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Nathan Goodyear

Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity - 0 views

www.sciencedirect.com/...S0031938416309817

nutrition diet obesity western diet

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    New study how the Western diet acts like a drug in the body.
Nathan Goodyear

Targeting gut microbiota in obesity: effects of prebiotics and probiotics : Article : N... - 0 views

www.nature.com/...nrendo.2011.126.html

LPS lipopolysaccharides gut microbiota dysbiosis inflammation obesity metabolic endotoxemia health probiotics

shared by Nathan Goodyear on 18 Jan 12 - No Cached
  • gut microbes have a role in the host's metabolic homeostasis
  • lipopolysaccharide (LPS)
  • Associations between circulating LPS level, consumption of a high-fat diet and the presence of obesity and type 2 diabetes mellitus have been confirmed in humans
  • ...8 more annotations...
  • associations have been proposed between high-fat diet, metabolic endotoxemia and levels of inflammatory markers (TLRs and SOCS3) in mononuclear cells
  • A link between energy intake (high-fat diet) and metabolic endotoxemia has also been described
  • high-fat diet induces metabolic endotoxemia in healthy individuals.
  • metabolic endotoxemia is associated with systemic and adipose tissue inflammation in pregnant women with obesity
  • A growing amount of evidence indicates that changes in the integrity of the intestinal barrier occur both in the proximal and the distal part of the gut, which can contribute to the entrance of LPS into the systemic circulation
  • intestinal endocannabinoid system
  • The low-grade systemic inflammation that characterizes the obese phenotype is controlled by peptides that are produced in the gut. These peptides are influenced by the presence or absence of the gut microbiota
  • these findings suggest that the gut microbiota modulates the biological systems that regulate the availability of nutrients, energy storage, fat mass development and inflammation in the host, which are all components of the obese phenotype
  • Nathan Goodyear on 18 Jan 12
     
    good look of how the the gut health, or lack there of, can influence energy homeostasis and contribute to obesity.  This article points to the presence of LPS playing a role in metabolic endotoxemia.  It does discuss the importance of the microbiota and their possible role in the low-grade systemic inflammation condition that is obesity.
Nathan Goodyear

Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer. - Pu... - 0 views

www.ncbi.nlm.nih.gov/...25855725

CB2 endocannabinoid HER2 HER-2 cancer breast cancer

shared by Nathan Goodyear on 18 Sep 18 - No Cached
  • Nathan Goodyear on 18 Sep 18
     
    CB2 overexpression found to upregulate HER2 expression in breast cancer.  This has prognostic and therapeutic value.
Nathan Goodyear

Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system - 0 views

www.ncbi.nlm.nih.gov/...PMC3883513

Nausea CBD THC "medical marijuana" Chemotherapy

shared by Nathan Goodyear on 28 Jan 19 - No Cached
  • Nathan Goodyear on 28 Jan 19
     
    Great read on the use of CBD, THC in nausea/vomiting. Data in humans is lacking and most of the data is related to prescription drugs.
Nathan Goodyear

Anti-Cancer Activity of Cannabis sativa Phytocannabinoids: Molecular Mechanisms and Pot... - 0 views

www.ncbi.nlm.nih.gov/...PMC9454933

CBD THC CBDA cannabinoids endocannabinoid cancer "medical cannabis"

shared by Nathan Goodyear on 30 Oct 22 - No Cached
  • Nathan Goodyear on 30 Oct 22
     
    Review of the targeted effects of CBDA CBD and THC in cancer treatment
Nathan Goodyear

The use of cannabinoids as anticancer agents - ScienceDirect - 0 views

www.sciencedirect.com/...S0278584615001190

CBD THC endocannabinoid cannabinoids cancer CBD1 CBD2 CBD receptors cannabis "medical cannabis"

shared by Nathan Goodyear on 30 Oct 22 - No Cached
  • Nathan Goodyear on 30 Oct 22
     
    Review of cannabinoids in cancer
Nathan Goodyear

Cannabidiol (CBD) Oil Does Not Display an Entourage Effect in Reducing Cancer Cell Viab... - 0 views

www.karger.com/...510256

cannabis endocannabinoid cancer entourage effect CBD

shared by Nathan Goodyear on 24 Oct 22 - No Cached
  • Nathan Goodyear on 24 Oct 22
     
    No entourage effect found with CBD and THC.
Nathan Goodyear

Insights into the effects of the endocannabinoid system in cancer: a review - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC6003657

tumors cannabidiol cancer CBD2 CBD1 pharmacokinetics CBD cannabis

shared by Nathan Goodyear on 20 Nov 23 - No Cached
  • Nathan Goodyear on 20 Nov 23
     
    the expression of CBD1 and CBD2 are altered in in many tumors, i.e., the tumor burden for some cancer will reflect an increase in CBD receptor expression.
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