Inflammation and insulin resistance 10.1016/j.febslet.2007.11.057 : FEBS Letters | Scie... - 0 views
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A subsequent study by Yuan et al. showed that Tnf treatment of 3T3L1 adipocytes induces insulin resistance and that this could be prevented by pretreatment of cells with aspirin
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Activation of the Tnf receptor results in stimulation of NFκB signaling via Ikkb
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Insulin is a pleiotropic hormone
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Obesity - Inducible Toll-like Receptor and NF-[kappa]B Regulatory Pathway Expression in... - 0 views
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TLRs are functionally inducible and associated with downstream NF-B activation and proinflammatory cytokine production.
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TLRs represent a family of receptors that are critical to the innate immune response against foreign pathogens and microorganisms
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LPS has been shown to induce proinflammatory chemokine gene expression in differentiated human adipocytes through TLR and NF-B action
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Inflammatory cause of metabolic syndrome via brain stress and NF-κB - 0 views
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Mechanistic studies further showed that such metabolic inflammation is related to the induction of various intracellular stresses such as mitochondrial oxidative stress, endoplasmic reticulum (ER) stress, and autophagy defect under prolonged nutritional excess
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intracellular stress-inflammation process for metabolic syndrome has been established in the central nervous system (CNS) and particularly in the hypothalamus
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the CNS and the comprised hypothalamus are known to govern various metabolic activities of the body including appetite control, energy expenditure, carbohydrate and lipid metabolism, and blood pressure homeostasis
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Leptin Resistance: A Possible Interface of Inflammation and Metabolism in Obesity-Relat... - 0 views
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The leptin axis has functional interactions with elements of metabolism, such as insulin, and inflammation, including mediators of innate immunity, such as interleukin-6
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Given that plasma levels of leptin and inflammatory markers are correlated and also predict cardiovascular risk
Metabolic endotoxemia: a molecular link between obesity and cardiovascular risk - 0 views
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Weight gain has been associated with a higher gut permeability
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a high-fat diet promotes LPS absorption
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higher concentrations of fatty acids impair intestinal barrier integrity
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VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to ... - 0 views
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CPA administered on an intermittent, every 6-day metronomic schedule stimulates tumor recruitment of macrophages, natural killer (NK) cells, and dendritic cells with regression of large established tumors, as seen in several implanted glioma models; also of note, VEGF inhibition inhibited this effect.
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