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Nathan Goodyear

JAMA Network | JAMA | Pharmaceutical Overdose Deaths, United States, 2010 - 1 views

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    2010 pharmaceutical overdose #'s.  Over 38.000.
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    i will be doing a lot of research on your articles. thank u. rita johnston
ashleyobama

Nembutal Liquid | pills nembutal |Nembutal Liquid | - 0 views

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    Nembutal Liquid is best quality and prices at First Trust Chemicals. Visit our website and place your order online. Nembutal Liquid Pentobarbital (trade name: Nembutal) is a drug from the barbiturate class. It was widely used during the 1940s and 1950s as a sleeping pill (i.e. hypnotic) or anti-anxiety drug (i.e. sedative). Unlike modern sleeping pills, Nembutal is highly lethal in overdose. Because it is very reliable and brings about peaceful death, it is one of drugs of choice for assisted suicide. Nembutal is used by euthanasia organizations in the United States (Oregon Death With Dignity Act), Switzerland (Dignitas) and The Netherlands. Nembutal Liquid Since it was so easy to overdose on Nembutal (whether accidentally or intentionally), it was almost universally taken off the market and replaced by safer sleeping pills. Nembutal was removed from the Australian prescribing schedule in 1998. However, Nembutal remains in use by veterinary surgeons in order to euthanase bigger animals. Many people were successful in obtaining veterinary Nembutal for their suicide. The famous American actress Marilyn Monroe supposedly used Nembutal to end her life. The brand name "Nembutal" was coined by Dr. John S. Lundy, who started using it in 1930, from the structural formula of the sodium salt-Na (sodium) + ethyl + methyl + butyl + al (common suffix for barbiturates). Nembutal is trademarked and manufactured by the Danish pharmaceutical company Lundbeck
Nathan Goodyear

High estrogen in men after injectable testosterone therapy: the low T experience. - Pub... - 0 views

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    This is what amounts to science?  As if high estrogen production from overdosing Testosterone only results in gynecomastia.  This study is trying to validate doping utilizing testosterone by saying that no one listed gynecomastia as the reason for AI therapy?!?! No evaluation on PSA, TNF-alpha, CRP...was done.  This study is worthless.
Nathan Goodyear

A Randomized Pilot Study of Monthly Cycled Testosterone Replacement or Continuous Testo... - 0 views

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    study looks at cycling Testosterone as athletes do.  The point to take from this study is that they lowered the standard Testosterone dosage by 50% and got the same results.  Traditional medicine drastically overdoses men with Testosterone.
Nathan Goodyear

N-Acetylcysteine: Multiple Clinical Applications - August 1, 2009 - American Family Phy... - 0 views

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    use of NAC provides many health benefits above and beyond tylenol overdose.
Nathan Goodyear

OASIS - 0 views

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    I look forward to the published results of this study as this abstract references the WHI as the "same entry" criteria.  I imagine the HRT would be the same too, but will wait to see.  There is a serious problem with proper reporting of synthetic estrogens as bioidentical estrogens and synthetic progestins as bioidentical progesterone;  Also, what is the dosage. Most individuals are massively overdosed.  This study was said to be a "landmark".  Could just be don't use synthetic hormones: which is what the WHI said.
Nathan Goodyear

Levothyroxine and lung cancer in females: the importance of oxidative stress - 0 views

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    Study links synthetic T4, synthroid, to increased risk of Lung cancer. The authors acknowledge that the limitations of this study are large. Yet, the association is evident. The proposed mechanism is likely the overdosing and the resultant ROS as a result.
Nathan Goodyear

The benefits and risks of testosterone replacement therapy: a review - 0 views

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    Benefits and risks of testosterone therapy discussed.  This study gives a brief history of hypogonadism,  highlights the different therapeutic techniques.  Most important, is the evidence based positive effects and side effects. The majority of the side effects occurs through overdosing and the physiologic dysfunction that occurs in these men's micronenvironments.
Nathan Goodyear

Testosterone replacement in prostate cancer survivors with hypogonadal symptoms - Leibo... - 0 views

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    Good article.  This article (case series) found that 40% of the men included had no increase in PSA with Testosterone.  One point on the Testosterone dosage is that they used androgen, which is an overdose of Testosterone.  That gives 60% that the PSA did increase.  These men had higher PSA to begin with which leads to the suggestion that the prostate cells were abnormal.  Those men that had a prostatectomy were more likely to have little if any increase in PSA.  This study did use a the 5 alpha reductase inhibitor dutasteride.
Nathan Goodyear

Adverse Events Associated with Testosterone Administration - NEJM - 0 views

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    study that found Testosterone therapy increased cardiovascular side effects was stopped due to massive, massive overdosing.
Nathan Goodyear

The mortality toll of estrogen avoidance:... [Am J Public Health. 2013] - PubMed - NCBI - 0 views

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    Yale study finds estrogen therapy in improves health in women ages 50-59.  The problems with hormone therapy is synthetics and overdosing.  The problem with the WHI was they used medroxy progesterone acetate--a synthetic progestin.   That is not progesterone.  This study estimated that 91,000 + died due to the uneducated view that estrogen HRT is dangerous.  What is dangerous is leaving the HRT and BHRT recommendations to those with conflicts of interest and a lack of knowledge of the science.
Nathan Goodyear

Acetaminophen Overdose with Altered Acetaminophen Pharmacokinetics and Hepatotoxicity A... - 0 views

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    IV NAC therapy treatment for tylenol toxicity.  NAC is the precursor to glutathione
Nathan Goodyear

Sex steroids and cardiovascular disease Yeap BB - Asian J Androl - 0 views

  • Levels of SHBG are higher in older men, therefore levels of free T decline more steeply than total T as men's age increases.
  • calculations based on mass action equations may not reflect precisely free T measured using a reference method
  • free T declines more steeply with age than total T in both cross-sectional [35] and longitudinal studies, [36] as does free E2 in comparison to total E2
  • ...22 more annotations...
  • T may slow development of or progression of atherosclerosis by modulating effects on insulin resistance, inflammation, endothelial function, preclinical atherosclerosis or the vasculature.
  • these cross-sectional and longitudinal studies support a relationship between low circulating T with CIMT and higher E2 with its progression
  • lower levels of T are biomarkers for aortic vascular disease
  • circulating free T was negatively associated with the presence of AAA
  • luteinizing hormone (LH) was positively associated.
  • low levels of total or bioavailable T were associated with aortic atherosclerosis manifested as calcified deposits detected by radiography
  • Men with total or free T in the lowest quartile had increased adjusted ORs for PAD defined as ABI <0.90, as did men with free E2 in the highest quartile of values
  • The apparent association of SHBG with intermittent claudication reflects the correlation of total T with SHBG, while the contribution of E2 to risk of PAD remains unclear
  • men with total T in the lowest quartile of values (<11.7 nmol l−1 ) experienced an increased incidence of stroke or transient ischemic attack
  • lower total T with increased incidence of CVD events
  • cohort studies in mostly older men have supported the association of lower androgen levels with higher mortality
  • lower total or free T levels were associated with mortality in older men, but with discordant results for cause-specific mortality and for associations of E2
  • several large studies identifying lower endogenous levels of total or free T as independent predictors of all-cause or CVD-related deaths in middle-aged and older men
  • T exhibits anti-inflammatory effects, enhances flow-mediated brachial artery reactivity, and reduces arterial stiffness
  • Short-term T therapy had a beneficial effect on exercise-induced myocardial ischemia in middle-aged men with coronary artery disease or chronic stable angina, [95],[96],[97] and reduced angina frequency in older men with diabetes and coronary artery disease
  • T therapy resulted in an increase in treadmill test duration and time to ST segment depression
  • there are interventional studies supporting a protective effect of exogenous T against myocardial ischemia in men with coronary artery disease
  • employ conservative doses
    • Nathan Goodyear
       
      This dosing is 100 fold higher then peak production of a  young man at 20-22.
  • Observational studies indicate that lower levels of endogenous T in older men are associated with the presence of carotid atherosclerosis, aortic and peripheral vascular disease, and incidence of CVD events and mortality
  • Interventional studies have shown beneficial effects of exogenous T on vascular function and on exercise-induced myocardial ischemia in men with coronary artery disease
    • Nathan Goodyear
       
      the therapies employed in these studies were massively overdosed.
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    Nice review of all the sex hormones and their relationship to CVD in men.  
Nathan Goodyear

Bromine/Bromide DRI/RDA, negative health/toxic side effects, overdose, toxicity, nutrit... - 0 views

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    those with thyroid problems should avoid bromine.  This discusses bromine, sources, and symptoms
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