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Nathan Goodyear

Autoimmunity following hepatitis B vaccine as part of ... [Lupus. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22235045

hepatitis B vaccine autoimmune

shared by Nathan Goodyear on 11 Nov 13 - No Cached
  • Nathan Goodyear on 11 Nov 13
     
    This study highlights 93 patients with a post Hepatitis B vaccine induced autoimmune reaction.  More and more of these cases are popping up.
Nathan Goodyear

ScienceDirect - Journal of Functional Foods : Effects of l-theanine on attention and re... - 0 views

www.sciencedirect.com/...S1756464611000351

l-theanine attention anxiety

shared by Nathan Goodyear on 08 Jun 11 - No Cached
  • Results evidently demonstrated that l-theanine clearly has a pronounced effect on attention performance and reaction time response in normal healthy subjects prone to have high anxiety.
  • Nathan Goodyear on 08 Jun 11
     
    l-Theanine for attention and anxiety
Nathan Goodyear

Effect of treatment with choline alphoscerate on h... [Brain Res. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16989788

alpha-GPC alpha GPC brain cerebrovascular disease glial aging

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • Nathan Goodyear on 27 Aug 14
     
    alpha-GPC, in rat model found to protect brain from glial reaction damage in cerebrovascular disease.
Nathan Goodyear

Redox Regulation in Cancer Stem Cells - 0 views

www.hindawi.com/...750798

Cancer redox cancer stem cells CSC

shared by Nathan Goodyear on 04 Dec 18 - No Cached
  • Nathan Goodyear on 04 Dec 18
     
    Redox reactions in cancer stem cells
Nathan Goodyear

Histological Inflammatory Response to Transvaginal Polypropylene Mesh for Pelvic Recons... - 0 views

www.researchgate.net/..._Pelvic_Reconstructive_Surgery

vaginal mesh mesh

shared by Nathan Goodyear on 07 Sep 18 - No Cached
  • Nathan Goodyear on 07 Sep 18
     
    vaginal mesh elicits chronic foreign body reaction
Nathan Goodyear

Inflammatory Reaction as Determinant of Foreign Body Reaction Is an Early and Susceptib... - 0 views

www.hindawi.com/...510807

vaginal mesh mesh inflammation

shared by Nathan Goodyear on 07 Sep 18 - No Cached
  • Nathan Goodyear on 07 Sep 18
     
    vaginal mesh
sofiawalker171

How Hypnotherapy can help you overcome fears and phobias? - 0 views

medium.com/...fears-and-phobias-4f9e1de55456

how to overcome fear and phobias

shared by sofiawalker171 on 23 Feb 18 - No Cached
  • sofiawalker171 on 23 Feb 18
     
    A phobia is an absurd fear of a particular situation or thing which can have weakening and destroying results. The physical reactions vary from delicate to excessive and include erratic heartbeat, nausea, sweaty palms, increased muscle tension, blurred vision, shortness of breath and fainting.
Nathan Goodyear

Vitamin C and cancer revisited - 0 views

www.ncbi.nlm.nih.gov/...PMC2516245

IV vitamin C cancer vitamin C H2O2 hydrogen peroxide Fe

shared by Nathan Goodyear on 05 Mar 18 - No Cached
  • It is well known that vitamin C, or ascorbic acid, is an effective biologic antioxidant and does not act as a pro-oxidant under normal conditions (5) because it does not readily autoxidize, i.e., react with oxygen (O2) to produce reactive oxygen species, such as superoxide radicals (O2•−) or H2O2
  • However, ascorbate readily donates an electron to redox-active transition metal ions, such as cupric (Cu2+) or ferric (Fe3+) ions, reducing them to cuprous (Cu+) and ferrous (Fe2+) ions, respectively
  • Reduced transition metal ions, in contrast to ascorbic acid, readily react with O2, reducing it to superoxide radicals (Reaction 2), which in turn dismutate to form H2O2 and O2
  • ...6 more annotations...
  • The H2O2 produced this way (Reactions 1–3) seems to be key to ascorbate's antitumor effect because H2O2 causes cancer cells to undergo apoptosis, pyknosis, and necrosis
  • In contrast, normal cells are considerably less vulnerable to H2O2
  • The reason for the increased sensitivity of tumor cells to H2O2 is not clear but may be due to lower antioxidant defenses
  • In fact, a lower capacity to destroy H2O2—e.g., by catalase, peroxiredoxins, and GSH peroxidases—may cause tumor cells to grow and proliferate more rapidly than normal cells in response to low concentrations of H2O2
  • These observations, combined with the inhibitory effect on xenograft growth, provide the proof of concept that millimolar concentrations of extracellular ascorbate, achievable by i.p. injection or i.v. infusion in experimental animals and humans, respectively, exert pro-oxidant, antitumor effects in vivo.
  • They also show that the concentration of the ascorbyl radical correlates with the concentration of H2O2 in interstitial fluid, whereas no H2O2 can be detected in blood or plasma
  • Nathan Goodyear on 05 Mar 18
     
    review of the mechanism of how extracellular AA, only obtainable from parenteral dosing, can produce H2O2 extracellularly to then be cytotoxic to cancer cells.
Nathan Goodyear

Fenton Reactions and Cancer - 0 views

csbl.bmb.uga.edu/...index.html

cancer fenton reaction

shared by Nathan Goodyear on 31 Mar 20 - No Cached
  • Nathan Goodyear on 31 Mar 20
     
    To be read
snfilms

April 2020 full moon - lockdown! - 0 views

#snfilms #snfpa #naturePhotography #fullMoon #coronaVirus #fightCorona #stayHomeSaveLives

shared by snfilms on 24 Aug 20 - No Cached
  • snfilms on 24 Aug 20
     
    EVERY ACTION HAS EQUAL AND OPPOSITE REACTION. Let's strictly maintain the lockdown individually to fight #covid19. If we can't stop daily grocery shopping and tea stall meetings even now, then we need to continue this lockdown and economic slowdown for few more months; and of course at the cost of many lives
Nathan Goodyear

Chemotherapy-generated cell debris stimulates colon carcinoma tumor growth via osteopontin - 0 views

www.ncbi.nlm.nih.gov/...PMC6355061

cancer metastasis Chemotherapy colon cancer

shared by Nathan Goodyear on 19 Aug 20 - No Cached
  • Nathan Goodyear on 19 Aug 20
     
    Chemotherapy induces metastasis of primary colon cancer via inflammatory reaction from cell die off.
fitspresso

https://www.thefastleanpro.us/ - 0 views

www.thefastleanpro.us

the fast lean pro us usa fastlean fastleanpro caps drops uk buy jar get customer benefits 2023 work scam pros ebay pro2023 drop price

shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    Fast Lean Pro™ (official) | weight lose Formula thefastleanpro.us · by Fast Lean Pro Fast Lean Pro Only $49/Bottle Limited Time Offer! Fast Lean Pro Special Deal + Special 51% Discount Save $300 + 180 Days Money Back Guarantee FastLeanPro The #1 Solution To natural metabolism booster helps you lose weight quickly without starving yourself. Fast Lean Pro is a natural powder supplement for weight loss that has recently been developed by Japanese scientists. Regular Price: $99/per bottle Only for: $49/per bottle What Is Fast Lean Pro? Fast Lean Pro is a powdered dietary powdery supplement designed to aid in weight loss. It contains a unique combination of ingredients that are believed to activate the body's "fasting switch" to optimize results. This product focuses not only on weight loss but also on promoting cellular rejuvenation, fasting, and a healthy metabolism. The concept behind Fast Lean Pro is that incorporating fasting into one's lifestyle can lead to positive outcomes irrespective of individual food choices and eating habits. To comprehend the mechanism of the Fast Lean Pro process, it is necessary to delve into its specific details. One of the few weight loss pills on the market that contains Fibersol is Fast Lean Pro. This safe, specialized fiber adds bulk to its weight when combined with water, curbing your appetite before it throws off your meal plan. If you're trying to lose weight or curb your appetite, Fast Lean Pro can help. Supporting substances such as niacin and chromium contribute to this. The body can further benefit from these nutrients, such as through improved metabolic regulation. Fast lean Pro is non-GMO, vegan friendly, and contains no artificial ingredients or stimulants. Fast Lean Pro is a weight loss product that promotes the body's natural self-feeding process. The body naturally removes old, damaged cells through a process known as autophagy to encourage cell regeneration and repair. Recent studies by a group
Nathan Goodyear

Will testosterone replacement therapy become a new treatment of chronic heart failure? ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4842839

low Testosterone low T Testosterone CHF heart failure congestive heart failure male hormones hormones

shared by Nathan Goodyear on 16 May 16 - No Cached
  • TRT could improve significantly the exercise capacity of patients, compared with placebo
  • it could be seen that the effect of TRT on SBP and DBP was controversial
  • in men with congestive heart failure, testosterone reduced the Q-Td, whereas placebo had no effects
  • ...5 more annotations...
  • The MVC and PTmax were significantly improved in TRT patients but remained unchanged in the placebo group
  • handgrip strength improved significantly with testosterone treatment
  • According to EF assessed by echocardiography, no differences were observed between the patients who were prescribed testosterone and those who received placebo
  • There were no differences between the groups in circulating levels of NT pro-BNP, and inflammatory markers were unchanged, except for a decrease in TNF-α from baseline in the placebo group
  • Testosterone supplementation therapy appeared to be safe, and the subjects who accepted testosterone treatment did not appear any obvious adverse reactions.
  • Nathan Goodyear on 16 May 16
     
    Testosterone therapy in men with CHF found to increase exercise capacity, reduced the Q-T interval in men, improved muscle strength in men, and was found to be safe in meta-analysis.
Nathan Goodyear

Glutathione prevents the early asthmatic reaction and airway hyperresponsiveness in gui... - 0 views

www.ncbi.nlm.nih.gov/...20228417

glutathione asthma GSH

shared by Nathan Goodyear on 07 Jul 16 - No Cached
  • Nathan Goodyear on 07 Jul 16
     
    animal model finds that glutathione depletion increases hyperactivity of bronchioles.  Early exposure to glutathione ethyl ester, a precursor to glutathione, blunted the airway hyperactivity.
Nathan Goodyear

The Complex Role of Estrogens in Inflammation - 0 views

edrv.endojournals.org/...521.full

estrogens inflammation

shared by Nathan Goodyear on 14 Aug 12 - No Cached
  • These studies suggest inflammation-dependent up-regulation of ERβ relative to ERα.
  • up-regulation of ERβ relative to ERα under hypoxic conditions, which might lead to a preponderance of signaling through ERβ pathways
  • it seems that E2 at periovulatory to pregnancy levels inhibited proinflammatory cytokines from PBMCs
  • ...26 more annotations...
  • it is clear that E2 can stimulate antibody production by B cells, probably by inhibiting T cell suppression of B cells
  • In cycling women, the largest quantities of Ig were detected before ovulation
  • In contrast, E2 at high concentrations leads to a suppression of B-lymphocyte lineage precursors
  • E2 at periovulatory to pregnancy serum levels is able to stimulate antibody secretion under healthy conditions but also in autoimmune diseases, whereas similar serum levels of E2 lead to a suppression of bone marrow B cell lineage precursors
  • In chronic inflammatory disorders, where B cells play a decisive role, E2 would promote the disease when autoaggressive B cells are already present, whereas chronically elevated E2 would inhibit initiation of an autoimmune disease when no such B cells are available. This might be a good reason why particularly B cell-dependent diseases such as SLE, mixed connective tissue disease (Sharp syndrome), IgA nephropathy, dermatitis herpetiformis, gluten sensitive enteropathy, myasthenia gravis, and thyroiditis appear in women in the reproductive years, predominantly, in the third or fourth decades of life
  • Th17 cells are thought to be the main responsible cells for chronic inflammatory tissue destruction in autoimmune diseases
  • IFN-γ, IL-12, and TNF were allocated to Th1 reactions
  • IL-4, IL-5, and IL-10 to Th2 responses
  • antiinflammatory T regulatory cells producing TGF-β and proinflammatory T helper type 17 cells (Th17) producing IL-17
  • no direct effects of estrogens on Th17 cells or IL-17 secretion have been described until now.
  • So-called Th17 cells producing IL-17 are the main T cells responsible for chronic inflammation.
  • Because IFN-γ has been allocated a Th17-inhibiting role (Fig. 1⇑), its increase by E2 at pregnancy doses and the E2-mediated inhibition of TNF must be viewed as a favorable effect in chronic inflammation
  • in humans and mice, E2 at periovulatory to pregnancy levels stimulates IL-4, IL-10, and IFN-γ but inhibits TNF from CD4+ T cells
  • In humans and mice, E3 and E2, respectively, at pregnancy levels inhibit T cell-dependent delayed type hypersensitivity
  • increased IL-4, IL-10, and IFN-γ in the presence of low TNF support an antiaggressive immune response
  • secretion of IL-1β is increased at periovulatory/proestrus to early pregnancy levels, whereas IL-1 secretion is inhibited at high pregnancy levels
  • The dichotomous effect of E2 on IL-1β and TNF at high and low concentrations is most probably due to inhibition of NF-κB at high concentrations
  • experiments with mouse and rat macroglial and microglial cells demonstrate that E2 at proestrus to pregnancy levels exerts neuroprotective effects by increasing TGF-β and by inhibiting iNOS and NO release, and reducing expression of proinflammatory cytokines and prostaglandin E2 production.
  • E2 at periovulatory to pregnancy levels inhibits NF-κB activation, which must be viewed as an antiinflammatory signal
  • It was shown that E2 concentrations equal to or above 10−10 m are necessary to inhibit NF-κB activation
  • important proinflammatory cytokines are typically inhibited at periovulatory (proestrus) to pregnancy levels of E2, which is evident for IL-6, IL-8, and TNF
  • low E2 concentrations were demonstrated to have no or even stimulatory effects
  • This renders a woman in the postmenopausal phase to a more proinflammatory situation
  • most in vitro studies demonstrated a stimulatory effect of E2 on secretion of IL-4, IL-10, and TGF-β typically at periovulatory to pregnancy levels
  • E2 at periovulatory to pregnancy levels has an ameliorating effect on chronic inflammatory diseases as long as B cell-dependent immunity or an overshooting fibrotic tissue repair process do not play a crucial pathogenic role. However, when the B cell plays an important role, E2 might even stimulate the disease process as substantiated by flare-ups in SLE during pregnancy
    • Nathan Goodyear
      Nathan Goodyear on 15 Aug 12
       
      SLE, mixed connective tissue disease (Sharp syndrome), IgA nephropathy, dermatitis herpetiformis, gluten sensitive enteropathy, myasthenia gravis, and thyroiditis
  • Short-term administration of E2 at pregnancy levels was shown to induce an inflammatory response specific to the lateral prostate of the castrated male rat
  • Nathan Goodyear on 14 Aug 12
     
    great review of the complex interaction between Estrogens and inflammation.  Reference here is in females.
Nathan Goodyear

Death by Medicine  By Gary Null - 0 views

www.whale.to/null9.html

medicine death side effects ADR adverse drug reactions

shared by Nathan Goodyear on 18 Dec 13 - No Cached
  • Nathan Goodyear on 18 Dec 13
     
    startling statistics on the damage done by prescribed medicine and medical therapies.
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