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Matti Narkia

Incident Invasive Breast Cancer, Geographic Location of Residence, and Reported Average... - 0 views

    ncident invasive breast cancer, geographic location of residence, and reported average time spent outside.
    Millen AE, Pettinger M, Freudenheim JL, Langer RD, Rosenberg CA,
    Mossavar-Rahmani Y, Duffy CM, Lane DS, McTiernan A, Kuller LH, Lopez AM, Wactawski-Wende J.
    Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):495-507. Epub 2009 Feb 3.
    PMID: 19190147
    doi: 10.1158/1055-9965.EPI-08-0652

    In conclusion, region of residence and geographic solar irradiance are not consistently related to risk of breast cancer and may not be sufficient proxy measures for sunlight/vitamin D exposure. The observed association between time spent outside and breast cancer risk support the hypothesis that vitamin D may protect against breast cancer.
Matti Narkia

The Association of Solar Ultraviolet B (UVB) with Reducing Risk of Cancer: Multifactori... - 0 views

    The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates.
    Grant WB, Garland CF.
    Anticancer Res. 2006 Jul-Aug;26(4A):2687-99.
    PMID: 16886679

    CONCLUSION: These results provide additional support for the hypothesis that solar UVB, through photosynthesis of vitamin D, is inversely-associated with cancer mortality rates, and that various other cancer risk-modifying factors do not detract from this link. It is thought that sun avoidance practices after 1980, along with improved cancer treatment, led to reduced associations in the latter period. The results regarding solar UVB should be studied further with additional observational and intervention studies of vitamin D indices and cancer incidence, mortality and survival rates.
Matti Narkia

Geographic variation in breast cancer mortality in the United States: A hypothesis invo... - 0 views

    Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation.
    Garland FC, Garland CF, Gorham ED, Young JF.
    Prev Med. 1990 Nov;19(6):614-22.
    PMID: 2263572

    Vitamin D from sunlight exposure may be associated with low risk for fatal breast cancer, and differences in ultraviolet light reaching the United States population may account for the striking regional differences in breast cancer mortality. The ecological nature of this study is emphasized, and the possibility that an indirect association with dietary and socioeconomic factors could explain these findings is discussed.
Matti Narkia

Geographic variation of prostate cancer mortality rates in the United States: Implicati... - 0 views

    Geographic variation of prostate cancer mortality rates in the United States: Implications for prostate cancer risk related to vitamin D.
    Grant WB.
    Int J Cancer. 2004 Sep 1;111(3):470-1; author reply 472. No abstract available.
    PMID: 15221981

    The implications of our results and those of Tuohimaa et al.[1] include the following. Vitamin D supplementation should be undertaken in wintertime, a period when it is impossible to produce vitamin D by solar UVB exposure in northeastern states.[13] Given these new results, the optimal vitamin D intake and production and serum 25(OH)-vitamin D3 levels for prostate cancer appear to be lower than for other cancers. However, when developing guidelines for vitamin D fortification, many factors should be included in the analysis, including all of the potential health benefits and possible risks of vitamin D, as well as age, sex, residence, child-bearing status, etc.[14] Also, the suggestion that daily vitamin D3 supplement doses of 100 g (4,000 IU)/day are safe[15] should be reexamined. Finally, in terms of preventing prostate cancer, more attention should be given to diet, which has the greatest environmental impact on risk of prostate cancer, with animal products being important risk factors and vegetable products, especially onions and other allium family members, being important risk-reduction factors.[16]
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