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Nathan Goodyear

Effects of vitamin D on immune disorders with special regard to asthma, COPD and autoim... - 0 views

www.expert-reviews.com/...ers.12.57

vitamin d vitamin autoimmune diseases asthma COPD

shared by Nathan Goodyear on 12 Aug 13 - No Cached
  • Nathan Goodyear on 12 Aug 13
     
    Vitamin D is an important immunomodulator.  Vitamin D shown to have benefit in Th1 and Th2 mediated disease states. Asthma and COPD benefit and other Th1 mediated diseases, such as MS, type 1 Diabetes, RA...
Nathan Goodyear

Aromatase and regulating the estr... [J Steroid Biochem Mol Biol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19896534

prostate disease cancer estrogen receptors ER Testosterone Estradiol estrogen hormone hormones men

shared by Nathan Goodyear on 16 Sep 13 - No Cached
  • Nathan Goodyear on 16 Sep 13
     
    Balance of Testosterone and Estradiol plays role in prostate disease.   With age in men comes declining Testosterone, yet estrogen productions stay the same to increase.  This significantly alters the estrogen receptors and prostate disease risk.
Nathan Goodyear

Nutrition Journal | Full text | Effects of coenzyme Q10 supplementation (300 ... - 0 views

www.nutritionj.com/...142

CoQ10 inflammation cytokines

shared by Nathan Goodyear on 19 Nov 13 - No Cached
Click Here . liked it
  • Nathan Goodyear on 19 Nov 13
     
    CoQ10 reduced inflammatory cytokines IL-6 and TNF-alpha.  CoQ10 also increased SOD, catalase, and glutathione perioxidase.  The duration of therapy was quite short--12 weeks.  The patients included in the study had pre-existing CAD.
  • Click Here . on 20 Nov 13
     
    study finds prolonged exposure to estrogen associated with increased colorectal cancer risk in postmenopausal women. So many unanswered questions. What was the ER status of these patients? What was the weight of these patients? One cannot simply compare estrogen exposure to colorectal cancer risk and say aha! What is the environment of the individual(s)?!Thanks visit; blog.hoop.la
Nathan Goodyear

Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androg... - 0 views

www.nature.com/...srep01528.html

prostate cancer 3-alpha androstanediol 3-beta androstanediol DHT metabolite metabolites

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • PSA levels in media were increased by 3α-diol
  • Similarly to 3α-diol, 3β-diol also increased PSA levels in media in a concentration-dependent manner
  • intracellular DHT is synthesized from inactive androgen 3α- and 3β-diol via different pathways in prostate cancer cells
  • ...12 more annotations...
    • Nathan Goodyear
      Nathan Goodyear on 15 Jul 15
       
      error in statement: DHT metabolites are not inactive, they just don't activate AR.
  • 3β-diol can be a precursor of DHT in prostate cancer cells.
  • serum 3α-diol G levels reflect the androgen milieu in localized prostate cancer patients receiving ADT
  • A few studies reported that 3β-diol is a potential ligand of estrogen receptor β (ERβ) and has an antiproliferative effect
  • our results revealed that 3β-diol is potentially a precursor of DHT in prostate cancer cells
  • Bauman et al. showed that 3α-diol is inactive at AR, but induces prostate growth
  • Prostate cancer cells promoted synthesis from the DHT metabolite 3α-diol during the long duration of ADT
    • Nathan Goodyear
      Nathan Goodyear on 15 Jul 15
       
      the authors highlight the suggestion is that 3alpha-diol's activity is via 3alpha-HSD, but fail to mention that it is known that 3alpha-diol interacts with the ER-alpha in the prostate.
  • verified the synthesis of DHT from 3α- or 3β-diol via different pathways in prostate cancer cells in this study
  • HSD17B6 expression levels in prostate cancer can be useful for the diagnosis of high-risk prostate cancer
  • serum 3α-diol G levels reflect the adrenal androgen milieu in localized prostate cancer patients
  • 3α- and 3β-diol has a much more significant role in intratumoral androgen metabolism during ADT
  • Nathan Goodyear on 27 Jan 14
     
    DHT metabolites play an important role of intra-prostate DHT synthesis in those following ADT.  This is a proposed mechanism for the failure rate and aggressive nature of prostate cancer that fails ADT.   3-alpha androstanediol is converted via 3 alpha HSD back to DHT.  In contrast, 3-beta androstanediol cannot.
Nathan Goodyear

Docosahexaenoic Acid Reduces ER Stress and Abnormal Protein Accumulation and Improves N... - 0 views

www.jneurosci.org/...3743.short

TBI traumatic brain injury brain injury DHA omega 3 omega-3 brain

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • Nathan Goodyear on 31 Aug 15
     
    Animal study finds DHA aids recovery from TBI.
Nathan Goodyear

http://joe.endocrinology-journals.org/content/167/2/281.full.pdf - 0 views

joe.endocrinology-journals.org/...281.full.pdf

estrogen metabolites 4-hydroxyestrone cancer estrogen hormones 2-hydroxyestrone 2-OH-estrone 4-OH-estrone

shared by Nathan Goodyear on 16 Jul 15 - No Cached
  • Nathan Goodyear on 16 Jul 15
     
    good discussion of the estrogen metabolites and increased estrogenic activity; including cancer risk.  Particular attention is given to the 4-hydroxyestrone metabolite.
Nathan Goodyear

Hormone Therapy, Estrogen Metabolism, and Risk of Breast Cancer in the Women's Health I... - 0 views

www.ncbi.nlm.nih.gov/...PMC3493689

breast cancer estrogen metabolites 2-OH-estrone 2:16 cancer hormones estrogen

shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • These results demonstrate that although 16α-OHE1 was increased more by E+P than by E-alone, the increase in the 2:16 ratio was similar for both HT regimens, due to ~4-fold greater increase in 2OHE-1 than 16α-OHE1 for both HT regimens
  • baseline and 1 year change in 16α-OHE1 showed little relationship to incident breast cancer
  • higher baseline 2-OHE1 and the 2:16 ratio were modestly associated with higher odds of incident breast cancer, but larger 1 year increase in 2-OHE-1 and the 2:16 ratio were also weakly associated with lower odds of breast cancer
  • Nathan Goodyear on 11 Sep 15
     
    Good review of the data from the WHI-HT on estrogen metabolites and breast cancer risk.  Increased 2-OHestrone and 2:16 ratio without statistical significance reached.
star yu

Hay un Tratamiento Eficaz para Curar la Etapa 3 de CKD con Quiste Renal - 0 views

www.enfermedad-renal.com/...2564.html

quiste renal

shared by star yu on 04 Oct 15 - No Cached
  • star yu on 04 Oct 15
     
    Si eres un paciente con quiste renal en la etapa 3,tieie un tratamiento eficaz para curarla? Tanto la enfermedad renal crónica y quiste renal son trastornos renales comunes.Etapa 3 de CKD indica riñones están funcionando con un 30% de la función renal ~ 59%, mientras que el quiste renal provoca quistes sac-fluido para desarrollar en los riñones.Si no se controla eficazmente, quistes renales agrandados reemplazarán los tejidos del riñón funcionando gradualmente.
star yu

Hay Algún Tratamiento para Curar la Enfermedad Renal con la Creatinina 3.8 - 0 views

www.enfermedad-renal.com/...2567.html

Micro-Medicina China osmoterapia

shared by star yu on 05 Oct 15 - No Cached
  • star yu on 05 Oct 15
     
    Hay algún tratamiento para curar la enfermedad renal con la creatinina 3.8? En clínica, la creatinina 3.8 es en la etapa 3 de la enfermedad renal, esta etapa es una etapa vital y puede ser controlado por el tratamiento oportuno.Si eres bastante afortunado para conseguir el tratamiento adecuado, puede obtener una oportunidad para invertir.
Nathan Goodyear

Hypothalamic IKKbeta/NF-kappaB and ER stress link ... [Cell. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18854155

hypothalamus NF-KappaB inflammation ikkbeta

shared by Nathan Goodyear on 22 Mar 11 - No Cached
  • Our results show that the hypothalamic IKKbeta/NF-kappaB program is a general neural mechanism for energy imbalance underlying obesity and suggest that suppressing hypothalamic IKKbeta/NF-kappaB may represent a strategy to combat obesity and related diseases
  • Nathan Goodyear on 22 Mar 11
     
    INflammation of hypothalamus through NF-KappaB leads to obesity and related diseases
Nathan Goodyear

Revealing Estrogen's Secret Role In Obesity - 0 views

www.sciencedaily.com/...070820145348.htm

estrogen obesity

shared by Nathan Goodyear on 07 Jun 11 - No Cached
  • researchers showed how estrogen receptors located in the hypothalamus serve as a master switch to control food intake, energy expenditure and body fat distribution.
  • This research seems to support a link between estrogen and regulation of obesity
  • ventromedial nucleus or VMN, is a key center for energy regulation.
  • ...2 more annotations...
  • When estrogen levels in the VMN dipped, the animals' metabolic rate and energy levels also plummeted
  • The findings suggested that the ER-alpha in this region plays an essential role in controlling energy balance, body fat distribution and normal body weight.
  • Nathan Goodyear on 07 Jun 11
     
    estrogen plays role in obesity in menopausal women.
Nathan Goodyear

Extended-release Tramadol (ULTRAM ER): a pharmacot... [Am J Ther. 2008 Mar-Apr] - PubMe... - 0 views

www.ncbi.nlm.nih.gov/...18356636

tramadol

shared by Nathan Goodyear on 17 May 11 - No Cached
  • Nathan Goodyear on 17 May 11
     
    Ultram is a weak norepinephrine and serotonin reuptake inhibitor
Nathan Goodyear

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling: Endocri... - 0 views

press.endocrine.org/...er.2008-0019

thyroid deiodinase T3 T4 hormone hormones

shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • From a broad perspective, this paradigm can be seen as an example of how hormones are activated or inactivated in a controlled fashion in specific extraglandular tissues, in an analogous role to 5α-reductase and P450 aromatase in sex steroid metabolism and to 11β-hydroxysteroid dehydrogenase in glucocorticoid metabolism.
  • Nathan Goodyear on 24 Nov 14
     
    better source for previous post on thyroid metabolism and deiodinase.
Nathan Goodyear

Risk of Breast Cancer in Relation to Combined Effects of Hormone Th... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25695354

breast cancer cancer women hormones hormone Testosterone Estrogen Estradiol ER+ estrogen receptors obesity overweight hormone therapy

shared by Nathan Goodyear on 23 Feb 15 - No Cached
  • Nathan Goodyear on 23 Feb 15
     
    Study finds increases serum Estradiol and Testosterone levels associated with increased risk of breast cancer.  Increased risk was also found associated with being overweight/obese, increased alcohol intake, alcohol combined with HT.  This was found in estrogen receptor + cases of breast cancer.
star yu

El Pronóstico de 10% de la Función Renal en la Insuficiencia Renal - 0 views

www.hospitalrenal.com/...649.html

insuficiencia renal crónica tratamiento

shared by star yu on 12 Apr 15 - No Cached
  • star yu on 12 Apr 15
     
    Como por lo general, la función renal es menos, el peor pronóstico es. La disminución de la función renal significa que hay mucho daño en sus riñones.Sin embargo, esto no significa que el pronóstico no se puede mejorar.Eres tú el que quiere mejorar el pronóstico de la función renal 10%, por favor lea lo siguiente para conocer más detalles.
jennifervenice

PAIN MEDICATION HERE FOR SALE - 0 views

Pain Medication of all type for sale at best available prices. we have pain mediation like: Roxy Tabs, Oxy Tabs,Xanies,Adderall, Percocet,Hydro,Valium,Subutex 8mg,Zohydro ER 40mg, Quaalude 300 mg,R...

http:__internationaldrugsstore.yolasite.com_

started by jennifervenice on 26 Mar 15 no follow-up yet
Nathan Goodyear

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stre... - 0 views

www.jci.org/...37948

Cancer THC autophagy medical marijuana glioblastoma

shared by Nathan Goodyear on 12 Nov 18 - No Cached
  • Nathan Goodyear on 12 Nov 18
     
    Describes the mechanism by which THC induces autophagy cell death of glioma cells.
Nathan Goodyear

Inborn-like errors of metabolism are determinants of breast cancer risk, clinical respo... - 0 views

www.ncbi.nlm.nih.gov/...PMC6114970

cancer metabolism breast cancer glutamine glutamate aspartate oncogenes

shared by Nathan Goodyear on 24 Sep 18 - No Cached
  • We now recognize that human cancers evolve in an environment of metabolic stress. Rapidly proliferating tumor cells deprived of adequate oxygen, nutrients, hormones and growth factors up-regulate pathways that address these deficiencies to overcome hypoxia (HIF), vascular insufficiency (VEGF), growth factor deprivation (EGFR, HER2) and the loss of hormonal support (ER, PR, AR) all to enhance survival and proliferation
  • RAS, PI3K, TP53 and MYC
  • The results suggest that breast cancer could be preceded by systemic subclinical disturbances in glucose-insulin homeostasis characterized by mild, likely asymptomatic, IEM-like biochemical changes
  • ...16 more annotations...
  • The process would include variable periods of hyperinsulinemia with the consequent systemic MYC activation of glycolysis, glutaminolysis, structural lipidogenesis and further exacerbation of hypoglycemia, the result of MYC's known role as an inhibitor of liver gluconeogenesis
  • The metabolic changes we describe in breast cancer arise in concert with IEM-like changes in oxidative phosphorylation as detected by increased values of the ratio lactate/pyruvate (Supplementary Table 2A, 2B) characteristic of Ox/Phos deficiency [25]. In our study, 76% (70/92) of the European breast cancer patients had lactate/pyruvate ratios values higher than the normal value of 25.8
  • four-fold higher frequency of cancer (including breast) in patients with energy metabolism disorders
  • growing recognition that cancer cells differ from their normal counterparts in their use of nutrients, synthesis of biomolecules and generation of energy
  • glutamine concentrations in the cancer patients were reduced to nearly 1/8 of the levels observed in the normal population
  • blood concentrations of aspartate (p = 1.7e-67, FDR = 8.3e-67) (Figure ​(Figure1E)1E) and glutamate (p = 6.4e-96, FDR = 6.2e-95) (Figure ​(Figure1F)1F) were nearly 10 fold higher than the normal ranges of 0–5 μM/L and 40 μM/L, respectively
  • glutamine consumption associated with parallel increases in glutamate and aspartate (Figure ​(Figure1A1A red arrows) is considered a hallmark of MYC-driven “glutaminolysis”
  • Gln/Glu ratio inversely correlates with i- late stage metabolic syndrome and with ii- increased chance of death
  • changes in glutamine consumption, reflected by the Gln/Glu ratio could provide a metabolic link between breast cancer initiation and diabetes, reflective of a systemic metabolic reprogramming from glucose to glutamine as the preferred source of precursors for biosynthetic reactions and cellular energy
  • lower Gln/Glu ratios inversely correlated with insulin resistance and the risk of diabetes
  • the metabolic dependencies of cancer characterized by excessive glycolysis, glutaminolysis and malignant lipidogenesis, previously considered a consequence of local tumor DNA aberration [23] could, instead, represent a systemic biochemical aberration that predates and very likely promotes tumorigenesis
  • these metabolic disturbances would be expected to remain extant after therapeutic interventions
  • accumulation of very long chain acylcarnitines such as C14:1-OH (p = 0.0, FDR = 0.0), C16 (p = 0.0, FDR = 0.0), C18 (p = 0.0, FDR = 0.0) and C18:1 (p = 1.73e-322, FDR = 1.16-321) and lipids containing VLCFA (lysoPC a C28:0) (p = 1.14-e95, FDR = 1.65e-95) in the blood of breast and colon cancer patients
  • Among the most powerful metabolic equations for MYC-activation is that which links the widely used MYC-driven desaturation marker ratio of SFA/MUFA to the MYC glutaminolysis-associated ratio of (Asp/Gln)
  • liver dysfunction shares many features with both IEM and cancer suggesting a role for hepatic dysfunction in carcinogenesis
  • cancer “conscripts” the human genome to meet its needs under conditions of systemic metabolic stress
  • Nathan Goodyear on 24 Sep 18
     
    Breast cancer is a metabolic disease.  Now, where have I heard that cancer is a metabolic disease?
Nathan Goodyear

A Novel Antiestrogenic Mechanism in Progesterone Receptor-transfected Breast Cancer Cells - 0 views

www.jbc.org/...17480.short

progesterone progesterone receptors hormones ER breast cancer

shared by Nathan Goodyear on 12 Oct 16 - No Cached
  • Nathan Goodyear on 12 Oct 16
     
    Progesterone receptor activation found to block proliferative estradiol effect in breast cancer cell lines.
Nathan Goodyear

The Contribution of Cytotoxic Chemotherapy to 5-year Survival in Adult Malignancies | C... - 0 views

www.scribd.com/...Survival-in-Adult-Malignancies

chemotherapy cancer

shared by Nathan Goodyear on 15 May 18 - No Cached
  • In this group, the 5-year survivalrateduesolelytocytotoxicchemotherapywas14%
  • There is also no convincing evidence that usingregimens with newer and more expensive drugs are anymore beneficial than the regimens used in the 1970s
  • two systematic reviews of chemotherapy inrecurrent or metastatic breast cancer have not been able toshow any survival benefit
  • ...12 more annotations...
  • The five most common adult malignancies (colorectal, breast, prostate, melanoma and lung cancer)
  • n breast cancer, the optimal regimen(s) for cytotoxicchemotherapy in recurrent/metastatic disease are still notdefined, despite over 30 years of ‘research’ and a plethora of RCTs since the original Cooper regimen was published in1969
  • The five most ‘chemo-sensitive’ cancers,namely testis, Hodgkin’s disease and non-Hodgkin’s lym- phoma, cervix and ovary
  • only 13 out of the 22 malignancies evaluated showed any improvement in 5-year survival, and theimprovement was greater than 10% in only three of those13 malignancies
  • the contribution of curative and adjuvant cytotoxic chemotherapy to 5-year survival in adults is 2.3% in Australia and 2.1% in the USA
  • a benefit of less than 2.5% is likely to be applicable in other developed countries
  •   Overview The Contribution o
  • the benefit of cytotoxic chemotherapy may have been overestimated for cancers of oesophagus, stomach,rectum and brain.
  • this reflects the presentation of results as a ‘reduction in risk’ rather than asan absolute survival benefit[89,90]and by exaggerating theresponse rates by including ‘stable disease’
  • recent studies have documented impaired cognitive function inwomen receiving adjuvant treatment for breast cancer
  • the 5-year survival rate due solely to cytotoxicchemotherapy was 1.6%
  • the value of palliative chemotherapy has beenquestioned
  • Nathan Goodyear on 15 May 18
     
    Incredibly low impact of cytotoxic chemotherapy despite its wide spread utilization.  This article referenced cost yet did not evaluate the cost of cytotoxic side effect.  The question to answer: is Cytotoxic chemotherapy a valid treatment, at all, for the majority of cancers.
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