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Nathan Goodyear

Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer. - Pu... - 0 views

www.ncbi.nlm.nih.gov/...25855725

CB2 endocannabinoid HER2 HER-2 cancer breast cancer

shared by Nathan Goodyear on 18 Sep 18 - No Cached
  • Nathan Goodyear on 18 Sep 18
     
    CB2 overexpression found to upregulate HER2 expression in breast cancer.  This has prognostic and therapeutic value.
Nathan Goodyear

The current state and future perspectives of cannabinoids in cancer biology - 0 views

www.ncbi.nlm.nih.gov/...PMC5852356

Cancer CBD THC cannabinoids

shared by Nathan Goodyear on 19 Sep 18 - No Cached
hoangkimchi liked it
  • The activation of each of them leads to an inhibition of adenylyl cyclase via G proteins (Gi/o), which in turn activates many metabolic pathways such as mitogen‐activated protein kinase pathway (MAPK), phosphoinositide 3‐kinase pathway (PI3K), cyclooxygenase‐2 pathway (COX‐2), accumulation of ceramide, modulation of protein kinase B (Akt), and ion channels
  • phytocannabinoids, endocannabinoids, and synthetic cannabinoids
  • Action of THC in human organism relies on mimicking endogenous agonists of CB receptors—endocannabinoids
  • ...8 more annotations...
  • The upregulated expression of CB receptors and the elevated levels of endocannabinoids have been observed in a variety of cancer cells (skin, prostate, and colon cancer, hepatocellular carcinoma, endometrial sarcoma, glioblastoma multiforme, meningioma and pituitary adenoma, Hodgkin lymphoma, chemically induced hepatocarcinoma, mantel cell lymphoma)
  • concentration of endocannabinoids, expression level of their receptors, and the enzymes involved in their metabolism frequently are associated with an aggressiveness of cancer
  • CB2 receptor contributes to human epidermal growth factor receptor (HER2) pro‐oncogenic signaling and an overexpression of CB2 increases susceptibility for leukemia development after leukemia viral infection
  • endocannabinoid‐degrading enzymes are upregulated in cancer cell lines and in human tumors
  • Many cannabinoids, ranging from phytocannabinoids (THC, CBD), endocannabinoids (2‐arachidonoylglycerol, anandamide), to synthetic cannabinoids (JWH‐133, WIN‐55,212‐2), have shown ability to inhibit proliferation, metastasis, and angiogenesis in a variety of models of cancer
  • Despite some inconsistent data, the main effect of cannabinoids in a tumor is the inhibition of cancer cells’ proliferation and induction of cancer cell death by apoptosis
  • CB1 and CB2 receptor agonists stimulate apoptotic cell death in glioma cells by induction of de novo synthesis of ceramide, sphingolipid with proapoptotic activity
  • process of autophagy is upstream of apoptosis in mechanism of cell death induced by cannabinoids
Nathan Goodyear

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition | Mol... - 0 views

molecular-cancer.biomedcentral.com/...1476-4598-9-196

Cancer "breast cancer" THC CBD "medical medical marijuana

shared by Nathan Goodyear on 12 Nov 18 - No Cached
  • Nathan Goodyear on 12 Nov 18
     
    Mouse study finds THC and CBD agonist reduce tumor growth, inhibit angiogenesis, induce apoptosis, and reduce metastasis. In addition, 91% of breast cancers in animal study expressed CB2 receptors.
Nathan Goodyear

Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT... - 0 views

www.sciencedirect.com/...S0028390813001238

CBD cannabinoids hemp oil brain excitotoxicity inflammation oxidative stress

shared by Nathan Goodyear on 11 Aug 17 - No Cached
  • Nathan Goodyear on 11 Aug 17
     
    Another animal study finds CBD is neuroprotective.  This study actually found that CBD reduced excitotoxicity, inflammation, and oxidative stress.
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