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Nathan Goodyear

Obesity Is a Major Determinant of the Association of C-Reactive Protein Levels and the ... - 0 views

diabetes.diabetesjournals.org/...2357.full

CRP fibrinogen obesity inflammation metabolic syndrome

shared by Nathan Goodyear on 14 Aug 11 - No Cached
  • Nathan Goodyear on 14 Aug 11
     
    obesity increases inflammation and Metabolic syndrome factors
Nathan Goodyear

Complement split products C3a and C... [Int Arch Allergy Immunol. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18270493

shared by Nathan Goodyear on 12 Sep 11 - No Cached
  • Nathan Goodyear on 12 Sep 11
     
    C3a and C4a useful in early acute lyme disease
Nathan Goodyear

Low Testosterone and High C-Reactive Protein Concentrations Predict Low Hematocrit in T... - 0 views

care.diabetesjournals.org/...2289.full

low testosterone CRP cardiovascular disease

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • In these patients, hematocrit is also inversely related to CRP concentration.
  • Nathan Goodyear on 12 Apr 11
     
    low T associated with elevated CRP and thus increased cardiovascular risk
Nathan Goodyear

Effect of wine phenolics on cytokine-induced C-reactive protein expression - KAUR - 200... - 0 views

onlinelibrary.wiley.com/...abstract

resveratrol wine inflammation

shared by Nathan Goodyear on 05 Apr 11 - No Cached
  • Wine phenolics inhibit CRP expression
  • Nathan Goodyear on 05 Apr 11
     
    Resveratrol in red wine reduces inflammation
Nathan Goodyear

ScienceDirect - Trends in Pharmacological Sciences : Pharmacological basis for the role... - 0 views

www.sciencedirect.com/science

curcumin disease inflammation anti-inflammatory

shared by Nathan Goodyear on 29 Mar 11 - No Cached
  • Extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of inflammatory transcription factors (such as nuclear factor κB), enzymes (such as cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6)
  • Nathan Goodyear on 29 Mar 11
     
    curcumin as anti-inflammatory in disease
Nathan Goodyear

ScienceDirect - Food and Chemical Toxicology : Neuroprotective effect of ginger on anti... - 0 views

www.sciencedirect.com/science

Ginger diabetes oxidative stress

shared by Nathan Goodyear on 27 Apr 11 - No Cached
  • A marked decrease in anti-oxidant marker enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), reduced glutathione (GSH) and increase in malondialdehyde (MDA) was observed in the diabetic rats
  • inger may be used as therapeutic agent in preventing complications in diabetic patients.
  • These results suggest that ginger exhibit a neuroprotective effect by accelerating brain anti-oxidant defense mechanisms and down regulating the MDA levels to the normal levels in the diabetic rats
  • Nathan Goodyear on 27 Apr 11
     
    Ginger reduces oxidative stress in diabetic rat model
Nathan Goodyear

ScienceDirect - Appetite : Deficiency of central dopamine in multiple obesity models. - 0 views

www.sciencedirect.com/science

shared by Nathan Goodyear on 29 Apr 11 - No Cached
  • Nathan Goodyear on 29 Apr 11
     
    overeating and obesity may be result of low dopamine levels
Nathan Goodyear

ScienceDirect - Acta Astronautica : Behavioral and biological effects of autonomous ver... - 0 views

www.sciencedirect.com/science

cortisol saliva salivary testing

shared by Nathan Goodyear on 04 May 11 - No Cached
  • salivary cortisol
  • Nathan Goodyear on 04 May 11
     
    not again: NASA using salivary cortisol testing to evaluate astronaut stress
Nathan Goodyear

ScienceDirect - The International Journal of Biochemistry & Cell Biology : Obesity: The... - 0 views

www.sciencedirect.com/science

ALA alpha Lipoic Acid Leptin obesity overweight weight loss

shared by Nathan Goodyear on 07 May 11 - No Cached
  • hypothalamic AMP-activated protein kinase plays a key role in regulating these processes. Leptin, insulin, glucose and alpha-lipoic acid have been shown to reduce food intake by lowering hypothalamic AMP-activated protein kinase activity,
  • Nathan Goodyear on 07 May 11
     
    ALA and leptin aids in weight loss
Nathan Goodyear

How environmental and genetic factors combine to c... [Neurotoxicology. 2008] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...18031821

autism spectrum disorders ASD

shared by Nathan Goodyear on 05 Jul 11 - No Cached
  • Genetic polymorphisms adversely affecting sulfur metabolism, methylation, detoxification, dopamine signaling and the formation of neuronal networks occur more frequently in autistic subjects.
  • a "redox/methylation hypothesis of autism" is described, in which oxidative stress, initiated by environment factors in genetically vulnerable individuals, leads to impaired methylation and neurological deficits secondary to reductions in the capacity for synchronizing neural networks.
  • Nathan Goodyear on 05 Jul 11
     
    proposed hypothesis of autism
Nathan Goodyear

Plasma testosterone, high density lipoprotein c... [Am J Cardiol. 1981] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7304438

testosterone lipids cholesterol HDL triglycerides VLDL male hormone hormones men

shared by Nathan Goodyear on 08 Jan 14 - No Cached
  • Nathan Goodyear on 08 Jan 14
     
    Free and total Testosterone in men found to be positively associated with HDL, but negatively associated with triglycerides and VLDL in this study.
Nathan Goodyear

Unveiling the Mechanisms for Decreased Glutathione in Individuals with HIV Infection - 0 views

connection.ebscohost.com/...ione-individuals-hiv-infection

glutathione GSH Nrf2 GSSG HIV inflammation oxidative Stress

shared by Nathan Goodyear on 07 Jan 15 - No Cached
  • Nathan Goodyear on 07 Jan 15
     
    men with HIV have GSH depleted macrophages.  GSH is the reduced, ready to act form of Glutathione.  In contrast, the macrophages were high in the oxidized form of Glutathione--GSSG.  In HIV, the high inflammation increased oxidative stress, likely overwhelmed Nrf2 activation and resulted in decreased GSH synthase transcription and thus decreased Glutathione production balance.
Nathan Goodyear

Marathons damage the hearts of less fit runners for up to three months - - Heart and St... - 0 views

www.heartandstroke.nb.ca/...content2.aspx

endurance training running runners marathon marathons heart health CVD exercise

shared by Nathan Goodyear on 09 Jan 15 - No Cached
  • Nathan Goodyear on 09 Jan 15
     
    Summary of 2010 report on marathons and the heart.  Less fit runners can do significant damage to the heart i.e. fibrosis compared to fit runners.  V02 max is a good way to assess aerobic endurance and differentiate between the two.  Dr Larose showed via MRI that it can take 3 months for the heart to recover.
Nathan Goodyear

Promoting effects and mechanisms of action of androgen in bladder c... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9129932

bladder cancer bladder cancer Testosterone men male hormone hormones

shared by Nathan Goodyear on 04 Jan 15 - No Cached
  • Nathan Goodyear on 04 Jan 15
     
    Another animal study finds Testosterone plays a role in bladder cancer development.  The study used anti androgen and 5 alpha reductase inhibitor therapy to see if these add on therapies provided anything to ADR whether via castration or pituitary suppression--the answer was no.  The authors concluded that Testosterone played more of a role with AR versus the more active 5alpha-DHT metabolite.
Nathan Goodyear

Fructose: A Key Factor in the Development of Metabolic Syndrome and Hypertension - 0 views

www.hindawi.com/...682673

fructose uric acid metabolic syndrome sugar

shared by Nathan Goodyear on 24 Aug 14 - No Cached
  • HFCS consists of fructose and glucose mixed in a variety of concentrations, but most commonly as 55% fructose and 45% glucose
  • In the United States, HFCS and sucrose are the major sources of fructose in the diet, and HFCS is a major ingredient in soft drinks, pastries, desserts, and various processed foods
  • fructose and glucose are metabolized in completely different ways and utilize different GLUT transporters
  • ...9 more annotations...
  • In the liver, fructose bypasses the two highly regulated steps of glycolysis, catalyzed by glucokinase/hexokinase and phosphofructokinase both of which are inhibited by increasing concentrations of their byproducts. Instead, fructose enters the pathway at a level that is not regulated and is metabolized to fructose-1-phosphate primarily by fructokinase or ketohexokinase
  • Fructokinase has no negative feedback system, and ATP is used for the phosphorylation process. As a result, continued fructose metabolism results in intracellular phosphate depletion, activation of AMP deaminase, and uric acid generation which is harmful at the cellular level
  • Uric acid, a byproduct of fructose degradation,
  • Uric acid inhibits endothelial NO both in vivo and in vitro, [15] and directly induces adipocyte dysfunction
  • Serum uric acid increases rapidly after ingestion of fructose, resulting in increases as high as 2 mg/dL within 1 hour
  • Uncontrolled fructose metabolism leads to postprandial hypertriglyceridemia, which increases visceral adipose deposition. Visceral adiposity contributes to hepatic triglyceride accumulation, protein kinase C activation, and hepatic insulin resistance by increasing the portal delivery of free fatty acids to the liver
  • Several reviews have concluded that intake of both fructose and HFCS by children and adults was associated with an increased risk of obesity and metabolic syndrome
  • Sucrose is a disaccharide that is comprised of fructose and glucose
  • Figure 2
  • Nathan Goodyear on 24 Aug 14
     
    great read and review of the role of fructose in metabolic syndrome.
Nathan Goodyear

A comparison of the use of urinary c... [J Clin Endocrinol Metab. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23150688

cortisol saliva salivary Cushing's testing

shared by Nathan Goodyear on 23 Aug 14 - No Cached
  • Nathan Goodyear on 23 Aug 14
     
    night time salivary cortisol found to correlate with early morning urine samples in those with Cushing's.  This in addition to the nocturnal salivary cortisol correlation found in past studies.  The positive studies on salivary cortisol testing continues to build.
Nathan Goodyear

Abstract 3608: Lipoprotein (a) Cholesterol, But Not Lp(a) Mass, Is An Independent Predi... - 0 views

circ.ahajournals.org/...II_818-c

Lp(a) Lp(a) mass lipoprotein(a) lipoprotein(a) mass heart health cardiovascular disease risk

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Lipoprotein (a) cholesterol is a better predictor of CAD and CVD events than Lipoprotein (a) mass.
Nathan Goodyear

C-Reactive Protein and All-Cause Mortality in a Large Hospital-Based Cohort - 0 views

www.clinchem.org/...343.long

CRP inflammation mortality cancer disease

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • Nathan Goodyear on 27 Aug 14
     
    low sensitivity CRP associated with increased short-term and long-term mortality in hospitalized patients.  Also associated with a 28 fold increase in cancer mortality.
Nathan Goodyear

Testosterone Supplementation Reverses Sarcopenia in Aging through Regulation of Myostat... - 0 views

www.ncbi.nlm.nih.gov/...PMC2817626

Testosterone Sarcopenia aging

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    animal study finds Testosterone reversed age associated sarcopenia.
Nathan Goodyear

Inhibition of 1,2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by dehyd... - 0 views

carcin.oxfordjournals.org/...57.abstract

colon cancer tumor DHEA dehydroepiandrosterone hormone hormones

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Nathan Goodyear on 19 Nov 14
     
    Only abstract available here.  DHEA, in mouse model, finds reduced malignant lesions in colon.
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