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Nathan Goodyear

Nutrition Care for Patients with Weight Regain after Bariatric Surgery - 0 views

www.hindawi.com/...256145

bariatric surgery weight loss surgery obesity obese weight loss nutrition

shared by Nathan Goodyear on 05 Mar 15 - No Cached
  • Nathan Goodyear on 05 Mar 15
     
    Bariatric surgery has a regain of 25-30% of weight loss and a 25% failure to achieve successful weight loss.
Nathan Goodyear

Dietary Weight Loss and Exercise Effects on Serum Biomarkers of Angiogenesis in Overwei... - 0 views

cancerres.aacrjournals.org/...4226

overweight obese inflammation exercise weight loss cancer diet nutrition VEGF PEDF PAI-1

shared by Nathan Goodyear on 19 Jul 16 - No Cached
  • Nathan Goodyear on 19 Jul 16
     
    only abstract available here.  Weight loss, through diet and exercise, decreased proteins important to tumor angiogenesis; thus weight loss associated with a reduction in VEGF, PEDF, and PAI-1 may reduce cancer risk, particularly in the overweight and obese. This is all the result of inflammation originating from obesity.
Nathan Goodyear

Effect of the Mediterranean diet with and without weight loss on markers of inflammatio... - 0 views

www.ncbi.nlm.nih.gov/...23505168

inflammation nutrition mediterranean diet CRP IL-6 TNF-alpha weight loss diet

shared by Nathan Goodyear on 27 Oct 15 - No Cached
  • Nathan Goodyear on 27 Oct 15
     
    Mediterranean diet plus weight loss results in a greater decrease in inflammation compared to weight loss alone.
fnfdoc

Habits That Ruin Your Weight Loss Plan | Health Blog - 0 views

fnfdoc.com/...its-ruin-your-weight-loss-plan

Weight Loss Plan Habits Diet Binge Eating

shared by fnfdoc on 19 Sep 18 - No Cached
  • fnfdoc on 19 Sep 18
     
    Some Habits That Ruin Your Weight Loss Plan. Although we may follow a strict diet plan and hit the gym.., sometimes it becomes nearly impossible to get rid of those extra pounds... The problem lies with the seemingly harmless everyday habits that we have nurtured over the years and...
  • fnfdoc on 19 Sep 18
     
    While most of us are aware that eating cheesy sausages every day for breakfast is not really good for the waistline, there are many other subtle bad habits that keep on adding more pounds to our bodies. These habits are harmful because they have the potential to sabotage our weight loss plan.
Pursuit Of Healthy Living

Find the Best Holistic Weight Loss Program in Ladysmith BC - 1 views

medium.com/...m-in-ladysmith-bc-7330f08528b5

Holistic Health Natural Health Holistic Weight loss Weight loss

shared by Pursuit Of Healthy Living on 20 Sep 18 - No Cached
  • Pursuit Of Healthy Living on 20 Sep 18
     
    Holistic Weight Loss is the next big thing in Health industry. Check out 6 Tips for gaining Holistic Weight Loss as suggested by a Natural Health Practitioner from Ladysmith BC Credits: Reflectiens.com (Holistic Healthcare in Ladysmith BC)
Nathan Goodyear

Testosterone and glucose metabolism in men: current concepts and controversies - 0 views

joe.endocrinology-journals.org/...R37.full

shared by Nathan Goodyear on 04 Feb 14 - No Cached
    • Nathan Goodyear
      Nathan Goodyear on 04 Feb 14
       
      80% of E2 production in men, that will cause low T in men, comes from SQ adiposity.  This leads to increase in visceral adiposity.
  • Only 5% of men with type 2 diabetes have elevated LH levels (Dhindsa et al. 2004, 2011). This is consistent with recent findings that the inhibition of the gonadal axis predominantly takes place in the hypothalamus, especially with more severe obesity
  • Metabolic factors, such as leptin, insulin (via deficiency or resistance) and ghrelin are believed to act at the ventromedial and arcuate nuclei of the hypothalamus to inhibit gonadotropin-releasing hormone (GNRH) secretion
  • ...32 more annotations...
  • kisspeptin has emerged as one of the most potent secretagogues of GNRH release
  • Consistent with the hypothesis that obesity-mediated inhibition of kisspeptin signalling contributes to the suppression of the HPT axis, infusion of a bioactive kisspeptin fragment has been recently shown to robustly increase LH pulsatility, LH levels and circulating testosterone in hypotestosteronaemic men with type 2 diabetes
  • Figure 4
  • Interestingly, a recent 16-week study of experimentally induced hypogonadism in healthy men with graded testosterone add-back either with or without concomitant aromatase inhibitor treatment has in fact suggested that low oestradiol (but not low testosterone) may be responsible for the hypogonadism-associated increase in total body and intra-abdominal fat mass
    • Nathan Goodyear
      Nathan Goodyear on 04 Feb 14
       
      This does not fit with the research on receptors, specifically estrogen receptors.  These studies that the authors are referencing are looking at "circulating" levels, not tissue levels.
  • A smaller study with a similar experimental design found that acute testosterone withdrawal reduced insulin sensitivity independent of body weight, whereas oestradiol withdrawal had no effects
  • Obesity and dysglycaemia and associated comorbidities such as obstructive sleep apnoea (Hoyos et al. 2012b) are important contributors to the suppression of the HPT axis
  • This is supported by observational studies showing that weight gain and development of diabetes accelerate the age-related decline in testosterone
  • Weight loss can reactivate the hypothalamic–pituitary–testicular axis
  • The hypothalamic–pituitary–testicular axis remains responsive to treatment with aromatase inhibitors or selective oestrogen receptor modulators in obese men
  • Kisspeptin treatment increases LH secretion, pulse frequency and circulating testosterone levels in hypotestosteronaemic men with type 2 diabetes
  • Several observational and randomised studies reviewed in Grossmann (2011) have shown that weight loss, whether by diet or surgery, leads to substantial increases in testosterone, especially in morbidly obese men
  • This suggests that weight loss can lead to genuine reactivation of the gonadal axis by reversal of obesity-associated hypothalamic suppression
  • There is pre-clinical and observational evidence that chronic hyperglycaemia can inhibit the HPT axis
  • in those men in whom glycaemic control worsened, testosterone decreased
  • successful weight loss combined with optimisation of glycaemic control may be sufficient to normalise circulating testosterone levels in the majority of such men
  • weight loss, optimisation of diabetic control and assiduous care of comorbidities should remain the first-line approach.
    • Nathan Goodyear
      Nathan Goodyear on 04 Feb 14
       
      This obviously goes against marketing-based medicine
  • In part, the discrepant results may be due to the fact men in the Vigen cohort (Vigen et al. 2013) had a higher burden of comorbidities. Given that one (Basaria et al. 2010), but not all (Srinivas-Shankar et al. 2010), RCTs in men with a similarly high burden of comorbidities reported an increase in cardiovascular events in men randomised to testosterone treatment (see section on Testosterone therapy: potential risks below) (Basaria et al. 2010), testosterone should be used with caution in frail men with multiple comorbidities
  • The retrospective, non-randomised and non-blinded design of these studies (Shores et al. 2012, Muraleedharan et al. 2013, Vigen et al. 2013) leaves open the possibility for residual confounding and multiple other sources of bias. These have been elegantly summarised by Wu (2012).
  • Effects of testosterone therapy on body composition were metabolically favourable with modest decreases in fat mass and increases in lean body mass
  • This suggests that testosterone has limited effects on glucose metabolism in relatively healthy men with only mildly reduced testosterone.
  • it is conceivable that testosterone treatment may have more significant effects on glucose metabolism in uncontrolled diabetes, akin to what has generally been shown for conventional anti-diabetic medications.
  • the evidence from controlled studies show that testosterone therapy consistently reduces fat mass and increases lean body mass, but inconsistently decreases insulin resistance.
  • Interestingly, testosterone therapy does not consistently improve glucose metabolism despite a reduction in fat mass and an increase in lean mass
  • the majority of RCTs (recently reviewed in Ng Tang Fui et al. (2013a)) showed that testosterone therapy does not reduce visceral fat
    • Nathan Goodyear
      Nathan Goodyear on 04 Feb 14
       
      visceral and abdominal adiposity are biologically different and thus the risks associated with the two are different.
    • Nathan Goodyear
      Nathan Goodyear on 04 Feb 14
       
      yet low T is associated with an increase in visceral adiposity--confusing!
  • testosterone therapy decreases SHBG
  • testosterone is inversely associated with total cholesterol, LDL cholesterol and triglyceride (Tg) levels, but positively associated with HDL cholesterol levels, even if adjusted for confounders
  • Although observational studies show a consistent association of low testosterone with adverse lipid profiles, whether testosterone therapy exerts beneficial effects on lipid profiles is less clear
  • Whereas testosterone-induced decreases in total cholesterol, LDL cholesterol and Lpa are expected to reduce cardiovascular risk, testosterone also decreases the levels of the cardio-protective HDL cholesterol. Therefore, the net effect of testosterone therapy on cardiovascular risk remains uncertain.
  • data have not shown evidence that testosterone causes prostate cancer, or that it makes subclinical prostate cancer grow
  • compared with otherwise healthy young men with organic androgen deficiency, there may be increased risks in older, obese men because of comorbidities and of decreased testosterone clearance
  • recent evidence that fat accumulation may be oestradiol-, rather than testosterone-dependent
Abdullah Kul

Phen375 Phentemine Fat Burner - 0 views

track.moreniche.com/hit.php

Weight Loss

shared by Abdullah Kul on 05 Oct 13 - No Cached
  • Abdullah Kul on 05 Oct 13
     
    Phen375 is a pharmacy grade food supplement with diet program included - both extensive diet plans and exercise video instructions. It is great choice for people who look for that extra to help them with losing weight and getting motivation. Phen375 is food supplement and would greatly compliment your existing weight loss and dieting promotions (especially those attracting American search traffic). Why to promote Phen375 - Most paying weight loss sector merchant - One of highest EPC amongst diet products - Most profitable merchant for the affiliates in 2011, 2012 and 2013 - Reorder ratios ranging between 21- 33% - Top range conversion rates Phen375 offers highly converting website, ensuring you get highest return possible on your traffic. Also you will find wealth of resources, such as articles, product images and banners to help with your promotions. Also if you have any questions or need help with promotions, please contact Phen375's dedicated affiliate manager - Catherine Day. You can see her details on the right.
Nathan Goodyear

Weight changes, sodium levels, and performance in the South African... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12466696

endurance athletes Ironman triathlon sodium body weight

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • Nathan Goodyear on 27 Jan 15
     
    Body weight post race was inversely associated with serum sodium i.e.  less weight loss was associated with lower serum sodium.  Body weight loss was unrelated to marathon time.
Nathan Goodyear

Effect of a High Protein Weight Loss Diet on Weight, High-Sensitivity C-Reactive Protei... - 0 views

www.hindawi.com/...971724

weight loss overweight obesity weight loss CRP protein diet

shared by Nathan Goodyear on 07 Aug 13 - No Cached
  • Nathan Goodyear on 07 Aug 13
     
    This study concludes that a energy restricted, high protein diet is more effective at weight loss than just a high protein diet.  There were also positive impacts on blood pressure, glucose, cholesterol, and hsCRP.
Nathan Goodyear

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-l... - 0 views

www.thelancet.com/...fulltext

obesity type 2 diabetes type II diabetes calorie restriction nutrition weight loss diet

shared by Nathan Goodyear on 11 Dec 17 - No Cached
  • Nathan Goodyear on 11 Dec 17
     
    study finds very low calorie diet reversed diabetes. The greatest weight loss was associated with greatest remission of diabetes at 86% with >15 kg weight loss.
Nathan Goodyear

TSH and free triiodothyronine concentrations are associated with weight loss in a lifes... - 0 views

www.eje-online.org/...323.abstract

free T3 T3 overweight obesity weight loss children

shared by Nathan Goodyear on 05 Mar 13 - No Cached
  • Nathan Goodyear on 05 Mar 13
     
    weight loss in obese children with low TSH and free T3 indicates high risk or regain of weight.  The important value here is the free T3.
Nathan Goodyear

Seasonality of reproductive function and weight loss in rural Nepali women - 0 views

humrep.oxfordjournals.org/...684.short

progesterone hormone hormones saliva salivary testing test evaluation BHRT weight weight loss

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    weight loss shown to have hormone component.  Decreasing progesterone associated with weight gain.  Saliva progesterone used to follow women in this study.
Nathan Goodyear

Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6... - 0 views

onlinelibrary.wiley.com/...abstract

metabolic syndrome metabolic syndrome low T Testosterone obesity overweight weight loss SHBG RBP4 men male hormones

shared by Nathan Goodyear on 13 Mar 14 - No Cached
  • Nathan Goodyear on 13 Mar 14
     
    Interesting study finds that men with low serum Total Testosterone, elevated RBP4 and low SHBG at baseline predict weight regain.  Thus Testosterone should be used as a biomarker of failure in weight loss and if low, Testosterone therapy should be employed to improved metabolic function.  Other parameters, such as leptin, adiponectin, prolactin, progesterone...were not predictive.
Nathan Goodyear

Benefits of Modest Weight Loss in Improving Cardiovascular Risk Factors in Overweight a... - 0 views

care.diabetesjournals.org/...1481.full

weight weight loss loss diabetes overweight individuals cardiovascular factors

shared by Nathan Goodyear on 30 Mar 12 - No Cached
  • Nathan Goodyear on 30 Mar 12
     
    Weight loss of just 5% reduced cardiovascular disease risk.  Lifestyle interventions are still some of the best treatment options available for many chronic diseases of aging. 
Nathan Goodyear

Reduction of Inflammatory Cytokine Concentrations and Improvement of Endothelial Functi... - 0 views

circ.ahajournals.org/...804

obesity overweight visceral adiposity adipose tissue cytokines adipocytokines TNF-alpha IL-6 P-selectin ICAM-1 VCAM-1 CVD cardiovascular disease weight loss weight loss

shared by Nathan Goodyear on 30 Mar 12 - No Cached
  • Nathan Goodyear on 30 Mar 12
     
    adipose tissue releases inflammatory markers (cytokines IL-6, TNF-alpha, V-CAM-1, ICAM-1, and P-selectin). Associated endovascular disfunction and eventually cardiovascular disease.  A direct link between obesity induced inflammation and endovascular dysfunction.  Weight loss in these obese women reduced secretion of the associated inflammatory cytokines and thus decreased vascular dysfunction.
Nathan Goodyear

JAMA Network | JAMA: The Journal of the American Medical Association | Effects of Dieta... - 0 views

jama.jamanetwork.com/article.aspx

low carb low carbohydrate diet calories overweight obesity weight-loss energy

shared by Nathan Goodyear on 27 Jun 12 - No Cached
  • Nathan Goodyear on 27 Jun 12
     
    small study shows that low carb results in greater calories burned in weight loss.  The least calories burned goes to low fat diet.  Many, many studies have show the negative benefits of a low fat diet.
Nathan Goodyear

Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet - NEJM - 0 views

www.nejm.org/...NEJMoa0708681

weight weight loss mediterranean loss diet overweight obesity

shared by Nathan Goodyear on 20 Dec 11 - No Cached
  • Nathan Goodyear on 20 Dec 11
     
    mediterranean and low-carb diets are effective diets to aid weight loss
Nathan Goodyear

Testosterone Levels Increase 50% with Weight Loss, Exercise - 0 views

www.diabetesincontrol.com/...e-50-with-weight-loss-exercise

low T Testosterone weight loss obesity men male hormone hormones

shared by Nathan Goodyear on 14 May 14 - No Cached
  • Nathan Goodyear on 14 May 14
     
    Weight loss increases Testosterone levels.  This author points to low Testosterone as merely a biomarker of poor health.  In some this is correct, but Testosterone can have significant positive effects.
Nathan Goodyear

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind... - 0 views

press.endocrine.org/...jc.2011-1329

T4 T3 hypothyroid hypothyroidism thyroid lipids weight loss metabolism cholesterol hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • tissue euthyroidism is the net result of multiple steps including conversion of the prohormone T4 into its active metabolite T3, which is ultimately responsible for signaling at the end-organ target level
  • The circulating and intracellular pools of T3 of treated hypothyroid patients (i.e. devoid of endogenous TH production) depend entirely on the conversion of exogenous l-T4 into T3
  • TH is the major regulator of basal metabolic rate
  • ...8 more annotations...
  • The substitution of l-T3 for l-T4 caused a significant weight loss
  • The substitution of l-T3 for l-T4 caused a significant reduction in lipid parameters
  • TH action is increased in the liver, and the SHBG increase supports this hypothesis
  • The changes in serum lipid metabolism parameters are similar to the effects observed with drugs approved for the treatment of dyslipidemia
  • This differential response appears to be limited to the lipid metabolism and SHBG, whereas no differences in indices of insulin resistance were detected. This is remarkable because hyperthyroid states are associated with an increase in hepatic gluconeogenesis (37), and overt thyrotoxicosis is a known cause of secondary diabetes.
  • Despite the increase in serum T3, the l-T3 treatment did not cause major changes in cardiovascular or musculoskeletal function, as indicated by the echocardiographic and maximal exercise tolerance tests and DXA studies.
  • Similarly, no significant differences were observed in blood pressure, heart rate, or endothelial vascular function
  • In conclusion, the results of this pharmacology, proof-of-concept study indicate that replacement therapy of hypothyroidism with l-T3, compared with l-T4 causes weight loss and favorable changes in the lipid profile without appreciable side effects
  • Nathan Goodyear on 24 Sep 14
     
    Crossover study finds T3 versus T4 results in more weight loss, improved lipid management and increased SHBG without any adverse cardiovascular effects.   The T3 was dosed 3 x daily due to its short half life compared to T4.
Nathan Goodyear

Human chorionic gonadotrophin and weight loss. A d... [S Afr Med J. 1990] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...2405506

HCG human chorionic gonadotrophin weight loss obesity

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • Subjects receiving HCG injections showed no advantages over those on placebo in respect of any of the variables recorded.
  • weight loss on our diet was similar to that on severely restricted intake
  • We conclude that there is no rationale for the use of HCG injections in the treatment of obesity.
  • Nathan Goodyear on 21 Apr 11
     
    HCG versus diet alone shows no difference in weight loss
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