It is an inflammatory, refractory disease which includes colon, rectum and little part of small intestine. The person who is suffering from Ulcerative colitis in tests shows ulcers inside the colon. Ulcerative colitis comes under the category of ...
It is an inflammatory, refractory disease which includes colon, rectum and little part of small intestine. The person who is suffering from Ulcerative colitis in tests shows ulcers inside the colon. Ulcerative colitis comes under the category of ...
serum Testosterone levels increasing in the normal range were found to be associated with a reduced risk of Crohn's disease in women. No such relationship was found with ulcerative colitis, with DHEA, or with SHBG.
Fecal Calprotectin found to be useful as monitor for Ulcerative colitis relapse. This was found more specific for UC than Crohn's disease. There was a 14 fold higher relapse risk in those with levels > 150.
SAMe found to be low in those with Crohn's and Ulcerative colitis disease. Is IBD a methylation disease? Is IBD a detoxification deficiency state due to lack of methylation?
Acute inflammation is a response to an alteration induced by a pathogen or a physical or chemical insult, which functions to eliminate the source of the damage and restore homeostasis to the affected tissue. However, chronic inflammation triggers cellular events that can promote malignant transformation of cells and carcinogenesis. Several inflammatory mediators, such as TNF-α, IL-6, TGF-β, and IL-10, have been shown to participate in both the initiation and progression of cancer. In this review, we explore the role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis. Finally, we will provide an in-depth analysis of the participation of these cytokines in two types of cancer attributable to chronic inflammatory disease: colitis-associated colorectal cancer and cholangiocarcinoma.