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sofiawalker171

The 3 Keys To Overcome Anxiety - Trina Blum - Medium - 0 views

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    Hypnosis Therapy for Anxiety is very varied depending on the type of disorder being treated. But these three keys are usually present in one way or another in all treatments. Exposure is a fundamental part of overcoming anxiety, because only when you demonstrate to yourself that you are capable of facing situations, can you have the confidence and confidence to feel good. It is necessary to insist in the expositions the time that is necessary until the levels of anxiety are nonexistent and the negative thoughts of threat and danger are not generated.
sofiawalker171

Benefit of A Clinical Hypnotherapist for Women - Trina Blum - Medium - 0 views

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    Hypnotherapy in our opinion is a self belief to overcome a problem. We personally believe that hypnosis will be optimally effective when the person is highly motivated to overcome his problem and when the hypnotherapist is well trained in general considerations relating to the treatment of their particular problem and hypnosis both. Some patients seem to have higher native hypnotic capacity and talent that may allow them to benefit more efficiently from hypnosis. For women there are many benefits of a clinical hypnotherapist for women
sofiawalker171

How Hypnotherapy can help you overcome fears and phobias? - 0 views

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    A phobia is an absurd fear of a particular situation or thing which can have weakening and destroying results. The physical reactions vary from delicate to excessive and include erratic heartbeat, nausea, sweaty palms, increased muscle tension, blurred vision, shortness of breath and fainting.
Nathan Goodyear

Steroid measurement with LC-MS/MS... [J Steroid Biochem Mol Biol. 2010] - PubMed - NCBI - 0 views

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    LC-MS/MS overcomes the limitations of immunoassays in hormone testing.  LC-MS/MS is the new gold standard with sensitivity, specificity, and ease second to none.  LC-MS/MS is the bench science now coming to the practice of medicine.
Nathan Goodyear

Testosterone 2% Gel Can Normalize Testosterone Con... [J Sex Med. 2013] - PubMed - NCBI - 0 views

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    Study finds that transdermal testosterone effective in normal and overweight men.  The dosing involved is supra physiologic, especially those with an elevated BMI.  This was likely due to the high dosing to overcome the underlying problem i.e. high aromatase activity.  These studies all need to assess estrogens and inflammatory cytokines to better follow these results
Jessica Wilton

Know About 5 Common Myths Regarding Counselling - 0 views

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    People are getting much busier day by day in their lives. They get minimum time to spend with their loved ones, which sometimes lead to a serious problem like a broken relationship or any kind of health disorders, like anxiety or depressions. But to overcome these problems counselling can be a very convenient option and is beneficial at the same time.
wheelchairindia9

Soma SM 150-3 - 0 views

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    Soma SM 150.3: The SM-150.3 is an aluminum alloy standard wheelchair that is economic, solid, and durable. Soma SM 150.3 Wheelchair Features: Elliptical frame The unique and stylish elliptical frame ensures that the chair is both rigid and robust. Integrated seating system For intensive wheelchair users, we provide seating system that can be free from hammock effect. The innovative and durable seating system makes it easy for you to detach seat upholstery for cleaning purpose. Secure non-slip footplate A non-slip and ergonomic footplate provides you with a stable and comfortable base for placing feet. Energy-saving tipping lever The ergonomic design allows caregivers to operate the lever without much effort so the casters can overcome obstacles such as thresholds and curbs. Item Code:WCI-201 MRP: Rs 12000 Our Price:Rs 9950 Net Price:Rs 9751 ( Apply Coupon Code 'MSW2365' Get 2% Discount ) Soma SM 150.3 Wheelchair Measurements: Seat Width(cm):43 Seat Depth(cm):42 Caster Size(inch):7
wheelchairindia9

Soma SM 100.3 - 0 views

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    Soma SM 100.3 The SM-100.3 is an aluminum alloy standard wheelchair that is economic, solid, and durable. Soma SM 100.3 Wheelchair Features: Elliptical frame The unique and stylish elliptical frame ensures that the chair is both rigid and robust. Integrated seating system For intensive wheelchair users, we provide seating system that can be free from hammock effect. The innovative and durable seating system makes it easy for you to detach seat upholstery for cleaning purpose. Secure non-slip footplate A non-slip and ergonomic footplate provides you with a stable and comfortable base for placing feet. Energy-saving tipping lever The ergonomic design allows caregivers to operate the lever without much effort so the casters can overcome obstacles such as thresholds and curbs. Soma SM 100.3 Wheelchair Measurements: Seat Width(cm):43 Seat Depth(cm):42 Caster Size(inch):7 Rear Wheel Size(Inch/QR) 16F/22F
therapy1on1

How Addiction Counselling Services Can Help to Overcome Addiction? - 0 views

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    Addictions can create from what might be viewed as fairly innocent, or at least common social propensities. Drinking alcohol, gambling, eating, engaging in sexual relations and utilizing the web can all turn from what is viewed as a common activity, to a darker, increasingly destructive compulsion. Addiction treatment, for example, addiction counselling services, is critical for helping individuals perceive the issue and make the steps to recuperation.
sofiawalker171

A Professional Hypnotherapist Providing Medical Hypnosis for Anxiety - 0 views

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    How to overcome fear and anxiety? Get in contact with Trina Blum providing sports performance hypnosis, hypnosis to cure anxiety, Life enrichment to Women
Nathan Goodyear

Hyperthermia Inhibits Recombination Repair of Gemcitabine-Stalled Replication Forks - 0 views

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    Hyperthermia helps to overcome HCC gemzar resistance. Exact mechanism undetermined.
indian-health

Overcome Heart Valve Disease With Valve Replacement Surgery India by Allyson James - 0 views

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    #Lowcostvalvereplacementsurgery #India is cheaper than a majority of #Countries in the #World. Read article https://bit.ly/2WTppCO #CostofValveReplacementSurgeryIndia #ValveReplacementSurgeonsinIndia #TopHeartTransplantHospitalsofDelhi #AffordableCostofCardiacSurgeryinDelhi #Top10ValveReplacementSurgeonsofIndia #BestHospitalsforValveReplacementIndia
pharmacybiz

Paxlovid : MHRA Approves Second Oral Covid-19 Antiviral - 0 views

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    UK regulator has approved a second oral antiviral for early treatment of Covid-19 in high-risk adults, after molnupiravir. The Medicines and Healthcare products Regulatory Agency (MHRA) gave its nod for a new treatment called Paxlovid (PF-07321332 and ritonavir), after finding it safe and effective at reducing the risk of hospitalisation and death in people diagnosed with mild Covid-19 infection. Developed by Pfizer, Paxlovid prevents the multiplying of virus, helping the body to overcome the infection. A clinical trial for the treatment in high risk individuals revealed that a five-days course of Paxlovid reduces the risk of hospitalisation and death by 89 per cent. It further revealed that Paxlovid is most effective when taken in the early stage of infection. Dr June Raine, MHRA chief executive, said: "We now have a further antiviral medicine for the treatment of Covid-19 that can be taken by mouth rather than administered intravenously. This means it can be administered outside a hospital setting, before Covid-19 has progressed to a severe stage."
spineneuro

Spine And Neuro Surgery Hospital India: Spinal Fusion Surgery: A Step Towards Pain Reli... - 0 views

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    Zimbabwe patients looking for inter-body fusion surgery cost can save between 40 to 60 percent on costs if they opt for this procedure in India. The top hospitals for spinal fusion surgery are dedicated to relieving patients from back pain and helping them overcome spine disorders. With the latest technology and top spine surgeons, inter-body fusion surgery costs boast an accuracy rate of about 80-90 percent.
Jackson Samuel

Small breakthroughs offer big hope of AIDS 'cure' - 0 views

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    Small but significant breakthrough studies on people who have been able to overcome or control HIV were presented at a major world conference on ways to stem the three-decade-old disease. One study focused on a group of 12 patients in France who began treatment on antiretroviral drugs within 10 weeks of becoming infected with human immunodeficiency virus, but then stopped the therapy after nearly three years.
wheelchairindia9

Karman S-Ergo 115 - 0 views

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    Ergonomic wheelchairs have been tested and proven to be effective for relieving pressure throughout the body; this is confirmed by pressure chart mapping. Feeling comfortable on a wheelchair is something every user demands out of their new wheelchair, the ergonomic cushion that is included with the ergonomic series provides a level of comfort that is unparalleled. Ergonomic Transport Wheelchair provides the perfect shape to fit the human body to relieve pressure, increase stabilization, weight distribution and lower the risk of pressure sores and scoliosis. Lightweight Ergonomic Wheelchair features wide arm pads for extra support, folding back rest, detachable swing-away footrests, and a Tube-in Center foot-plate that provides extra support for the leg muscles. This wheelchair can hold up to daily use and is excellent for traveling. Ergonomic features flip-back armrest and swing away footrests. A lightweight frame that is 25 lbs. without footrests and a folding backrest allows easy travel or storage. The chair comes equipped with a padded anti-bacterial upholstery that is comfortable and washable. Karma Ergo Lite 2501 Wheelchair: The extremely lightweight Ergo Lite 2501 Transport Wheelchair weighs only 8.16 kg. and features an ergonomically-designed seat and backrest, making it one of the most comfortable transport chairs on the market. The folding seat and backrest make the S-Ergo ideal for storage or travel, and the built in AEGIS anti-bacterial cushion provides added comfort and support. Despite its light weight, the S-Ergo features a 115 kg. weight capacity along with large, 14" flat-free polyurethane rear tires. Karma Ergo Lite 2501 Wheelchair Features: Lightest transporter on the market! Patented S-Style Ergonomic Seat Frame 6061 T-6 Aircraft-grade Aluminum Only 18 lb . (w/ footrests) Built in Silver Aegis Anti-bacterial Cushion Fixed Armrests w/Concaved Armpads Pocket Behind Backrest & Small Carry Pouch on Each Armrest 6" x 1" Polyurethane
Nathan Goodyear

Inborn-like errors of metabolism are determinants of breast cancer risk, clinical respo... - 0 views

  • We now recognize that human cancers evolve in an environment of metabolic stress. Rapidly proliferating tumor cells deprived of adequate oxygen, nutrients, hormones and growth factors up-regulate pathways that address these deficiencies to overcome hypoxia (HIF), vascular insufficiency (VEGF), growth factor deprivation (EGFR, HER2) and the loss of hormonal support (ER, PR, AR) all to enhance survival and proliferation
  • RAS, PI3K, TP53 and MYC
  • The results suggest that breast cancer could be preceded by systemic subclinical disturbances in glucose-insulin homeostasis characterized by mild, likely asymptomatic, IEM-like biochemical changes
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  • The process would include variable periods of hyperinsulinemia with the consequent systemic MYC activation of glycolysis, glutaminolysis, structural lipidogenesis and further exacerbation of hypoglycemia, the result of MYC's known role as an inhibitor of liver gluconeogenesis
  • The metabolic changes we describe in breast cancer arise in concert with IEM-like changes in oxidative phosphorylation as detected by increased values of the ratio lactate/pyruvate (Supplementary Table 2A, 2B) characteristic of Ox/Phos deficiency [25]. In our study, 76% (70/92) of the European breast cancer patients had lactate/pyruvate ratios values higher than the normal value of 25.8
  • four-fold higher frequency of cancer (including breast) in patients with energy metabolism disorders
  • growing recognition that cancer cells differ from their normal counterparts in their use of nutrients, synthesis of biomolecules and generation of energy
  • glutamine concentrations in the cancer patients were reduced to nearly 1/8 of the levels observed in the normal population
  • blood concentrations of aspartate (p = 1.7e-67, FDR = 8.3e-67) (Figure ​(Figure1E)1E) and glutamate (p = 6.4e-96, FDR = 6.2e-95) (Figure ​(Figure1F)1F) were nearly 10 fold higher than the normal ranges of 0–5 μM/L and 40 μM/L, respectively
  • glutamine consumption associated with parallel increases in glutamate and aspartate (Figure ​(Figure1A1A red arrows) is considered a hallmark of MYC-driven “glutaminolysis”
  • Gln/Glu ratio inversely correlates with i- late stage metabolic syndrome and with ii- increased chance of death
  • changes in glutamine consumption, reflected by the Gln/Glu ratio could provide a metabolic link between breast cancer initiation and diabetes, reflective of a systemic metabolic reprogramming from glucose to glutamine as the preferred source of precursors for biosynthetic reactions and cellular energy
  • lower Gln/Glu ratios inversely correlated with insulin resistance and the risk of diabetes
  • the metabolic dependencies of cancer characterized by excessive glycolysis, glutaminolysis and malignant lipidogenesis, previously considered a consequence of local tumor DNA aberration [23] could, instead, represent a systemic biochemical aberration that predates and very likely promotes tumorigenesis
  • these metabolic disturbances would be expected to remain extant after therapeutic interventions
  • accumulation of very long chain acylcarnitines such as C14:1-OH (p = 0.0, FDR = 0.0), C16 (p = 0.0, FDR = 0.0), C18 (p = 0.0, FDR = 0.0) and C18:1 (p = 1.73e-322, FDR = 1.16-321) and lipids containing VLCFA (lysoPC a C28:0) (p = 1.14-e95, FDR = 1.65e-95) in the blood of breast and colon cancer patients
  • Among the most powerful metabolic equations for MYC-activation is that which links the widely used MYC-driven desaturation marker ratio of SFA/MUFA to the MYC glutaminolysis-associated ratio of (Asp/Gln)
  • liver dysfunction shares many features with both IEM and cancer suggesting a role for hepatic dysfunction in carcinogenesis
  • cancer “conscripts” the human genome to meet its needs under conditions of systemic metabolic stress
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    Breast cancer is a metabolic disease.  Now, where have I heard that cancer is a metabolic disease?
Nathan Goodyear

Multiple Myeloma Tumor Cells are Selectively Killed by Pharmacologically-dosed Ascorbic... - 0 views

  • Recent reports indicate that a certain ROS concentration is required for high-dose vitamin C to induce cytotoxicity in cancer cells.
  • The generation of ascorbyl- and H2O2 radicals by PAA increases ROS stress in cancer cells
  • In this study, we report that PAA is efficacious in killing MM cells in vitro and in vivo models, which generated levels of 20–40 mM ascorbate and 500 nM ascorbyl radicals after intraperitoneal administration of 4 g ascorbate per kilogram of body weight (Chen et al., 2008Chen et al., 2008), in xenograft MM mice
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  • These data suggest that PAA may show a therapeutic advantage to blood cancers vs solid tumors because of the communication between tumor cells and blood plasma
  • These results strongly suggest that the mechanism of PAA killing of MM cells is indeed iron-dependent
  • These results suggest that PAA administration in SMM may be able to prevent progression to symtomatic MM
  • A recent study by Yun and colleagues demonstrated that vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH, but spares normal cells
  • RAS family genes show the most frequent mutations in MM. KRAS, NRAS and BRAF are mutated in 22%, 20% and 7% of MM samples
  • the disease stage rather than the mutation of RAS and/or BRAF is the major predictive factor for PAA sensitivity in MM treatment
  • Other molecular mechanisms including ATP depletion and ATM-AMPK signaling have been reported to explain PAA-induced cell death
  • our pilot study also suggested that PAA could overcome drug resistance to bortezomib in MM cells
  • Our findings complement reported studies and further address the mechanism of action using clinical samples in which we observed that PAA killed tumor cells with high iron content, suggesting that iron might be the initiator of PAA cytotoxicity
  • combination of PAA with standard therapeutic drugs, such as melphalan, may significantly reduce the dose of melphalan needed
  • Combined treatment of reduced dose melphalan with PAA achieved a significantly longer progression-free survival than the same dose of melphalan alone.
  • These data also suggest that the bone marrow suppression induced by high-dose melphalan can be ameliorated by the combination of PAA with lower dose of melphalan because of the lack of toxicity of PAA on normal cells with low iron content.
  • if creatinine clearance is <30 mL/min, high dose ascorbic acid should be not administrated.
  • In MM preclinical and clinical studies, ascorbate was used as an adjunct drug and showed controversial results (Harvey et al., 2009, Perrone et al., 2009, Held et al., 2013, Sharma et al., 2012, Nakano et al., 2011, Takahashi, 2010, Sharma et al., 2009, Qazilbash et al., 2008). However, none of these tests used pharmacological doses of ascorbate and intravenous administration
  • Multiple myeloma (MM) is a plasma cell neoplasm.
  • Cameron and Pauling reported that high doses of vitamin C increased survival of patients with cancer
  • pharmacologically dosed ascorbic acid (PAA) 50–100 g (Chen et al., 2008, Padayatty et al., 2004, Hoffer et al., 2008, Padayatty et al., 2006, Welsh et al., 2013), administered intravenously, has potent anti-cancer activity and its role as anti-cancer therapy is being studied at the University of Iowa and in other centers
  • In the presence of catalytic metal ions like iron, PAA administered intravenously exerts pro-oxidant effects leading to the formation of highly reactive oxygen species (ROS), resulting in cell death
  • the labile iron pool (LIP) is significantly elevated in MM cells
  • The survival of CD138+ cells in vitro was significantly decreased following PAA treatment in all 9 MM
  • In contrast, no significant change of cell viability was observed in CD138− BM cells from the same patients
  • The same effect of PAA was also observed in the SMM patients
  • no response to PAA was detected in CD138+ cells from the 2 MGUS patients
  • the combination of melphalan plus PAA showed greater tumor burden reduction than each drug alone, suggesting a synergistic activity between these two drugs
  • Both catalase and NAC protect cells from oxidative damage
  • cells pretreated with NAC and catalase became resistant to PAA even at high doses
  • adding deferoxamine (DFO), an iron chelator, to OCI-MY5 cells before PAA treatment was also sufficient to prevent PAA-induced cellular death
  • iron is essential for PAA to achieve its anti-cancer activity
  • PAA induced early necrosis (Fig. 3Fig. 3A, 60 min) followed by late apoptosis
  • results further indicated that PAA induced mitochondria-mediated apoptosis
  • PAA by reacting with LIP and generating ROS induces mitochondria-mediated apoptosis in which AIF1 cleavage is important for cell death.
  • ROS and H2O2 are well known factors mediating PAA-induced cancer cell death
  • PAA was sensitive to all 9 MMs and 2 SMMs
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    animal study finds high-dose, pharmacologic vitamin C found to kill multiple myeloma cells via pro-oxidant effect found in similar studies in dealing with different cancers.
Nathan Goodyear

Ivermectin: enigmatic multifaceted 'wonder' drug continues to surprise and exceed expec... - 0 views

  • The avermectins are known to possess pronounced antitumor activity
  • Over the past few years, there have been steadily increasing reports that ivermectin may have varying uses as an anti-cancer agent, as it has been shown to exhibit both anti-cancer and anti-cancer stem cell properties
  • In human ovarian cancer and NF2 tumor cell lines, high-dose ivermectin inactivates protein kinase PAK1 and blocks PAK1-dependent growth
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  • PAK1 is essential for the growth of more than 70% of all human cancers, including breast, prostate, pancreatic, colon, gastric, lung, cervical and thyroid cancers, as well as hepatoma, glioma, melanoma, multiple myeloma and for neurofibromatosis tumors
  • Ivermectin suppresses breast cancer by activating cytostatic autophagy, disrupting cellular signaling in the process, probably by reducing PAK1 expression
  • Cancer stem cells are a key factor in cancer cells developing resistance to chemotherapies and these results indicate that a combination of chemotherapy agents plus ivermectin could potentially target and kill cancer stem cells, a paramount goal in overcoming cancer
  • Triple-negative breast cancers, which lack estrogen, progesterone and HER2 receptors, account for 10–20% of breast cancers and are associated with poor prognosis
  • Ivermectin addition led to transcriptional modulation of genes associated with epithelial–mesenchymal transition and maintenance of a cancer stem cell phenotype in triple-negative breast cancers cells, resulting in impairment of clonogenic self-renewal in vitro and inhibition of tumor growth and metastasis in vivo
  • ivermectin synergizes with the chemotherapy agents cytarabine and daunorubicin to induce cell death in leukemia cells
  • Ivermectin-induced cytostatic autophagy also leads to suppression of tumor growth in breast cancer xenografts, causing researchers to believe there is scope for using ivermectin to inhibit breast cancer cell proliferation and that the drug is a potential treatment for breast cancer
  • Ivermectin inhibits proliferation and increases apoptosis of various human cancers
  • Activation of WNT-TCF signaling is implicated in multiple diseases, including cancers of the lungs and intestine,
  • A new screening system has found that ivermectin inhibits the expression of WNT-TCF targets
  • It represses the levels of C-terminal β-catenin phosphoforms and of cyclin D1 in an okadaic acid-sensitive manner, indicating its action involves protein phosphatases
  • In vivo, ivermectin selectively inhibits TCF-dependent, but not TCF-independent, xenograft growth without side effects
  • ivermectin has an exemplary safety record, it could swiftly become a useful tool as a WNT-TCF pathway response blocker to treat WNT-TCF-dependent diseases, encompassing multiple cancers.117
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    Ivermectin shows promise and usefullness in several cancer types.  This is a review article.
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