Study finds a decrease in gut bacterial load in women with breast cancer versus those without. The authors propose that a decrease in bacterial load in healthy individuals might be a means to estimate breast cancer risk. Could it all start in the gut?
the energy supplied to rephosphorylate
adenosine diphosphate (ADP) to adenosine triphosphate (ATP) during and following intense
exercise is largely dependent on the amount of phosphocreatine (PCr) stored in the
muscle
Creatine is chemically known as a non-protein nitrogen
It is synthesized in the liver and pancreas from the amino acids arginine, glycine,
and methionine
Approximately 95% of the body's creatine is stored in skeletal muscle
About two thirds of the creatine found in skeletal muscle is stored as phosphocreatine
(PCr) while the remaining amount of creatine is stored as free creatine
The body breaks down about 1 – 2% of the creatine pool per day (about 1–2 grams/day)
into creatinine in the skeletal muscle
The magnitude of the increase in skeletal muscle creatine content is important because
studies have reported performance changes to be correlated to this increase
"loading" protocol. This protocol is characterized by ingesting approximately
0.3 grams/kg/day of CM for 5 – 7 days (e.g., ≃5 grams taken four times per day) and
3–5 grams/day thereafter [18,22]. Research has shown a 10–40% increase in muscle creatine and PCr stores using this
protocol
Additional research has reported that the loading protocol may only need to be 2–3
days in length to be beneficial, particularly if the ingestion coincides with protein
and/or carbohydrate
A few studies have reported protocols with no loading
period to be sufficient for increasing muscle creatine (3 g/d for 28 days)
Cycling protocols involve the consumption of "loading" doses for 3–5 days every 3
to 4 weeks
Most of these forms of creatine have been reported to be no
better than traditional CM in terms of increasing strength or performance
Recent studies do suggest, however, that adding β-alanine to CM
may produce greater effects than CM alone
These investigations indicate that the
combination may have greater effects on strength, lean mass, and body fat percentage;
in addition to delaying neuromuscular fatigue
creatine
phosphate has been reported to be as effective as CM at improving LBM and strength
Green et al. [24] reported that adding 93 g of carbohydrate to 5 g of CM increased total muscle creatine
by 60%
Steenge et al. [23] reported that adding 47 g of carbohydrate and 50 g of protein to CM was as effective
at promoting muscle retention of creatine as adding 96 g of carbohydrate.
It appears that combining CM with carbohydrate or carbohydrate and protein produces
optimal results
Studies suggest that increasing skeletal muscle creatine uptake may
enhance the benefits of training
Nearly 70% of these studies have
reported a significant improvement in exercise capacity,
Long-term CM supplementation appears to enhance the overall quality of training,
leading to 5 to 15% greater gains in strength and performance
Nearly all studies indicate that "proper" CM supplementation increases body mass
by about 1 to 2 kg in the first week of loading
short-term adaptations reported from
CM supplementation include increased cycling power, total work performed on the bench
press and jump squat, as well as improved sport performance in sprinting, swimming,
and soccer
Long-term adaptations when combining CM supplementation with training include increased
muscle creatine and PCr content, lean body mass, strength, sprint performance, power,
rate of force development, and muscle diameter
subjects taking CM typically gain about twice as much body
mass and/or fat free mass (i.e., an extra 2 to 4 pounds of muscle mass during 4 to
12 weeks of training) than subjects taking a placebo
The gains in muscle mass appear to be a result of an improved ability to perform
high-intensity exercise via increased PCr availability and enhanced ATP synthesis,
thereby enabling an athlete to train harder
there is no evidence to support the notion
that normal creatine intakes (< 25 g/d) in healthy adults cause renal dysfunction
no long-term side effects have been observed in athletes (up to 5 years),
One cohort of patients taking 1.5 – 3 grams/day of CM has been monitored since 1981
with no significant side effects
Great article from 2008 that discusses glycemic index and glycemic load. What is great about this article is the supplementary appendix listing the above for > 1000 items.
Powerchairs are generally four-wheeled or six-wheeled and non-folding, however some folding designs exist and other designs may have some ability to partially dismantle for transit. Four general styles of powerchair drive systems exist: front, centre or rear wheel drive and all-wheel drive. Powered wheels are typically somewhat larger than the trailing/castoring wheels, while castoring wheels are typically larger than the castors on a manual chair. Centre wheel drive powerchairs have castors at both front and rear for a six-wheel layout.
Angel Wheelchair
Electric standing wheelchair Standing up, driving function by power.
Head and signal light (controlled by joystick).
Adjustable headrest.
Adjustable footplate.
Detachable backrest Rigid steel framework W/liquid coating
Flip-backward armrest
Max speed: 9.15KM/H
Front castor: 2.80/2.50-4
pneumatic castor (9")
Rear wheels: 3.00-8
pneumatic tire (14")
Available seat width: A (46 cm), D (42 cm)
Max loading: A size: 135 kg
Net weight w/o battery: 62.7 kg
A powerchairs is a wheelchair that is propelled by means of an electric motor rather than manual power. Power wheelchairs are useful for those unable to propel a manual wheelchair or who may need to use a wheelchair for distances or over terrain which would be fatiguing in a manual wheelchair. They may also be used not just by people with 'traditional' mobility impairments, but also by people with cardiovascular and fatigue based condition. An powerwheelchair powers more than just chair. It gives the power to safely travel long distances on own. It empowers to navigate through home, backyard, school, workplace or local park. It gives power to do the things,want to do. It gives power. When accidents occur that leave permanent leg injuries, or as age sets in and joint pain becomes unbearable, the power chair acts as a gateway to continue living life to the fullest. The powerwheelchairs in our lineup are all battery powered, yet each device fills
GI is a measure of carbohydrate quality in relation
to glucose availability and is independent of quantity, whereas GL is a measure of the total glycemic effect and hence is
anindicator of the insulin demand of the diet. High-glycemic diets are in fact generally associated with greater insulin secretion
the consumption of large quantities of high-GI foods rather than the consumption of high quantities of carbohydrates
is linked to the development of breast cancer.
High glycemic index diet was found to be associated with increased risk of colon and bladder cancer where as a high glycemic load was associated with increased risk of colon cancer and other diabetes-related cancers.
GM LITE POWER WHEELCHAIR
GM Lite Brushless Power Wheelchair with Batteries is a revolutionary light weight power wheelchair using brushless motor. It is the most economic power wheelchair without sacrificing safety & durability. The wheelchair promotes pressure redistribution, reduces downward sliding and helps maintain good posture.
Specifications:
10 times longer life
Lightest - 23 kg
5 year long life, safe LiFePO4 battery (10ah)
High efficiency brushless hub motor
5 seconds folding and unfolding
Easy to carry
Load : 120 kg
Speed : 8km/hr
Range: 15 km
Slope : 12%
24V180W brushless
8-inch gear hub motor
In a cohort of well-trained athletes, we demonstrated that intense endurance exercise causes an acute reduction in RV function that increases with race duration and correlates with increases in biomarkers of myocardial injury
no relationship between LV function and biomarker levels
focal gadolinium enhancement and increased RV remodelling were more prevalent in those athletes with a longer history of competitive sport, suggesting that repetitive ultra-endurance exercise may lead to more extensive RV change and possible myocardial fibrosis
he cardiac impact of both acute and cumulative exercise is greatest on the RV.
Greater reductions in RV function occurred in those athletes competing for a longer duration, suggesting that the heart has a finite capacity to maintain the increased work demands of exercise
cardiac injury is greatest in the least trained
Previous investigators have documented reductions in RV function in less trained subjects over the marathon distance
We enrolled elite and subelite athletes and found a significant association between fitness (VO2max) and the reduction in post-race RVEF
Even after many years of detraining, cardiac dilation may not completely regress in elite athletes
The focus on well-trained athletes may be of particular relevance, given that they perform exercise of highest intensity and duration most frequently, and, thus, may be at a greater risk of cumulative injury.
The lack of correlation between increases in troponin and changes in LV function seen in this study has been previously interpreted as evidence that post-exercise elevations in cardiac biomarkers are benign.
a significant correlation between changes in RVEF and post-race biomarker levels and this relationship was even stronger in the athletes who completed the race of longest duration, the ultra-triathlon
The correlations with RVEF, but not LVEF, provide further evidence of the differential effects of intense exercise on RV and LV function
BNP release during intense exercise is associated with greater relative increases in RV systolic pressures, but not LV pressures
BNP may provide a measure of both acute RV load and the resultant fatigue which occurs when this load is sustained
It has been demonstrated that ventricular load increases with exercise intensity and is greater for the RV than the LV,29 thus potentially explaining why the RV is more susceptible to fatigue after prolonged exercise.
This study demonstrates, for the first time, an association between endurance exercise of increasing duration and structural, functional, and biochemical markers of cardiac dysfunction in highly trained athletes
Functional abnormalities were confined to the RV and were largely reversible 1 week following the event
there remained a significant minority of athletes in whom there was evidence of myocardial fibrosis in the interventricular septum
RV abnormalities may be acquired through cumulative bouts of intense exercise and provides direction for prospective investigations aimed at elucidating whether extreme exercise may promote arrhythmias in some athletes.
the acute injury and chronic remodelling of the myocardium both disproportionately affect the RV and it remains possible that the two are linked.
focal DGE was confined to the interventricular septum and commonly at the site of RV attachment
emerging evidence that intense endurance exercise may be associated with an excess in arrhythmic disorders, the mechanisms for which remain unexplained
RVEF (and not LVEF) was reduced in athletes with complex ventricular arrhythmias when compared with healthy athletes and non-athletes without arrhythmias
it is premature to conclude that these changes may represent a proarrhythmic substrate
Study finds endurance racing results in reduce Right ventricle ejection fraction even in elite athletes. This post-race RVEF reduction is associated with VO2max.
Study finds link between higher glycemic index and glycemic load with increased breast cancer risk. The proposed mechanisms are: hyperinsulinemia and its affinity for IGF-1 receptor resulting in a + growth signal. Increased IGF-1 via the same mechanism. Insulin and IGF-1 have negative regulation effects on SHBG.
This all makes sense as insulin receptors are highly expressed on cancer cells.
This study links glycine to increased blood pressure. However, meat is the primary source of glycine. So, if the meat is loaded with omega-6, hormones...these will be the source of the inflammation and resultant increase in blood pressure, not the glycine. One must read these studies closely. No conclusion can be made from this study.
with a team of experts who are loaded with skills and high-quality training techniques to resolve all the windows software related queries, just dial our Windows technical support number 1-800-261-4071 and get in touch with our best qualified experts. you can aslo visit our websiters as http://technicalsupportnumberforwindows.com
Loading dose of creatine, 20 grams/day, over 5-6 days increases total muscle creatine levels. This has been shown to improve athletic performance. The phosphocreatine in Type II muscle fibers are particularly increased. This can be maintained at 2 grams/day.
Creatine supplementation shown to improve muscle recovery in injury. The dosing included the standard loading dose at 0.3 g/kg of body weight divided in multiple doses. Maintenance was at 0.1 g/kg of body weight.