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digitalorainfo

Candid Photography - Candid Wedding Photographers in Banglore Hydrabad - 0 views

yellowredphotography.com/candid-photography

Best Candid Photography Banglore

shared by digitalorainfo on 20 May 20 - No Cached
  • digitalorainfo on 20 May 20
     
    We have an elite team of candid photographers equipped with people skills. With a friendly approach, they make you feel ease and help you face the camera without being nervous. They thump interesting conversation and intermingle just like your long known friend. This is the appreciable quality of our candid photographer that makes them your first preference over the traditional photographer.
hadiyasafdar

Cosmetic Surgeons on United Arab Emirates: Things you should know about tummy tuck surgery - 0 views

dubaicosmeticsurgeryclinics.blogspot.com/...uld-know-about-tummy-tuck.html

#tummytuckdubai #tummytucksharjah #abdominoplastydubai #abdominoplastysharjah #tummytucksurgerydubai #tummytucktreatmentdubai #liposuctionDubai

shared by hadiyasafdar on 10 Jan 17 - No Cached
  • hadiyasafdar on 10 Jan 17
     
    If you are suffering from any serious medical condition, you may not qualify for a tummy tuck treatment. You should delay the surgery if you are pregnant. If you have excessive fat deposits but minimal skin, you are not an ideal candidate for a tummy tuck surgery. You can opt for liposuction in Dubai for fat removal.
Nathan Goodyear

Informa Healthcare - Stress - 13(4):324 - Summary - 0 views

informahealthcare.com/...10253891003642394

salivary saliva cortisol testing

shared by Nathan Goodyear on 04 May 11 - No Cached
  • salivary cortisol measurements
  • Nathan Goodyear on 04 May 11
     
    salivary cortisol measurements in special force candidates
Nathan Goodyear

A critical view on transgenerational epigenetic inheritance in humans | Nature Communic... - 0 views

www.nature.com/...s41467-018-05445-5

intergenerational inheritance epigenetics fetal programming

shared by Nathan Goodyear on 29 Jul 23 - No Cached
  • Nathan Goodyear on 29 Jul 23
     
    Is there something here missed on the authors. If one had ill intentions, could one not recommend a pregnant mother as the ideal candidate to program, or reprogram the offspring. Changes induced to F2 are called inter generational inheritance.
Nathan Goodyear

Estrogen Receptor-α as a Drug Target Candidate for Preventing Lung Inflammation - 0 views

www.ncbi.nlm.nih.gov/...PMC2803150

ER-alpha ER estrogen receptor alpha inflammation

shared by Nathan Goodyear on 23 Nov 12 - No Cached
  • Nathan Goodyear on 23 Nov 12
     
    ER alpha promotes lung inflammation.  In this study, they found that ER alpha could be a potential target to reduce lung inflammation.
Nathan Goodyear

Evaluation of a Candidate Reference Measurement Procedure for Serum Free Testosterone B... - 0 views

www.clinchem.org/...2101.long

GC-MS testosterone hormone hormones testing

shared by Nathan Goodyear on 03 Mar 13 - No Cached
  • Nathan Goodyear on 03 Mar 13
     
    Though this study looked  at serum testosterone, GC-MS was shown to be valid technique to evaluate testosterone levels.
Nathan Goodyear

Tongkat Ali (Eurycoma longifolia): a possible therapeutic candidate against Blastocysti... - 0 views

parasitesandvectors.biomedcentral.com/...s13071-015-0942-y

blastocystis hominis gut Tongkat Ali long jack

shared by Nathan Goodyear on 28 Jun 16 - No Cached
  • Nathan Goodyear on 28 Jun 16
     
    treatment of blastocystis hominis with long jack
Nathan Goodyear

Prostate cancer risk in testoster... [J Steroid Biochem Mol Biol. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17113983

Testosterone treatment therapy prostate prostate cancer testosterone deficiency men hormone hormones cancer

shared by Nathan Goodyear on 05 Jul 12 - No Cached
  • In hypogonadal men who were candidates for testosterone therapy, a 14% incidence of occult cancer was found
  • Data from all published prospective studies on circulating level of total and free testosterone do not support the hypothesis that high levels of circulating androgens are associated with an increased risk of prostate cancer
  • Indeed, high-grade prostate cancer has been associated with low plasma level of testosterone.
  • Nathan Goodyear on 05 Jul 12
     
    testosterone therapy does not increase prostate cancer.
Nathan Goodyear

Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC3888699

low T Testosterone hypogonadism MetS metabolic syndrome men male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • Hypogonadism and MetS are strongly associated [12, 13, 16], having even been demonstrated that with the increasing number of MetS parameters there is a proportional raise in the incidence of hypogonadism
  • increasing number of MetS components is inversely associated with T levels
  • the presence of MetS did not prove to be a significant determinant of hypogonadism, as it did not lead to a decline in T levels, in MetS patients with already established hypogonadism, the increasing number of MetS features was associated with further decline in T
  • ...15 more annotations...
  • In the setting of MetS, hypertriglyceridemia and increased WC have been reported as the most important determinants of hypogonadism
  • recent literature consistently associates obesity not only with higher risk of hypogonadism [4, 6, 27] but also with lower T levels
  • Visceral adiposity has been particularly related with reduction of T and SHBG levels (independent of other metabolic disorders)
  • WC was one of the MetS parameters with the greatest influence in T levels decrease, presenting itself as a strong risk factor for hypogonadism development
  • MetS-related T decline was not accompanied by an increase in pituitary LH levels, suggesting impairment in gonadotropin secretion
  • The molecules behind this smoothing compensatory effect of GnRH/LH are still unknown, but estrogens and insulin, as well as leptin, TNF-α, and other adipokines, were proposed candidates
  • fat stores undertake an increase aromatization of androgens, therefore raising estrogen levels [9, 15], which in turn decrease LH secretion
  • our data contradicts the concept that estradiol exerts a negative feedback on hypothalamic GnRH secretion
  • taking into account that high estradiol levels have already been described as the only abnormality in a subset of patients with ED, the hypothesis that the later might not only be caused by androgen deficiency is becoming increasingly evident
  • it has been reported that the chronic exposure to phosphodiesterase type 5 inhibitors (PDE5i), widely used for the treatment of ED, may influence serum estradiol levels
  • thyroid disorders (specially hyperthyroidism) have been related to ED and hypogonadism, and so must be considered in a sexual-dysfunction setting
  • It is clear from the current literature that collecting a more thorough hormonal panel might be a wise approach to further uncover hormonal relations
    • Nathan Goodyear
      Nathan Goodyear on 05 Feb 14
       
      outstanding point.  This hits to the point that Low T is the effect not the cause.
  • We concluded that in ED patients with hypogonadism and MetS, the attenuated response of HPG axis (normal or low LH levels) might not always be due to an underlying adiposity-dependent estrogen-raising effect.
  • our findings indicate that ED, aging, and estradiol might have a stronger connection than what is currently described in the literature.
  • this study underlines the importance of the collection of a full hormonal panel in ED men
  • Nathan Goodyear on 05 Feb 14
     
    low T strongly associated with metabolic syndrome in men.
Nathan Goodyear

(n-3) Fatty Acids and Cancer Therapy - J. Nutr. - 0 views

jn.nutrition.org/...3427S.abstract

Omega-3 cancer

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • Used alone, an (n-3) supplement may be a useful alternative therapy for patients who are not candidates for standard toxic cancer therapies.
  • Nathan Goodyear on 11 Feb 11
     
    Omega-3 reduce inflammation, inhibit tumor growth, inhibit angiogenesis, induce cancer cell death, and inhibit estrogen signaling
Nathan Goodyear

Relationship of UV exposure to prevalence of multi... [Neurology. 2011] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...21502600

Vitamin D MS UK

shared by Nathan Goodyear on 17 May 11 - No Cached
  • The effect of UVB on generating vitamin D seems the most likely candidate for explaining its relationship with MS
  • UVB exposure and IM together can explain a substantial proportion of the variance of MS
  • Nathan Goodyear on 17 May 11
     
    Vitamin D and MS in the UK
becomea paramedic

I Passed The Paramedic Recruitment Process on My First Attempt - 1 views

I really wanted to become a paramedic in the UK. That is why I went online and sought out the help of HowToBecomeAParamedic. They gave me useful insider tips, advice and products (which I bought,...

become a paramedic

started by becomea paramedic on 29 Sep 11 no follow-up yet
Nathan Goodyear

Alpha-lipoic acid supplementation: a tool for obes... [Curr Pharm Des. 2010] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...20388095

alpha lipoic acid weight loss obesity

shared by Nathan Goodyear on 05 Apr 11 - No Cached
  • Our study indicated that LA is an ideal antioxidant candidate for the therapy of obesity related diseases
  • Nathan Goodyear on 05 Apr 11
     
    Alpha Lipoic Acid improves weight loss
Nathan Goodyear

Hypothalamic-Pituitary-Testicular Axis Disruptions in Older Men Are Differentially Link... - 0 views

press.endocrine.org/...jc.2007-1972

low T low Testosterone low T Testosterone aging LH hormone hormones men male SHBG

shared by Nathan Goodyear on 03 Sep 14 - No Cached
  • 0.4–2% annual decline
  • the age trend in free T was more substantial (−1.3% per annum)
  • The core hormonal pattern with increasing age is suggestive of incipient primary testicular dysfunction with maintained total T and progressively blunted free T associated with higher LH.
  • ...16 more annotations...
  • Obesity was associated with progressively lower total and free T independent of the simultaneous decrease in SHBG.
  • our data highlight the fact that LH was unchanged or even lower in older men in the face of lower T in obesity, suggesting that there may be a failure at the hypothalamic-pituitary level.
  • a change in BMI from nonobese to obese may be equivalent to a 15 yr fall in T.
  • This pattern supports the hypothesis that different underlying mechanisms influence the functions of the HPT axis: age predominantly affects testicular function, whereas obesity impairs hypothalamic/pituitary function.
  • the effects of aging on testicular function can be moderated by increased LH compensation for many decades
  • obesity impairs hypothalamic/pituitary function independent of age, arguably an adaptive response for which there should be no compensatory mechanism.
  • the concurrent but opposite (and separate) effects of obesity and age on SHBG
  • SHBG was negatively associated with increasing strata of obesity
  • Obesity is associated with insulin resistance (28), and the increased circulating insulin inhibits hepatic SHBG synthesis
  • the SHBG increase with age may be related to relative IGF-I deficiency (27), although this has not been directly proven.
  • Obesity is associated with peripheral and central insulin resistance (30) and proinflammatory cytokine production (TNFα and IL-6) from adipocytes (31) and central nervous system endocannibinoid release (32), all of which are potential candidates for abrogating hypothalamic endocrine and downstream reproductive axis functions.
    • Nathan Goodyear
      Nathan Goodyear on 03 Sep 14
       
      The HPA axis effect may be the result of inflammation.
  • The relationship between obesity and T can be bidirectional: low T may be the cause rather than consequence of obesity
  • chronic alcohol abuse is known to suppress LH (40), our data showed no significant association among the three hormones or SHBG and alcohol intake.
  • increase in total T in smokers occurs through a primary increase in SHBG with a compensatory rise in LH
  • the effects of obesity (BMI or waist circumference) was by far the most important determinant of variance in total T, whereas age per se was important for SHBG, LH, and free T with comorbidity and smoking being comparatively minor contributors
  • It is noteworthy that these predisposing lifestyle and health factors are modifiable. This implies that the apparent age-related decline in T may constitute a barometer of health and thus be potentially preventable and/or reversible.
  • Nathan Goodyear on 03 Sep 14
     
    Age induced decline in Testosterone is more associated with a decline in leydig cell function and thus elevated LH will be associated.  In contrast, obesity is more of a HPA axis disruption and thus LH may be normal to low.  The pulse amplitude is decrease.  No change in pulse frequency is noted.   With obesity, a decline in TT and fT was independent of SHBG. Aging is associated with a greater decrease in fT versus TT.
Nathan Goodyear

Therapeutic Testosterone Administration Preserves Excitatory Synaptic Transmission in t... - 0 views

www.jneurosci.org/...12312.long

Testosterone polyneuropathy MS multiple Sclerosis Estriol hormones autoimmune disease

shared by Nathan Goodyear on 17 Mar 15 - No Cached
  • direct androgen receptor activation is not a mutually exclusive requirement of testosterone-mediated neuroprotection.
  • Testosterone treatment after EAE induction restores synaptic transmission and corresponding synaptic protein levels within the hippocampus during EAE
  • A growing body of evidence suggests that testosterone enhances hippocampal synaptogenesis
  • ...7 more annotations...
  • This study demonstrates that testosterone treatment either before or after EAE disease induction partially restores deficits in synaptic transmission, preserves presynaptic and postsynaptic integrity, and prevents hippocampal pathology.
  • treatment with a pregnancy estrogen, estriol, can prevent deficits in excitatory synaptic transmission in the hippocampus during EAE
  • testosterone is important to the maintenance of normal synaptic spine density in the hippocampus
  • estriol treatment was also capable of preserving levels of synaptic proteins that are known to orchestrate functional synaptic transmission within the hippocampus.
  • Estriol is a therapeutic candidate in MS because it has widespread effects on the immune system and the CNS
  • MS patients have significantly decreased relapse rates during the third trimester of pregnancy, when estriol levels are most elevated, and relapse rates rebound during the postpartum period coinciding with an abrupt decline in serum estriol levels
  • In nonpregnant MS patients, estriol treatment has been shown to significantly reduce gadolinium-enhancing lesion number and volumes measured by MRI
  • Nathan Goodyear on 17 Mar 15
     
    Testosterone restores/preserves nerve synapsis within the hippocampus in autoimmune demyelinating disease.  Testosterone appears to have neuroprotection.  The authors conclude that the majority of the protective effect was through aromatase activity.
Nathan Goodyear

Evaluation of candidal colonization and specific humoral responses against Candida albi... - 0 views

onlinelibrary.wiley.com/...abstract

candida candida albicans candidiasis yeast psoriasis dermatology

shared by Nathan Goodyear on 03 Dec 15 - No Cached
  • Nathan Goodyear on 03 Dec 15
     
    higher colonization of candida albicans found in people with psoriasis vs controls.  Higher in oral cultures vs skin.
Nathan Goodyear

Estrogenic regulation of skeletal muscle proteome: a study of premenopausal women and p... - 0 views

onlinelibrary.wiley.com/...full

estradiol menopause muscle hormones mitochondria aging female

shared by Nathan Goodyear on 10 Oct 17 - No Cached
  • Female aging is characterized by menopausal change in sex steroid hormones concomitant to increase in aging-related decrements in skeletal muscle performance that can be attenuated by HRT use
  • The major canonical pathways found to be differentially regulated included mitochondrial dysfunction, oxidative phosphorylation, glycolysis, and TCA-cycle, strong indicators for affected energy metabolism
  • E2 to exert anti-apoptotic effects in muscle progenitor cells by improving mitochondrial function
  • ...2 more annotations...
  • E2 is a major regulator of human skeletal muscle signaling in women
  • After menopause, when ovarian E2 production is ceased, the prevalence of cardio-metabolic diseases increases. Our result that different trajectories of the energy pathways in the skeletal muscle may be regulated by E2 provides candidate molecules as key targets for future interventions to prevent or treat postmenopausal metabolic dysregulation
  • Nathan Goodyear on 10 Oct 17
     
    Study finds Estradiol regulates human skeletal muscle cell signaling (mitochondrial function, oxidative phosphorylation, glycolysis, and TCA cycle) in study of pre/post menopause women through proteome analysis. This study would have been complete if they had carried to search beyond that of protein to epigenetics.
Nathan Goodyear

microRNA Expression in Ethnic Specific Early Stage Breast Cancer: an Integration and Co... - 0 views

www.nature.com/...s41598-017-16978-y

genetics cancer epigenetics breast cancer

shared by Nathan Goodyear on 06 Feb 18 - No Cached
mamdouh_hfz liked it
  • dysregulated miRNA could be involved in tumor cell proliferation and growth as well as cell cycle progression
  • under-expression of miR-497, 376c and 1271 in Lebanese breast cancer tissues
  • The upregulated miR-183 in our samples was predicted to be responsible for the decrease in expression of the BTG1 mRNA whose protein is involved in cell cycle arrest and apoptosis in breast cancer cells18.
  • ...9 more annotations...
  • nother molecule related to cell proliferation that was over-expressed in our data and suggested as a target of downregulated miR-376c is AURKA
  • the over-expression of miR-183 and miR-21 in Lebanese breast cancer tissues is consistent with downregulation of two important tumor suppressor predicted targets: AKAP12 whose protein regulates cellular adhesion dynamics by controlling cytoskeletal architecture, cell migration, and mitogenic signaling20; and LATS2 whose protein causes cell cycle arrest
  • dysregulation in cancer particularly in breast cancer highlights their importance in tumor development
  • mRNA-miRNA integration analysis of early breast cancer revealed a potential role of miRNA in increasing cellular proliferation and progression, and decreasing invasion and migration
  • most of the miRNA dysregulated in Lebanese breast cancer patients are similar to those dysregulated in American patients, differences in miRNA expression exist and could be attributed either to the patients’ age at diagnosis or to ethnic variation in miRNA epigenetic regulation and sequence variation of pre-miRNA
  • the number one cancer killer of women worldwide
  • microRNA (miRNA) are small non-coding 18–25 nucleotide RNA molecules currently being studied as potential diagnostic, prognostic and therapeutic biomarkers for cancer and other diseases
  • Extensive research on these post-transcriptional modulators has proven that they are deregulated in breast cancerous tissues and even in biological fluids from breast cancer patients
  • five candidate miRNAs (miR-10b, miR-148b, miR-221, miR-21, and miR-155)
  • Nathan Goodyear on 06 Feb 18
     
    Epigenetics plays a role, via disregulated miRNA, in increased cell growth, progression, and invasion in Lebanese women with breast cancer.  It is not just genetics that play a role, but epigenetics.
digitalorainfo

Photography Tips For Couple - Candid Wedding Photographers in Banglore Hydrabad - 0 views

yellowredphotography.com/photography-tips-for-couple

Wedding photography Bangalore

shared by digitalorainfo on 22 May 20 - No Cached
  • digitalorainfo on 22 May 20
     
    Are you imagining yourself with your partner in a beautiful portrait? Do you want to capture your romantic moments with your beloved in the most amazing locations? No worry! Get photographed like this amorous couple. Get some bonus tips from Yellow red photographers' team of Wedding photography Bangalore expertise in a couple photoshoot.
digitalorainfo

Professional Photography - Candid Wedding Photographers in Banglore Hydrabad - 0 views

yellowredphotography.com/professional-photography

Best Professional Wedding Photographers in Bangalore

shared by digitalorainfo on 21 May 20 - No Cached
  • digitalorainfo on 21 May 20
     
    we have all covered with highly Professional Wedding Photographers with their high quality lenses and gears that will surely astonish you. So let us convert your happy ceremonies to some reminiscence days.
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