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Fluid Balance During and After an Ironman Triathlon - ResearchGate - 0 views

www.researchgate.net/...and_After_an_Ironman_Triathlon ironman triathlon endurance athletes athletes athlete endurance IV fluids
shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • Nathan Goodyear on 27 Jan 15
     
    ultra distance triathlon athletes lost 2.5 kg weight during event.  Athletes that developed hyponatremia appeared to be fluid overloaded during event.
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Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation - 0 views

www.hindawi.com/...575647 thymidine kinase 1 TK-1 cancer breast cancer
shared by Nathan Goodyear on 19 Feb 15 - No Cached
  • Thymidine kinase 1 (TK1), a proliferation marker involved in DNA repair
  • prognostic potential
  • TK1 upregulation is an early event in tumor tissue formation
  • Nathan Goodyear on 19 Feb 15
     
    Upregulation of TK-1 found to be an early event in breast tumor development. This has implications in precancerous tissue and elevations correlate to stage of cancer. TK-1 has also been found to correlate with Cancer recurrence.
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Study finds testosterone supplementation reduces heart attack risk in men with heart di... - 0 views

www.eurekalert.org/...imc-sft040116.php low T low Testosterone Testosterone coronary artery disease CAD heart health heart disease heart men hormones
shared by Nathan Goodyear on 06 Apr 16 - No Cached
  • Nathan Goodyear on 06 Apr 16
     
    This is simply a public release prior to publication.  Study found that Testosterone therapy in men with existing CAD did not increased adverse events; in fact, it appeared to decrease the adverse events when compared to that of the non-treatment group.  Study not yet available to read the specific design, stats, and results which would be required to better analyze the actually results.
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Best AC Banquet halls in Coimbatore | Party event Meeting halls - 0 views

www.123coimbatore.com/banquet-halls-in-coimbatore party halls in coimbatore outdoor event venues function mini small banquet
shared by Ritu Bhalla on 24 Jun 19 - No Cached
  • Ritu Bhalla on 24 Jun 19
     
    Are you in search of banquet halls in Coimbatore? Find here the list of best outdoor party, event, wedding function banquet halls details at 123Coimbatore.
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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease - NEJM - 0 views

www.nejm.org/...NEJMoa1707914 inflammation lipids cholesterol atherothrombosis cardiovascular disease CRP myocardial infarction stroke cardiovascular death
shared by Nathan Goodyear on 05 Sep 17 - No Cached
  • Nathan Goodyear on 05 Sep 17
     
    new study challenges the cholesterol = cardiovascular event story?  Good science asks questions and challenges dogma.  The authors claim the inflammatory hypothesis of atherothrombosis is yet unproven?  Maybe they need to get out and read more.  The point here Is not the drug in question, but the fact that a reduction in inflammation reduced recurrent cardiovascular events independent of cholesterol.
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Cheap Flights, Airline Tickets & Airfares - Find Deals on Flights at WayAway.io - 0 views

wayaway.tp.st/H2IZEX39 hotel
shared by forestgood on 15 Aug 23 - No Cached
  • forestgood on 15 Aug 23
     
    Here's some additional information about the specific hotels and brand offers available through our platform: Hotels: Our handpicked selection of hotels caters to a variety of tastes and preferences. Whether you're seeking a tranquil beachfront retreat, a vibrant city center stay, or a cozy countryside escape, we have partnered with top-notch establishments to ensure a memorable experience. Each hotel offers unique amenities, luxurious accommodations, and exceptional service, ensuring your stay is nothing short of extraordinary. Tickets: Our ticket offerings encompass a wide range of events and attractions. From sports games and concerts to theater performances and cultural exhibitions, we provide access to sought-after experiences. With our ticket deals, you can secure coveted seats, enjoy VIP access, and immerse yourself in the excitement of live entertainment. Enhance your travel itinerary with unforgettable memories. Brand Offers: We have collaborated with renowned brands to bring you exclusive offers and promotions across various industries. From fashion and beauty to technology and lifestyle, our brand partners have crafted special deals tailored to our community. Enjoy discounts, unique packages, and access to limited-edition products, elevating your everyday life with exceptional quality and value. By going straight to the product page, our platform ensures a streamlined and user-friendly experience. This allows you to explore the details, features, and pricing of each hotel, ticket, or brand offer directly, increasing the convenience and efficiency of your purchase process. Discover extraordinary accommodations, secure tickets to unforgettable events, and indulge in exclusive brand offers through our platform. Begin your journey and unlock remarkable experiences today! VISIT THIS BY CLICKING HERE: https://sharecta.com/l/40x4cx4xarc44
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Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil... - 0 views

www.nature.com/...s12276-022-00784-2 TME NETosis metastasis surgery cancer tumor microenvironment
shared by Nathan Goodyear on 20 Apr 23 - No Cached
  • tumor surgery must be carefully considered because the risk of metastasis could be increased by the surgical procedure.
  • NETosis, which is the process of forming neutrophil extracellular traps (NETs)
  • surgery-induced metastasis
  • ...61 more annotations...
  • surgery per se can promote cancer metastasis through a series of local and systemic events
  • surgery results in a serious wound that disrupts the structural barrier preventing the outspreading of cancer cells, change the properties of the cancer cells and stromal cells remaining in the tumor microenvironment, or impairs the host defense systems against cancers
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Key point; add to presentation on surgery and metastasis
  • After the primary tumor is surgically removed, the metastases can start to grow vigorously via neoangiogenesis because the circulating inhibitors disappear
  • infection and inflammation during the postoperative period have been reported to increase the risk of cancer recurrence in patients
  • Surgeons have long suspected that surgery, even if it is a necessary step in cancer treatment, facilitates cancer metastasis
  • Surgery-induced cancer metastasis has been well established in animal models
  • tumor cell dissemination, tumor-favoring immune responses, and neoangiogenesis
  • the surgical resection of primary tumors is beneficial is controversial
  • CTCs abruptly increase just after surgery
  • Even externally palpitating tumors for diagnosis could increase the numbers of CTCs in skin cancer and breast cancer
  • excessive glucocorticoids negatively modulate immune functions
  • immune surveillance against tumors is considered to be impaired by surgical stress
  • In addition to glucocorticoids, during stimulation of the HPA axis, the catecholamine hormones epinephrine and norepinephrine are released from the adrenal medulla
  • NK cell suppression may be attributed to increased levels of catecholamines as well as glucocorticoids
  • In mice bearing a primary tumor, it was observed that the removal of the primary tumor facilitated the growth of highly vascularized metastases
  • primary tumors may secrete angiogenic inhibitors as well as angiogenic activators
  • second phase of tumor recurrence and metastasis, which are newly acquired events, rather than just outcomes of incomplete treatment.
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Another key point
  • double-edged sword
  • HIF-1 in neutrophils plays a critical role in NETosis and bacteria-killing activity
  • neutrophils play various roles in the initiation and progression of cancer
  • NETosis
  • many inflammatory and neoplastic diseases
  • formation of neutrophil extracellular traps (NETs), which are large extracellular complexes composed of chromatin and cytoplasmic/granular proteins1
  • NETosis has been highlighted as an inflammatory event that promotes cancer metastasis
  • Once activated, neutrophils produce intracellular precursors by using DNA, histones, and granular and cytoplasmic proteins and then spread the mature form of NETs out around themselves
  • A series of these events is called NETosis.
  • neutrophil elastase, myeloperoxidase, cathepsin G, proteinase 3, lactoferrin, gelatinase, lysozyme C, calprotectin, neutrophil defensins, and cathelicidins
  • innate immune response against infection
  • Neutrophils are the most abundant type of granulocytes, comprising 40–70% of all white blood cells
  • two types of NEToses, suicidal (or lytic) NETosis and vital NETosis
  • Suicidal NETosis mainly depends on the production of reactive oxygen species (ROS)
  • Since neutrophils die during this process, it is called suicidal NETosis.
  • vital NETosis
  • vital NETosis occurs independently of ROS production
  • Vital NETosis can be induced by Gram-negative bacteria. LPS
  • NETs are present in a variety of cancers, such as lung cancer, colon cancer, ovarian cancer, and leukemia
  • neutrophils actively undergo NETosis in the tumor microenvironment
  • Hypoxia
  • NETosis plays a pivotal role in noninfectious autoimmune diseases,
  • cytokines
  • tumor-derived proteases
  • tumor exosomes
  • NETosis generally actively progresses in the tumor microenvironment.
  • the proliferative cytokines TGFβ and IL-10 and the angiogenic factor VEGF are representative of neutrophil-derived tissue repair proteins.
  • NETosis is a defense system to protect the body from invading pathogens
  • when neutrophils are excessively stimulated, they produce excess NETs, thereby leading to pathological consequences
  • plasma levels of NETosis markers are elevated after major surgeries
  • local invasion, intravasation into the blood or lymphatic vessels, escape from the immune system, anchoring to capillaries in target organs, extravasation into the organs, transformation from dormant cells to proliferating cells, colonization to micrometastases, and growth to macrometastases
  • NETs promote metastasis at multiple steps
  • NETs loosen the ECM and capillary wall to promote the intravasation of cancer cells
  • NETs and platelets wrap CTCs, which protects them from attack by immune cells and shearing force by blood flow
  • NETs promote the local invasion of cancer cells by degrading the extracellular matrix (ECM)
  • neutrophil elastase, matrix metalloproteinase 9, and cathepsin G
  • NETs also promote the intravasation of cancer cells
  • millions of tumor cells are released into the circulation every day,
  • NETs can wrap up CTCs with platelets
  • β1-integrin plays an important role in the interaction between CTCs and NETs
  • NET-platelet-CTC aggregates.
  • After metastasizing to distant tissues, tumor cells are often found to remain dormant for a period of time and unexpectedly regrow late
  • NETs are believed to participate in the reactivation of dormant cancer cells in metastatic regions
  • NET-associated proteases NE and MMP-9 were found to be responsible for the reactivation of dormant cancer cells
  • Nathan Goodyear on 20 Apr 23
     
    Surgery induced metastasis: it is real and steered by NETosis.
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Low testosterone is associated with an increased r... [J Sex Med. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20102478 low T low t testosterone MACE cardiovascular disease events men hypogonadal hypogonadism
shared by Nathan Goodyear on 10 Nov 12 - No Cached
  • Nathan Goodyear on 10 Nov 12
     
    low T associated with significant increase in the incidence in major adverse cardiovascular events (MACE).
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JAMA Network | JAMA | Evaluation of the Association of Maternal Pertussis Vaccination W... - 0 views

jama.jamanetwork.com/article.aspx vaccine vaccines vaccinations Tdap pertussis chorioamnionitis pregnancy
shared by Nathan Goodyear on 11 May 16 - No Cached
  • Nathan Goodyear on 11 May 16
     
    Study finds no increased adverse events in Tdap in pregnant mothers; however, RR finds 19% increase in chorioamnionitis.  
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Dietary patterns and the risk of major adverse cardiovascular events in a global study ... - 0 views

eurheartj.oxfordjournals.org/...eurheartj.ehw125 mediterranean diet nutrition CAD coronary artery disease CVD cardiovascular disease heart disease heart
shared by Nathan Goodyear on 02 May 16 - No Cached
  • Nathan Goodyear on 02 May 16
     
    Mediterranean diet reduces major cardiovascular event incidence in those individuals with coronary artery disease.
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Endothelial progenitor cells correlate wit... [Basic Res Cardiol. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17932708 EPCs endothelial progenitor cells CVD cardiovascular events EPC
shared by Nathan Goodyear on 10 Jul 12 - No Cached
  • Nathan Goodyear on 10 Jul 12
     
    Endothelial Progenitor cells (EPC) help to predict cardiovascular events.  Low EPCs increase cardiovascular risk.
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Circulating Endothelial Progenitor Cells and Cardiovascular Outcomes - NEJM - 0 views

www.nejm.org/...NEJMoa043814 EPCs endothelial progenitor cells CVD cardiovascular disease cardiovascular events cardiovascular risk heart cardiology
shared by Nathan Goodyear on 10 Jul 12 - No Cached
  • Nathan Goodyear on 10 Jul 12
     
    Endothelial progenitor cells predict cardiovascular events and mortality.  Higher EPCs associated with a 70% less mortality from cardiovascular causes.
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JAMA Network | JAMA: The Journal of the American Medical Association | Effect of Homocy... - 0 views

jama.jamanetwork.com/article.aspx Folic acid folate vitamin B12 B6 CVD cardiovascular events homocysteine The swiss heart study
shared by Nathan Goodyear on 23 Jul 12 - No Cached
  • Nathan Goodyear on 23 Jul 12
     
    This is a very good study.  Folic acid, Vitamin B12 and Vitamin B6 was found to lower Cardiovascular events through lowering homocysteine levels.  
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Journal of General Internal Medicine, Online First™ - SpringerLink - 0 views

www.springerlink.com/...b042807u865853t7 diet soda coke cardiovascular events stroke heart attack MI
shared by Nathan Goodyear on 10 Feb 12 - No Cached
  • Nathan Goodyear on 10 Feb 12
     
    diet soda a day increases the risk of cardiovascular events.   This proved to be a 43% increase.
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Adverse Events Associated with Testosterone Administration - NEJM - 0 views

www.nejm.org/...NEJMoa1000485 Testosterone therapy low T treatment men male hormone hormones
shared by Nathan Goodyear on 31 Jan 14 - No Cached
  • Nathan Goodyear on 31 Jan 14
     
    Study of 209 men > 65 on Testosterone therapy was stopped early due to increase cardiovascular adverse events  The likely reason was the amazingly high dosing.  The men in this study were just doped.  The dosing was 100 mg + which is in stark contrast to the 5-10 mg daily production of a young man at 22.
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Postmenopausal Women with a History of Irregular Menses and Elevated Androgen Measureme... - 0 views

www.ncbi.nlm.nih.gov/...PMC2291491 CVD PCOS women female hormone hormones CAD cardiovascular disease
shared by Nathan Goodyear on 20 Mar 14 - No Cached
  • Nathan Goodyear on 20 Mar 14
     
    This study looked at post menopause women and found that those with PCOS had an increase in CAD and worse cardiovascular event survival.  PCOS is a metabolic syndrome, in part, driven by elevated androgens in women.
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An Unexpected Effect of Proton Pump Inhibitors: Elevation of the Cardiovascular Risk Fa... - 0 views

circ.ahajournals.org/...ULATIONAHA.113.003602.abstract PPI proton pump inhibitors PPI's cardiovascular disease events PPIs
shared by Nathan Goodyear on 16 Jul 13 - No Cached
  • Nathan Goodyear on 16 Jul 13
     
    Not only do PPIs increase risk of recurrent cardiovascular events in those with prior history, but they increase risk in those individuals with no preexisting history
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Abstract 21277: Homocysteine and Cardiovascular Risk in Low Risk Healthy Adults - An An... - 0 views

circ.ahajournals.org/...A21277 homocysteine cardiovascular CAD disease
shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • Homocysteine significantlyimproves risk prediction of cardiovascular events in healthyadults
  • Nathan Goodyear on 03 Aug 11
     
    homocysteine found to be helpful in predicting cardiovascular events in healthy adults
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Chelation therapy reduces cardiovascular events for older patients with diabetes - 0 views

www.nih.gov/...nccam-19.htm EDTA chelation EDTA chelation CVD cardiovascular disease diabetes
shared by Nathan Goodyear on 19 Dec 13 - No Cached
  • Nathan Goodyear on 19 Dec 13
     
    Significant statement of benefit of EDTA chelation in the prevention of CVD disease/events in those with diabetes.
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Life events are positively associated with luteinizin... [Stress. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24881484 cortisol LH leutenizing hormone stress hormone hormones men male low T Testosterone
shared by Nathan Goodyear on 03 Jun 14 - No Cached
  • Nathan Goodyear on 03 Jun 14
     
    Elevated Cortisol, life events as this study refers to, is associated with low Testosterone.  The authors found a positive association of cortisol with LH.  The result is elevated cortisol, low Testosterone, increased LH.
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