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Nathan Goodyear

Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumat... - 0 views

  • The changes in SPECT images after treatment indicate that HBOT led to reactivation of neuronal activity in stunned areas that seemed normal under CT and MRI imaging. While SPECT imaging has a limited spatial resolution (compared, for example, to fMRI), the changes in activity were sufficiently robust to be clearly detected by the SPECT images.
  • HBOT might initiate a cellular and vascular repair mechanism and improve cerebral vascular flow
  • HBOT induces regeneration of axonal white matter [61], [62], [63], [64], has positive effect upon the myelinization and maturation of injured neural fibers [65], and can stimulate axonal growth and increase the ability of neurons to function and communicate with each other
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  • HBOT was found to have a role in initiation and/or facilitation of angiogenesis and cell proliferation processes needed for axonal regeneration [67].
  • The observed reactivation of neuronal activity in the stunned areas found here, along with similar results in post-stroke patients
  • At the cellular level, HBOT can improve cellular metabolism, reduce apoptosis, alleviate oxidative stress and increase levels of neurotrophins and nitric oxide through enhancement of mitochondrial function (in both neurons and glial cells)
  • HBOT may promote the neurogenesis of endogenous neural stem cells
  • With regard to secondary injury mechanisms in mTBI, HBOT can initiate vascular repair mechanism and improve cerebral vascular flow [58], [59], [68], [69], promote blood brain barrier integrity and reduce inflammatory reactions [28] as well as brain edema
  • It might be possible that HBOT enables the metabolic change simply by supplying the missing energy/oxygen needed for those regeneration processes.
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    Hbot therapy, according to study, induces neuroplasticity and improves brain function in post concussion syndrome and those with mTBI.  The important point about this study was that the study was done years after the injury; what if the therapy was employed immediately after...
Nathan Goodyear

Quercetin Reduces Inflammatory Responses in LPS-Stimulated Cardiomyoblasts - 0 views

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    Quercetin lowers LPS levels
Nathan Goodyear

Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms: Expert... - 0 views

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    Statins cause atherosclerosis, not reverse it.  New study describes the mechanism.
Nathan Goodyear

Progesterone-induced stimulation of mammary tumorigenesis is due to the proge... - 0 views

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    5 alpha reductase inhibitor, finasteride inhibits pro-tumor progesterone metabolite pathway.
Nathan Goodyear

Chemotherapy-generated cell debris stimulates colon carcinoma tumor growth via osteopontin - 0 views

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    Chemotherapy induces metastasis of primary colon cancer via inflammatory reaction from cell die off.
spineneuro

Dr Paresh Doshi Helps Creating Guidelines for Neurodegenerative Disorders - 0 views

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    Dr. Paresh Doshi top neurosurgeon at Jaslok Hospital Mumbai outlines best practices in the control of these difficult-to-treat disorders.
Nathan Goodyear

Targeted near infrared hyperthermia combined with immune stimulation for optimized ther... - 0 views

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    Quercetin inhibits HSP70 and improves efficacy of HT in thyroid cancer in vitro and in vivo studies.
Nathan Goodyear

Ozone therapy: A clinical review - 0 views

  • Its basic function is to protect humans from harmful effects of UV radiation
  • Its effects are proven, consistent and with minimal side effects
  • Medical O3, used to disinfect and treat disease, has been around for over 150 years
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  • O3 not only remedied infection, but also had hemodynamic and anti-inflammatory properties
  • Stimulation of oxygen metabolism
  • In fungi, O3 inhibits cell growth at certain stages
  • With viruses, the O3 damages the viral capsid and upsets the reproductive cycle by disrupting the virus-to-cell contact with peroxidation.
  • Inactivation of bacteria, viruses, fungi, yeast and protozoa: Ozone therapy disrupts the integrity of the bacterial cell envelope through oxidation of the phospholipids and lipoproteins
  • Activation of the immune system
  • 30 and 55 μg/cc
  • production of interferon and the greatest output of tumor necrosis factor and interleukin-2
  • Mechanism of action of O3 on the human lung
  • cascade of reactions like peroxidation of lipids leading to changes in membrane permeability,[41] lipid ozonation products (LOP) act as signal transducer molecules
  • Dietary antioxidants or free radical scavengers like vitamin E, C, etc., can prevent aforementioned effects of O3
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    Ozone therapy review
spineneuro

Discover the Expertise of Dr. Paresh Doshi at Jaslok Hospital Mumbai - 0 views

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    Top neurosurgeon at Jaslok Hospital Mumbai provides comprehensive, superior quality, cutting edge, specialty care in a compassionate and efficient manner. Over 90% success rate is achieved on patients suffering from Parkinson's disease by Dr. Paresh Doshi.
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