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Nathan Goodyear

Thyroid Hormones (T3 and T4): Dual Effect on Human Cancer Cell Proliferation - 0 views

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    The effects of T3 on cancer cell lines varies.  All cell lines came from the same tissue. It doesn't appear that simply stating T3 promotes cellular metabolism and thus provides an increase in cancer progression risk.  Some cell lines studies actually had an inhibition of cell growth, whereas others saw an increase.  
Nathan Goodyear

Implication from thyroid function decreasing during chemotherapy in breast cancer patie... - 0 views

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    Article points to potential chemosensitizing effect of T3 in cancer treatment.  Chemotherapy with increased metabolic demand with T3 may improve cancer kill rate.
Nathan Goodyear

Crosstalk between Integrin αvβ3 and Estrogen Receptor-α Is Involved in Thyroi... - 0 views

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    Integrin αvβ3 cross talk with ER-alpha + lung cancer
Nathan Goodyear

Implication from thyroid function decreasing during chemotherapy in breast cancer patie... - 0 views

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    chemotherapy decreases thyroid hormone levels; T3 therapy improves chemosensitization via increase S phase from G0 and G1 phases of growth
Nathan Goodyear

Insulin resistance is another factor that increase... [Endocrine. 2014] - PubMed - NCBI - 0 views

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    Interesting that insulin resistance appears to be associated with treatment failure and recurrent disease in papillary thyroid cancer.
Nathan Goodyear

Thyrotropin suppression by metformin in a cohort of patients with differentiated thyroi... - 0 views

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    Again, showing that metformin suppresses TSH secretion without change in actual thyroid hormone levels.  We know that inflammation plays a role in HPA suppression, why not with TSH?
Nathan Goodyear

Non-genomic Actions of Thyroid Hormones Regulate the Growth and Angiogenesis of T Cell ... - 0 views

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    Non-genomic signaling of thyroid hormone signals angiogenesis.
Nathan Goodyear

Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac rem... - 0 views

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    T3 in the post MI individual decreases the MI infarct size and the progression to heart failure. What is really  interesting about this study is that the T3 induced mitochondrial biogenesis and activity which is a great thing in recovery of MI and also in disease i.e. cancer.  However, it appears to increase HIF-1alpha and angiogenesis which is stimulated by retrograde signaling.  There is a muddied picture here.  Because T3 stimulates oxidative phosphorylation and mitochondria biogenesis which is favorable for health.  However, in this study of rats, it induced HIF-1alpha and angiogenesis in post MI, which is favorable to recovery, yet this is unfavorable for cancer.    Yet oxidative phosphorylation is favorable to cancer prevention/elimination and MI recovery.
Nathan Goodyear

Increased serum reverse triiodothyronine levels at diagnosis of hepatocellula... - 0 views

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    Elevated rT3 as a part of non-thyroid all illness syndrome
Nathan Goodyear

Frontiers | Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clin... - 0 views

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    To be read
Nathan Goodyear

IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while prom... - 0 views

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    IL-6 decreases deiodinase type I and 2; but increases type 3. The result is an increase in rT3 and in cancer-growth.
Nathan Goodyear

Clinicopathological and molecular characterizatio... [Mod Pathol. 2011] - PubMed - NCBI - 0 views

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    Though nuclear expression of estrogen and progesterone receptors were increased in papillary cancer, only progesterone receptor expression was decreased in aggressive cancer.
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