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Study finds association between elevated Estradiol in young men and obesity.  No correlation was found with Testosterone.  This fits other research that points to early increased Estradiol production and late decrease in low T.  The men in this study were "young".  Testing was done in saliva.

The results of this study: body composition i.e. fat, effects hormone levels, rather then hormone effecting body composition.  

In men, Testosterone is shown to provide negative feedback on LH; but FSH is primarily regulated by estradiol.

In rat model, Estradiol shown to increase inflammation in lateral lobes of the prostate.  Androgens, Testosterone > DHT, shown to inhibit this inflammatory response.  

aromatase inhiibition via anastrozole decreased Estradiol and allowed for an increase in Testosterone production.  Estradiol has a negative feedback at both the hypothalamus and the pituitary.

Study finds that lower SHBG, higher Estradiol, Estrone, Testosterone levels, and free androgen index is associated with increased CRP in "healthy" postmenopausal women.