[Vitamin K and Bone Update. In vivo Metabolism of Vitamin K. - In relation to the conversion of vitamin K(1) to MK-4 -]
Okano T, Nakagawa K, Kamao M.
Clin Calcium. 2009 Dec;19(12):1779-87. Japanese.
PMID: 19949269
Phylloquinone is a major form (>90%) of dietary vitamin K, but the form of vitamin K that exists at the highest concentrations in tissues of animals and humans is menaquinone-4 (MK-4) . Despite this great difference, the origin of tissue MK-4 had not been clarified until recently. We demonstrated that deuterium-labeled phylloquinone was converted into deuterium-labeled MK-4 in mice and this conversion occurred following an oral or enteral administration, but not parenteral administration. By the oral route, the phylloquinone with the deuterium-labeled side chain (phytyl side-chain) was clearly converted into menaquinone-4 with a non-deuterium-labeled side chain (geranylgeranyl side-chain) , implying that phylloquinone was converted into menaquinone-4 via integral side-chain removal. Our results suggest that cerebral menaquinone-4 originates from phylloquinone intake and the release of menadione from phylloquinone in the intestine followed by the prenylation of menadione into menaquinone-4 in the intestine or tissues
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If you don't learn something about the foods you eat, you will gain the weight back when you reestablish old eating habits. Following are some of the major side effects associated with bad diets.
Ursolic acid, a natural pentacyclic triterpenoid carboxylic
acid, is the major component of some traditional medicine
herbs and is well known to possess a wide range of
biological functions, such as antioxidative,
anti-inflammatory, antihyperlipidemic and anticancer
activities, that are able to counteract endogenous and
exogenous biological stimuli.
Ursolic acid has been noted for their antitumor-promotion
activities. Ursolic acid is capable of inducing apoptosis in
tumor cells on one side and to prevent malignant
transformation of normal cells on the other side. It also
interferes with numerous enzymes, including the ones
serving directly to DNA synthesis
Mainstream medical treatment of cancer revolves around surgery, chemotherapy, and radiation therapy, used either alone or in combination (Isobe T et al 2005; Ostoros G et al 2005). Chemotherapy and radiation therapy cannot discriminate between cancer cells and healthy cells; thus, they damage both types of cells and cause serious and often debilitating side effects, frequently forcing patients to abandon treatment (Ettinger DS 2005; Giraud P et al 2004; Munden RF et al 2005). Therefore, it is not surprising that many cancer patients now opt to complement conventional treatments with alternative therapies that may not only temper the adverse side effects of conventional cancer therapy, but also improve its effectiveness via independent anti-cancer effects.
Mangoes are the richest source of most important vitamins (A, C, B, E, K), minerals, dietary fibbers, electrolytes and iron which are mostly required by the for better growth and development as well as being healthy and live life without any diseases and infections. It is liked by all people due to its nice color, taste, flavor and quality health aspects. I have mentioned below the few beneficial aspects of the mangoes which you must know to enhance your interest while eating mangoes:
Benefits of Mango juice for Cancer Prevention
Mango fruit has antioxidant compounds (such as quercetin, fisetin, astragalin, gallic acid, isoquercitrin, methyl gallate and etc) and lots of enzymes which help in protecting against various body organs cancers like colon, leukemia, breast, stomach, prostate, lungs, cervical, oral cavity cancers and etc. These compounds include, as well as the abundant.
Polyphenols found in it acts as an anti inflammatory agent and restricts the growth of cancerous cells.
The soluble dietary fibers, pectin found in it has property of decreasing the action of protein (galectin) found in the cancerous cells.
Benefits of Mango juice for Heart health
It contains highest level of soluble dietary fibers (pectin) and vitamin C which involves in lowering the bad serum cholesterol levels means Low-Density Lipoproteins as well as enhancing the good serum cholesterol levels means High-Density Lipoproteins thus keeps the heart healthy by keeping all the heart problems away.
It is the rich source of potassium which involves in controlling the blood pressure thus heart rate.
Benefits of Mango juice for Skin
It is beneficial for the skin in both ways whether it is eaten or applied externally on the skin.
It India juice has antioxidants which make the skin healthy, smooth, glowing and wrinkles free.
It clear out the blocked pores and provides solution to get free from the pimples if applied on the face.
It makes the skin glowing by reducing the dark spot
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The prostate gland is an important part of the male reproductive system, and it plays a crucial role in the production of semen. However, as men age, their risk of developing prostate-related health problems, such as prostate cancer, increases. This is where Urinoct comes in.
With Urinoct, you can expect to experience reduced inflammation and increased ability for bladder emptying. Plus, your confidence will get a boost. Every ingredient in Urinoct is sourced from the purest and most potent sources, and the ratios are carefully balanced. Furthermore, each element of the formula is backed by scientific data, ensuring positive results without any risk of side effects.
Urinoct is a groundbreaking supplement specifically formulated to address the root causes of Benign Prostatic Hyperplasia (BPH) and urinary issues in men. With its unique combination of natural ingredients, Urinoct not only alleviates the symptoms associated with an enlarged prostate but also promotes overall prostate and urinary health.
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Ikaria Lean Belly Juice for losing belly fat before. As the name suggests, this Ikaria belly fat-burning juice is based on a daily ritual of the healthiest part of the world, Ikaria.
Researchers found that a number of natural ingredients, fruits, and plant extracts available on the island can help lose weight by eliminating toxic lipid molecules and reducing high uric acid levels in the human body.
Ikaria Lean Belly Juice is an effective weight loss diet supplement that is made up of several effective, scientifically-proven ingredients that can help you lose weight.
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The formula of the supplement has been prepared under strict conditions in an FDA-registered facility, and its blend of natural ingredients like milk thistle supports weight loss incredibly.
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A lot of people have questions rega
Some medications are changed and broken down by the liver.
Berberine might decrease how quickly the liver breaks down some medications. Taking berberine along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking berberine, talk to your healthcare provider if you are taking any medications that are changed by the liver.
Some medications changed by the liver include cyclosporin (Neoral, Sandimmune), lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and many others."
Side Effects and Warnings
Berberine has been reported to cause nausea, vomiting, hypertension (high blood pressure), respiratory failure and paresthesias (abnormal sensations such as numbness or tingling); however, clinical evidence of such adverse effects is not prominent in the literature. Rare adverse effects including headache, skin irritation, facial flushing, headache, bradycardia (slowed heart rate) have also been reported with the use of berberine. Use cautiously when taking berberine for longer than eight weeks due to theoretical changes in bacterial gut flora.
Use cautiously in individuals with diabetes, as both human and animal studies indicate that berberine may decrease blood sugar levels. Also use cautiously in individuals with hypotension (low blood pressure), as berberine may have antihypertensive effects.
Patients with cardiovascular disease should also use caution as berberine has been associated with the development of ventricular arrhythmias in subjects with congestive heart failure.
Although not well studied in humans, berberine may also theoretically cause delays in small intestinal transit time or increase the risk of bleeding.
Berberine may cause abortion, eye or kidney irritation, nephritis (inflamed kidneys), dyspnea (difficulty breathing), flu-like symptoms, giddiness, lethargy, or liver toxicity.
Patients with leukopenia (abnormally low white blood cell count) should use cautiously due to the potential for development of leukopenia symptoms.
When injected under the skin, berberine may cause hyperpigmentation in the arm. Use berberine cautiously in individuals with high exposure to sunlight or artificial light due to potential for adverse phototoxic reactions.
Avoid in newborns due to potential for increase in free bilirubin, jaundice, and development of kernicterus (brain damage caused by severe newborn jaundice). Use berberine cautiously in children due to a lack of safety information.
Pregnancy and Breastfeeding
Berberine is not recomme
Lemon Juice Advantages
Drinking lemon juice assists in the good digestion by eliminating body waste products very easily.
It provides relief from the constipation, diarrhea and other digestive problems by smoothing the bowel functions.
It is used in variety of ways because of its therapeutic, antibacterial, antiviral and antiseptic properties.
It has immune-boosting powers which enhances the immune functioning of the body thus protects from the various types of infections.
Lemon juice is a very good blood purifier which protects the major organs of the body as well as enhances their functioning.
Its high potassium and low sodium content availability makes the heart healthy by keeping blood pressure under control.
Because of its availability with citric acid, vitamin C, bioflavonoids, calcium, magnesium, pectin and limonene, it is a good immune booster and infection fighter.
It provides relief from various health problems like heartburn, kidney problems or gall bladder problems.
Drinking lemon juice provides instant relief from the fatigue, dizziness, exhaustion, nervousness, anxiety and tension.
It is a good home remedy for providing relief from the chills and fevers of any causes. Drink 1 lemon juice by mixing it with a cup of hot water and honey every 2 hours till it relieves the problem.
Nimbu juice is a natural detoxifier which detoxifies the liver and enhances the kidney and liver functions.
Applying paste of lemon juice and amla to the hair helps in reducing hair fall as well as dandruff problem.
Oral Health Benefits of Lemon
It protects the teeth enamel if drinking, rubbing, chewing or rinsing mouth with lemon juice half an hour before going to brush the teeth.
Lemon refreshes the one's breath just after using any spices, alcohol or cigarettes.
It provides relief from the toothache by eliminating the pain and curing bleeding gums.
COPD consists of multiple lung infections and is considered incurable by most physicians. Can timely diagnosis, on the bright side, slow down its progress?
COPD consists of multiple lung infections and is considered incurable by most physicians. Can timely diagnosis, on the bright side, slow down its progress?
A new study showing a reduction in the toxic side effects of ROS-generating chemotherapies with concurrent antioxidant supplementation will be presented at the 43rd Annual Meeting of the American Society of Clinical Oncology (ASCO) that takes place June 1-5 at McCormick Place in Chicago. According to the study's authors, mitigating chemotherapy toxicity by supplementing with antioxidants may improve survival rates and tumor response by helping patients complete their prescribed treatment cycles.
"Cancer lies dormant in all of us," he wrote in his new book, "Anticancer: A New Way of Life" (Viking, $25.95). "But our bodies are also equipped with a number of mechanisms that detect and keep such (defective) cells in check." Cancer rears its ugly head when things get out of balance, Servan-Schreiber said in an interview. And that can happen if the bad guys that promote the growth of cancer cells (tobacco, excessive alcohol, excessive sugar, hydrogenated fats, environmental pollutants) outnumber the good guys that support our natural defenses (cancer-fighting phytochemicals found in fruits, vegetables, herbs and teas; physical activity; and stress management techniques). But conventional treatment, while indispensable, focuses on a single target: destroying cancer cells. Doctors rarely address the other side: teaching patients how to fortify themselves using nutrition, exercise and stress-management techniques to create an inhospitable environment for cancer.
Phosphatidylserine (abbreviated Ptd-L-Ser, or PS) is a phospholipid component, usually kept on the inner-leaflet, the cytosolic side, of cell membranes by an enzyme called flippase. When a cell undergoes apoptotic cell death phosphatidylserine is no longer restricted to the cytosolic part of the membrane, but becomes exposed on the surface of the cell.
First pilot studies indicate that PS supplementation might be beneficial for children with attention-deficit hyperactivity disorder
PS can be found in meat fish, but is most abundant in the brain and in innards such as liver and kidney. Only small amounts of PS can be found in dairy products or in vegetables, with the exception of white beans.
Vitamin D's days of obscurity seem pretty much over. Once just an afterthought to most people-relegated to the sides of milk cartons and the pages of medical texts-it's now on the cusp of becoming a full-fledged disease prevention star. Although vitamin D has long been known as an important factor in bone health, a quickly growing body of evidence now shows that it may also help lower the risk of cancer, heart disease, and even premature death.[1], [2] Not surprisingly, scientists and the public have started to take note, particularly of vitamin D's potential to protect against cancer