World Cancer Research Fund launches new policy report: 'Policy and action for cancer prevention'\nOver 40 per cent of bowel and breast cancer cases in the UK are preventable through healthy patterns of diet, physical activity and weight maintenance, according to estimates in a landmark report that has set out recommendations for policies and actions to reduce the global number of cancer cases.\nThe report, Policy and Action for Cancer Prevention, has estimated that about 43 per cent of bowel cancer cases and 42 per cent of breast cancer cases in the UK could be prevented in this way.
A prospective study of egg consumption and risk of cardiovascular disease in men and women.
Hu FB, Stampfer MJ, Rimm EB, Manson JE, Ascherio A, Colditz GA, Rosner BA, Spiegelman D, Speizer FE, Sacks FM, Hennekens CH, Willett WC.
JAMA. 1999 Apr 21;281(15):1387-94.
PMID: 10217054
Results We documented 866 incident cases of CHD and 258 incident cases of stroke in men during 8 years of follow-up and 939 incident cases of CHD and 563 incident cases of stroke in women during 14 years of follow-up. After adjustment for age, smoking, and other potential CHD risk factors, we found no evidence of an overall significant association between egg consumption and risk of CHD or stroke in either men or women. The relative risks (RRs) of CHD across categories of intake were less than 1 per week (1.0), 1 per week (1.06), 2 to 4 per week (1.12), 5 to 6 per week (0.90), and >=1 per day (1.08) (P for trend=.75) for men; and less than 1 per week (1.0), 1 per week (0.82), 2 to 4 per week (0.99), 5 to 6 per week (0.95), and >=1 per day (0.82) (P for trend=.95) for women. In subgroup analyses, higher egg consumption appeared to be associated with increased risk of CHD only among diabetic subjects (RR of CHD comparing more than 1 egg per day with less than 1 egg per week among diabetic men, 2.02 [95% confidence interval, 1.05-3.87; P for trend=.04], and among diabetic women, 1.49 [0.88-2.52; P for trend=.008]).
Conclusions These findings suggest that consumption of up to 1 egg per day is unlikely to have substantial overall impact on the risk of CHD or stroke among healthy men and women. The apparent increased risk of CHD associated with higher egg consumption among diabetic participants warrants further research.
Vitamin D for cancer prevention: global perspective.
Garland CF, Gorham ED, Mohr SB, Garland FC.
Ann Epidemiol. 2009 Jul;19(7):468-83. Review.
PMID: 19523595
RESULTS/CONCLUSIONS: It is projected that raising the minimum year-around serum 25(OH)D level to 40 to 60 ng/mL (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three fourths of deaths from these diseases in the United States and Canada, based on observational studies combined with a randomized trial. Such intakes also are expected to reduce case-fatality rates of patients who have breast, colorectal, or prostate cancer by half. There are no unreasonable risks from intake of 2000 IU per day of vitamin D(3), or from a population serum 25(OH)D level of 40 to 60 ng/mL. The time has arrived for nationally coordinated action to substantially increase intake of vitamin D and calcium.
Vitamin D replacement in Asians with diabetes may increase insulin resistance.
Taylor AV, Wise PH.
Postgrad Med J. 1998 Jun;74(872):365-6.
PMID: 9799895
We report three cases of vitamin D replacement in British Asians with vitamin D deficiency and non-insulin-dependent diabetes mellitus. In all cases, replacement resulted in an increase in insulin resistance and a deterioration of glycaemic control
Intravenously administered vitamin C as cancer therapy: three cases.\nPadayatty SJ, Riordan HD, Hewitt SM, Katz A, Hoffer LJ, Levine M.\nCMAJ. 2006 Mar 28;174(7):937-42.\nPMID: 16567755 \ndoi:10.1503/cmaj.050346.
Improvement of chronic back pain or failed back surgery with vitamin D repletion: a case series.\nSchwalfenberg G.\nJ Am Board Fam Med. 2009 Jan-Feb;22(1):69-74.\nPMID: 19124636
Postoperative active specific immunotherapy with supportive measures in patients suffering from recurrent metastasized melanoma: case reports of six patients.\nTallberg T, Kalima T, Halttunen P, Tykkä H, Mahlberg K, Matous B, Sundell B.\nJ Surg Oncol. 1986 Oct;33(2):115-9.\nPMID: 3762183
A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers.
Stolzenberg-Solomon RZ, Vieth R, Azad A, Pietinen P, Taylor PR, Virtamo J, Albanes D.
Cancer Res. 2006 Oct 15;66(20):10213-9.
PMID: 17047087
Higher vitamin D concentrations were associated with a 3-fold increased risk for pancreatic cancer (highest versus lowest quintile, >65.5 versus <32.0 nmol/L: OR, 2.92; 95% CI, 1.56-5.48, Ptrend = 0.001) that remained after excluding cases diagnosed early during follow-up. Contrary to expectations, subjects with higher prediagnostic vitamin D status had an increased pancreatic cancer risk compared with those with lower status. Our findings need to be replicated in other populations and caution is warranted in their interpretation and implication. Our results are intriguing and may provide clues that further the understanding of the etiology of this highly fatal cancer.
In conclusion, contrary to expectation, subjects with higher 25(OH)D concentrations were at greater risk for pancreatic cancer compared with those with lower concentrations in our prospective study with long-term follow-up. Caution is warranted in the interpretation and implication of our findings, however, as vitamin D inadequacy is an important public health problem and adequate status is desirable to prevent bone and other diseases (5). Our results, however, are intriguing and may provide clues that further the understanding of the etiology of this highly fatal cancer.
Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).
Travis RC, Crowe FL, Allen NE, Appleby PN, Roddam AW, Tjønneland A, Olsen A, Linseisen J, Kaaks R, Boeing H, Kröger J, Trichopoulou A, Dilis V, Trichopoulos D, Vineis P, Palli D, Tumino R, Sieri S, Bueno-de-Mesquita HB, van Duijnhoven FJ, Chirlaque MD, Barricarte A, Larrañaga N, González CA, Argüelles MV, Sánchez MJ, Stattin P, Hallmans G, Khaw KT, Bingham S, Rinaldi S, Slimani N, Jenab M, Riboli E, Key TJ.
Am J Epidemiol. 2009 May 15;169(10):1223-32. Epub 2009 Apr 9.
PMID: 19359375
In summary, the results of this large nested case-control study provide no evidence in support of a protective effect of circulating concentrations of vitamin D on the risk of prostate cancer.
Intravenous vitamin C as a chemotherapy agent: a report on clinical cases.\nRiordan HD, Riordan NH, Jackson JA, Casciari JJ, Hunninghake R, González MJ, Mora EM, Miranda-Massari JR, Rosario N, Rivera A.\nP R Health Sci J. 2004 Jun;23(2):115-8.\nPMID: 15377059
Shannon J, King IB, Moshofsky R, Lampe JW, Li Gao D, Ray RM, Thomas DB.
Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China.
Am J Clin Nutr. 2007 Apr;85(4):1090-7.
PMID: 17413110 [PubMed - in process]
Nutritional intervention with omega-3 Fatty acids in a case of\nmalignant fibrous histiocytoma of the lungs.
Pardini RS, Wilson D, Schiff S, Bajo SA, Pierce R.
Nutr Cancer. 2005;52(2):121-9.
PMID: 16201843
Nutritional intervention with omega-3 Fatty acids in a case of
malignant fibrous histiocytoma of the lungs.
Pardini RS, Wilson D, Schiff S, Bajo SA, Pierce R.
Nutr Cancer. 2005;52(2):121-9.
PMID: 16201843
San Diego, CA (PRWEB) May 25, 2009 -- Coming on the heels of the publishing in the Annals of Epidemiology of a new study led by Dr. Cedric Garland, on the preventive measures of vitamin D, GrassrootsHealth D*action Project is calling on physicians, health clinics and groups throughout the country to recognize the need for determining vitamin D levels and to ensure the public have their blood levels of vitamin D tested.
According to research from the newly published study by Cedric F. Garland, Dr. P.H., FACE, Department of Family and Preventive Medicine and Moores Cancer Center of the University of California, San Diego (UCSD), "It is projected that raising the minimum year-around serum 25(OH)D level to 40-60 ng/ml (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three quarters of deaths from these diseases, in the US and Canada."
A recently completed study from researchers at Colorado State University supported by the Division of Vector-Borne Infectious Diseases with the Centers for Disease Control and Prevention (CDC) has demonstrated that AHCC(R) (Active Hexose Correlated Compound) enhances host resistance by boosting protective immune responses specific to the West Nile Virus.
Since its discovery in the United States in 1999, infections caused by the West Nile Virus have become a major public health concern. West Nile Virus is caused by people being bitten by mosquitoes infected with the virus. According to the CDC, there have been 28,018 reported cases with 1,092 deaths since 1999. In 2003, the highest number of cases was reported at nearly 10,000. Currently there is no effective treatment for the disease.
Serum Vitamin D and Risk of Prostate Cancer in a Case-Control Analysis Nested Within the European Prospective Investigation into Cancer and Nutrition (EPIC).
Travis RC, Crowe FL, Allen NE, Appleby PN, Roddam AW, Tjønneland A, Olsen A, Linseisen J, Kaaks R, Boeing H, Kröger J, Trichopoulou A, Dilis V, Trichopoulos D, Vineis P, Palli D, Tumino R, Sieri S, Bueno-de-Mesquita HB, van Duijnhoven FJ, Chirlaque MD, Barricarte A, Larrañaga N, González CA, Argüelles MV, Sánchez MJ, Stattin P, Hallmans G, Khaw KT, Bingham S, Rinaldi S, Slimani N, Jenab M, Riboli E, Key TJ.
Am J Epidemiol. 2009 Apr 9. [Epub ahead of print]
PMID: 19359375
doi:10.1093/aje/kwp022
Knight JA, Lesosky M, Barnett H, Raboud JM, Vieth R.
Vitamin D and reduced risk of breast cancer: a population-based case-control study.
Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):422-9.
PMID: 17372236 [PubMed - indexed for MEDLINE]
"A large 10-year study found that half of all fatal heart disease cases and a quarter of all non-fatal cases are linked to being overweight and having a high body mass index (BMI) or large waist.
Body mass index and waist circumference are well known risk factors for cardiovascular diseases but the Dutch researchers said their work showed BMI and waist size could actually help predict the risk of dying from or developing heart disease."
Serum vitamin D concentration and prostate cancer risk: a nested case-control study.
Ahn J, Peters U, Albanes D, Purdue MP, Abnet CC, Chatterjee N, Horst RL, Hollis BW, Huang WY, Shikany JM, Hayes RB; Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Project Team.
J Natl Cancer Inst. 2008 Jun 4;100(11):796-804. Epub 2008 May 27.
PMID: 18505967
doi:10.1093/jnci/djn152
CONCLUSION: The findings of this large prospective study do not support the hypothesis that vitamin D is associated with decreased risk of prostate cancer; indeed, higher circulating 25(OH)D concentrations may be associated with increased risk of aggressive disease.
In summary, results from this large prospective study of men who underwent standardized prostate cancer screening in the context of a screening trial do not support the hypothesis that higher serum vitamin D status is associated with decreased risk of prostate cancer. The study showed no association of vitamin D level with nonaggressive disease; however, it raises the possibility that higher vitamin D level may be associated with increased risks for aggressive disease, although a clear monotonic dose-response relationship was lacking. Along with recent reports of adverse associations for higher vitamin D status and risk of pancreatic (32) and esophageal (33,34) cancer, caution should be taken in recommending high doses of vitamin D or sunlight exposure to the general public for prostate cancer prevention. Future analyses are warranted to confirm these results and to further clarify the effects of vitamin D on aggressive prostate cancer.