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Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology. Peterlik M, Cross HS. Eur J Clin Nutr. 2009 Dec;63(12):1377-86. Epub 2009 Sep 2. PMID: 19724293 doi:10.1038/ejcn.2009.105 A compromised vitamin D status, characterized by low 25-hydroxyvitamin D (25-(OH)D) serum levels, and a nutritional calcium deficit are widely encountered in European and North American countries, independent of age or gender. Both conditions are linked to the pathogenesis of many degenerative, malignant, inflammatory and metabolic diseases. Studies on tissue-specific expression and activity of vitamin D metabolizing enzymes, 25-(OH)D-1alpha-hydroxylase and 25-(OH)D-24-hydroxylase, and of the extracellular calcium-sensing receptor (CaR) have led to the understanding of how, in non-renal tissues and cellular systems, locally produced 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and extracellular Ca2+ act jointly as key regulators of cellular proliferation, differentiation and function. Impairment of cooperative signalling from the 1,25-(OH)2D3-activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency causes cellular dysfunction in many organs and biological systems, and, therefore, increases the risk of diseases, particularly of osteoporosis, colorectal and breast cancer, inflammatory bowel disease, insulin-dependent diabetes mellitus type I, metabolic syndrome, diabetes mellitus type II, hypertension and cardiovascular disease. Understanding the underlying molecular and cellular processes provides a rationale for advocating adequate intake of vitamin D and calcium in all populations, thereby preventing many chronic diseases worldwide.

A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers. Stolzenberg-Solomon RZ, Vieth R, Azad A, Pietinen P, Taylor PR, Virtamo J, Albanes D. Cancer Res. 2006 Oct 15;66(20):10213-9. PMID: 17047087 Higher vitamin D concentrations were associated with a 3-fold increased risk for pancreatic cancer (highest versus lowest quintile, >65.5 versus <32.0 nmol/L: OR, 2.92; 95% CI, 1.56-5.48, Ptrend = 0.001) that remained after excluding cases diagnosed early during follow-up. Contrary to expectations, subjects with higher prediagnostic vitamin D status had an increased pancreatic cancer risk compared with those with lower status. Our findings need to be replicated in other populations and caution is warranted in their interpretation and implication. Our results are intriguing and may provide clues that further the understanding of the etiology of this highly fatal cancer. In conclusion, contrary to expectation, subjects with higher 25(OH)D concentrations were at greater risk for pancreatic cancer compared with those with lower concentrations in our prospective study with long-term follow-up. Caution is warranted in the interpretation and implication of our findings, however, as vitamin D inadequacy is an important public health problem and adequate status is desirable to prevent bone and other diseases (5). Our results, however, are intriguing and may provide clues that further the understanding of the etiology of this highly fatal cancer.

The average three-year old child should have twenty deciduousor baby teeth.

Current micronutrient recommendations in Europe: towards understanding their differences and similarities. Doets EL, de Wit LS, Dhonukshe-Rutten RA, Cavelaars AE, Raats MM, Timotijevic L, Brzozowska A, Wijnhoven TM, Pavlovic M, Totland TH, Andersen LF, Ruprich J, Pijls LT, Ashwell M, Lambert JP, van 't Veer P, de Groot LC. Eur J Nutr. 2008 Apr;47 Suppl 1:17-40. PMID: 18427858 DOI: 10.1007/s00394-008-1003-5 Full text: http://www.eurreca.org/downloadattachment/3199/1535/ejn%201003ov.pdf

You may be familiar with 'almonds are healthy' from your mother and father and consumed them, understanding that they are excellent resources of natural vitamins. But do you know the actual wellness advantages of these delicious nuts? We impress you with a few... Health benefits of almonds

One of the leading company cnlab.ca is the manufacture of such nutritional supplements, which at the other hand provides customs manufacturing and OEM service for not only nutritional soft gel products but also tablet, hard gelatin capsules. It is a company of Private label in China who understands the science and cultures of natural health supplements. To meet all customer's requirement this company provides a cost-effective solution from ingredients and product development, to manufacturing and packaging etc. So friend, at any point of time, if you feel you need to take support of these natural health supplements to make a healthy and active life then you can log on to cnlab.ca for availing these supplementation products.

Continuous changes in the healthcare reimbursement criteria require executives across the industry to focus on enterprise-wide changes that have a positive effect on supply chain savings. It's a complex problem and it's easy to get distracted on one issue when having the ability to see a clear BIG picture of your entire supply chain is what can lead to the most dramatic results and return on investments. Register for MHS' webinar on November 01 (2:00pm EST) to learn about how their customers experience an average 4:1 ROI with continual savings into the millions and a positive financial impact to their bottom line through inventory reduction, avoidance of obsolete and expired inventory, improved charge capture for each patient, and physician preference card optimization. Click on http://bit.ly/UvD3nq Presenters *Michael Ferris: Co-Founder, MHS with over 30 years of supply chain management experience *Steve Basiliere: Former Director of Supply Chain Services at Saints Medical Center, Lowell, MA *Art Kozyrovicius: Finance and Procurement Systems Support at New York-Presbyterian Hospital, New York, NY WHY ATTEND? Join a unique discussion with healthcare supply chain thought leaders and understand how to drive significant and sustainable supply chain operational improvements. Get a jump on making an immediate and positive impact on your bottom line as you head into 2013. Register by clicking on http://bit.ly/UvD3nq Note: Event will be online, through WebEx Please Register at http://bit.ly/UvD3nq

we are moving along with the new technology and build up a clear understanding of all issues solutions. We also provide guidance to clients who need help on troubleshooting issues themselves over our Windows Technical Help Number at 1-800-485-4057

clat coaching centers in bangalore , BRICS CA Institute in Bangalore has particularly designed CLAT Coaching programs which stresses out on diverse teaching policies, theoretical clarity and better understanding of subjects. BRICS experienced faculty members give exceptional support to the students all through their CLAT Exam preparation process

How do we really understand the similarities and differences between Natural and Organic? Are they the same? Is there overlap? Does one end where the other begins? Read the full article and watch the video

Since it was first approved for use in food products by the FDA back in 1981, aspartame has been a very controversial substance. Everyone from the American Cancer Society to Gizmodo has written about this artificial sweetener. Because aspartame is found in everything from yogurt to diet soda to gum, it's important to understand why this substance has such a controversial reputation.

The best creatine monohydrate supplements can be considered to be quite ideal for any person who is eager to gain a good amount of mass or to lose weight. -

ScienceDaily (Feb. 12, 2009) - Diet - and how it has shaped our genome - occupies much of an evolutionary scientist's time. Anne Stone, associate professor of anthropology in Arizona State University's School of Human Evolution and Social Change, will discuss how diet holds keys to understanding who we are, how we live and form societies, and how we evolved from hunter-gatherers to agriculturists, all the way to modern urban dwellers, at the American Association for the Advancement of Science annual meeting.

The Nutrition and Prostate Cancer guide summarizes the "best of the best" data and information available in the research arena today, and is designed to help everyone affected by or at risk for prostate cancer understand how key nutritional strategies can

Protein plays a litany of roles in living systems: structural elements, peptide hormones, cell recognition, antibodies… the list is staggering and continues to grow as our understanding of biology expands. What, however, is the role of dietary protein i

WEST LAFAYETTE, Ind. - Researchers have uncovered new evidence suggesting factors other than genes could cause obesity, finding that genetically identical cells store widely differing amounts of fat depending on subtle variations in how cells process insulin. Learning the precise mechanism responsible for fat storage in cells could lead to methods for controlling obesity. "Insights from our study also will be important for understanding the precise roles of insulin in obesity or Type II diabetes, and to the design of effective intervention strategies," said Ji-Xin Cheng, an assistant professor in Purdue University's Weldon School of Biomedical Engineering and Department of Chemistry. Findings indicate that the faster a cell processes insulin, the more fat it stores.

ScienceDaily (May 26, 2009) - A protein that plays a key role in tumor formation, oxygen metabolism and inflammation is involved in a pathway that extends lifespan by dietary restriction. The finding, which appears in the May 22, 2009 edition of the online journal PLoS Genetics, provides a new understanding of how dietary restriction contributes to longevity and cancer prevention and gives scientists new targets for developing and testing drugs that could extend the healthy years of life.

Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ. Diabetes. 2008 Oct;57(10):2619-25. Epub 2008 Jun 30. PMID: 18591391 doi: 10.2337/db08-0593 CONCLUSIONS: This prospective study reports inverse associations between baseline serum 25(OH)D and future glycemia and insulin resistance. These associations are potentially important in understanding the etiology of abnormal glucose metabolism and warrant investigation in larger, specifically designed prospective studies and randomized controlled trials of supplementation.

January 1, 2009 - A biochemist and cook explains that cooking is all about chemistry and knowing some facts can help chefs understand why recipes go wrong. Because cooking is essentially a series of chemical reactions, it is helpful to know some basics. For example, plunging asparagus into boiling water causes the cells to pop and result in a brighter green. Longer cooking, however, causes the plant's cell walls to shrink and releases an acid. This turns the asparagus an unappetizing shade of grey.