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Nathan Goodyear

http://orthomolecular.org/library/jom/1992/pdf/1992-v07n01-p005.pdf - 0 views

orthomolecular.org/...1992-v07n01-p005.pdf

vitamin C CVD Pauling Linus Pauling Lp(a) cardiovascular disease hypertension

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    This is the unified paper theory of CVD and vitamin C as published by Pauling and Rath.  Vitamin C deficiency results in a decrease in the integrity and stability of the vascular wall.  Chronic deficiency results in in an increase in and accumulation of Lp(a) which leads to atherosclerotic plaques.
Nathan Goodyear

Copper | Linus Pauling Institute | Oregon State University - 0 views

lpi.oregonstate.edu/...copper

copper

shared by Nathan Goodyear on 22 Dec 15 - No Cached
  • Nathan Goodyear on 22 Dec 15
     
    good read on copper deficiency by the Linus Pauling Institute.
Nathan Goodyear

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC431183/pdf/pnas00040-0366.pdf - 0 views

www.ncbi.nlm.nih.gov/...pnas00040-0366.pdf

vitamin c IV vitamin C cancer Linus Pauling ascorbic acid

shared by Nathan Goodyear on 08 Dec 17 - No Cached
  • Nathan Goodyear on 08 Dec 17
     
    Some of the early research by Linus Pauling that showed that IV vitamin C is safe and increases survival time of patients with advanced cancer.  
Nathan Goodyear

Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongat... - 0 views

www.ncbi.nlm.nih.gov/...PMC336151

vitamin C IV vitamin C Fe cancer ferritin

shared by Nathan Goodyear on 08 Jul 19 - No Cached
  • Nathan Goodyear on 08 Jul 19
     
    This is the republication of the original Pauling and Cameron study. This re-analysis actually revealed better outcomes than the original. Also, they found that vitamin C likely is responsible for the release of Fe from ferritin required for the cytotoxicity with vitamin C.
Rageed Hassan

Clippers have strong interest in adding Carmelo Anthony to Big Three - 0 views

goo.gl/aeAgBs

men hormones

shared by Rageed Hassan on 27 Jan 17 - No Cached
  • Rageed Hassan on 27 Jan 17
     
    CLOSE LOS ANGELES - Even before all the talk of Carmelo Anthony joining the Clippers came up, Chris Paul had a message worth sharing when it came to his embattled team: he's as confident as ever that they're title contenders.
Nathan Goodyear

Linus Pauling Institute at Oregon State University - 0 views

lpi.oregonstate.edu/...sterols

plant sterols plant sterols

shared by Nathan Goodyear on 27 Aug 12 - No Cached
  • Nathan Goodyear on 27 Aug 12
     
    nice read on plant sterols.  
buha3351

AT LAST A LIFE - 0 views

atlastalifereview.com

PANIC ATTACK TREATMENT

shared by buha3351 on 15 Sep 13 - No Cached
  • buha3351 on 15 Sep 13
     
    ARE YOU FELLING GUILTY? MOST PEOPLE WHO HAVE ANXIETY AND PANIC ATTACKS OFTEN FIND THEMSELVES WITH OUT A RESOURCE ON HOW TO GET HELP OR HOW TO HELP THEMSELVES TO FEEL BETTER. ANXIETY AND PANIC ARE A VERY REAL SUBJECT AND SHOULD BE ADDRESSED IN A TIMELY FASHION TO HELP IMPROVE YOUR QUALITY OF LIFE; THEY CAN AFFECT ANYONE AT ANY TIME. SO IF YOU ARE FEELING LIKE IT'S THE LAST DAY OF YOUR LIFE, YOUR NOT ALONE, JUST UNDERSTAND THAT THERE'S HELP THROUGH SELF KNOWLEDGE AND READING. THAT WHY I AM RECOMMENDING THIS BOOK "AT LAST A LIFE." BY PAUL DAVID.
Nathan Goodyear

Ascorbic Acid and Cancer: A Review - 0 views

cancerres.aacrjournals.org/...663.full.pdf+html

vitamin C vitamin C cancer linus Pauling

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Vitamin C and Cancer. 
Nathan Goodyear

Folate | Linus Pauling Institute | Oregon State University - 0 views

lpi.oregonstate.edu/...folate

Folate folic acid MTHFR micronutrients

shared by Nathan Goodyear on 23 Aug 15 - No Cached
  • Nathan Goodyear on 23 Aug 15
     
    Nice review on the difference b/t Folate and Folic acid.  Also, brief but worthy of a read, review of the MTHFR polymorphism 677.
Nathan Goodyear

Linus Pauling Institute at Oregon State University - 0 views

lpi.oregonstate.edu/...selenium

selenium

shared by Nathan Goodyear on 05 Mar 11 - Cached
  • Nathan Goodyear on 05 Mar 11
     
    wonderful review on the benefits of selenium
Nathan Goodyear

Linus Pauling Institute at Oregon State University - 0 views

lpi.oregonstate.edu/...chromium

chromium

shared by Nathan Goodyear on 23 Feb 11 - Cached
  • Nathan Goodyear on 23 Feb 11
     
    everything you ever wanted to know about chromium
Nathan Goodyear

Multiple Myeloma Tumor Cells are Selectively Killed by Pharmacologically-dosed Ascorbic... - 0 views

www.ebiomedicine.com/...fulltext

multiple myeloma vitamin C IV vitamin C smoldering myeloma cancer

shared by Nathan Goodyear on 25 Sep 17 - No Cached
  • Recent reports indicate that a certain ROS concentration is required for high-dose vitamin C to induce cytotoxicity in cancer cells.
  • The generation of ascorbyl- and H2O2 radicals by PAA increases ROS stress in cancer cells
  • In this study, we report that PAA is efficacious in killing MM cells in vitro and in vivo models, which generated levels of 20–40 mM ascorbate and 500 nM ascorbyl radicals after intraperitoneal administration of 4 g ascorbate per kilogram of body weight (Chen et al., 2008Chen et al., 2008), in xenograft MM mice
  • ...33 more annotations...
  • These data suggest that PAA may show a therapeutic advantage to blood cancers vs solid tumors because of the communication between tumor cells and blood plasma
  • These results strongly suggest that the mechanism of PAA killing of MM cells is indeed iron-dependent
  • These results suggest that PAA administration in SMM may be able to prevent progression to symtomatic MM
  • A recent study by Yun and colleagues demonstrated that vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH, but spares normal cells
  • RAS family genes show the most frequent mutations in MM. KRAS, NRAS and BRAF are mutated in 22%, 20% and 7% of MM samples
  • the disease stage rather than the mutation of RAS and/or BRAF is the major predictive factor for PAA sensitivity in MM treatment
  • Other molecular mechanisms including ATP depletion and ATM-AMPK signaling have been reported to explain PAA-induced cell death
  • our pilot study also suggested that PAA could overcome drug resistance to bortezomib in MM cells
  • Our findings complement reported studies and further address the mechanism of action using clinical samples in which we observed that PAA killed tumor cells with high iron content, suggesting that iron might be the initiator of PAA cytotoxicity
  • combination of PAA with standard therapeutic drugs, such as melphalan, may significantly reduce the dose of melphalan needed
  • Combined treatment of reduced dose melphalan with PAA achieved a significantly longer progression-free survival than the same dose of melphalan alone.
  • These data also suggest that the bone marrow suppression induced by high-dose melphalan can be ameliorated by the combination of PAA with lower dose of melphalan because of the lack of toxicity of PAA on normal cells with low iron content.
  • if creatinine clearance is <30 mL/min, high dose ascorbic acid should be not administrated.
  • In MM preclinical and clinical studies, ascorbate was used as an adjunct drug and showed controversial results (Harvey et al., 2009, Perrone et al., 2009, Held et al., 2013, Sharma et al., 2012, Nakano et al., 2011, Takahashi, 2010, Sharma et al., 2009, Qazilbash et al., 2008). However, none of these tests used pharmacological doses of ascorbate and intravenous administration
  • Multiple myeloma (MM) is a plasma cell neoplasm.
  • Cameron and Pauling reported that high doses of vitamin C increased survival of patients with cancer
  • pharmacologically dosed ascorbic acid (PAA) 50–100 g (Chen et al., 2008, Padayatty et al., 2004, Hoffer et al., 2008, Padayatty et al., 2006, Welsh et al., 2013), administered intravenously, has potent anti-cancer activity and its role as anti-cancer therapy is being studied at the University of Iowa and in other centers
  • In the presence of catalytic metal ions like iron, PAA administered intravenously exerts pro-oxidant effects leading to the formation of highly reactive oxygen species (ROS), resulting in cell death
  • the labile iron pool (LIP) is significantly elevated in MM cells
  • The survival of CD138+ cells in vitro was significantly decreased following PAA treatment in all 9 MM
  • In contrast, no significant change of cell viability was observed in CD138− BM cells from the same patients
  • The same effect of PAA was also observed in the SMM patients
  • no response to PAA was detected in CD138+ cells from the 2 MGUS patients
  • the combination of melphalan plus PAA showed greater tumor burden reduction than each drug alone, suggesting a synergistic activity between these two drugs
  • Both catalase and NAC protect cells from oxidative damage
  • cells pretreated with NAC and catalase became resistant to PAA even at high doses
  • adding deferoxamine (DFO), an iron chelator, to OCI-MY5 cells before PAA treatment was also sufficient to prevent PAA-induced cellular death
  • iron is essential for PAA to achieve its anti-cancer activity
  • PAA induced early necrosis (Fig. 3Fig. 3A, 60 min) followed by late apoptosis
  • results further indicated that PAA induced mitochondria-mediated apoptosis
  • PAA by reacting with LIP and generating ROS induces mitochondria-mediated apoptosis in which AIF1 cleavage is important for cell death.
  • ROS and H2O2 are well known factors mediating PAA-induced cancer cell death
  • PAA was sensitive to all 9 MMs and 2 SMMs
  • Nathan Goodyear on 25 Sep 17
     
    animal study finds high-dose, pharmacologic vitamin C found to kill multiple myeloma cells via pro-oxidant effect found in similar studies in dealing with different cancers.
Nathan Goodyear

Intravenous Ascorbate as a Tumor Cytotoxic Chemotherapeutic Agent - 0 views

www.seanet.com/...d_hypotheses_1995-v44-p207.htm

vitamin C cancer IV vitamin C ascorbic acid

shared by Nathan Goodyear on 05 Mar 18 - No Cached
  • There is a 10 — 100-fold greater content of catalase in normal cells than in tumor cells
  • induce hydrogen peroxide generation
  • Ascorbic acid and its salts (AA) are preferentially toxic to tumor cells in vitro (6 — 13) and in vivo
  • ...36 more annotations...
  • related to intracellular hydrogen peroxide generation
  • only be obtained by intravenous administration of AA
  • Preferentially kills neoplastic cells
  • Is virtually non-toxic at any dosage
  • Does not suppress the immune system, unlike most chemotherapy agents
  • Increases animal and human resistance to infectious agents by enhancing lymphocyte blastogenesis, enhancing cellular immunity, strengthening the extracellular matrix, and enhancing bactericidal activity of neutrophils and modulation of complement protein
  • Strengthens the structural integrity of the extracellular matrix which is responsible for stromal resistance to malignant invasiveness
  • 1969, researchers at the NCI reported AA was highly toxic to Ehrlich ascites cells in vitro
  • In 1977, Bram et al reported preferential AA toxicity for several malignant melanoma cell lines, including four human-derived lines
  • Noto et al reported that AA plus vitamin K3 had growth inhibiting action against three human tumor cell lines at non-toxic levels
  • Metabolites of AA have also shown antitumor activity in vitro
  • The AA begins to reduce cell proliferation in the tumor cell line at the lowest concentration, 1.76 mg/dl, and is completely cytotoxic to the cells at 7.04 mg/dl
  • the normal cells grew at an enhanced rate at the low dosages (1.76 and 3.52 mg/dl)
  • preferential toxicity of AA for tumor cells. >95% toxicity to human endometrial adenocarcinoma and pancreatic tumor cells (ATCC AN3-CA and MIA PaCa-2) occurred at 20 and 30 mg/dl, respectively.
  • No toxicity or inhibition was demonstrated in the normal, human skin fibroblasts (ATCC CCD 25SK) even at the highest concentration of 50 mg/dl.
  • the use of very high-dose intravenous AA for the treatment of cancer was proposed as early as 1971
  • Cameron and Pauling have published extensive suggestive evidence for prolonged life in terminal cancer patients orally supplemented (with and without initial intravenous AA therapy) with 10 g/day of AA
  • AA, plasma levels during infusion were not monitored,
  • the long-term, oral dosage used in those experiments (10 g/day), while substantial and capable of producing immunostimulatory and extracellular matrix modulation effects, was not high enough to achieve plasma concentrations that are generally cytotoxic to tumor cells in culture
  • This low cytotoxic level of AA is exceedingly rare
  • 5 — 40 mg/dl of AA is required in vitro to kill 100% of tumor cells within 3 days. The 100% kill levels of 30 mg/dl for the endometrial carcinoma cells and 40 mg/dl for the pancreatic carcinoma cells in Figure 2 are typical
  • normal range (95% range) of 0.39-1.13 mg/dl
  • 1 h after beginning his first 8-h infusion of 115 g AA (Merit Pharmaceuticals, Los Angeles, CA), the plasma AA was 3.7 mg/dl and at 5 h was 19 mg/dl. During his fourth 8-h infusion, 8 days later, the 1 h plasma level was 158 mg/dl and 5 h was 185 mg/dl
  • plasma levels of over 100 mg/dl have been maintained in 3 patients for more than 5 h using continuous intravenous infusion
  • In rare instances of patients with widely disseminated and rapidly proliferating tumors, intravenous AA administration (10 — 45 g/day) precipitated widespread tumor hemorrhage and necrosis, resulting in death
  • Although the outcomes were disastrous in these cases, they are similar to the description of tumor-necrosis-factor-induced hemorrhage and necrosis in mice (52) and seem to demonstrate the ability of AA to kill tumor cells in vivo.
  • toxic effects of AA on one normal cell line were observed at 58.36 mg/dl and the lack of side effects in patients maintaining >100 mg/dl plasma levels
  • Although it is very rare, tumor necrosis, hemorrhage, and subsequent death should be the highest priority concern for the safety of intravenous AA for cancer patients.
  • Klenner, who reported no ill effects of dosages as high as 150 g intravenously over a 24-h period
  • Cathcart (55) who describes no ill effects with doses of up to 200 g/d in patients with various pathological conditions
  • following circumstances: renal insufficiency, chronic hemodialysis patients, unusual forms of iron overload, and oxalate stone formers
  • Screening for red cell glucose-6-phosphate dehydrogenase deficiency, which can give rise to hemolysis of red blood cells under oxidative stress (57), should also be performed
  • any cancer therapy should be started at a low dosage to ensure that tumor hemorrhage does not occur.
  • patient is orally supplementing between infusions
  • a scorbutic rebound effect can be avoided with oral supplementation. Because of the possibility of a rebound effect, measurement of plasma levels during the periods between infusions should be performed to ensure that no such effect takes place
  • Every effort should be made to monitor plasma AA levels when a patient discontinues intravenous AA therapy.
  • Nathan Goodyear on 05 Mar 18
     
    Older study, 1995, but shows the long-standing evidence that IVC preferentially is cytotoxic to cancer cells.`
trungtamnamkhoa

Orthomol Fertil Plus - Nhà Thuốc Nam Khoa - Men's Health Pharmacy - 2 views

nhathuocnamkhoa.com/...-cho-nam-gioi-mong-muon-co-con

pharmacy men health healthy hormones cancer hormone Disease Male

shared by trungtamnamkhoa on 25 Jun 19 - No Cached
  • trungtamnamkhoa on 25 Jun 19
     
    Orthomol Fertil plus nâng cao chất lượng tinh trùng theo những tiêu chí: Khả năng chuyển động của tinh trùng, Mật độ tinh trùng, hình dạng thông thường của tinh trùng. Orthomol Fertil plus là sản phẩm bổ sung vitamin, khoáng vật, các yếu tố vi lượng nhu yếu cho nam giới. Được lớn mạnh dựa trên "Liệu pháp dinh dưỡng Orthomolecular" của tấn sĩ hóa sinh Linus Pauling (người hai lần đoạt giải Nobel 1954, 1962). Orthomol Natal - thương hiệu nổi tiếng của Đức. Các lưu ý giúp cải thiện chất lượng tinh trùng Nhiệt độ trong tinh hoàn luôn thấp hơn hai ° C so có nhiệt độ cơ thể. Nhiệt độ quá cao sở hữu thể ảnh hưởng đến giai đoạn sản xuất tinh trùng. Hạn chế khiến cho nóng ghế trong xe và mặc quần quá bó. Giữa hiện trạng thể chất và chất lượng tinh trùng của bạn với 1 sự ảnh hưởng lẫn nhau. Kể cách thức khác, ví như bạn khỏe mạnh, thì càng nâng cao thời cơ tinh trùng khỏe mạnh và đầy nhựa sống. lúc đạt cực khoái cổ tử cung tương trợ chuyên chở tinh trùng về phía dạ con. Do đó để thụ tinh thuận tiện thì người nữ giới phải đạt đỉnh sau người đàn ông và ko ngược lại.
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