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Matti Narkia

Vitamin D Status and the Risk of Lung Cancer: A Cohort Study in Finland - Cancer Epidem... - 0 views

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    Vitamin D status and the risk of lung cancer: a cohort study in Finland.
    Kilkkinen A, Knekt P, Heliövaara M, Rissanen H, Marniemi J, Hakulinen T, Aromaa A.
    Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3274-8.
    PMID: 18990771v

    In conclusion, although there was no overall association between vitamin D and lung cancer risk, women and young participants with a higher level of vitamin D were observed to have a lower lung cancer risk. Although experimental data support the suppressing effect of vitamin D on the development of lung cancer, large epidemiologic studies from different populations with repeated measurements of vitamin D are warranted to confirm this finding. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3274-8)
Matti Narkia

Vitamin D Status and the Risk of Cardiovascular Disease Death -- Kilkkinen et al., 10.1... - 0 views

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    Vitamin D Status and the Risk of Cardiovascular Disease Death.
    Kilkkinen A, Knekt P, Aro A, Rissanen H, Marniemi J, Heliövaara M, Impivaara O, Reunanen A.
    Am J Epidemiol. 2009 Sep 17. [Epub ahead of print]
    PMID: 19762371
    doi:10.1093/aje/kwp227

    A low vitamin D level may be associated with higher risk of a fatal CVD event, particularly cerebrovascular death. These findings need to be replicated in other populations. To demonstrate a causal link between vitamin D and CVD, randomized controlled trials are required.
Matti Narkia

Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes : Epidemiology - 0 views

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    Serum vitamin D and subsequent occurrence of type 2 diabetes.
    Knekt P, Laaksonen M, Mattila C, Härkänen T, Marniemi J, Heliövaara M, Rissanen H, Montonen J, Reunanen A.
    Epidemiology. 2008 Sep;19(5):666-71.
    PMID: 18496468
    doi: 10.1097/EDE.0b013e318176b8ad

    Conclusions: The results support the hypothesis that high vitamin D status provides protection against type 2 diabetes. Residual confounding may contribute to this association.
Matti Narkia

Serum 25-Hydroxyvitamin D Concentration and Subsequent Risk of Type 2 Diabetes - Diabet... - 0 views

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    Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes.
    Mattila C, Knekt P, Männistö S, Rissanen H, Laaksonen MA, Montonen J, Reunanen A.
    Diabetes Care. 2007 Oct;30(10):2569-70. Epub 2007 Jul 12.
    PMID: 17626891
    doi: 10.2337/dc07-0292

    We found a significant inverse association between serum 25OHD and risk of type 2 diabetes in the simple model. However, the association was attenuated in the multivariate analysis, adjusting for potential risk factors of type 2 diabetes. To our knowledge, this is the first cohort study investigating the association between serum 25OHD and incidence of type 2 diabetes. Our results are in line with those from the Nurses' Health Study (5), where an inverse association was observed for the intake of vitamin D supplements. We could not differentiate whether the results depended on the effect of vitamin D deficiency on β-cell function or on insulin resistance.

    In summary, the results are in line with the hypothesis that a high serum 25OHD concentration may reduce the risk of type 2 diabetes. Further research is needed to confirm the association and to distinguish between the independent role of vitamin D and the role of healthy dietary and lifestyle patterns in reducing the risk of type 2 diabetes.
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