25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort.
Hyppönen E, Boucher BJ, Berry DJ, Power C.
Diabetes. 2008 Feb;57(2):298-305. Epub 2007 Nov 14.
PMID: 18003755
doi: 10.2337/db07-1122
CONCLUSIONS-Serum 25(OH)D is inversely associated with metabolic syndrome, whereas the inverse association with IGF-1 was found only among those without hypovitaminosis D. These results suggest that metabolic syndrome prevalence is the lowest when both 25(OH)D and IGF-1 are high.
Although it is not a condition that is commonly accepted by most medical practitioners, leaky gut syndrome is nonetheless a disease from which many people claim to suffer. Leaky gut syndrome is purportedly a condition that affects the intestinal lining whereby unwanted substances such as toxins "leak" into the bloodstream.
Vitamin D is safe when used in physiological doses (those used by Nature). Physiological doses are 3,000-5,000 IU/day, from all sources (sun, diet and supplements). Should hypercalcemia occur with such doses, it is due to vitamin D hypersensitivity syndrome, not vitamin D toxicity. Vitamin D hypersensitivity syndromes include conditions such as primary hyperparathyroidism, occult cancers (especially lymphoma) or granulomatous disease (especially sarcoidosis). In such cases, treatment of vitamin D deficiency should be done under the care of a knowledgeable physician. A serum 25(OH)D, serum 1,25(OH)D, PTH and SMA will lead the clinician in the right direction.
According to peer-reviewed clinical research, inadequacies of vitamin D have been linked to chronic musculoskeletal pain of various types, muscle weakness or fatigue, fibromyalgia syndrome, rheumatic disorders, osteoarthritis, hyperesthesia, migraine headaches, and other somatic complaints. It also has been implicated in the mood disturbances of chronic fatigue syndrome and seasonal affective disorder.
Current best evidence demonstrates that supplemental vitamin D can help to resolve or alleviate chronic pain and fatigue syndromes in many patients who have been unresponsive to other therapies. Vitamin D therapy is easy for patients to self-administer, is well tolerated, and is very economical. The documents on this page provide detailed background information and practice recommendations.
Acute Ingestion of Long-Chain (n-3) Polyunsaturated Fatty Acids Decreases Fibrinolysis in Men with Metabolic Syndrome.
Montegaard C, Tulk HM, Lauritzen L, Tholstrup T, Robinson LE.
J Nutr. 2009 Nov 4. [Epub ahead of print]
PMID: 19889809
doi:10.3945/jn.109.111427
Individuals with metabolic Syndrome (MetS) often have elevated plasma plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA), contributing to an increased risk of cardiovascular disease. PAI-1 and t-PA may be affected by chronic (n-3) long-chain PUFA [(n-3)LCPUFA] supplementation; however, the acute impact of fat ingestion on these risk factors has not been established. Our objective was to investigate the acute effect of (n-3)LCPUFA on plasma PAI-1, t-PA, and platelet aggregation. We conducted a randomized crossover study in which men (n = 8, ≥45 y) with MetS consumed water or a high-saturated fat beverage (1 g fat/kg body weight) with either a high or low content of (n-3)LCPUFA. Blood samples were collected over 8 h to measure triacylglycerol (TAG), PAI-1, t-PA, and platelet aggregation. Both fat loads resulted in a significant increase in whole blood TAG concentration, plasma PAI-1 and t-PA concentrations, and PAI-1 activity, as well as a significant decrease in t-PA activity during the postprandial period. Interestingly, PAI-1 concentration and activity increased more following the high (n-3)LCPUFA compared with the low (n-3)LCPUFA beverage (P < 0.05). Furthermore, the high (n-3)LCPUFA beverage resulted in a lower t-PA activity (P < 0.05), whereas the effects of the 2 fat loads on the plasma t-PA concentration and platelet aggregation did not differ. Overall, acute intake of a high (n-3)LCPUFA beverage shifted the balance between plasma PAI-1 and t-PA, which might indicate a lower capacity for fibrinolysis
"Should you eat low carbohydrate and high saturated fat, or high carbohydrate and low fat, that is the question? This question is causing a tremendous back and forth in the medical and nutrition industry. It is unbelievable that the medical profession has not at least thoroughly tested the question. How is it that a magnificent experiment had been going on for 2.5 million years, the hunter gatherer Paleolithic life. This continued up to and until about about 10,000 years ago, with the advent of agriculture. After that time is when the diseases of the metabolic syndrome started to appear. This information is a matter of history. If a layman like me can recognize the validity of an experiment that continued for 2,5 million years, and produced healthy individuals, relative to the diseases of the metabolic syndrome, such as: obesity, diabetes type 2, cardiovascular disease and stroke, and some cancers to name just a few, then how is it, that the consensus opinion of the medical profession and nutritionists think that the hunter gatherer lifestyle of our ancient ancestors is unhealthful or dangerous? The consensus opinion says that low fat (trim all visible fat from the animal protein) and high carbohydrate food is the "healthy eating" choice for us. I personally know that instead of being healthy,it is unhealthy, because by following my doctors advice over the last 50 years many of the above mentioned diseases started to appear on my charts. "
"* Low levels of vitamin D were associated with increased risk of high blood pressure, high blood sugar and metabolic syndrome in teenagers.
* The highest levels of vitamin D were found in whites, the lowest levels in blacks and intermediate levels in Mexican-Americans.
PALM HARBOR, Fla., March 11, 2009 - Low levels of vitamin D were associated with an increased risk of high blood pressure, high blood sugar and metabolic syndrome in teenagers, researchers reported at the American Heart Association's 49th Annual Conference on Cardiovascular Disease Epidemiology and Prevention."
"March 18, 2009 | Marlene Busko
Palm Harbor, FL - In a large study of adolescents, low serum levels of 25-dihydroxyvitamin D (25[OH]D) strongly predicted prevalence of hypertension, hyperglycemia, and metabolic syndrome [1]. The findings were reported at the AHA 49th Annual Conference on Cardiovascular Disease Epidemiology and Prevention.
Adolescents with vitamin-D levels in the lowest quartile were almost four times more likely to have metabolic syndrome than those with vitamin-D levels in the highest quartile. "I think that is quite alarming," lead author Dr Jared P Reis (Johns Hopkins Medical Institutions, Baltimore, MD) said in an AHA podcast issued to the media."
About eighty-five percent of all women suffer from PMS or PMDD at some point in their lives. Premenstrual Syndrome is a dreadful condition that precedes your period and causes uncomfortable symptoms like backaches and cramps. Luckily, there are a number of tried remedies to live happier with PMS.
Depression, cramps, and headaches are some of the symptoms that mark the onset of the "Oh So Dreadful" days as most women associate with. These are the days when women suffer from Premenstrual Syndrome or PMS. It has become such a common term these days that it needs no introduction. Premenstrual Syndrome is a group of signs and symptoms that affect women during the week preceding the start of their period.
Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional study.
Hjelmesaeth J, Hofsø D, Aasheim ET, Jenssen T, Moan J, Hager H, Røislien J, Bollerslev J.
Cardiovasc Diabetol. 2009 Feb 3;8:7.
PMID: 19187564
doi:10.1186/1475-2840-8-7
CONCLUSION: The PTH level, but not the vitamin D level, is an independent predictor of MS in treatment seeking morbidly obese Caucasian women and men. Randomized controlled clinical trials, including different therapeutic strategies to lower PTH, e.g. calcium/vitamin D supplementation and weight reduction, are necessary to explore any cause-and-effect relationship.
Dietary magnesium intake is related to metabolic syndrome in older Americans.
McKeown NM, Jacques PF, Zhang XL, Juan W, Sahyoun NR.
Eur J Nutr. 2008 Jun;47(4):210-6. Epub 2008 Jun 16.
PMID: 18560789
DOI: 10.1007/s00394-008-0715-x
(NaturalNews) Adding a daily serving of mixed nuts to the traditional Mediterranean diet (which consists of whole grain cereals, vegetables, fruits and olive oil, a moderate intake of fish and alcohol and a low intake of dairy, meats and sweets) is a delicious, natural and effective way to treat metabolic syndrome in older adults who are at high risk for heart disease. That's the conclusion of research just published in the December issue of Archives of Internal Medicine, a journal of the American Medical Association.
Vitamin D deficiency is the cause of common obesity.
Foss YJ.
Med Hypotheses. 2009 Mar;72(3):314-21. Epub 2008 Dec 2.
PMID: 19054627
doi:10.1016/j.mehy.2008.10.005
Common obesity and the metabolic syndrome may therefore result from an anomalous adaptive winter response. The stimulus for the winter response is proposed to be a fall in vitamin D. The synthesis of vitamin D is dependent upon the absorption of radiation in the ultraviolet-B range of sunlight. At ground level at mid-latitudes, UV-B radiation falls in the autumn and becomes negligible in winter. It has previously been proposed that vitamin D evolved in primitive organisms as a UV-B sensitive photoreceptor with the function of signaling changes in sunlight intensity. It is here proposed that a fall in vitamin D in the form of circulating calcidiol is the stimulus for the winter response, which consists of an accumulation of fat mass (obesity) and the induction of a winter metabolism (the metabolic syndrome). Vitamin D deficiency can account for the secular trends in the prevalence of obesity and for individual differences in its onset and severity. It may be possible to reverse the increasing prevalence of obesity by improving vitamin D status.
Herbal Pain Relief Product - Our Herbal Products helps you to get remedies from joint pain, headaches, back pain, muscle pain, myofascial pain syndrome and lumber strain
Drinking more than one soda a day -- even if it's the sugar-free diet kind -- is associated with an increased incidence of metabolic syndrome, a cluster of risk factors linked to the development of diabetes and cardiovascular disease, a study finds