PLOS ONE: Microbial Dysbiosis in Colorectal Cancer (CRC) Patients - 0 views
-
differences in the colon microbiota in individuals with colon cancer versus those with a normal colonoscopy
-
qPCR revealed significant elevation of the Bacteroides/Prevotella population in cancer patients that appeared to be linked with elevated IL17 producing cells in the mucosa of individuals with cancer.
-
Bacteroides genus populations and more specifically those of Bacteroides fragilis, have recently been shown to produce a metalloprotease in colon cancer patients, but not in controls [12] suggesting this species sub population might favor carcinogenesis
- ...3 more annotations...
-
A relationship between dysbiosis and colon cancer appears to be present. Particularly an increase in Bacteroidetes and Prevotella species were found in those with colon cancer versus those without. An inflammatory up regulation of IL-17 appears to be involved. Whether this is a cause or effect is yet to be determined, but the presence of elevated Bacteroidetes species with increased IL17 could be used as sensitive biomarkers.