2011a) or biochemical castration, and from mice lacking the androgen receptor.
  • Several large prospective studies have shown that weight gain or development of type 2 diabetes is major drivers of the age-related decline in testosterone levels
  • there is increasing evidence that healthy ageing by itself is generally not associated with marked reductions in testosterone
  • Circulating testosterone, on an average 30%, is lower in obese compared with lean men
  • increased visceral fat is an important component in the association of low testosterone and insulin resistance
  • The vast majority of men with metabolic disorders have functional gonadal axis suppression with modest reductions in testosterone levels
  • obesity is a dominant risk factor
  • men with Klinefelter syndrome have an increased risk of metabolic disorders. Interestingly, greater body fat mass is already present before puberty
  • Only 5% of men with type 2 diabetes have elevated LH levels
  • inhibition of the gonadal axis predominantly takes place in the hypothalamus, especially with more severe obesity
  • Metabolic factors, such as leptin, insulin (via deficiency or resistance) and ghrelin are believed to act at the ventromedial and arcuate nuclei of the hypothalamus to inhibit gonadotropin-releasing hormone (GNRH) secretion from GNRH neurons situated in the preoptic area
  • kisspeptin has emerged as one of the most potent secretagogues of GNRH release
  • hypothesis that obesity-mediated inhibition of kisspeptin signalling contributes to the suppression of the HPT axis, infusion of a bioactive kisspeptin fragment has been recently shown to robustly increase LH pulsatility, LH levels and circulating testosterone in hypotestosteronaemic men with type 2 diabetes
  • A smaller study with a similar experimental design found that acute testosterone withdrawal reduced insulin sensitivity independent of body weight, whereas oestradiol withdrawal had no effects
  • suppression of the diabesity-associated HPT axis is functional, and may hence be reversible
  • Obesity and dysglycaemia and associated comorbidities such as obstructive sleep apnoea (Hoyos et al. 2012b) are important contributors to the suppression of the HPT axis
  • weight gain and development of diabetes accelerate the age-related decline in testosterone
  • Modifiable risk factors such as obesity and co-morbidities are more strongly associated with a decline in circulating testosterone levels than age alone
  • 55% of symptomatic androgen deficiency reverted to a normal testosterone or an asymptomatic state after 8-year follow-up, suggesting that androgen deficiency is not a stable state
  • Weight loss can reactivate the hypothalamic–pituitary–testicular axis
  • Leptin treatment resolves hypogonadism in leptin-deficient men
  • The hypothalamic–pituitary–testicular axis remains responsive to treatment with aromatase inhibitors or selective oestrogen receptor modulators in obese men
  • Kisspeptin treatment increases LH secretion, pulse frequency and circulating testosterone levels in hypotestosteronaemic men with type 2 diabetes
  • change in BMI was associated with the change in testosterone (Corona et al. 2013a,b).
  • weight loss can lead to genuine reactivation of the gonadal axis by reversal of obesity-associated hypothalamic suppression
  • There is pre-clinical and observational evidence that chronic hyperglycaemia can inhibit the HPT axis
  • in men who improved their glycaemic control over time, testosterone levels increased. By contrast, in those men in whom glycaemic control worsened, testosterone decreased
  • testosterone levels should be measured after successful weight loss to identify men with an insufficient rise in their testosterone levels. Such men may have HPT axis pathology unrelated to their obesity, which will require appropriate evaluation and management.
  • Nathan Goodyear on 04 Feb 14
     
    Article discusses the expanding evidence of low T and Metabolic syndrome.
Nathan Goodyear

Inhibition of HCG-induced ovarian and uterine weig... [Proc Soc Exp Biol Med. 1976] - P... - 0 views

www.ncbi.nlm.nih.gov/...781690

HCG weight loss overweight obesity

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • HCG augmented weight gain
  • Nathan Goodyear on 21 Apr 11
     
    HCG weight gain used as a measurement to follow in study; again, no weight loss
Nathan Goodyear

Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet... - 0 views

ajpendo.physiology.org/...E906.full

L-Arginine weight loss diet overweight obesity insulin-resistant diabetic patients

shared by Nathan Goodyear on 09 Jul 11 - No Cached
  • L-arginine supplementation further decreased FM (P < 0.05) and waist circumference (P < 0.0001), preserving FFM (P < 0.03), and improved mean daily glucose profiles (P < 0.0001) and fructosamine (P < 0.03). Moreover, change in area under the curve of cGMP (second messenger of nitric oxide; P < 0.001), superoxide dismutase (index of antioxidant capacity; P < 0.01), and adiponectin levels (P < 0.02) increased, whereas basal endothelin-1 levels (P < 0.01) and leptin-to-adiponectin ratio (P < 0.05) decreased in the L-arginine group.
  • Nathan Goodyear on 09 Jul 11
     
    L-Arginine helps to preserve muscle, while increase fat loss.  This will help to prevent fat rebound in weight loss programs.  Additionally, insulin resistance improved.
Nathan Goodyear

ScienceDirect.com - Biochemical Pharmacology - CARBOXYLESTERASE-2 IS A HIGHLY SENSITIVE... - 0 views

www.sciencedirect.com/...S0006295212007678

Alli xenical toxicity orlistat weight loss drugs weight loss drugs

shared by Nathan Goodyear on 11 Dec 12 - No Cached
  • Nathan Goodyear on 11 Dec 12
     
    popular weight loss drug Alli linked to liver, pancreatic, and kidney toxicity.
anonymous

Weight Loss Advice - 0 views

weightlossadvicess.blogspot.com/...weight-loss-advice.html

weight-loss fat-burning nutrition muscle-building supplements workouts fitness diet recipes beauty cardio fitness-equipment motivation

shared by anonymous on 06 Jun 13 - No Cached
  • Weight Loss, Fat Burning, Nutrition, Muscle Building, Supplements, Workouts,Fitness, Diet, Recipes, Beauty, Cardio, Fitness Equipment, Motivation
Nathan Goodyear

A Review of Very Low Carbohydrate Diets for Weight Loss - 0 views

www.turner-white.com/...jcom_jul99_lowcarb.pdf

low carb low carbohydrates diet weight loss overweight obesity

shared by Nathan Goodyear on 08 Feb 13 - No Cached
  • Nathan Goodyear on 08 Feb 13
     
    Low carb diets result in significant weight loss. This is a meta-analysis.
Nathan Goodyear

Effects of weight loss on leptin, sex hormones, and measures of adiposity in obese chil... - 0 views

www.ncbi.nlm.nih.gov/...11444441

leptin hormones fat obesity weight-loss Testosterone male hormones

shared by Nathan Goodyear on 04 Feb 17 - No Cached
  • Nathan Goodyear on 04 Feb 17
     
    weight loss decreases leptin in boys and the result is an increase in Testosterone
Nathan Goodyear

Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue o... - 0 views

jcem.endojournals.org/...3338.full

weight loss overweight obesity adipose tissue adipocytes IL-6 leptin inflammation

shared by Nathan Goodyear on 15 Mar 12 - No Cached
  • Nathan Goodyear on 15 Mar 12
     
    weight loss resulted in reduction in IL-6 and leptin.  The reduction of IL-6 reflects a decrease in inflammation. The reduction in leptin reflects an improved leptin sensitivity.
Nathan Goodyear

Reduced-Calorie Dietary Weight Loss, Exercise, and Sex Hormones in Postmenopausal Women... - 0 views

jco.ascopubs.org/...JCO.2011.37.9792.abstract

obesity obese overweight weight-loss aromatase breast cancer testosterone estradiol estrogen hormones women

shared by Nathan Goodyear on 22 May 12 - No Cached
  • Nathan Goodyear on 22 May 12
     
    Not surprising, but nice to see in study.  Dr. McTiernan showed that weight loss as little as 5% reduces breast cancer risk.  The reason?  Decreased Testosterone production in women due to insulin resistance and decreased fat for aromatase conversion of Testosterone to Estradiol and decreased androstenedione to estrone.  This study confirms the importance of the obesity epidemic to health.
Nathan Goodyear

FDA says HCG weight-loss products are illegal - - CNN.com Blogs - 0 views

thechart.blogs.cnn.com/...-weight-loss-drugs-are-illegal

FDA HCG natural calorie-restriction

shared by Nathan Goodyear on 10 Dec 11 - No Cached
  • Nathan Goodyear on 10 Dec 11
     
    I agree with the fact that studies have not shown HCG helps with weight loss in addition to the 500 cal diet. We have many studies in diigo supporting this.  However, the FDA is stepping out of its authorized scope.  
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