first study that I have seen that looked at the issue of Testosterone transmission through laundered clothing. Only abstract available here, but 13% was transmitted to clothing through skin application and 3% remained following laundry of the clothing.
this is a pdf article only and not much is available for public read: estrogen found to have antiviral activity against influenza A in women via ER-beta activation.
study finds both Testosterone therapy and aromatase inhibition in men > 65 both increase Testosterone levels. Increase in prostate size was only seen in the Testosterone only group; not in the AI group. This implicates aromatase activity in the increase in prostate volume.
Opiates and prescription meds are a common cause of low T in men. In this study with men with metabolic dysfunction and opiate induced low T, Testosterone therapy did not worsen inflammatory/metabolic markers. Of note, this study did not find improvement in the metabolic and inflammatory markers as other studies have shown.
new study finds Testosterone therapy in men with low T significantly reduces fat, increases lean muscle mass, and reduces fasting glucose and insulin levels. Improvements in total cholesterol, triglycerides and HDL was also seen. Only abstract available currently.
study finds no association between total Testosterone, free Testosterone, and 3alpha-andorstanediol glucuronide and prostate cancer. Included: no association with SHBG and estrogen to Testosterone ratio.
No surprise that Testosterone therapy improves Testosterone levels in men with low T, but aromatase inhibition (AI) did as well. In this study, only lean mass increased compared to Testosterone therapy and placebo. Strength increased in both Testosterone and AI.
In this study of men with low TT levels and without prior MI or stroke, normalization of TT levels using TRT is associated with lower all-cause mortality, fewer MIs, and ischaemic strokes.
retrospective study
significant benefit is observed only if the dose is adequate to normalize the TT levels
the mechanisms for these effects remain speculative
It can be postulated that the beneficial effect of normal T levels on adipose tissue, insulin sensitivity, and lipid profiles or by its anti-inflammatory and anticoagulant properties, as reported by other investigators, might have contributed to our findings
off-label use of TRT remains a concern
Recent FDA analyses suggest that currently only half of the men on TRT had been diagnosed with hypogonadism
25% of users did not have their T concentrations tested prior to initiating therapy
21% of those prescribed TRT did not have their levels tested at any time during treatment
two very recent meta-analyses suggested a lack of convincing evidence posed by TRT.
men without a history of previous MI or stroke who have low TT levels, TRT might be associated with decreased risks of MI, ischaemic stroke, and all-cause mortality in long-term follow-up
TRT should aim for doses resulting in normalization of TT level as this was shown to be associated with reduction in adverse CV events