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Nathan Goodyear

Postmenopausal Hormone Therapy and Risk of Idiopathic Venous Thromboembolism: Results F... - 0 views

atvb.ahajournals.org/...340

biodentical hormone therapy postmenopausal stroke

shared by Nathan Goodyear on 30 Mar 11 - No Cached
  • Transdermal estrogens alone or combined with progesterone might be safe with respect to thrombotic risk.
  • Oral but not transdermal estrogens were associated with an increased thrombotic risk
  • There was no significant association of venous thromboembolism with progesterone
  • Nathan Goodyear on 30 Mar 11
     
    bioidentical hormones do not increase stroke risk; also, route of delivery impacts stroke risk
Nathan Goodyear

Arch Gen Psychiatry -- Abstract: Neural Correlates of Food Addiction, April 4, 2011, Ge... - 0 views

archpsyc.ama-assn.org/...archgenpsychiatry.2011.32

food overweight obesity neurotransmitters addiction

shared by Nathan Goodyear on 07 Apr 11 - No Cached
  • Similar patterns of neural activation are implicated in addictive-like eating behavior and substance dependence: elevated activation in reward circuitry in response to food cues and reduced activation of inhibitory regions in response to food intake.
  • Nathan Goodyear on 07 Apr 11
     
    Similar neurochemical changes with food as seen in other addictions
Nathan Goodyear

Leptin Resistance: A Possible Interface of Inflammation and Metabolism in Obesity-Relat... - 0 views

content.onlinejacc.org/...1201

leptin resistance obesity inflammation

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • The leptin axis has functional interactions with elements of metabolism, such as insulin, and inflammation, including mediators of innate immunity, such as interleukin-6
  • Given that plasma levels of leptin and inflammatory markers are correlated and also predict cardiovascular risk
  • Nathan Goodyear on 12 Apr 11
     
    leptin resistance, inflammation and obesity
Nathan Goodyear

Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with D... - 0 views

jcem.endojournals.org/...1834

low testosterone insulin resistance diabetes overweight obesity

shared by Nathan Goodyear on 13 Apr 11 - No Cached
  • Low testosterone levels were independently associated with insulin resistance in men with type 1 diabetes as well as type 2 diabetes
  • Nathan Goodyear on 13 Apr 11
     
    low Testosterone associated with insulin resistance
Nathan Goodyear

Axillary Dissection vs No Axillary Dissection in Women With Invasive Breast Cancer and ... - 0 views

jama.ama-assn.org/...569.abstract

axillary dissection breast cancer node

shared by Nathan Goodyear on 14 Apr 11 - No Cached
  • Nathan Goodyear on 14 Apr 11
     
    axillary lymph node dissection in breast cancer patients did not change survival rate when compared to sentinal Lymph node removal
Nathan Goodyear

Arch Surg -- Abstract: Long-term Outcomes of Laparoscopic Adjustable Gastric Banding, M... - 0 views

archsurg.ama-assn.org/...archsurg.2011.45v1

obesity obese overweight Gastric banding Lap

shared by Nathan Goodyear on 15 Apr 11 - No Cached
  • nearly 50% of the patients required removal of their bands (contributing to a reoperation rate of 60%), LAGB appears to result in relatively poor long-term outcomes.
  • Nathan Goodyear on 15 Apr 11
     
    Gastric Banding has poor long-term outcomes and results in 50% removal rate
Nathan Goodyear

Chorionic Gonadotropin in Weight Control, November 29, 1976, Young et al. 236 (22): 249... - 0 views

jama.ama-assn.org/...2495.abstract

HCG weight loss obesity

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • here was no statistically significant difference between those receiving HCG vs placebo during any phase of this study
  • Nathan Goodyear on 21 Apr 11
     
    NO difference in weight loss in those receiving HCG injections
Nathan Goodyear

Chorionic Gonadotropin in Weight Control, November 29, 1976, Young et al. 236 (22): 249... - 0 views

jama.ama-assn.org/...2495.short

HCG human chorionic gonadotropin

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • There was no statistically significant difference between those receiving HCG vs placebo during any phase of this study (P>.1).
  • Nathan Goodyear on 21 Apr 11
     
    ditto: HCG no better than placebo in weight loss
Nathan Goodyear

Potassium Intake, Stroke, and Cardiovascular Disease: A Meta-Analysis of Prospective St... - 0 views

content.onlinejacc.org/...1210

potassium stroke cardiovascular disease

shared by Nathan Goodyear on 27 Apr 11 - No Cached
  • Nathan Goodyear on 27 Apr 11
     
    DIetary Potassium intake linked to reduced rates of stroke and cardiovascular disease
Nathan Goodyear

Long-Term Vitamin C Treatment Increases Vascular Tetrahydrobiopterin Levels and Nitric ... - 0 views

circres.ahajournals.org/...88

Vitamin C tetrahydrobiopterin

shared by Nathan Goodyear on 29 Apr 11 - No Cached
  • beneficial effect of vitamin C on vascular endothelial function appears to be mediated in part by protection of tetrahydrobiopterin and restoration of eNOS enzymatic activity
  • Nathan Goodyear on 29 Apr 11
     
    Vitamin C helps to preserve tetrahydrobiopterin levels
Nathan Goodyear

Folates and Cardiovascular Disease -- Verhaar et al. 22 (1): 6 -- Arteriosclerosis, Thr... - 0 views

atvb.ahajournals.org/...6

cardiovascular folates disease folate folic acid

shared by Nathan Goodyear on 29 Apr 11 - No Cached
  • benefits of folates independent of homocysteine lowering have also been reported. Potential mechanisms include antioxidant actions, effects on cofactor availability, or direct interactions with the enzyme endothelial NO synthase
  • beneficial effects of folates on cardiovascular risk
  • Nathan Goodyear on 29 Apr 11
     
    Folate improves cardiovascular disease risk
Nathan Goodyear

Brain dopamine transporters in obesity -- Yao et al. 51 (1002): 1820 -- Society of Nucl... - 0 views

jnumedmtg.snmjournals.org/...1820

dopamine transporters obesity receptors brain

shared by Nathan Goodyear on 29 Apr 11 - No Cached
  • The dopaminergic deficiency mechanism in obesity may primarily involve in dopamine receptors, but not dopamine transporters in a subset of non-binge eating obesity
  • Nathan Goodyear on 29 Apr 11
     
    Dopamine transporters don't appear to have role in overeating and obesity; more likely involves dopamine receptors
Nathan Goodyear

Availability of Comparative Efficacy Data at the Time of Drug Approval in the United St... - 0 views

jama.ama-assn.org/...1786.abstract

FDA

shared by Nathan Goodyear on 04 May 11 - No Cached
  • Nathan Goodyear on 04 May 11
     
    50% of new drugs to market lack good evidence from FDA in 2000-2010 review
Nathan Goodyear

Role of Antibiotics and Fungal Microbiota in Driving Pulmonary Allergic Responses -- No... - 0 views

iai.asm.org/...4996

antibiotics infection immunity immune system allergy asthma GI gut tract

shared by Nathan Goodyear on 29 Jun 11 - No Cached
  • Nathan Goodyear on 29 Jun 11
     
    Amazing study that displays how the environment in the gut can effect the immune system in the lung.
Nathan Goodyear

Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic P... - 0 views

atvb.ahajournals.org/...949

Copper iron arteriosclerosis metal plaques

shared by Nathan Goodyear on 06 Jul 11 - No Cached
  • Statistically elevated levels of iron were detected in the intima of lesions compared with healthy controls
  • Elevated levels of copper were also detected (7.51 versus 2.01 pmol/mg tissue, lesion versus healthy control, respectively
  • These data support the hypothesis that iron accumulates in human lesions and may contribute to disease progression
  • Nathan Goodyear on 06 Jul 11
     
    Iron and Copper accumulation in blood vessel wall may play role in diesease progression
Nathan Goodyear

Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation,... - 0 views

jama.ama-assn.org/...1539.full

overweight weight loss obesity calorie restriction metabolism

shared by Nathan Goodyear on 11 Jul 11 - No Cached
  • Nathan Goodyear on 11 Jul 11
     
    prolonged calorie restriction results in loss of muscle mass, which results in decreased metabolism
Nathan Goodyear

Arch Intern Med -- Abstract: Dietary Supplements and Mortality Rate in Older Women: The... - 0 views

archinte.ama-assn.org/...1625

dietary supplements junk science health study

shared by Nathan Goodyear on 12 Oct 11 - No Cached
  • Nathan Goodyear on 12 Oct 11
     
    Terrible study published in medical journal that provides no scientific valuable information
Nathan Goodyear

Calprotectin is a stronger predictive marker of relapse in ulcerative colitis than in C... - 0 views

gut.bmj.com/...364.abstract

Calprotectin IBD inflammatory bowel disease inflammation GI gut ulcerative colitis

shared by Nathan Goodyear on 21 May 14 - No Cached
  • Nathan Goodyear on 21 May 14
     
    Fecal Calprotectin found to be useful as monitor for Ulcerative colitis relapse.  This was found more specific for UC than Crohn's disease.  There was a 14 fold higher relapse risk in those with levels > 150.
Nathan Goodyear

Testosterone deficiency and cardiovascular mortality Morgentaler A, - Asian J Androl - 0 views

www.ajandrology.com/preprintarticle.asp

testosterone low t low Testosterone CVD cardiovascular mortality therapy

shared by Nathan Goodyear on 01 Dec 14 - No Cached
  • overall mortality and CV mortality were inversely associated with serum T concentrations.
  • men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
  • lower T levels were significantly associated with the presence of any CV disease
  • ...19 more annotations...
  • more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
  • lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
  • the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
  • The study by Vigen et al. [7] has already undergone two published corrections,
  • 29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
  • Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
  • The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
  • HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
  • men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
  • tripling in T prescriptions in the US over the last decade
  • a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
  • Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
  • In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
  • TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
  • improved glycemic control
  • reductions in insulin resistance.
  • the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
  • analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
  • Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
  • Nathan Goodyear on 01 Dec 14
     
    Great review by Morgentaler of Testosterone and CVD.  He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks.  Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries.  The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.
Nathan Goodyear

The endurance athletes heart: acute stress and chronic adaptation -- George et al. 46 (... - 0 views

bjsm.bmj.com/...i29.full

heart health endurance athletes endurance exercise athletes athletic heart

shared by Nathan Goodyear on 10 Jan 15 - No Cached
  • Nathan Goodyear on 10 Jan 15
     
    acute and chronic heart changes to endurance training/events.
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