In a cohort of well-trained athletes, we demonstrated that intense endurance exercise causes an acute reduction in RV function that increases with race duration and correlates with increases in biomarkers of myocardial injury
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Exercise-induced right ventricular dysfunction and structural remodelling in endurance ... - 0 views
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focal gadolinium enhancement and increased RV remodelling were more prevalent in those athletes with a longer history of competitive sport, suggesting that repetitive ultra-endurance exercise may lead to more extensive RV change and possible myocardial fibrosis
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Greater reductions in RV function occurred in those athletes competing for a longer duration, suggesting that the heart has a finite capacity to maintain the increased work demands of exercise
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We enrolled elite and subelite athletes and found a significant association between fitness (VO2max) and the reduction in post-race RVEF
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Previous investigators have documented reductions in RV function in less trained subjects over the marathon distance
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The focus on well-trained athletes may be of particular relevance, given that they perform exercise of highest intensity and duration most frequently, and, thus, may be at a greater risk of cumulative injury.
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The lack of correlation between increases in troponin and changes in LV function seen in this study has been previously interpreted as evidence that post-exercise elevations in cardiac biomarkers are benign.
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a significant correlation between changes in RVEF and post-race biomarker levels and this relationship was even stronger in the athletes who completed the race of longest duration, the ultra-triathlon
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It has been demonstrated that ventricular load increases with exercise intensity and is greater for the RV than the LV,29 thus potentially explaining why the RV is more susceptible to fatigue after prolonged exercise.
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BNP release during intense exercise is associated with greater relative increases in RV systolic pressures, but not LV pressures
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BNP may provide a measure of both acute RV load and the resultant fatigue which occurs when this load is sustained
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The correlations with RVEF, but not LVEF, provide further evidence of the differential effects of intense exercise on RV and LV function
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This study demonstrates, for the first time, an association between endurance exercise of increasing duration and structural, functional, and biochemical markers of cardiac dysfunction in highly trained athletes
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Functional abnormalities were confined to the RV and were largely reversible 1 week following the event
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there remained a significant minority of athletes in whom there was evidence of myocardial fibrosis in the interventricular septum
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RV abnormalities may be acquired through cumulative bouts of intense exercise and provides direction for prospective investigations aimed at elucidating whether extreme exercise may promote arrhythmias in some athletes.
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the acute injury and chronic remodelling of the myocardium both disproportionately affect the RV and it remains possible that the two are linked.
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emerging evidence that intense endurance exercise may be associated with an excess in arrhythmic disorders, the mechanisms for which remain unexplained
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RVEF (and not LVEF) was reduced in athletes with complex ventricular arrhythmias when compared with healthy athletes and non-athletes without arrhythmias
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Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle: Cell Metabolism - 0 views
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our results provide evidence to suggest that acute exercise induces gene-specific DNA hypomethylation in human skeletal muscle
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Our results suggest that DNA methylation is a component of the exercise-induced effect on expression of these genes.
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the effect of exercise on DNA methylation in human skeletal muscle and provide evidence that acute exercise alters promoter methylation of exercise-responsive genes in a dose-dependent manner
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DNA methylation was unaltered 48 hr after a 3-week exercise training program, whereas RNA expression of PGC-1α and TFAM promoters was elevated (data not shown), further suggesting that DNA hypomethylation is a transient mechanism involved in mRNA synthesis
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Our findings that ionomycin, AICAR, or ROS production increased mRNA expression without altering promoter methylation may support the notion that DNA methylation does not exclusively control exercise-induced gene expression
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shared by Nathan Goodyear on 13 Jan 15
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Intravenous Fluid Use in Athletes - 0 views
www.ncbi.nlm.nih.gov/...PMC3435915
IV intravenous fluid nutrition athletes athlete sports medicine sports exercise
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Treatment of exercise-associated hyponatremia with hypertonic IV infusion to correct plasma sodium levels is also a standard and accepted use of IV fluid infusions
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athletes who present for medical care with hypernatremia who cannot tolerate oral fluids can benefit from IV fluids
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Vaporization of sweat accounts for 80% of heat loss in hot, dry atmospheric conditions. This mechanism of water loss is the major contributor for exercise-associated dehydration
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Pre- and postexercise body weight measurements are the most common means to estimate overall water loss but are condition specific
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In highly trained endurance athletes, plasma volume and sodium serum concentration were preserved despite a 5% body weight loss
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In Ironman triathletes, dehydration to 5% body weight loss did not correlate with occurrence of medical complications
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hydration should begin hours prior to exercise, especially if known deficits are present, and fluids should be consumed at a slow, steady rate, with 5 to 7 mL/kg taken 4 hours prior to exercise
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Sodium concentration did not produce significant changes in the rate of absorption but was primarily dependent on carbohydrate concentration
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IV treatment of severe dehydration (>7% body weight loss), exertional heat illness, nausea, emesis, or diarrhea, and in those who cannot ingest oral fluids for other reasons, is clinically indicated
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A recent survey of the National Football League teams revealed that 75% (24 of 32) of the teams utilized IV infusion of fluids for prehydration in at least some otherwise healthy individuals
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In the National Football League, an average of 1.5 L of normal saline was administered approximately 2.5 hours prior to competition
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after 2 hours of exercise, the rectal temperature was 0.6° higher in the group not receiving IV infusion. Also, stroke volume and cardiac output were 11% to 16% lower in the control group versus the IV infusion group.
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Recent evidence suggests the etiology of EAMC is related to muscle fatigue and neuronal excitability
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there may be a subset of muscle cramping that is associated with a loss of both body fluid and sodium
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elevation of plasma volume by 200 to 300 mL via dextran infusion resulted in 15% increase in stroke volume, 4% increase in VO2 max, and an increase in the exercise time to fatigue
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Neither the tonicity nor mode of hydration resulted in improved speed of rehydration, greater fluid retention, or improved performance
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There are beneficial anecdotal reports of EAMC treatment in elite and professional-level athletes with IV hydration during the course of an event
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Plasma volume was better restored during rehydration with IV fluids at preexercise and 5 minutes of exercise. At 15 minutes, there was no difference between IV and oral rehydration
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More rapid restoration of plasma volume was accomplished in the IV treatment group with no advantages over oral rehydration in physiological strain, heat tolerance, ratings of perceived effort, or thermal sensations
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No difference was found in exercise time to exhaustion. IV and oral rehydration methods were equally effective. Heart rates were statistically higher in the oral rehydration group through 75 minutes of exercise, and there were higher increases in norepinephrine plasma concentrations
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No significant differences between the groups were found for time to recovery, number of days with pain, number of days with stiffness, sleep disturbance, fatigue, rectal temperature, and loss of appetite
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There may be physiological benefits of decreased heart rate and norepinephrine in athletes rehydrated via IV route
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Postexercise blood 1 hour and 24 hours showed no differences in circulating myoglobin or creatine kinase
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this should be reserved for high-level athletes with strong histories of symptoms in well-monitored settings.
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shared by wheelchairindia9 on 24 Feb 16
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Hip Cycle - 0 views
www.wheelchairindia.com/...Hip-Cycle
Hip Cycle buy hip cycle exerciser hip cycle exerciser Vissco Hip Cycle Exerciser Vissco Hip Cycle hip cycles new hip cycle exerciser new hip cycle hip cycle home exerciser
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Hip Cycle is a stationary regular cycle exerciser used in physical therapy and as a sports fitness aid. Cycling is a low-impact exercise to increase muscle strength and mobility of the hips and knees. Cycling assists in hip toning by muscle growth and burning of calories. Hip Cycle Features Pedaling uses thigh muscles: quadriceps to push down, and hamstrings to pull up during the circular motion Cycling workout results in isometric engagement of the abdomen as a supporting muscle group Range of motion exercises help improve joint function Reduce hip pain caused by bone diseases such as osteoarthritis and necrosis Hip Cycle can be used in preferably recumbent position or in sitting position
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Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Deg... - 0 views
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exercise for 6 months is associated with epigenetic changes, e.g., decreased DNA methylation of RUNX1 and MEF2A, two key transcription factors involved in exercise training (42–44), of THADA, previously associated with T2D (1), and of NDUFC2, which is part of the respiratory chain (45) was observed after exercise
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exercise changed both DNA methylation and expression of a number of genes, including ADIPOR1, ADIPOR2, and BDKRB2, encoding receptors for adiponectin and bradykinin, respectively, which both regulate metabolism in muscle
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we cannot draw a conclusion as to whether differential expression is a consequence rather than a cause of changes in methylation
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ageing is associated with increased DNA methylation and decreased expression of genes involved in oxidative phosphorylation in human muscle
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exercise can induce genome-wide epigenetic changes in human muscle and that the response may differ in people with different genetic predispositions to metabolic disease
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Six months of exercise induce epigenetic changes through decrease in methylation. This study was designed to look at those with a family risk of DM. They found a difference in the methylation status of muscle between those with a family h/o diabetes and those without. This would have implications in therapeutic difference prior to diagnosis. Even a increased VO2max and skeletal muscle mitochondrial density was found to be the result of decreased methylation of the NDUFC2 gene after exercise.
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shared by Nathan Goodyear on 03 Sep 14
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Effect of resistance exercise on muscle steroidogenesis | Journal of Applied Physiology - 0 views
jap.physiology.org/...1754
resistance resistance training training exercise Testosterone male female hormone hormones muscle
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skeletal muscle cell cultures incubated with DHEA produced testosterone in a DHEA dose-dependent manner
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testosterone appears to have a role in the maintenance of muscle mass in women, although the importance of this role has not yet been fully established.
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Circulating testosterone concentrations are generally elevated following a bout of resistance exercise in men (24, 31, 46, 52), whereas findings for the effect of resistance exercise on circulating testosterone in women are equivocal, with increases (10, 42) and no changes observed (22, 31)
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swimming (51) and treadmill running (2) can significantly increase muscle testosterone concentrations in male and female rats
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This upregulation of muscle testosterone in rats appears, at least in part, to be due to an increase in 3β-HSD and 17β-HSD type 1 expression
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The primary finding in this study was that muscle steroidogenesis (i.e., testosterone production) in highly resistance-trained humans was not affected by an acute bout of heavy resistance exercise
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A secondary finding was that the apparent molecular mass of 17β-HSD type 3 was increased following a single bout of heavy resistance exercise.
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No differences were found for muscle testosterone or steroidogenic enzyme (17β-HSD type 3 and 3β-HSD types 1 and 2) concentrations between sexes or in response to resistance exercise
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In conclusion, heavy resistance exercise did not induce changes in muscle steroidogenesis as measured by muscle concentrations of testosterone, 3β-HSD types 1 and 2, and 17β-HSD type 3 in highly resistance-trained young men and women.
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shared by wheelchairindia9 on 16 Mar 16
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Tubular Elastic Bandage - 0 views
www.wheelchairindia.com/...Tubular-Elastic-Bandage
Exercising Ball Excellent Physiotherapy Device relieves patients from arthritic pain High patient compliance uniform compression and support substitute for elastic wraps help to minimize inflammation easy to apply and comfortable
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Tubular Elastic Bandage provides uniform compression and support of the appendages with minimal risk of constriction. It is easy to apply and comfortable to wear, without the need of any clips or tape to hold it in place. Compressive strength remains consistent over a long period of use. This versatile, bandage is an economical and a better substitute for elastic wraps, and other general supports. Holds cold/hot packs or bandages in place. It offers good compression and help to minimize inflammation.The compression can be increased by increasing the layers of the bandage. Washable. Breathable and Hypo allergenic. Remains cool in summers and warm in winters. Uniform compression. Soft to touch, good to feel. Tubular Elastic Bandage Features High Quality Cotton Yarn Is breathable, hypo allergic, dermophilic, remains cool in summers & warm in winters. It is soft to touch, good to feel and is washable. State of Art Knitting Provides uniform compression, long functional life and firm fitting. Tubular Design Quick and easy wearing, without any pins or tapes. Provides complete freedom of movement. Fawn Colored Matches skin color, has better aesthetics. Can be worn inconspicuously under clothing.
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Transaminase Levels and Vigorous Exercise - 0 views
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Some physicians, whether they are gastroenterol-ogists or internists, forget that exercise can cause this abnormality
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we see a trend toward improved ALT and AST levels in patients performing moderate exercise, regardless of the etiology of their liver disease
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We therefore discourage very heavy exercise in these patients, but a moderate amount does not cause a problem
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once enzymes are abnormal, they remain abnormal for up to 1 week. Were subjects to exercise vigorously again during that week, transaminase levels could increase further
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there is a ratio that in healthy individuals is considered normal. AST levels normally measure at approximately 0.8 of ALT levels. A dysregularity of this ratio can also signal hepatic illness but usually inflammation of any kind affects both measures
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Influence of Exercise Order on Maximum Strength and Muscle Thickness in Untrained Men - 0 views
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shared by Nathan Goodyear on 03 Oct 17
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A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern i... - 0 views
journals.plos.org/...article
exercise epigenetics methylation obesity diabetes type 2 diabetes type II diabetes
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In skeletal muscle, HDAC4 has been found to be exported from the nucleus during exercise, suggesting that removal of the transcriptional repressive function could be a mechanism for exercise adaptation [50]. For HDAC4, we observed increased levels of DNA methylation and a simultaneous decrease in mRNA expression in adipose tissue in response to the exercise intervention. Additionally, the functional experiments in cultured adipocytes suggested increased lipogenesis when Hdac4 expression was reduced
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NCOR2 also exhibited increased levels of DNA methylation and a simultaneous decrease in mRNA expression in adipose tissue in response to the exercise intervention, and furthermore we observed increased lipogenesis when Ncor2 expression was down regulated in the 3T3-L1 cell line. NCOR2 is a nuclear co-repressor, involved in the regulation of genes important for adipogenesis and lipid metabolism, and with the ability to recruit different histone deacetylase enzymes, including HDAC4
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Study finds 6 month exercise program in men induced epigenetic change via DNA methylation of CPG islands in adipose cells effecting metabolism and altering obesity and type II diabetes risk. The study looked at 2 genes: HDAC4 and NCOR2 and found that exercise decreased expression via methylation altering adipogenesis and lipid metabolism.
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An integrative analysis reveals coordinated reprogramming of the epigenome and the tran... - 0 views
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Differential DNA methylation was predominantly observed in enhancers, gene bodies and intergenic regions and less in CpG islands or promoters
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highly consistent and associated modifications in methylation and expression, concordant with observed health-enhancing phenotypic adaptations, are induced by a physiological stimulus
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The health benefits following exercise training are elicited by gene expression changes in skeletal muscle, which are fundamental to the remodeling process
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there is increasing evidence that more short-term environmental factors can influence DNA methylation
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dietary factors have the potency to alter the degree of DNA methylation in different tissues, 9,10 including skeletal muscle
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In one study, a single bout of endurance-type exercise was shown to affect methylation at a few promoter CpG sites
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In the context of diabetes, exercise training has been shown to affect genome-wide methylation pattern in skeletal muscle,13 as well as in adipose tissue.
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the findings from this tightly controlled human study strongly suggest that the regulation and maintenance of exercise training adaptation is to a large degree associated to epigenetic changes, especially in regulatory enhancer regions
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Endurance training [after training (T2) vs. before training (T1)] induced significant (false discovery rate, FDR< 0.05) methylation changes at 4919 sites across the genome in the trained leg
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a complementary approach revealed that over 600 CpG sites correlated to the increase in citrate synthase activity, an objective measure of training response (Figure S4 and Dataset S14). This might imply that some of these sites could influence the degree of training response.
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As expected by a physiological environmental trigger on adult tissue, the observed effect size on DNA methylation was small in comparison to disease states such as cancer
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negative correlation was more prominent for probes in promoter/5′UTR/1st exon regions, while gene bodies had a stronger peak of positive correlation
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The significant changes in DNA methylation, that primarily occurred in enhancer regions, were to a large extent associated with relevant changes in gene expression
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The main findings of this study were that 3 months of endurance training in healthy human volunteers induced significant methylation changes at almost 5000 sites across the genome and significant differential expression of approximately 4000 genes
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DMPs that increased in methylation were mainly associated to structural remodeling of the muscle and glucose metabolism, while the DMPs with decreased methylation were associated to inflammatory/immunological processes and transcriptional regulation
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This suggests that the changes in methylation seen with training were not a random effect across the genome but rather a controlled process that likely contributes to skeletal muscle adaptation to endurance training
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Correlation of the changes in DNA methylation to the changes in gene expression showed that the majority of significant methylation/expression pairs were found in the groups representing either increases in expression with a concomitant decrease in methylation or vice versa
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The fraction of genes showing both significant decrease in methylation and upregulation was 7.5% of the DEGs or 2.3% of all genes detected in muscle tissue with at least one measured DNA methylation position. Correspondingly, 7.0% of the DEGs or 2.1% of all genes showed both significant increase in methylation and downregulation
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we show that DNA methylation changes are associated to gene expression changes in roughly 20% of unique genes that significantly changed with training
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Examples of structural genes include COL4A1, COL4A2 and LAMA4. These genes have also been identified as important for differences in responsiveness to endurance training
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Among the metabolic genes, MDH1 catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle and NDUFA8 plays an important role in transferring electrons from NADH to the respiratory chain
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In the present study, methylation predominantly changed in enhancer regions with enrichment for binding motifs for different transcription factors suggesting that enhancer methylation may be highly relevant also in exercise biology
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Of special interest in the biology of endurance training may be that MRFs, through binding to the PGC-1α core promoter, can regulate this well-studied co-factor for mitochondrial biogenesis
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That endurance training led to an increased methylation in enhancer regions containing motifs for the MRFs and MEFs is somewhat counterintuitive since it should lead to the repression of the action of the above discussed transcription factors
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this study demonstrates that the transcriptional alterations in skeletal muscle in response to a long-term endurance exercise intervention are coupled to DNA methylation changes
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We suggest that the training-induced coordinated epigenetic reprogramming mainly targets enhancer regions, thus contributing to differences in individual response to lifestyle interventions
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a physiological health-enhancing stimulus can induce highly consistent modifications in DNA methylation that are associated to gene expression changes concordant with observed phenotypic adaptations
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Exercise alters gene expression via methylation--the power of epigenetics. Interestingly, the majority of the methylation was outside the CPG island regions. This 3 month study found methylation of 5,000 sites across the genome resulting in altered expression of apps 4,000 genes. The altered muscle changes of the endurance training was linked to DNA methylation changes.
Primary Health Enhancer - 2 views
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Cordyceps sinensis promotes exercise endura... [J Ethnopharmacol. 2011] - PubMed - NCBI - 0 views
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shared by Nathan Goodyear on 20 Mar 15
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Muscle Hypertrophy 2011 - 0 views
www.unm.edu/...hypertrophy2011UNM.html
resistance training weight lifting muscle exercise weight training
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mechanical tension, muscle damage and metabolic stress are the three primary factors that promote hypertrophy from exercise
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The mechanical tension is directly related to intensity of the exercise, which is the key to stimulating muscle growth
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Muscle damage, that leads to muscle soreness, from exercise training initiates an inflammatory response, which activates satellite cells growth processes
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metabolic stress that is a result of the byproducts of anaerobic metabolism (i.e., hydrogen ions, lactate, inorganic phosphates) is now also believed to promote hormonal factors leading to muscle hypertrophy
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weightlifters and powerlifters show more favorable hypertrophy of type II (fast twitch) muscle fibers
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body builders appear to have comparable hypertrophy in both the type I (slow twitch) and type II muscle fibers
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Multi-joint exercises have been shown to produce larger increases of anabolic hormones than single-joint exercises
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shared by Nathan Goodyear on 29 Jul 14
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Testosterone physiology in resistance exercise an... [Sports Med. 2010] - PubMed - NCBI - 0 views
www.ncbi.nlm.nih.gov/...21058750
resistance exercise physiology testosterone men male hormone hormones
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In general, testosterone concentration is elevated directly following heavy resistance exercise in men
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Findings on the testosterone response in women are equivocal with both increases and no changes observed in response to a bout of heavy resistance exercise
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Aging beyond 35-40 years is associated with a 1-3% decline per year in circulating testosterone concentration in men
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In women, circulating testosterone concentration also gradually declines until menopause, after which a drastic reduction is found.
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shared by Nathan Goodyear on 10 Feb 16
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The Role of Post-Exercise Nutrient Administration on Muscle Protein Synthesis and Glyco... - 0 views
www.ncbi.nlm.nih.gov/...PMC3761704
exercise athlete athletes recovery exercise recovery training protein carbohydrates glycogen muscle
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Free form amino acid ingestion acts similarly to whey by displaying a rapid and strong increase in aminoacidemia
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it appears that protein synthesis rapidly increases for up to two hours after amino acid administration
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The intervention of dietary protein or amino acid supplementation in conjunction with resistance training has proven to effectively increase protein synthesis rates
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291% increase in protein synthesis following the exercise bout, while protein degradation remained unchanged from baseline quantities
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it has been established that post-exercise EAA supplementation stimulates protein synthesis, in conjunction with a positive protein balance, comparable to that of intravenous infusion of amino acids
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Casein and whey protein ingestion yielded similar values of net positive protein balance, and thus an overall increase in protein synthesis
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A later analysis revealed that soy protein increased protein synthesis in rats similar to that of whey after a treadmill exercise protocol
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A human trial, however, concluded that milk proteins (caseins and whey) in comparison to soy promoted greater muscle protein accretion when they were ingested after regular resistance training
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Whey hydrolysate ingested after a resistance exercise bout acutely stimulated mixed muscle protein synthesis 31% greater than soy
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adequate amount of protein (20 g) is ingested (Tipton et al., 2009) immediately before or after a resistance exercise bout
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slow phase, which can last up to several hours if carbohydrate availability is high and insulin levels remain elevated
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Effects of Acute Exposure to M... [Res Sports Med. 2014 July-September] - PubMed - NCBI - 0 views
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Article looked at the anabolic effect of low-intensity resistance exercise. This study found a decrease in cortisol post-exercise, but no increase in anabolic effects: GH and total Testosterone. The exercise was in untrained men, which could explain some of the decrease in the anabolic effect with the men in this study.