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Pot Valet

THC and CBD - What's the Difference? | Pot Valet News - 0 views

www.potvalet.com/...c-and-cbd-whats-the-difference

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shared by Pot Valet on 11 Jan 17 - No Cached
  • Pot Valet on 11 Jan 17
     
    If you're new to the world of marijuana, you might wonder what THC and CBD are and how are they different. It's important to understand the effects of these two substances before you choose what type of marijuana you want.
meonepop

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started by High Syn on 13 Jun 11 1 follow-up, last by meonepop on 13 Sep 20
Sonny Cher

Just Smoke and Fly - 1 views

There goes that saying, "Do not drink and drive, just smoke and fly!" Now, that is promising and believe it or not, OnlinePartyPills (OPP) offers legal pot and legal Marijuana. You could party resp...

Marijuana

started by Sonny Cher on 02 May 11 no follow-up yet
meonepop

buy moonrocks online - 1 views

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started by meonepop on 13 Sep 20 no follow-up yet
Nathan Goodyear

Anticancer mechanisms of cannabinoids - 0 views

www.ncbi.nlm.nih.gov/...PMC4791144

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shared by Nathan Goodyear on 18 Sep 18 - No Cached
  • modulating key cell signalling pathways involved in the control of cancer cell proliferation and survival
  • cannabinoids inhibit angiogenesis and decrease metastasis in various tumour types in laboratory animals
  • Cannabis sativa L. (marijuana)
  • ...41 more annotations...
  • of the approximately 108 cannabinoids produced by C. sativa, Δ9-tetrahydrocannabinol (thc) is the most relevant because of its high potency and abundance in plant preparations
  • Tetrahydrocannabinol exerts a wide variety of biologic effects by mimicking endogenous substances—the endocannabinoids anandamide3 and 2-arachidonoylglycerol4,5—that engage specific cell-surface cannabinoid receptors
  • the cb2 receptor was initially described to be present in the immune system6, but was more recently shown to also be expressed in cells from other origins
  • transient receptor potential cation channel subfamily V, member 1
  • orphan G protein–coupled receptor 55
  • Most of the effects produced by cannabinoids in the nervous system and in non-neural tissues rely on cb1 receptor activation
  • two major cannabinoid-specific receptors—cb1 and cb2
  • cardiovascular tone, energy metabolism, immunity, and reproduction
  • cannabinoids are well known to exert palliative effects in cancer patients
  • best-established use is the inhibition of chemotherapy-induced nausea and vomiting
  • thc and other cannabinoids exhibit antitumour effects in a wide array of animal models of cancer
  • cannabinoid receptors and their endogenous ligands are both generally upregulated in tumour tissue compared with non-tumour tissue
  • cb2 promotes her2 (human epidermal growth factor receptor 2) pro-oncogenic signalling in breast cancer
  • pharmacologic activation of cannabinoid receptors decreases tumour growth
  • endocannabinoid signalling can also have a tumour-suppressive role
  • pharmacologic stimulation of cb receptors is, in most cases, antitumourigenic. Nonetheless, a few reports have proposed a tumour-promoting effect of cannabinoids
  • most prevalent effect is the induction of cancer cell death by apoptosis and the inhibition of cancer cell proliferation
  • impair tumour angiogenesis and block invasion and metastasis
  • thc and other cannabinoids induce the apoptotic death of glioma cells by cb1- and cb2-dependent stimulation
  • Autophagy is primarily a cytoprotective mechanism, although its activation can also lead to cell death
  • autophagy is important for cannabinoid antineoplastic activity
  • autophagy is upstream of apoptosis in the mechanism of cannabinoid-induced cell death
  • the effect of cannabinoids in hormone- dependent tumours might rely, at least in part, on the ability to interfere with the activation of growth factor receptors
  • glioma cells), pharmacologic blockade of either cb1 or cb2 prevents cannabinoid-induced cell death with similar efficacy
  • other types of cancer cells (pancreatic48, breast24, or hepatic43 carcinoma cells, for example), antagonists of cb2 but not of cb1 inhibit cannabinoid antitumour actions
  • thc promotes cancer cell death in a cb1- or cb2-dependent manner (or both) at lower concentrations
  • cannabidiol (cbd), a phytocannabinoid with a low affinity for cannabinoid receptors15, and other marijuana-derived cannabinoids57 have also been proposed to promote the apoptotic death of cancer cells acting independently of the cb1 and cb2 receptors
  • In cancer cells, cannabinoids block the activation of the vascular endothelial growth factor (vegf) pathway, an inducer of angiogenesi
  • In vascular endothelial cells, cannabinoid receptor activation inhibits proliferation and migration, and induces apoptosis
  • cb1 or cb2 receptor agonists (or both) reduce the formation of distant tumour masses in animal models of both induced and spontaneous metastasis, and inhibit adhesion, migration, and invasiveness of glioma64, breast65,66, lung67,68, and cervical68 cancer cells in culture
  • the ceramide/p8–regulated pathway plays a general role in the antitumour activity of cannabinoids targeting cb1 and cb2
  • cbd, by acting independently of the cb1 and cb2 receptors, produces a remarkable anti-tumour effect—including reduction of invasiveness and metastasis
  • cannabinoids can also enhance immune system–mediated tumour surveillance in some contexts
  • ability of thc to reduce inflammation75,76, an effect that might prevent certain types of cancer
  • recent observations suggest that the combined administration of cannabinoids with other anticancer drugs acts synergistically to reduce tumour growth
  • combined administration of gemcitabine (the benchmark agent for the treatment of pancreatic cancer) and various cannabinoid agonists synergistically reduced the viability of pancreatic cancer cells
  • Other reports indicated that anandamide and HU-210 might also enhance the anticancer activity of paclitaxel89 and 5-fluorouracil90 respectively
  • Combined administration of thc and cbd enhances the anticancer activity of thc and reduces the dose of thc needed to induce its tumour growth-inhibiting activity
  • Preclinical animal models have yielded data indicating that systemic (oral or intraperitoneal) administration of cannabinoids effectively decreases tumour growth
  • Combinations of cannabinoids with classical chemotherapeutic drugs such as the alkylating agent temozolomide (the benchmark agent for the management of glioblastoma80,84) have been shown to produce a strong anticancer action in animal models
  • pharmacologic inhibition of egfr, erk83, or akt enhances the cell-death-promoting action of thc in glioma cultures (unpublished observations by the authors), which suggests that targeting egfr and the akt and erk pathways could enhance the antitumour effect of cannabinoids
  • Nathan Goodyear on 18 Sep 18
     
    Good review of the anticancer effects of cananbinoids.
freshbombsusa

How to Find Quality CBD Products- Fresh Bombs - 0 views

freshbombsusa.over-blog.com/...e-quality-of-cbd-products.html

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shared by freshbombsusa on 01 May 20 - No Cached
  • freshbombsusa on 01 May 20
     
    Cannabidiol or CBD is found in marijuana and is used to reduce the symptoms of seizures, pain, and anxiety. It is very essential to choose qualitative CBD products from the trustable store. You can also search 'Fresh Bombs' on a reliable search engine to buy quality CBD-infused products. To know more about how to choose quality CBD products then read our blog.
Nathan Goodyear

Medical Marijuana for Chronic Lymphocytic Leukemia | Marijuana Doctors - 0 views

www.marijuanadoctors.com/...chronic-lymphocytic-leukemia

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shared by Nathan Goodyear on 27 May 21 - No Cached
  • Nathan Goodyear on 27 May 21
     
    Not a research article, but some interesting information
Sonny Cher

Getting High Legally! - 1 views

After getting out of rehab, I still cannot shake off my need to get high. However, I vowed not to resort to illegal drugs again. After consulting a friend about it, he introduced legal drugs and ma...

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started by Sonny Cher on 27 May 11 no follow-up yet
Sonny Cher

Who Says Smoking Pot is Illegal? - 1 views

I have always been addicted to marijuana. It started out with my friends at high school, since then I cannot turn myself away from experiencing high times puffing marajuana. It feels so nice. Howev...

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started by Sonny Cher on 01 Jun 11 no follow-up yet
Sonny Cher

Who Says Smoking Pot is Illegal? - 1 views

I have always been addicted to marijuana. It started out with my friends at high school, since then I cannot turn myself away from experiencing high times puffing marajuana. It feels so nice. Howev...

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started by Sonny Cher on 18 May 11 no follow-up yet
High Syn

Safe and Legal Pot - 4 views

You can say that I love to party and get high occasionally. But, then again getting addicted to the real thing is a big NO NO. Gladly a friend of mine introduced me to Kronic. It is a brand of herb...

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started by High Syn on 13 Jun 11 no follow-up yet
Sonny Cher

Who Says Smoking Pot is Illegal? - 1 views

I have always been addicted to marijuana. It started out with my friends at high school, since then I cannot turn myself away from experiencing high times puffing marajuana. It feels so nice. Howev...

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started by Sonny Cher on 16 Jun 11 no follow-up yet
Nathan Goodyear

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition | Mol... - 0 views

molecular-cancer.biomedcentral.com/...1476-4598-9-196

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shared by Nathan Goodyear on 12 Nov 18 - No Cached
  • Nathan Goodyear on 12 Nov 18
     
    Mouse study finds THC and CBD agonist reduce tumor growth, inhibit angiogenesis, induce apoptosis, and reduce metastasis. In addition, 91% of breast cancers in animal study expressed CB2 receptors.
Nathan Goodyear

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stre... - 0 views

www.jci.org/...37948

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shared by Nathan Goodyear on 12 Nov 18 - No Cached
  • Nathan Goodyear on 12 Nov 18
     
    Describes the mechanism by which THC induces autophagy cell death of glioma cells.
mj-freeway

Cannabis Compliance Software - 1 views

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shared by mj-freeway on 14 Dec 18 - No Cached
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Nathan Goodyear

A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma | Molecu... - 0 views

mct.aacrjournals.org/...90.long

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shared by Nathan Goodyear on 18 Sep 18 - No Cached
  • Δ9-Tetrahydrocannabinol (THC; Supplementary Fig. 1), the main active component of the hemp plant Cannabis sativa
  • CB1, abundantly expressed in the brain and at many peripheral sites
  • CB2, expressed in the immune system and also present in some neuron subpopulations and glioma cells
  • ...3 more annotations...
  • antitumoral agents
  • Aside from THC, C. sativa produces approximately 70 other cannabinoids, although, unlike THC, many of them exhibit little affinity for CB receptors (10, 20). Of interest, at least one of these components, namely, cannabinol (CBD; Supplementary Fig. 1), has been shown to reduce the growth of different types of tumor xenografts including gliomas
  • the combined administration of THC and CBD is being therapeutically explored (10, 20, 26), although its effects on the proliferation and survival of cancer cells have only been analyzed in vitro
  • Nathan Goodyear on 18 Sep 18
     
    THC found to augment chemotherapy in the glioblastoma cell culture study.
Nathan Goodyear

Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9771884

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shared by Nathan Goodyear on 18 Sep 18 - No Cached
  • Nathan Goodyear on 18 Sep 18
     
    THC induces apoptosis of glioblastoma cells via CB1 receptor signaling.
Nathan Goodyear

The role of cannabinoids in prostate cancer: Basic science perspective and potential cl... - 0 views

www.ncbi.nlm.nih.gov/...PMC3339795

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shared by Nathan Goodyear on 13 Feb 19 - No Cached
  • Nathan Goodyear on 13 Feb 19
     
    THC and prostate cancer
Nathan Goodyear

In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines - 0 views

file.scirp.org/...5-2500510_47691.htm

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shared by Nathan Goodyear on 13 Feb 19 - No Cached
  • Nathan Goodyear on 13 Feb 19
     
    High CBD downregulates prostate CBD1, CBD2, chemosensitizes CSCs, suppressed cancer cell formation, down regulated IL-6 and IL-8, decreased PSA, and VEGF.
Nathan Goodyear

Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system - 0 views

www.ncbi.nlm.nih.gov/...PMC3883513

Nausea CBD THC "medical marijuana" Chemotherapy

shared by Nathan Goodyear on 28 Jan 19 - No Cached
  • Nathan Goodyear on 28 Jan 19
     
    Great read on the use of CBD, THC in nausea/vomiting. Data in humans is lacking and most of the data is related to prescription drugs.
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