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Nathan Goodyear

Annals of Internal Medicine | Long-Term Effects of Dihydrotestosterone Treatment on Pro... - 0 views

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    DHT at 70 mg daily shown to have no adverse effects in the prostate of "healthy" men older than 50.  However, it did increase DHT metabolites (3 alpha androstane-diol and 3 beta androstane-diol), decreased LH, Testosterone, Estradiol, FSH, increased hemoglobin, creatinine, lean mass and decreased fat.
Nathan Goodyear

In Older Men an Optimal Plasma Testosterone Is Associated With Reduced All-Cause Mortal... - 0 views

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    Older men, 70-89, Testosterone in the middle range of normal and higher DHT was associated with the lowest death rates.  Estradiol was not found to be associated.  This study only looked at Total levels, free bioavailable levels were not assessed.  This study also highlights the basic thought, that more is not always better as it pertains to Testosterone.  It also highlights the importance of DHT.  Testosterone is a pro hormone.
Nathan Goodyear

In Older Men an Optimal Plasma Testosterone Is Associated With Reduced All-Cause Mortal... - 0 views

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    Australian study of older men, 70-89, found that normal Testosterone and DHT levels were associated with lower death rates.  This is important as this is the first study to find the positive health benefit of DHT as well as Testosterone.  
Nathan Goodyear

Androgen Exposure Increases Human Monocyte Adhesion to Vascular Endothelium and Endothe... - 0 views

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    DHT shown to increase VCAM-1 adhesion to endothelial cells.  This was a cell culture study of human umbilical vein endothelial cells exposed to postmenopausal female serum and then DHT.  Not exactly physiologic.
Nathan Goodyear

Testosterone, Dihydrotestosterone and Incident Cardiovascular Disease and Mortality in ... - 0 views

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    Abstract published ahead of print finds that DHT and calculated free DHT was associated with CVD and all-cause mortality.  This cohort found that Total Testosterone and calculated free Testosterone were not.  
Nathan Goodyear

Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotest... - 0 views

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    sulforaphane reduces DHT through increased metabolism of DHT.
Nathan Goodyear

Testosterone at high concentrations interacts ... [Endocrinology. 1990] - PubMed - NCBI - 0 views

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    DHT binds to androgen receptor with higher affinity and stays bound with receptor up to 5 x longer.
Nathan Goodyear

More evidence intratumoral DHT synthesis drives castration-resistant prostate cancer Wi... - 0 views

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    Mouse model shows that intratumor conversion of DHEA to DHT stimulates tumor growth in prostate cancer model.
Nathan Goodyear

Reduced breast cancer incidence in women treated with subcutaneous testosterone, or tes... - 0 views

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    Study finds that Testosterone therapy in women with breast cancer reduces breast cancer incidence if DHT is the final product. Anastrozole as an AI was added to ensure estradiol was not the final product and DHT was.
Nathan Goodyear

Pre-receptor regulation of the androgen receptor - 0 views

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    Great read on the regulation of the androgen receptor by the different iso forms of 5-alpha reductase and HSD.
Nathan Goodyear

Stable Intraprostatic Dihydrotestosterone in Healthy Medically Castrate Men Treated wit... - 0 views

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    Study finds that intraprostatic DHT levels correlate to Testosterone in TRT.  
Nathan Goodyear

Elevated Dihydrotestosterone is Associated with Testosterone-Induced Erythrocytosis - 0 views

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    study proposes evaluation DHT levels in men with erythrocytosis on Testosterone therapy.
Nathan Goodyear

A Double-Blind, Placebo-Controlled, Randomized Clinical Trial of Transdermal Dihydrotes... - 0 views

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    3 months of transdermal DHT found to be effective in androgenic effect and safety.
Nathan Goodyear

Dihydrotestosterone Treatment in Adolescents with Delayed Puberty: Does it Explain Insu... - 0 views

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    DHT found to have no effect insulin and insulin resistance in young men.
Nathan Goodyear

Dihydrotestosterone: a rati... [Baillieres Clin Endocrinol Metab. 1998] - PubMed - NCBI - 0 views

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    DHT as a Testosterone alternative
Nathan Goodyear

JCEM | Mobile - 0 views

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    DHT found to be a good, safe alternative to testosterone in androgen replacement for men.
Nathan Goodyear

A double-blind, placebo-controlled, ran - PubMed Mobile - 0 views

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    DHT found to be good androgen replacement alternative for men.  
Nathan Goodyear

Long-term effects of dihydrotestosteron - PubMed Mobile - 0 views

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    Study finds no effects on prostate from DHT.  
Nathan Goodyear

Matrix metalloproteinases in the pathogenesis of estradiol-induced nonbacterial prostat... - 0 views

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    In rat model, Estradiol shown to increase inflammation in lateral lobes of the prostate.  Androgens, Testosterone > DHT, shown to inhibit this inflammatory response.  
Nathan Goodyear

Increased muscular dehydroepiandrosterone levels are associated with improved hyperglyc... - 0 views

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    Exercise, DHEA, and DHT increased GLUT4 uptake of glucose, increasing glycemic control.
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