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wheelchairindia9

Folding Power Wheelchair - 0 views

disabilityproduct.in/...POWER-WHEELCHAIR

Power wheelchair Convenient For Disabled People direction by a joystick sort Folding Power Wheelchair transport for elder people allows moving freely karma power wheelchair kp-10.3

shared by wheelchairindia9 on 10 Sep 15 - No Cached
  • wheelchairindia9 on 10 Sep 15
     
    GM LITE POWER WHEELCHAIR GM Lite Brushless Power Wheelchair with Batteries is a revolutionary light weight power wheelchair using brushless motor. It is the most economic power wheelchair without sacrificing safety & durability. The wheelchair promotes pressure redistribution, reduces downward sliding and helps maintain good posture. Specifications: 10 times longer life Lightest - 23 kg 5 year long life, safe LiFePO4 battery (10ah) High efficiency brushless hub motor 5 seconds folding and unfolding Easy to carry Load : 120 kg Speed : 8km/hr Range: 15 km Slope : 12% 24V180W brushless 8-inch gear hub motor
Nathan Goodyear

A potential role of endogenous progesterone in mod... [Clin Endocrinol (Oxf). 2009] - P... - 0 views

www.ncbi.nlm.nih.gov/...19222493

progesterone HGH human growth hormone

shared by Nathan Goodyear on 20 May 11 - No Cached
  • These data also suggest that endogenous progesterone could play a modulation role on pituitary hormone secretion, stimulating GH and PRL release and enhancing the inhibitory action of sleep on TSH secretion.
  • normally cycling young women, daytime GH and PRL secretions are increased in luteal phase
  • Nathan Goodyear on 20 May 11
     
    normal luteal progesterone production stimulate HGH release
Nathan Goodyear

The role of lactate in the exercise-induced human growth hormone response: evidence fro... - 0 views

bjsm.bmj.com/...521.abstract

exercise induces HGH release

shared by Nathan Goodyear on 20 May 11 - No Cached
  • Nathan Goodyear on 20 May 11
     
    passing lactate threshold in exercise stimulates HGH release Evidence supported by following people with McArdle disease
Nathan Goodyear

Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibrobla... - 0 views

www.ncbi.nlm.nih.gov/...PMC3478457

warburg effect Cancer cancer associated fibroblasts CAFs reverse warburg effect lactate aerobic glycolysis mitochondria oxidative stress ROS H2O2

shared by Nathan Goodyear on 11 Nov 14 - No Cached
  • L-lactate functions as an onco-metabolite, stimulating mitochondrial biogenesis and OXPHOS in adjacent cancer cells, directly providing energy for tumor growth
  • Oxidative stress in stromal fibroblasts then induces their metabolic conversion into cancer-associated fibroblasts. Such oxidative stress drives the onset of autophagy, mitophagy, and aerobic glycolysis in fibroblasts, resulting in the local production of high-energy mitochondrial fuels (such as L-lactate, ketone bodies, and glutamine). These recycled nutrients are then transferred to cancer cells, where they are efficiently burned via oxidative mitochondrial metabolism (OXPHOS)
  • stromal L-lactate serves as a high-energy mitochondrial “fuel” for cancer cells. We have termed this new model of cancer metabolism “Two-Compartment Tumor Metabolism”, where two opposing metabolic compartments co-exist, side-by-side, with stromal glycolysis fueling OXPHOS in cancer cells
  • ...10 more annotations...
  • Two-Compartment Tumor Metabolism
  • Reverse Warburg Effect”, is that catabolic fibroblasts should promote tumor growth, without any increases in angiogenesis
  • when cancer cells use L-lactate as a mitochondrial fuel source, this metabolic phenotype is a predictor of lethal cancer metabolism
  • tumor microenvironment is intimately involved in tumor development and progression
  • mitochondrial dysregulation is likely the “root cause” of several human disease(s), and especially epithelial cancers
  • Both in vitro and in vivo studies have now provided convincing evidence that “activated” stromal fibroblasts, a.k.a., myofibroblasts, may play a critical role in initiating tumor recurrence, via paracrine interactions with adjacent tumor epithelial cells
  • A new hypothesis is that cancer is not a cell autonomous disease, but rather a disease of the tumor microenvironment
  • cancer cells behave as metabolic parasites, by inducing oxidative stress in adjacent normal fibroblasts
  • recent experimental evidence indicates that cancer-associated fibroblasts have a catabolic phenotype, and undergo autophagy and mitophagy, resulting in the onset of glycolytic metabolism, driving L-lactate production, and its release into the tumor microenvironment
  • oncogenic mutations in cancer cells lead to ROS production and the “secretion” of hydrogen peroxide species
  • Nathan Goodyear on 11 Nov 14
     
    A good discussion of what is proposed the Reverse Warburg effect.  A process by which the local environment dictates tumor progression.  The cancer cells release ROS primarily in the form of H2O2 and this leads to Cancer Associated Fibroblasts (CAFs) in the stroma.  The altered stromal environment increases ROS further and promotes ocogenic metabolites through the classic Warburg effect.  This high lactate production from the CAFs then is used by the cancer cells via classic oxidative phosphorylation.  Complex, beautiful and still an the understanding is a work in progress.   This study/article points to the importance of oxidative stress in some cancer development through CAFs.
Nathan Goodyear

Immunotherapy targets metastatic breast cancer-cell mutations - National Cancer Institute - 0 views

www.cancer.gov/...gets-breast-cancer-case-report

immunotherapy cancer tumor-infiltrating lymphocytes TILs

shared by Nathan Goodyear on 08 Jun 18 - No Cached
  • Nathan Goodyear on 08 Jun 18
     
    This is simply a press release from the NCI, but it highlights the move to immunotherapy as the future of cancer therapy.
Nathan Goodyear

Hyperthermia as an immunotherapy strategy for cancer - 1 views

www.ncbi.nlm.nih.gov/...PMC2828267

cancer hyperthermia

shared by Nathan Goodyear on 29 Nov 18 - No Cached
  • the notion of treating human cancers with heat dates back to the writings of Hippocrates
  • enhance the efficiency of standard cancer therapies, such as chemotherapy and radiation treatment
  • After antigen uptake at tumor sites, APCs have the ability to create a robust response by entering lymphoid compartments and programming lymphocytes
  • ...36 more annotations...
  • Hyperthermia differs fundamentally from fever in that it elevates the core body temperature without changing the physiological set point
  • hyperthermia is induced by increasing the heat load and/or inactivating heat dissipation
  • mor cells [2]. Although significant cell killing could be achieved by heating cells or tissues to temperatures > 42°C for 1 or more hours, the application, measurement and consistency of this temperature range within the setting of cancer clinical trials
  • mild temperature hyperthermia (ie, within the fever-range, 39–41°C)
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      101.2 to 105.8
  • moderate hyperthermia (41°C)
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      105.8 F
  • Hsps are a family of stress-induced proteins
  • they are key regulators of cellular protein activity, turnover and trafficking
  • Hsps ensure appropriate post-translational protein folding, and are able to refold denatured proteins, or mark irreversibly damaged proteins for destruction
  • the ability of fever-range hyperthermia to induce reactive immunity against tumor antigens through DCs and NK-cells is likely mediated by Hsps
  • thermotolerance
  • Hsps support the malignant phenotype of cancer cells by not only affecting the cells’ survival, but also participating in angiogenesis, invasion, metastasis and immortalization mechanisms
  • Hsps released from stressed or dying cells activate dendritic cells (DCs), transforming them into mature APCs
  • In theory, fever-range hyperthermia may take advantage of tumor cell Hsps by inducing their release from tumor cells and augmenting DC priming against tumor antigens
  • In several models of hyperthermia, heat-treated tumors exhibited improved DC priming and generation of systemic immunity to tumor cell
  • hyperthermia alone can enhance antigen display by tumor cells, thus rendering them even more susceptible to programmed immune clearance
  • Fever-range hyperthermia may also induce Hsps
  • Hsps may exert an adjuvant effect by bolstering MHC class II and co-stimulatory molecule expression by DCs
  • thermal ablation of liver tumors in particular has demonstrated an ability to potentiate immune responses [57, 58] and elicit robust T-cell infiltrates at ablation sites
  • specific Hsp, Hsp70, directly inhibits apoptosis pathways in cancer cells, as demonstrated in human pancreatic, prostate and gastric cancer cells
  • Cross-priming is the ability of extracellular Hsps complexed to tumor peptides to be internalized and presented in the context of MHC class I molecules on APCs, thus allowing potent priming of CTLs against tumor antigens
  • It has been reported that Hsps are generated from necrotic tumor cell lysates, but not from tumor cells undergoing apoptosis
  • tumor cells exposed to hyperthermia in the heat shock range (42°C for 4h) prior to lysing, DC activation and cross-priming were significantly enhanced with the application of heat
  • Due to the ability of Hsps to activate DCs directly by chaperoning tumor antigens upon their release [28], it is possible that both local and regional immune stimulation can be achieved with hyperthermia.
  • support the use of hyperthermia as an inducer of Hsps to serve as ‘danger signals’, activating antitumor immune responses
  • whole-body hyperthermia not only augments immune responses, but also stimulates the migration of skin-derived DCs to draining lymph nodes
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      This allows for the activation of lymphocytes by the activated dendritic cells.
  • suggest a valuable role of hyperthermia in DC cancer vaccine strategies
  • In mice treated with fever-range whole-body hyperthermia, tumor growth was significantly inhibited and NK-cell infiltration increased
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      Hyperthermia increased NK cell activation, proliferation, and infiltration, which equals increased cytotoxicity.
  • exposure to fever-range hyperthermia resulted in improved endogenous NK-cell cytotoxicity to several cancer types
  • improved activation and function of DCs and NK cells following hyperthermia
  • Hyperthermia increases the expression ICAM-1 a key adhesion molecule,
  • The combined effects of hyperthermia on lymphoid tissue endothelium and lymphocytes can promote immune surveillance and increase the probability of naive lymphocytes leaving the circulation and encountering their cognate antigen displayed by DCs in lymphoid organs.
  • In independent clinical studies, whole-body hyperthermia resulted in a transient decrease in circulating lymphocytes in patients with advanced cancer [12, 94, 99, 100], a finding which mirrored observations in animal models in which lymphocyte entry into lymph noeds was increased following hyperthermia treatment [93]. Enhanced recruitment of lymphocytes to lymphoid tissues may be exploited in the treatment of malignancies.
  • The initial tumor antigen presentation and initiation of clonal expansion of CTLs transpires in the lymph nodes and cannot take place outside this specialized compartment
  • the ability of DCs present in the lymph nodes to stimulate an anti-tumor immune response is critical
  • hyperthermia has been shown to improve immune surveillance by T-cell
  • and to increase DC trafficking to lymph nodes
  • Nathan Goodyear on 29 Nov 18
     
    Great review of hyperthermia.
Nathan Goodyear

Artesunate in combination with oxacillin protect sepsis model mice challenged with leth... - 0 views

www.sciencedirect.com/...S1567576911001202

sepsis inflammation artesunate cytokine storm

shared by Nathan Goodyear on 07 Apr 20 - No Cached
  • Nathan Goodyear on 07 Apr 20
     
    Artesunate found to inhibit cytokine release in therapy with oxacillin in MRSA as a part of sepsis induction-inhibits cytokine storm.
Nathan Goodyear

Hormone Replacement Therapy Associated with Lower Mortality - American College of Cardi... - 0 views

www.acc.org/...ssociated-with-lower-mortality

HRT hormone replacement therapy hormones menopause atherosclerosis cardiovascular disease hormone therapy

shared by Nathan Goodyear on 22 Mar 17 - No Cached
  • Nathan Goodyear on 22 Mar 17
     
    Just a press release of yet to be published study that finds women on HRT have lower atherosclerosis, calcium score, and death than younger women not on HRT.
Nathan Goodyear

Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Me... - 0 views

journals.plos.org/...article

dopamine melatonin sleep

shared by Nathan Goodyear on 07 Jun 17 - No Cached
  • Nathan Goodyear on 07 Jun 17
     
    dopamine inhibits melatonin production and release disrupting sleep.
snfilms

New Released Of Wiz Khalifa - 0 views

Sdtunes NewReleased Wiz-Khalifa

shared by snfilms on 23 Apr 21 - No Cached
  • snfilms on 23 Apr 21
     
    Check out latest released #musicvideos from #WizKhalifa on #sdtunes http://www.sdtunes.com/.../wiz-khalifa-huge-hit-music...
snfilms

New Music Releases Of Katy Perry - 0 views

sdtunes NewReleases katyperry

shared by snfilms on 12 May 21 - No Cached
  • snfilms on 12 May 21
     
    Latest releases from #KatyPerry | Check out I'll cry about it later, Not the End of the World and more on #sdtunes http://www.sdtunes.com/.../katy-perry-huge-hit-music...
indiacardiacsurg

Best Robotic Cardiac Surgery Hospital in India in 2021 Launch Robot-Assisted Unit - 101... - 0 views

www.101pressrelease.com/021-launch-robot-assisted-unit

Robotic Cardiac Surgery in India robotic cardiac surgery Best robotic cardiac surgery hospital in India in 2021 affordable robotic heart surgery affordable robotic heart surgery cost India Minimally Invasive cardiac surgeons in India top 5

shared by indiacardiacsurg on 08 Nov 21 - No Cached
  • indiacardiacsurg on 08 Nov 21
     
    Best robotic cardiac surgery hospital in India in 2021 said, "The development of a robot-assisted cardiac surgical remedy utility offers affordable robotic heart surgery cost India with a top-notch amount of self-control and instruction, and we are proud to have released a devoted application for the first time in India. Get Consultation International Helpline Number : +91-9370586696 Email id: enquiry@indiacardiacsurgerysite.com
Nathan Goodyear

Update in TSH Receptor Agonists and Antagonists - 0 views

jcem.endojournals.org/...4287.abstract

receptors receptor thyroid TSHR

shared by Nathan Goodyear on 06 Dec 12 - No Cached
  • Nathan Goodyear on 06 Dec 12
     
    Just abstract is available to this just released article, but the opening sentence shows the importance of receptors: "the physiological role of the TSH receptor (TSHR) as a major regulator of thyroid functions is well understood..."
Nathan Goodyear

Prolonged effects of tumor necrosis factor-alpha on... [Peptides. 1995] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7479297

TSH TSH suppression TNF-alpha inflammation inflammatory cytokine thyroid

shared by Nathan Goodyear on 01 Feb 13 - No Cached
  • Nathan Goodyear on 01 Feb 13
     
    TNF-alpha shown to inhibit TSH release from the anterior pituitary.
Nathan Goodyear

ScienceDirect.com - Cell Metabolism - Estrogen Receptors and the Metabolic Network - 0 views

www.sciencedirect.com/...S1550413111003123

ER-alpha ER-beta estrogen receptor receptors metabolic syndrome MetS hormone hormones

shared by Nathan Goodyear on 11 Oct 12 - No Cached
  • The pro-opiomelanocortin (POMC) neurons have an anorexigenic action and, when activated, reduce food intake through the release of two peptides, α-melanocyte-stimulating hormone (α-MSH) and cocaine-and-amphetamine-regulated transcripts (CART). The neuropeptide Y (NPY) neurons, on the other hand, release NPY hormone and agouti gene-related protein (AgRP), which prevent the binding of α-MSH to MC3R and MC4R, increasing food intake
  • This suggests that the central anorexic effects of E2 may occur via ERβ
  • The main hypothalamic areas involved in food intake and satiety are the arcuate nucleus (ARC), the lateral hypothalamus (LH), the paraventricular nucleus (PVN), the ventromedial hypothalamus (VMH), and the dorsomedial hypothalamus (DMH)
  • ...22 more annotations...
  • Leptin is a potent anorexigenic and catabolic hormone secreted by adipose cells that reduces food intake and increases energy expenditure
  • E2 not only modulates leptin receptor mRNA in the ARC and VMH, but also increases hypothalamic sensitivity to leptin, altering peripheral fat distribution
  • ghrelin. It acts on growth hormone secretagogue receptors (GHSR1a) located in the ARC and is a potent stimulator of food intake
  • It thus appears that of the two ERs, ERα plays a predominant role in the CNS regulation of lipid and carbohydrate homeostasis.
  • Both ERs have been identified in the ARC
  • Stimulation of MCH neurons increases food intake and fat accumulation while its inhibition leads to decreased food intake and reduced fat accumulation.
  • Both ERs have been identified in the LH
  • both ERs have been identified in this nucleus
  • The PVN is the region of the hypothalamus with the highest expression of ERβ and is reported to be weakly ERα positive
  • The VMH is ERα regulated
  • Skeletal muscle is responsible for 75% of the insulin-induced glucose uptake in the body
  • GLUT4 is highly expressed in muscle and represents a rate-limiting step in the insulin-induced glucose uptake
  • data suggest that in the physiological range, E2 is beneficial for insulin sensitivity, whereas hypo- or hyperestrogenism is related to insulin resistance
  • In aging female rats, E2 treatment improves glucose homeostasis mainly through its ability to increase muscle GLUT4 content on the cell membrane
  • It is evident that ERα and ERβ have distinct actions and that much more research is needed to clearly identify the function of each receptor in muscle.
  • E2 prevents accumulation of visceral fat, increases central sensitivity to leptin, increases the expression of insulin receptors in adipocytes, and decreases the lipogenic activity of lipoprotein lipase in adipose tissue
  • In rats, ovariectomy increases body weight, intra-abdominal fat, fasting glucose and insulin levels, and insulin resistance followed by decreased phosphorylation of AMPK and its substrate acetyl-CoA carboxylase in adipose tissue
  • decreased adiponectin, PPARγ coactivator-1α (PGC-1α), and uncoupling protein 2 (UCP2) and increased resistin
  • Men with aromatase deficiency have truncal obesity, elevated blood lipids, and severe insulin resistance
  • Although not all studies are in agreement, polymorphisms of ERα in humans have been associated with risk factors for CVDs
  • Human subcutaneous and visceral adipose tissues express both ERα and ERβ, whereas only ERα mRNA has been identified in brown adipose tissue
  • suggesting that ERα is the main regulator of GLUT4 expression in adipose tissue
  • Nathan Goodyear on 11 Oct 12
     
    very nice article that looks at the balance of ER-alpha/ER-beta and their role in metabolic syndrome.  This article discusses the balance of  these receptors are tissue dependent in their effect.  I like their conclusion: "...but these mechanisms will never be completely understood if they are not considered in the context of a whole system.
Nathan Goodyear

Neuroestradiol in the Hypothalamus Contributes to the Regulation of Gonadotropin Releas... - 0 views

www.jneurosci.org/...19051.full

estrogen hormones brain neurotransmitter.

shared by Nathan Goodyear on 30 Sep 16 - No Cached
  • Nathan Goodyear on 30 Sep 16
     
    Estrogen appears to play a role as a neurotransmitter in the female brain.  The authors call it neuroestradiol.
Nathan Goodyear

The Ketogenic Diet and Sport: A Possible Marriage? : Exercise and Sport Sciences Reviews - 0 views

journals.lww.com/..._and_Sport___A_Possible.8.aspx

nutrition diet ketogenic ketogenic diet sports athletes exercise sports medicine

shared by Nathan Goodyear on 16 Nov 16 - No Cached
  • It is important to note that, although the blood level of glucose drops, it still remains at a physiological level (23), which is maintained through gluconeogenesis involving glucogenic amino acids and also glycerol released from triglycerides
  • “physiological ketosis” where KB levels may rise to 7 to 8 mmol L-1 (but without any pH change). In “pathological diabetic ketoacidosis,” on the other hand, ketonemia can exceed 20 mmol L-1 and also cause lowering of blood pH
  • in the initial phase of KD, about 16% of glucose comes from glycerol (released from triglyceride hydrolysis) and the bulk (60–65 g) from proteins via gluconeogenesis (proteins may be of either dietary or endogenous origin
  • ...5 more annotations...
  • the protein supply consumed during a KD “preserves,” as demonstrated, lean body mass
  • The importance of glycerol as a glucose source increases progressively during ketosis; in fact, glycerol passes from supplying 16% of total glucose to an average of 60% after many days (>7 d) of complete fasting (from 38% in lean individual to 79% in the obese).
  • The possible reasons for the effectiveness of KD for weight loss may be listed as follows, in order of evidence, strongest first: Figure 3Image Tools 1. Appetite reduction: protein satiety, effects on appetite-related hormones such as ghrelin, and possibly a sort of direct appetite-blocking effect of KB 2. Reduced lipogenesis and increased fat oxidation 3. A reduction in respiratory quotient may indicate a greater metabolic efficiency in fat oxidation 4. A thermic effect of proteins and increased energy usage by gluconeogenesis
  • all data regarding biochemical and molecular mechanisms suggest that it is very difficult to increase muscle mass during a KD; use of which really should be limited to the few days immediately before competition in bodybuilding.
  • a long-term KD can interfere with some muscle hypertrophy mechanisms and this could be counterproductive if the aim of the athlete is to gain muscle mass
  • Nathan Goodyear on 16 Nov 16
     
    Great read on the ketogenic  and its application to sports/training...
wheelchairindia9

Tynor Elastic Knee Support - 0 views

www.wheelchairindia.com/...Tynor-Elastic-Knee-Support

Tynor Knee Immobilizer Give Extra Protection extra Patellar strap Elastic knee Support free movement of the knee joint provides great relief rigid lateral immobilization highly durable perfect grip to the leg

shared by wheelchairindia9 on 16 Mar 16 - No Cached
  • wheelchairindia9 on 16 Mar 16
     
    Tynor Elastic Knee Support Elastic knee Support is a versatile knee support which offers the advantage of controlled compression around the knee and a rigid lateral immobilization and support of a splint. It allows normal flexion and free movement of the knee joint. Patellar Opening. Easy application. Controlled compression. Perfect lateral splinting. Mimics movement of natural joint. Tynor Elastic Knee Support Features Strong aluminum Hinges Rigid side splinting Free flexion movement. Open patella design Release patellar pressure. Hold the patella in position Can be used for Patellofemoral diseases Wrap design Easy application and removal on swollen or asymmetric knees Easy application and removal for weak or geriatric patients. Allows customized compression Offers flexibility in sizing Patellar cushion Improves patient comfort Improves compression Improves grip of the product Large dorsal opening Ensures no buckling on bending No vaso constriction on the dorsal area Improves patient comfort and compliance.
Nathan Goodyear

Histamine and histamine intolerance - 0 views

www.ajcn.org/...1185.full

Histamine intolerance allergies allergy histamine DAO diamine oxidase

shared by Nathan Goodyear on 08 May 12 - No Cached
  • Nathan Goodyear on 08 May 12
     
    Histamine intolerance?  Can the massive increase in allergies and thus histamine release be creating problems with metabolism of histamine?  Or can some people struggle with inborn deficits of diamine oxidase?  
Nathan Goodyear

Reduction of Inflammatory Cytokine Concentrations and Improvement of Endothelial Functi... - 0 views

circ.ahajournals.org/...804

obesity overweight visceral adiposity adipose tissue cytokines adipocytokines TNF-alpha IL-6 P-selectin ICAM-1 VCAM-1 CVD cardiovascular disease weight loss weight loss

shared by Nathan Goodyear on 30 Mar 12 - No Cached
  • Nathan Goodyear on 30 Mar 12
     
    adipose tissue releases inflammatory markers (cytokines IL-6, TNF-alpha, V-CAM-1, ICAM-1, and P-selectin). Associated endovascular disfunction and eventually cardiovascular disease.  A direct link between obesity induced inflammation and endovascular dysfunction.  Weight loss in these obese women reduced secretion of the associated inflammatory cytokines and thus decreased vascular dysfunction.
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