Skip to main content

Home/ Dr. Goodyear/ Group items tagged flare

Rss Feed Group items tagged

Nathan Goodyear

Prostate-specific antigen flare induced by cabazitaxel-based chemotherapy in patients w... - 0 views

  •  
    Taxanes associated with PSA flare. The authors concluded that the flar within 12 weeks of therapy was not associated with any change in outcomes and could be ignored. The Taxanes as a whole group appears to be associated with this PSA flare pheonomenon.
Nathan Goodyear

Ovarian failure and flares of systemic lupus... [Arthritis Rheum. 1999] - PubMed - NCBI - 0 views

  •  
    Low estrogen levels in ovarian failure patients found to reduce flares in those with Lupus.  Estrogen can promote inflammation, especially high estrone levels.  It is easy to see how ovarian failure and a drop in estrogen could reduce inflammation and thus autoimmune flares.
Nathan Goodyear

Co-introduction of a steroid with docetaxel chemotherapy for metastatic castration-resi... - 0 views

  •  
    Corticoidsteroid found to be associated with docetaxol associated PSA flare.
Nathan Goodyear

Prostate-specific antigen flare phenomenon with docetaxel-based chemotherapy in patient... - 0 views

  •  
    PSA flare is associated with docetaxol chemotherapy in men undergoing treat for prostate cancer.
Nathan Goodyear

Dehydroepiandrosterone treatment of women with mil... [Arthritis Rheum. 2002] - PubMed ... - 0 views

  • CONCLUSION: The overall results confirm that DHEA treatment was well-tolerated, significantly reduced the number of SLE flares, and improved patient's global assessment of disease activity.
  •  
    DHEA reduces SLE flares
Nathan Goodyear

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bju.13554 - 0 views

  •  
    Good brief review of the evidence of the psa flare
Nathan Goodyear

The effect of combined estrogen and progester... [Ann Intern Med. 2005] - PubMed - NCBI - 0 views

  •  
    HRT, particularily estrogen therapy, is shown to increase mild to moderate flares of lupus.
Nathan Goodyear

Evaluation of dairy allergy among ulcerative colitis patients - 0 views

  •  
    dairry sensitivity associated with ulcerative colitis; intake associated with flare in colitis.
Nathan Goodyear

Curcumin attenuates the development of allergic airway inflammation and hyper-responsiv... - 0 views

  •  
    curcumin shown to inhibit allergic airway inflammation, through NF-kappaB inhibition.  This has implications in asthma flares.
Nathan Goodyear

Systemic lupus erythematosus and hormone repla... [Menopause Int. 2007] - PubMed - NCBI - 0 views

  •  
    Women with SLE enter menopause earlier.  This study comments on the need for hormone testing in women with SLE and appropriate therapy as indicated.  This study recommended against estrogen therapy due to studies revealing increased flares.  The problem with those studies is that they looked at OCPs and synthetic HRT.
Nathan Goodyear

Dehydroepiandrosterone suppresses interleukin 10 synthesis in women with systemic lupus... - 0 views

  •  
    DHEA lowers Lupus Flares in CHinese women
Nathan Goodyear

The Role of Serum Immunoglobulin Free Light Chain in Response and Progression in Walden... - 0 views

  •  
    Free Light Chains are useful in monitoring treatment success in Waldenstrom's Macroglobulinemia. On average, a response was seen 1 month earlier with the sFLC's than in the IgM. Also, appx 50% of patients receive rituxin had an IgM flare early in treatment.
Nathan Goodyear

The Complex Role of Estrogens in Inflammation - 0 views

  • These studies suggest inflammation-dependent up-regulation of ERβ relative to ERα.
  • up-regulation of ERβ relative to ERα under hypoxic conditions, which might lead to a preponderance of signaling through ERβ pathways
  • it seems that E2 at periovulatory to pregnancy levels inhibited proinflammatory cytokines from PBMCs
  • ...26 more annotations...
  • it is clear that E2 can stimulate antibody production by B cells, probably by inhibiting T cell suppression of B cells
  • In cycling women, the largest quantities of Ig were detected before ovulation
  • In contrast, E2 at high concentrations leads to a suppression of B-lymphocyte lineage precursors
  • E2 at periovulatory to pregnancy serum levels is able to stimulate antibody secretion under healthy conditions but also in autoimmune diseases, whereas similar serum levels of E2 lead to a suppression of bone marrow B cell lineage precursors
  • In chronic inflammatory disorders, where B cells play a decisive role, E2 would promote the disease when autoaggressive B cells are already present, whereas chronically elevated E2 would inhibit initiation of an autoimmune disease when no such B cells are available. This might be a good reason why particularly B cell-dependent diseases such as SLE, mixed connective tissue disease (Sharp syndrome), IgA nephropathy, dermatitis herpetiformis, gluten sensitive enteropathy, myasthenia gravis, and thyroiditis appear in women in the reproductive years, predominantly, in the third or fourth decades of life
  • Th17 cells are thought to be the main responsible cells for chronic inflammatory tissue destruction in autoimmune diseases
  • IFN-γ, IL-12, and TNF were allocated to Th1 reactions
  • IL-4, IL-5, and IL-10 to Th2 responses
  • antiinflammatory T regulatory cells producing TGF-β and proinflammatory T helper type 17 cells (Th17) producing IL-17
  • no direct effects of estrogens on Th17 cells or IL-17 secretion have been described until now.
  • So-called Th17 cells producing IL-17 are the main T cells responsible for chronic inflammation.
  • Because IFN-γ has been allocated a Th17-inhibiting role (Fig. 1⇑), its increase by E2 at pregnancy doses and the E2-mediated inhibition of TNF must be viewed as a favorable effect in chronic inflammation
  • in humans and mice, E2 at periovulatory to pregnancy levels stimulates IL-4, IL-10, and IFN-γ but inhibits TNF from CD4+ T cells
  • In humans and mice, E3 and E2, respectively, at pregnancy levels inhibit T cell-dependent delayed type hypersensitivity
  • increased IL-4, IL-10, and IFN-γ in the presence of low TNF support an antiaggressive immune response
  • secretion of IL-1β is increased at periovulatory/proestrus to early pregnancy levels, whereas IL-1 secretion is inhibited at high pregnancy levels
  • The dichotomous effect of E2 on IL-1β and TNF at high and low concentrations is most probably due to inhibition of NF-κB at high concentrations
  • experiments with mouse and rat macroglial and microglial cells demonstrate that E2 at proestrus to pregnancy levels exerts neuroprotective effects by increasing TGF-β and by inhibiting iNOS and NO release, and reducing expression of proinflammatory cytokines and prostaglandin E2 production.
  • E2 at periovulatory to pregnancy levels inhibits NF-κB activation, which must be viewed as an antiinflammatory signal
  • It was shown that E2 concentrations equal to or above 10−10 m are necessary to inhibit NF-κB activation
  • important proinflammatory cytokines are typically inhibited at periovulatory (proestrus) to pregnancy levels of E2, which is evident for IL-6, IL-8, and TNF
  • low E2 concentrations were demonstrated to have no or even stimulatory effects
  • This renders a woman in the postmenopausal phase to a more proinflammatory situation
  • most in vitro studies demonstrated a stimulatory effect of E2 on secretion of IL-4, IL-10, and TGF-β typically at periovulatory to pregnancy levels
  • E2 at periovulatory to pregnancy levels has an ameliorating effect on chronic inflammatory diseases as long as B cell-dependent immunity or an overshooting fibrotic tissue repair process do not play a crucial pathogenic role. However, when the B cell plays an important role, E2 might even stimulate the disease process as substantiated by flare-ups in SLE during pregnancy
    • Nathan Goodyear
       
      SLE, mixed connective tissue disease (Sharp syndrome), IgA nephropathy, dermatitis herpetiformis, gluten sensitive enteropathy, myasthenia gravis, and thyroiditis
  • Short-term administration of E2 at pregnancy levels was shown to induce an inflammatory response specific to the lateral prostate of the castrated male rat
  •  
    great review of the complex interaction between Estrogens and inflammation.  Reference here is in females.
1 - 16 of 16
Showing 20 items per page