Scary study. This study seems to show that state laws are the way to reduce BMI. BMI is not a reliable measurement of Percent fat. So, I question this study all together. But their conclusion seems to be to attack obesity through legislation. You should attack obesity through education.
This is a short interview of the author on a recent retrospective review that revealed no increase in cardiovascular events in men. The author rightly points out his data, which is quite different than the previous JAMA and PLOSone publications which showed an increase in cardiovascular events.
However, the lead author points out the main problem with comparisons: his study group was younger and healthier. So, the comparison is apples to oranges. Studies still point to increased risk of Testosterone therapy in men with pre-existing CVD. This new study does not refute this point at all.
Another serious flaw here, is that only Testosterone was followed. This logic is seriously flawed as I have previously documented. The author points out the flaw in the levels in the JAMA study post treatment. But he fails to account for the the lack of adequate pathway assessment i.e.aromatazation. Also, no inflammatory cytokine evaluation was performed in that study. Both of these should have been highlighted.
In contrast, a positive was the length of follow.
Very real and scary statistics. Obesity is the greatest health problem facing the US today. 42%-51% by 2030...Ouch! Ever seen WALL-E. However, it is not the govt responsibility to control what we eat. Their regulations are in part responsible for this. This needs to be attacked through education, personal responsibility, and changing the way medicine works (of which many of the current medical boards/associations are opposed too).
Cause and effect cannot be taken from this study. However, TNF-alpha is known to disrupt testicular function, in this case the study found decreased sperm motility, lower Testosterone levels, and increased LH and FSH at baseline. Improvement was seen after anti-TNF-alpha therapy. The point of this study should be why the elevated TNF-alpha and attack there.
Calorie restriction aids fight against cancer on several fronts. Granted this is a mouse study, but Cancer should be attacked through nutrition just as through surgery and chemo/radiation.
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Life extesnsions rebuttal to recent JAMA study. There was several significant flaws in that study and thus limited evidence can be gained by that study. In fact, I find no useful clinical information from that study.
In the rebuttal, there are flaws. The reference the low serum T after treatment and correctly discuss aromatase activity. But they fail the mention that the less than optimal serum T is likely the result of the high aromatase activity in these men. Age, stress, and weight are primary causes of increases estrogen production in these men. These would be why likely high estrogen production occurred and less than optimal serum T resulted. And, increased E2 will cause an increase in CRP which can precipitate CVD events.
Androgen deprivation therapy increases fatal heart attack risk in those with prostate cancer. Also of note, the ADT therapy group did not provide a survival benefit over that of radiation alone.
leptin and ghrelin and how they manipulate what you eat. Instead of focusing on what target to create to attack, how about how to balance them to create healthy eating habits
Beta glucans have both an innate and adaptive effect to enhance the environment in/and around tumor. Beta glucans stimulate the immune system signaling to attack tumors.