Ketogenic diet (low carb/high fats) slows malignant melanoma proliferation no matter the genomic mutations present. It matches with most BRAF+ as this points to increased GLUT1 expression.
Those with Alzheimer's disease have associated dysfunction of glucose metabolism in the brain, particularly in the hippocampus. It has been reported that a ketogenic diet can improve cognitive function in these individuals. In this study, the ketone bodies were initiated through a diet high in medium chain fatty acids. The ketone bodies served as an alternative fuel source for the brain.
ketogenic diet found to not deplete muscle glycogen in endurance athletes. The metabolism of the endurance athletes can do this via the high fat oxidation--estimates of 80%.
good review of the impact of ketones on TBI. The authors conclude that precursors to ketones may be the right approach to treatment. This would be MCT's and ketones.