Group items tagged

positive correlation of CARS score with both mercury and copper,

suggesting a predominantly TH2 response.

mmunohistochemistry confirms a distinct lymphocytic colitis in autistic spectrum disorders

This is consistent with increasing evidence for gut epithelial dysfunction in autism.

Worldwide, the rate of autism has been steadily rising.

Genetic polymorphisms of cytochrome P450 enzymes have also been linked to autism, specifically CYP27B1 that is essential for proper vitamin D metabolism

There are several environmental factors in concert with genetic susceptibilities that are contributing to this rise. Impaired methylation and mutations of mecp2 have been associated with autistic spectrum disorders, and related Rett syndrome.

Genetic polymorphisms adversely affecting sulfur metabolism, methylation, detoxification, dopamine signaling and the formation of neuronal networks occur more frequently in autistic subjects.

a "redox/methylation hypothesis of autism" is described, in which oxidative stress, initiated by environment factors in genetically vulnerable individuals, leads to impaired methylation and neurological deficits secondary to reductions in the capacity for synchronizing neural networks.