Group items tagged

Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9. Ho YT, Yang JS, Li TC, Lin JJ, Lin JG, Lai KC, Ma CY, Wood WG, Chung JG. Cancer Lett. 2009 Jul 8;279(2):155-62. Epub 2009 Feb 28. PMID: 19251361 doi:10.1016/j.canlet.2009.01.033 There is increasing evidence that urokinase-type plasminogen activator (u-PA) and matrix metalloproteinases (MMPs) play an important role in cancer metastasis and angiogenesis. Inhibition of u-PA and MMPs could suppress migration and invasion of cancer cells. Berberine, one of the main constituents of the plant Rhizoma coptidis, is a type of isoquinoline alkaloid, reported to have anti-cancer effects in different human cancer cell lines. There is however, no available information on effects of berberine on migration and invasion of human tongue cancer cells. Here, we report that berberine inhibited migration and invasion of human SCC-4 tongue squamous carcinoma cells. This action was mediated by the p-JNK, p-ERK, p-p38, IκK and NF-κB signaling pathways resulting in inhibition of MMP-2 and -9 in human SCC-4 tongue squamous carcinoma cells. Our Western blowing analysis also showed that berberine inhibited the levels of urokinase-plasminogen activator (u-PA). These results suggest that berberine down-regulates u-PA, MMP-2 and -9 expressions in SCC-4 cells through the FAK, IKK and NF-κB mediated pathways and a novel function of berberine is to inhibit the invasive capacity of malignant cells.

ncident invasive breast cancer, geographic location of residence, and reported average time spent outside. Millen AE, Pettinger M, Freudenheim JL, Langer RD, Rosenberg CA, Mossavar-Rahmani Y, Duffy CM, Lane DS, McTiernan A, Kuller LH, Lopez AM, Wactawski-Wende J. Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):495-507. Epub 2009 Feb 3. PMID: 19190147 doi: 10.1158/1055-9965.EPI-08-0652 In conclusion, region of residence and geographic solar irradiance are not consistently related to risk of breast cancer and may not be sufficient proxy measures for sunlight/vitamin D exposure. The observed association between time spent outside and breast cancer risk support the hypothesis that vitamin D may protect against breast cancer.

Natural Herbalism, or herbology, will comprehensively cover all the latest news on the best herbal products, informative herbal facts and natural herbal therapy treatments. Natural herbalism is now a growing alternative medicine. More patients with medical conditions are looking towards natural treatments like herbalism to avoid invasive procedures. Please email me at webmaster@naturalherbalism.com if there are any enquires on natural herbalism.

Apigenin inhibits growth and motility but increases gap junctional coupling intensity in rat prostate carcinoma (MAT-LyLu) cell populations. Czernik M, Sroka J, Madeja Z, Czyz J. Cell Mol Biol Lett. 2008;13(3):327-38. Epub 2008 Feb 21. PMID: 18292973 DOI: 10.2478/s11658-008-0003-z This in vitro data indicates that apigenin may affect cancer development in general, and prostate carcinogenesis in particular, via its influence on cellular activities decisive for both cancer promotion and progression, including cell proliferation, gap junctional coupling and cell motility and invasiveness.

"LOS ANGELES (September 29, 2009) -- A simple, non-invasive test appears to be an effective screening tool for identifying patients with silent heart disease who are at risk for a heart attack or sudden death. Coronary artery calcium scans can be done without triggering excessive additional testing and costs, according to the multi-center EISNER (Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) study, led by investigators at the Cedars-Sinai Heart Institute. The findings appear in today's issue of the findings appear in today's issue of the Journal of the American College of Cardiology."

"Berberine is a quaternary ammonium salt from the group of isoquinoline alkaloids. It is found in such plants as Berberis, goldenseal (Hydrastis canadensis), and Coptis chinensis, usually in the roots, rhizomes, stems, and bark. Berberine is strongly yellow colored, which is why in earlier times berberis species were used to dye wool, leather and wood. Wool is still today dyed with berberine in Northern India Berberine (BBR) is a natural compound with up-regulating activity on both low-density-lipoprotein receptor (LDLR) and insulin receptor (InsR). This one-drug-multiple-target characteristic might be suitable for the treatment of metabolic syndrome.[12] Berberine has been tested and used successfully in experimental[13] and human diabetes mellitus.[14][15][16] Berberine has been shown to lower elevated blood glucose as effectively as metformin.[17] The mechanisms include inhibition of aldose reductase,[18] inducing glycolysis,[19] preventing insulin resistance[20] through increasing insulin receptor expression[14] and acting like incretins. Berberine has drawn extensive attention towards its antineoplastic effects.[43][44] It seems to suppress the growth of a wide variety of tumor cells including breast cancer,[45] leukemia, melanoma,[46] epidermoid carcinoma, hepatoma, oral carcinoma, tongue carcinoma,[47] glioblastoma, prostate carcinoma, gastric carcinoma.[48][49] Animal studies have shown that berberine can suppress chemical-induced carcinogenesis, tumor promotion, tumor invasion,[50][51][52][53][54] prostate cancer,[55][56][57][58] neuroblastoma,[59][60] and leukemia.[34][61] It is a radiosensitzer of tumor cells but not of normal cells

Cutera was founded in 1998 and has quickly become a leader in the laser and light-based aesthetic market. Their lasers are used widely by primary care physicians, dermatologists, plastic surgeons and gynecologists for safe, effective and non-invasive aesthetic treatments for their patients.

After weathering the patriotic fervor that led to "freedom fries" when France opposed the U.S. invasion of Iraq in 2003, the humble spud is now getting mashed for its impact on the school lunch program.

Jodi Mardesich works at the Ann Wigmore Institute, a living foods school in Puerto Rico. She was previously a staff writer for Fortune and the San-Jose Mercury News. Seven months ago, I wasn't even a vegetarian. I thought I'd skip most classes, but once I got here, I became morbidly fascinated with colon health, digestion, and the benefits of wheat grass, and I didn't miss a single class. At first I felt like utter crap-I had headaches daily, and I felt bitchy and exhausted. Detoxing, everyone at the institute called it. (They blame every unpleasant symptom on detoxing.) But about a week into my stay, I started to feel different. Energized. Mentally sharper. Happier. More serene. Lighter. (I lost 10 pounds in the first week and didn't really need to lose weight.) I slept less. I started waking at dawn and going to bed earlier than I would have left the house for a night of partying back home in New York. My eyes even started changing color. Not just the whites, which got whiter, but my irises changed, too-from very dark to a richer, reddish brown.

thank you for the article.

Wearing any magnetic bracelet or Bracelets for Pain might ease the pain caused due to arthritis of hips and knees, as the UK researchers proved. Anecdotal benefits already has been reported by the wearers yet studies are there which compare such bracelets with dumb version have produced a mixed result. The present study by the Medical Journal, British found the significant reduction of pain among more than 65 wearers. Again the Peninsular School Medical team said that the effect can be real and again depend on the individual's faith. Also, a magnet with high strength (about 170mTesla and above) is required to have an effect on the pain. Whatever is the mechanism, the benefits of magnetic bracelets seemed clinically useful. Women's are found to be wearing sleek stylish or broad bracelets of either silver plated, pure copper, bronze or gold plated which actually look good and many of you must have wondered what are these and if they are any sort of style statement or trend and many must have known what they actually are and wanted to know if they work or not. These are the magnetic therapy bracelets for women or Bracelets for Pain and you have guessed right so far, we are going to discuss, in this article. There is a variety of Bracelets for Pain. Simple magnetic copper bracelets, Turquoise leaf copper magnetic bracelets, copper double hearted magnetic bracelets, bracelets of copper with black onyx, copper leaf tiger eye magnetic bracelets, Two worlds copper bracelets, heavy magnetic bracelets with a cuff mirror touch, cuff solid shiny vines and flowery bracelet, crossroads magnetic bracelets with price range of $13-$49 are pretty popular, matching varied tastes of women with sleek, bold, beautiful designs and come with warranty and discounts too. It is advisable from some sources for pregnant women to not wear these Bracelets for Pain. People into sports can use these, these magnetic therapy bracelets for peop