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Nathan Goodyear

Oncotarget | Metformin and berberine, two versatile drugs in treatment of common metabo... - 0 views

www.oncotarget.com/index.php

"pancreatic cancer" berberine metformin cancer

shared by Nathan Goodyear on 28 Nov 18 - No Cached
  • Nathan Goodyear on 28 Nov 18
     
    Great review on the anti-tumor activity of metformin and berberine.
Nathan Goodyear

Metformin in cancer prevention and therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC4200668

Metformin cancer mTOR IGF-1 insulin

shared by Nathan Goodyear on 27 Nov 17 - No Cached
  • relative risks imparted by diabetes are greatest (about two fold or higher) for cancers of the liver, pancreas, and endometrium, and lesser (about 1.2-1.5 fold) for cancers of the colon and rectum, breast, and bladder
  • Nathan Goodyear on 27 Nov 17
     
    Metformin useful in the prevention of cancer, but also on the treatment as an adjunct.  Good review through possible mechanisms, mToR, insulin, IGF-1...
Nathan Goodyear

Metformin overcomes resistance to cisplatin in triple-negative breast cancer (TNBC) cel... - 0 views

breast-cancer-research.biomedcentral.com/...s13058-019-1204-2

cisplatin breast cancer metformin triple negative breast cancer

shared by Nathan Goodyear on 05 Aug 21 - No Cached
  • Nathan Goodyear on 05 Aug 21
     
    Metformin restores chemosensitivity in TNBC.
Nathan Goodyear

Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndr... - 0 views

care.diabetesjournals.org/...828.long

low T low testosterone testosterone therapy testosterone treatment metabolic syndrome diabetes metformin

shared by Nathan Goodyear on 27 Feb 13 - No Cached
  • Nathan Goodyear on 27 Feb 13
     
    testosterone therapy in men with metabolic syndrome or type II diabetes is shown to equal that of metformin therapy.  Hypogonadism in this study was determined by serum testosterone levels.
Nathan Goodyear

Hyperhomocysteinemia, deep vein thrombosi... [J Formos Med Assoc. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17908667

vitamin B12 homocysteine DVT blood clots MS methionine synthase metformin DM diabetes insulin resistance IR

shared by Nathan Goodyear on 23 Jan 12 - No Cached
  • Nathan Goodyear on 23 Jan 12
     
    Vitamin B12 deficiency will decrease methionine synthase activity, which will result in elevated homocysteine and the risk of DVT increases as a result.  In this article, the cause of the vitamin B12 depletion was metformin.  Diabetics and those with insulin resistance are already at an increased risk of blood clots.
Nathan Goodyear

Vitamin D and diabetes - 0 views

www.ncbi.nlm.nih.gov/...PMC2426990

vitamin D insulin resistance insulin sensitivity metformin

shared by Nathan Goodyear on 01 Dec 15 - No Cached
  • Nathan Goodyear on 01 Dec 15
     
    vitamin D in those with vitamin D deficiency and insulin resistance have improved insulin sensitivity.  The doses used in the case studies presented are low.  This article highlights the fact that vitamin D outperforms metformin in improved insulin sensitivity.
Nathan Goodyear

ScienceDirect - 0 views

www.sciencedirect.com/...S2212492618300745

"pancreatic cancer" cancer metformin chloroquine berberine

shared by Nathan Goodyear on 27 Nov 18 - No Cached
  • Nathan Goodyear on 27 Nov 18
     
    metformin augments chemotherapy in the treatment of pancreatic cancer. It promotes the anti-proliferative effects of mTORC and inhibits the proliferative PI3k/mTOR. It also works synergistically with the known anti-tumor anti-malarial drugs chloroquine and with the herb berberine.
Nathan Goodyear

Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracel... - 0 views

www.nature.com/...s41421-018-0033-2

metformin Wnt cancer

shared by Nathan Goodyear on 15 Sep 20 - No Cached
  • Nathan Goodyear on 15 Sep 20
     
    metformin inhibits Wnt/beta-Catenin pathway.
Nathan Goodyear

Journal of Endocrinological Investigation - 0 views

www.jendocrinolinvest.it/...abstract.cfm

birth control oral contraceptives cardiovascular risk PCOS polycystic ovary syndrome

shared by Nathan Goodyear on 28 May 13 - No Cached
  • Nathan Goodyear on 28 May 13
     
    The point of this post is not that the author concludes that metformin an statin therapy should be used in PCOS women on birth control with elevated cardiovascular risk; but that with struggling with PCOS should have cardiovascular risk assessment prior to starting birth control.  Again, back to the individualized approach paradigm.
Nathan Goodyear

Does hormone therapy affect blood pressure changes... [Menopause. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23942251

hormone therapy estrogen blood pressure menopause

shared by Nathan Goodyear on 20 Aug 13 - No Cached
  • Nathan Goodyear on 20 Aug 13
     
    The author's conclusion of this study found no difference in decline in blood pressure with/without estrogen therapy.  However, if you look at the results, the nonusers of estrogen did not have a decline in systolic blood pressure as in the users of estrogen.  So, I don't know where that conclusion comes from.  This study looked at lifestyle changes.  This study also found no benefit of metformin in blood pressure
Nathan Goodyear

Cancers | Free Full-Text | A Second WNT for Old Drugs: Drug Repositioning against WNT-D... - 0 views

www.mdpi.com/htm

cancer Niclosamide ivermectin Wnt

shared by Nathan Goodyear on 16 Apr 18 - No Cached
  • To date nearly half of known human tumors show a dysregulation of the WNT signaling pathway
  • It should be also noted that the WNT pathway is not exclusively employed during development or overactivated in cancer. In adults many healthy tissues rely on it for renewal and homeostasis maintenance, most notably the intestine, haematopoietic system, hair, bones and skin. Therefore one might expect adverse reactions in all these organ systems, which has indeed been observed for many WNT-targeting compounds upon attempts to push them into the clinics
  • The intestine seems to be the most vulnerable in this regard
  • ...8 more annotations...
  • Ivermectin inhibits proliferation of human colon cancer and lung cancer cells both in vitro and in vivo
  • The anti-proliferative action, affecting both the bulk tumor cells and CSCs, was linked in this study to inhibition of WNT signaling
  • the anti-WNT IC50 of ivermectin is 5–10 times (~1–2 µM vs. 10 µM) lower than that of its toxic effect against chloride channels
  • oral bioavailability of the drug, as for other antiparasitic drugs discussed in this section, is very low
  • Toxicity studies in vivo have also demonstrated a wide therapeutic index for ivermectin
  • Its anti-proliferative activity has been demonstrated in a wide array of cancer cell lines representative of WNT-dependent cancers: non-small lung carcinoma [96], multiple myeloma [97], hepatoma [98], adrenocortical carcinoma [99], ovarian cancer [100] and glioblastoma
  • Niclosamide inhibits the canonical WNT pathway
  • In addition to inhibiting the canonical WNT pathway, niclosamide may mediate its anticancer activities through several other signaling pathways such as NOTCH [107], MTOR [108], NF-κB [97] and STAT3 [96]
  • Nathan Goodyear on 16 Apr 18
     
    review article highlights older medications that have anti-Wnt pathway effects in cancer.  Roughly, 50% of cancer involve upregulated Wnt pathway activity. Other drugs of note: metformin
Nathan Goodyear

Melatonin and Metformin Failed to Modify the Effect of Dacarbazine in Melanoma - Novik ... - 0 views

theoncologist.onlinelibrary.wiley.com/...onco.13761

chemotherapy melatonin metformin

shared by Nathan Goodyear on 28 Sep 22 - No Cached
  • Nathan Goodyear on 28 Sep 22
     
    This study was designed to fail; or, worse was designed out of ignorance of proper melatonin dosing.
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