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Nathan Goodyear

Estrogen Receptor β Expression Is Associated with Tamoxifen Response in ERα-N... - 0 views

clincancerres.aacrjournals.org/...1987.long

ER beta ER-beta estrogen receptors breast cancer tamoxifen estrogen receptor estrogen receptor women hormone hormones

shared by Nathan Goodyear on 08 Oct 14 - No Cached
  • Nathan Goodyear on 08 Oct 14
     
    Increased survival in those with ER beta + and ER alpha -.  Early relapse was associated with lack of ER beta expression.  ER beta is transcribed from a different genomic location than ER alpha.  
Nathan Goodyear

BMC Cancer | Full text | Estrogen receptor alpha/beta ratio and estrogen rece... - 0 views

www.biomedcentral.com/...425

breast cancer ER alpha ER-alpha ER beta ER-beta SERM tamoxifen anastrazole women hormone hormones female

shared by Nathan Goodyear on 08 Oct 14 - No Cached
  • 75% of human BCs express estrogen receptors (ERs)
  • Nathan Goodyear on 08 Oct 14
     
    ER beta expression and the ratio of ER alpha/ER beta is important in prognosis and effectiveness of SERM therapy like tamoxifen.  This study looked at the aromatase inhibitor anastrazole as well.
Nathan Goodyear

Estrogen receptor α and β in the normal immune system and in lymphoid maligna... - 0 views

www.sciencedirect.com/...S0303720713002207

ER estrogen receptors ER beta cancer lymphoma hormone hormones receptors

shared by Nathan Goodyear on 25 Jun 13 - No Cached
  • Nathan Goodyear on 25 Jun 13
     
    ER beta receptors have future in the treatment of cancer.  ER beta is a known growth inhibitor and this study proposes that ER beta is a means to aid lymphoma treatment.
Nathan Goodyear

Estrogen receptor (ER) β, a modulator of ERα in the uterus - 0 views

www.pnas.org/...5936.full

receptors ER-alpha ER-beta hormones hormone

shared by Nathan Goodyear on 16 Aug 12 - No Cached
  • induction of PR is an ERα-mediated event and repression of epithelial PR is ERβ mediated.
  • Nathan Goodyear on 16 Aug 12
     
    ER alpha and ER beta have different effects on the uterus in this mice model.  ER beta modulates ER alpha.  ER beta decreases PR, whereas ER alpha increases PR.
Nathan Goodyear

Estrogen Receptors in Colorectal Cancer: Goalkeepers, Strikers, or Bystanders? - 0 views

cancerpreventionresearch.aacrjournals.org/...897.full

estrogen colon cancer ER beta ER-beta breast

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • one can conclude that ERβ has an overall antiproliferative effect, thereby inhibiting cancer cell proliferation and antagonizing ERα function in the breast
  • HRT with estrogen alone did not increase the risk of breast cancer in the Women's Health Initiative clinical trials program
  • colorectal normal or cancer epithelium does not coexpress ERα and ERβ
  • ...7 more annotations...
  • ERβ expression resulted in the inhibition of proliferation and G1 phase cell-cycle arrest
  • ERβ expression strongly inhibited cMyc and tumor growth in a xenograft mouse model
  • induced ERβ in CRC cells has an antiproliferative, tumor-suppressive function that is independent of ERα
  • ERs also have the ability to bind many other compounds with an estrogen-like structure, including phytoestrogens and xenoestrogens (or endocrine disruptors)
  • Phytoestrogens are a diverse class of natural compounds with structural similarity to estradiol
  • Barone et al. recently found that two ERβ-selective phytoestrogens effectively counteracted CRC tumorigenesis and surprisingly increased ERβ expression in mice with mutations of the tumor-suppressor gene adenomatous polyposis coli
  • We can conclude that estrogens are important in protecting against CRC initiation and progression, and that the protective effect most likely is mediated by ERβ
  • Nathan Goodyear on 19 Nov 13
     
    ER beta is a new potential mode of therapy in colon cancer.  ER beta stimulation has been shown to inhibit colon cancer cell growth.
Nathan Goodyear

Loss of ERβ expression as a common step in estrogen-dependent tumor progression - 0 views

www.ncbi.nlm.nih.gov/...PMC2072930

ER beta hormones ER-beta estrogen receptor estrogen receptor beta ER alpha ER-alpha estrogen cancer tumor carcinogenesis

shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • Nathan Goodyear on 11 Sep 15
     
    loss of ER-beta expression is associated with increased carcinogenesis, suggesting a protective role for ER-beta against tumor proliferation.
Nathan Goodyear

Presence of Estrogen Receptor β in the Human Endometrium through the Cycle: E... - 0 views

jcem.endojournals.org/...1379.long

ER-alpha ER-beta estrogen receptor alpha estrogen receptor beta estrogen receptor alpha beta endometrium menstrual cycle

shared by Nathan Goodyear on 07 Dec 12 - No Cached
  • Nathan Goodyear on 07 Dec 12
     
    estrogen receptor Beta and alpha discussed in the endometrium through menstrual cycle.  This study focus' on human endometrium
Nathan Goodyear

Frequent Loss of Estrogen Receptor-β Expression in Prostate Cancer - 0 views

cancerres.aacrjournals.org/...5331.long

ER beta prostate cancer prostate cancer estrogen receptor estrogen receptor receptors hormone hormones

shared by Nathan Goodyear on 05 Feb 13 - No Cached
  • Nathan Goodyear on 05 Feb 13
     
    Loss of ER-beta expression in the prostate associated with increased progression from a normal prostate to prostate cancer.
Nathan Goodyear

Estrogen receptors alpha and beta in the normal, hyperplastic and carcinomatous human p... - 0 views

joe.endocrinology-journals.org/...447

ER-alpha ER-beta inflammation prostatitis BPH prostate cancer hyperplasia

shared by Nathan Goodyear on 01 May 12 - No Cached
  • Nathan Goodyear on 01 May 12
     
    ER alpha and ER beta receptors play role in BPH and prostate cancers.  ER alpha is proliferative and inflammatory: ER beta is inhibitory.
Nathan Goodyear

Comparative Studies of the Estrogen Receptors β and α and the Androgen Recept... - 0 views

ajp.amjpathol.org/...fulltext

ER beta ER-beta AR androgen receptors ER alpha ER-alpha prostate disease cancer estrogen receptor hormone hormones men male

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • ER-β is predominately immunolocalized in basal cells and to a lesser extent in stromal cells of the morphologically normal human prostate
  • ER-α is detected in stromal cells and rarely in basal cells of the normal gland
  • AR was predominately localized in the nuclei of differentiated secretory cells and variably in basal cells of the normal acinar/duct unit as well as in stromal cells
  • ...9 more annotations...
  • Hall and colleagues44 have reported that ER-β functions as a transdominant inhibitor of ER-α transcription and that it acts to decrease overall cellular sensitivity to estradiol
  • The expression of ER-β was diminished in high-grade dysplasias when compared to normal glands and lower grade lesions.
  • The transition from normal to low/moderate dysplastic glands in the peripheral zone was marked by the appearance of ER-β homogeneously immunostained nuclei in secretory as well as basal cells with no changes in the localization of the other receptors.
  • proliferative signals mediated by AR in basal cells or by ER-α and AR in stromal cells may be opposed by the purported growth-inhibitory action of ER-β25, 26, 27, 28 localized in basal cells.
  • The diminution of ER-β expression in high-grade dysplasias and grade 4/5 cancers may be therefore related to the alteration of DNA methylation pattern in CpG islands of the promoter, resulting in down-regulation of the receptor at the transcriptional level
  • based on the proposed anti-proliferative function of the receptor,25, 26, 27, 28 the presence of ER-β in secretory cells of low/moderate-grade lesions may represent a transient abortive attempt to counter growth of these cells
  • the attrition of receptor-positive basal cells in the high-grade dysplasias may signify a continuing loss of growth inhibitory function mediated by ER-β in these precursor lesions
  • Our findings in prostate therefore differ from those reported for human colon cancer in which Folley and colleagues48 demonstrated that a selective loss of ER-β protein but not receptor message expression occurs in these neoplasms
  • Our findings therefore differed from those of Bonkhoff and colleagues33 who found immunostaining for the receptor in high-grade dysplasias and grade 4/5 carcinomas. Using in situ hybridization these authors also reported that a high percentage of dysplasias and carcinomas in their study contained cells that expressed ER-α message
  • Nathan Goodyear on 21 Jan 14
     
    Very nice study.  The authors looked at normal prostate, early disease and late stage prostate cancer.  The authors found that ER beta expression, as a general rule, was lost as progression occurred to the high-grade dysplasias and grad 4/5 carcinomas of the prostate.  Early low/moderate dysplasia was associated with an increase in ER beta--the authors propose that this was due to an attempt of the basal epithelium to counter the paracrine effect of ER alpha.   In contrast, androgen receptors appeared to be equally expressed across all.
Nathan Goodyear

Dynamic Regulation of Estrogen Receptor-β Expression by DNA Methylation Durin... - 0 views

ajp.amjpathol.org/...fulltext

prostate cancer ER beta ER-beta methylation male men hormone hormones

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Nathan Goodyear on 21 Jan 14
     
    Methylation of the ER beta gene promoter region decreases ER beta expression and this has been associated with carcinogenesis of the prostate.
Nathan Goodyear

Expression of estrogen receptor β in prostate carcinoma cells inhibits invasi... - 0 views

www.sciencedirect.com/...S0014579304004806

estrogen receptor receptors ER-beta ER beta prostate cancer male hormone hormones men

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Nathan Goodyear on 21 Jan 14
     
    Study finds that ER beta inhibits invasion, proliferation and actually triggers cell death of prostate cancer cells.  This fits with the other data that loss of ER beta promotes carcinogenesis.
Nathan Goodyear

The Estrogen Receptor β Subtype: A Novel Mediator of Estrogen Action in Neuro... - 0 views

www.sciencedirect.com/...S0091302298901704

Estrogen receptors receptor ER alpha ER-alpha ER beta ER-beta hormone hormones

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • Nathan Goodyear on 27 Jan 14
     
    Estrogen receptors are one mechanism of the transmission of the estrogen signal.  The signal can be from estrogens themselves, estrogenic like compounds (xenoestrogens) and via non-estrogens like 3-beta androstane idol that interacts with ER beta to decrease prostate cancer cell proliferation.
Nathan Goodyear

The Androgen Derivative 5α-Androstane-3β,17β-Diol Inhibits Prostate Cancer Ce... - 0 views

cancerres.aacrjournals.org/...5445.short

prostate cancer DHT metabolite 3-alpha androstanediol ER beta ER-beta E-cadherin male hormone hormones men

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • the dihydrotestosterone metabolite 5α-androstane-3β,17β-diol (3β-Adiol), a steroid which does not bind androgen receptors, but efficiently binds the estrogen receptor β (ERβ), exerts a potent inhibition of prostate cancer cell migration through the activation of the ERβ signaling
  • estradiol is not active
  • 3β-Adiol, through ERβ, induces the expression of E-cadherin, a protein known to be capable of blocking metastasis formation in breast and prostate cancer cells
  • Nathan Goodyear on 27 Jan 14
     
    DHT metabolite 3-beta androstanediol inhibits prostate cancer via its interaction with ER beta not AR.  This study finds increased E-cadherin transcription to reduce metastasis.  Estrogen was not active, according to this study.  This implies that estrogen in early disease may have a different signal than late.
Nathan Goodyear

Dihydrotestosterone may inhibit hypothalamo-pi... [Neurosci Lett. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15234470

hormone hormones DHT metabolite metabolites 3-beta androstanediol 3-beta-diol ER estrogen receptor ER beta ER-beta

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    Mouse study finds that DHT metabolite provides negative feedback to HPA via 3beta androstaendiol.  What is interesting is that this signaling occurred through ER beta.  Androgen signaling processed through estrogen receptors.
Nathan Goodyear

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-D... - 0 views

www.jneurosci.org/...1448.long

DHT metabolite metabolites 3-beta androstanediol 3-beta-diol HPA stress ER estrogen receptor ER beta ER-beta hormone hormones

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    Full article of previously posted abstract.  DHT metabolite 3beta-diol inhibits HPA stress response via ER beta.  
Nathan Goodyear

Oestrogen and colorectal cancer: mechan... [Int J Colorectal Dis. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23319136

estrogen estriol estradiol estrone colon cancer ER beta ER-beta

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    Estrogen early protects against colon cancer, but estrogen increases proliferation late.  The problem here is the estrogens involved.  If ER beta is shown to be highly expressed in the colon, then Estriol would be of benefit as it preferentially binds to ER beta at a rate of 5:1 and Estradiol at a rate of 1:1.  Estriol is currently used in Europe in advanced breast cancer.
Nathan Goodyear

Tumor Repressive Functions of Estrogen Receptor β in SW480 Colon Cancer Cells - 0 views

cancerres.aacrjournals.org/...6100.long

colon colon cancer cancer estrogen ER beta ER-beta

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    Stimulation of ER-beta provides inhibition of colon cancer cell proliferation.  ER-beta is the prominent ER in the colon.
Nathan Goodyear

Resistance training restores muscle sex steroid hormone steroidogenesis in older men - 0 views

www.fasebj.org/...1891.long

resistance training hormone hormones low T Testosterone aging 3 beta HSD 17 beta HSD)

shared by Nathan Goodyear on 07 May 14 - No Cached
  • Nathan Goodyear on 07 May 14
     
    I like this study.  So many men, and women for that matter, focus on cardio for health and weight loss.  In men, low Testosterone is associated with aging as is weight.  This inverse relationship leads to the sarcopenic (belly, manboobs, and thin arms/legs) obesity so prevalent in older men today.  This study found that older men do have lower levels of enzymes and androgens from muscle biopsies as compared to younger men.  A 12 week resistance training regimen of only knee flexion and extension (simple) resulted in increased 3-beta-hydroxysteroid dehydrogenase and 17-beta-hydroxysteroid dehydrogenase.  
Nathan Goodyear

ERβ Has Nongenomic Action in Caveolae: Molecular Endocrinology: Vol 16, No 5 - 0 views

press.endocrine.org/...mend.16.5.0827

ER estrogen receptor estrogen receptors ER-alpha ER alpha ER beta ER-beta hormone hormones

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    Estrogen receptors are primarily located inside the nucleus and in the cytoplasm; not on the cell membrane surface. This article specifically focus' on the non-genomic action of ER-beta.  ER-alpha and ER-beta are classic transcription factors.
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