Skip to main content

Home/ Groups/ Honors Scientific Research 2023-2024
Rss Feed
Sort By: Most Recent | Popular Filter: All | Bookmarks | Topics Simple Middle
Isabella Tungjaroenkul

Anténor Firmin challenged anthropology's racist roots 150 years ago - 1 views

www.sciencenews.org/...rmin-anthropology-racism-haiti

HSR HSR-2023 statistical analysis biology anthropology

shared by Isabella Tungjaroenkul on 13 Jun 23 - No Cached
  • “This is hardly surprising since most of the early [Black] pioneers of anthropology have only recently been brought to light.”
    • Isabella Tungjaroenkul
      Isabella Tungjaroenkul on 13 Jun 23
       
      Sadly not surprising. There are many amazing discoveries that are overlooked and even forgotten because they were performed or written by women or non-white people.
  • It did not take long for Firmin to question his membership in a group openly hostile to people who looked like him. Faced with such a tough environment, Firmin remained silent at meetings.
Isabella Tungjaroenkul

The new human pangenome could help unveil the biology of everyone - 0 views

www.sciencenews.org/...angenome-biology-dna-diversity

HSR HSR-2023 biology DNA RNA pangenome

shared by Isabella Tungjaroenkul on 13 Jun 23 - No Cached
Sean Nash liked it
  • Being able to assess where some people have extra DNA and others are missing DNA, called structural variants, adds a more nuanced view of human genetics, O’Connor says, revealing more of its complexity (SN: 4/10/09).
  • Conversely, another study found that the very short arms of certain chromosomes, including chromosomes 13, 14 and 21, are becoming more like each other as they swap DNA.
katherine-medina

In Vitro and In Vivo Evaluation of the Effectiveness and Safety of Amygdalin as a Cance... - 0 views

www.ncbi.nlm.nih.gov/...PMC9697812

potential research idea HSR-2023 rat-experiments Amygdalin cancer-fighting Natural-remides

shared by katherine-medina on 11 Jun 23 - No Cached
Sean Nash liked it
  • ]. Approximately 80% of all medications approved by the FDA in the last three decades have been derived from natural sources
  • Transdermal drug delivery is a promising route for cancer treatment compared with the oral route due to its low side effects and improved efficacy and selectivity
  • All ALN formulations containing DDP exhibited a higher percent of EE and smaller particle size and PDI than those that did not have DDP at the molar ratio investigated.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      If I am to do my research project over the affects of amygdalin patches on cancer, I will need to keep this section of text in mind.
  • ...9 more annotations...
  • The optimum ALN gel formulation reduced mean relative carcinoma volume (MCV) at a higher rate (p < 0.05) compared with free amygdalin solution and free tamoxifene suspension.
  • that the optimum ALN gel formulation reduced mean relative carcinoma volume (MCV) compared with the DMBA control.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      reduced carcinoma in comparison to control group
  • . The value of the zeta potential indicated a negative surface charge, which is considered advantageous for transdermal drug delivery and for electrostatic stabilization due to the electrostatic repulsions between vesicles
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      Good to note.
  • 3. Materials and Methods3.1. MaterialsAmygdalin was attained from Nature’s Only Choice Company (Tbilisi, GA, USA). Sigma Aldrich (Agitech Company, Cairo, Egypt) provided Tween 60, Span 60, cholesterol, 7, 12-dimethylbenz[a] anthracene (DMBA), triethanolamine, and dihexadecyl phosphate. Carbopol 934, methanol, acetone, and chloroform were attained from Corner-Lab Company (Cairo, Egypt).
  • Histological examination of the oral tamoxifen suspension treated group (Figure 7C) revealed the presence of hyperkeratosis and acanthosis in the surface epithelium of the epidermis with signs of a diffuse inflammatory response and edema in the dermis and sub-cutaneous tissue.
  • Histological examination of the optimum ALN gel treated group (Figure 7F) showed clearly healed skin with normal covering epithelium and marked improvement in all signs of the epidermis and dermis that were better than those of the oral amygdalin solution. These results confirmed the effectiveness of amygdalin loaded niosomes gel as a cancer therapy in vivo.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      Cool, so they tested and confirmed that ALN gel does work to treat cancer of the skin.
  • Histological examination of the optimum ALN gel-treated group (Figure 8B) showed clearly healed skin with normal covering epithelium.
  • The group treated with plain niosomes gel showed MCV nearly similar to that of the DMBA control group.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      SO the niosome gel doesn't do much.
  • The optimum ALN gel enhanced the permeation of amygdalin into deep skin layers and showed significant anti-tumor activity compared with oral tamoxifen.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      I think that Amygdalen could be one of my research topics for this upcoming year.
  • katherine-medina on 11 Jun 23
     
    A really cool study that showed that Amygdalin in a gel form can prove to be very sucsessful at healing tumors from the epidermis.
katherine-medina

Dandelion root extract affects colorectal cancer proliferation and survival through the... - 0 views

www.ncbi.nlm.nih.gov/...PMC5341965

Dandelions Cancer-fighting HSR-2023 potential research idea botany colon-cancer

shared by katherine-medina on 09 Jun 23 - No Cached
Sean Nash liked it
  • of an aqueous dandelion root extract
  • caspase-8 activation was not essential for the induction of cell death in colon cancer cells as an inhibition of caspase-8 activation did not alter the cytotoxicity of DRE
  • We have been able to identify four pharmacologically active components, α-amyrin, β-amyrin, lupeol and taraxasterol, in two out of the six bioactive fractions, but the anti-cancer activities of the individual compounds were not as strong as that of the unfractionated DRE indicating, clearly, the benefits of using the whole extract.
  • ...16 more annotations...
  • which might represent a novel non-toxic alternative to conventional cancer therapy available today.
  • These results clearly indicate that dandelion root extract can inhibit the ability of colorectal cancer cells to migrate and invade, and therefore metastasize to secondary locations.
    • katherine-medina
      katherine-medina on 09 Jun 23
       
      Wow. I like to see that in 3 different studies DRE was proven to selectively pick the cancer cells, and ignore the normal cells.
  • morphological differences in tissue slices between the control untreated and the DRE treated group
  • aken together, these results established that systemic oral intake of the DRE was safe and its anti-cancer efficacy should be further investigated.
    • katherine-medina
      katherine-medina on 09 Jun 23
       
      I love the fact that they yet again state that I should look more into this topic.
  • , but the DRE treatment efficiently suppressed the growth of both p53 WT and p53 mutant tumors in-vivo (Figure 4B – 4C)
    • katherine-medina
      katherine-medina on 09 Jun 23
       
      great, they suppressed the growth of the tumors.
  • with no difference between the control and DRE treated samples of NCM460
    • katherine-medina
      katherine-medina on 09 Jun 23
       
      I would not have thought that the mitochondria would be left alone by the drug.
  • Others suggest that following activation, caspases re-localize to the mitochondria, where they interact with other pro-apoptotic proteins during the progression of apoptosis [15]. A third option, put forward by Qin and colleagues, suggests that inactive caspases are kept in the mitochondria, but following apoptotic stimuli and activation, they are released from the mitochondria into the cytoplasmic peri-nuclear space [
  • The results showed a progressive destabilization of the mitochondrial membrane following the DRE treatment, which was observed as early as 30 minutes post treatment (Figure ​6C). Pro-caspase-8 (green) was localized in the mitochondria (red) in control untreated cells; however, following the DRE treatment, activated caspase-8 was released from the mitochondria into cytoplasmic space, as indicated by the dispersed green fluorescence (Figure ​6C
    • katherine-medina
      katherine-medina on 09 Jun 23
       
      Pro-capase-8 helps to fight against the cancer
  • suggesting that in HT-29 colorectal cancer cells the DRE-induced cell death was caspase-8 independent.
    • katherine-medina
      katherine-medina on 09 Jun 23
       
      So essentially caspase 8 had nothing to do with it
  • We observed a decrease in the viability of cells treated with α-amyrin, with 10 μM as the most effective concentration.
    • katherine-medina
      katherine-medina on 09 Jun 23
       
      Hmm. the beginnings of narrowing down what it is about the plant that is able to fight cancer.
  • However, these results indicate that DRE and its anti-cancer components must be absorbed and circulated, in order to reach the site of the tumor (in order to inhibit tumor growth).
    • katherine-medina
      katherine-medina on 09 Jun 23
       
      So it needs to be drank, or swallowed in a pill form to work.
  • , we confirmed the vulnerability of cancer cell mitochondria by showing that the DRE treatment led to a decrease in the mitochondrial membrane potential and increase in ROS levels in the isolated mitochondria.
  • caspase-8 specific inhibitor, IETD-fmk, did not change the DRE response in these cells. This was in contrast to our previous study in leukemia and pancreatic cancer cells
    • katherine-medina
      katherine-medina on 09 Jun 23
       
      For each different cancer a new slightly different result is produced
  • he pro-apoptotic genes including Caspase-1, Interferon gamma and the TNF ligands and receptors, were up-regulated in HT-29 cells, prior to the apoptosis induction, while the same genes were down-regulated in NCM460 cells.
  • Previous findings show that taraxasterol has anti-inflammatory and chemopreventive activit
  • suggesting its importance in the anti-cancer activity of dandelion root extract, especially on the expression levels of COX-2. Additionally, we show that 10 μM lupeol is not very effective on its own
  • katherine-medina on 09 Jun 23
     
    Yet another article about how DRE can fight against cancer.
katherine-medina

The Efficacy of Dandelion Root Extract in Inducing Apoptosis in Drug-Resistant Human Me... - 0 views

www.ncbi.nlm.nih.gov/...PMC3018636

Dandelions Cancer-fighting botany HSR-2023 potential research idea Melanoma

shared by katherine-medina on 07 Jun 23 - No Cached
Sean Nash liked it
  • 2. Materials and Methods
  • 2. Materials and Methods
    • katherine-medina
      katherine-medina on 07 Jun 23
       
      If I plan on doing some sort of experiment with Dandelion root, I will likely need to come back and look at how this study did it.
  • After a long exposure of 96 hours, NHFs did not exhibit any reduction in cell viability
    • katherine-medina
      katherine-medina on 07 Jun 23
       
      Wow, so even after 3 days the Dandelion Root did nothing to the NHF aka. normal human cells.
  • ...15 more annotations...
  • With DRE having proven its efficacy in successfully killing this aggressive, chemoresistant form of skin cancer, DRE toxicity on normal cells had to be evaluated
    • katherine-medina
      katherine-medina on 07 Jun 23
       
      Always remember to hav e a control.
  • DRE was found to reduce cell viability in a dose-dependent fashion, over time, in A375 melanoma cells as was measured by WST-1 assay. Based on metabolic activity of A375s, it was confirmed that treatment at 2.5 mg/mL DRE resulted in ~50% reduction in cell viability against control within 24 hours (Figure 1(a))
  • Higher doses were then used and a response was observed at a concentration of 10 mg/mL (
    • katherine-medina
      katherine-medina on 07 Jun 23
       
      For different types of melanoma a different amount of DRE is needed.
  • Typical apoptotic morphology was observed in G361 cells treated with DRE starting at 5 mg/mL concentrations for 72 hours
  • . However, there has been little scientific advancement made in this field with regard to the effect of dandelion root extract on cancer, and even more so on chemoresistant, human malignant melanoma skin cancer.
    • katherine-medina
      katherine-medina on 07 Jun 23
       
      I do so love it when the author identifies the fact that there is so few research papers about DRE.
  • ) is more than a worthy chemopreventative, it is fast-acting, nontoxic, and therefore specific in its targeting of human melanoma cancer cells, making it a valuable chemotherapeutic. We have investigated the induction of apoptosis in human malignant melanoma cells and observed its long-term effects in human melanoma cancer.
    • katherine-medina
      katherine-medina on 07 Jun 23
       
      alrighty then.
  • We are yet to determine the effect of each of the individual components (such as the family of triterpene alcohols and phenolic acids—found in the roots—and cinnamic acids, flavinoids and coumarins—that are found in the leaves
    • katherine-medina
      katherine-medina on 07 Jun 23
       
      Maybe I could look into the specific component that kills the cancer, so that in future years after I had figured this out I could put it into practice.
  • Given that DRE has traditionally been used naturopathically for a variety of ailments, we assume that it would be relatively nontoxic to healthy cells. Our results show that the Normal Human Fibroblasts (NHFs) (which were treated at a low population doubling where NHFs have the best proliferation rate) and Peripheral Blood Mononuclear Cells remained unaffected and healthy after a 96-hour and 48- hour exposure to DRE, respectively (Figures 2(a)–2(d)).
  • Lupeol,
    • katherine-medina
      katherine-medina on 07 Jun 23
       
      What is Lupeol. (I should probably look into that.)
  • taraxasterol
  • More importantly, an increase in ROS production indicates prooxidant behaviour of DRE on cancer cell mitochondria, which is contrary to the antioxidant convictions of traditional medicine and previous studies on Taraxacum extracts citing reductions in NO, ROS, RNS, and COX-2 [10, 11] in mouse macrophages.
    • katherine-medina
      katherine-medina on 07 Jun 23
       
      That is very important and interesting.
  • There are two main points that must be stated here: firstly, that noncancerous cells are unaffected by DRE treatment, and secondly, melanoma cells retain the signals to commit suicide long after DRE has been removed from the system
    • katherine-medina
      katherine-medina on 07 Jun 23
       
      Good to restate.
  • Metformin acts as a metabolism interfering compound that debilitates cancer cells, and the case of G361-resistant melanoma cells, combining DRE with metformin reduces cell viability at even lower doses (Figures 9(a) and 9(b)).
  • By 48 hours, human melanoma A375 cells uncharacteristically showed susceptibility to apoptosis induction by DRE
  • We believe that this nontoxic extract can undergo precipitous translation from bench top to bedside, with dandelion products that are already commercially available in the form of tea and supplements.
  • katherine-medina on 07 Jun 23
     
    Essentially it is an article that figured out that DRE can induce apoptosis in melanoma cells, and it also proved that DRE is non-toxic to normal human cells.
ryleighnyp

Electrical grounding technique may improve health outcomes of NICU babies -- ScienceDaily - 2 views

www.sciencedaily.com/...170803120627.htm

HSR HSR-2023 potential research idea

shared by ryleighnyp on 07 Jun 23 - No Cached
Sean Nash liked it
  • "What we can conclude is that a baby's autonomic nervous system is able to sense the electrical environment and it seems as though a baby is more relaxed when grounded,"
  • redesigning incubators to ground babies and cancel out the electrical field
  • ryleighnyp on 07 Jun 23
     
    I think a possible research idea could be redesigning NICU incubators to allow for less electromagnet interference with the babies with the use of grounding.
  • Sean Nash on 07 Jun 23
     
    Interesting, for sure. Two things... the actual measurements they made on children (skin tests, etc.) are a no-go for us. I'm not sure what our model system could be for checking the electrical outputs of whatever design changes were made. We would need to know a lot more about the current setup in NICUs. There is no doubt a lot of design in how things are currently set up. Essentially: why things are set up the way they are right now? You would have to know every variable currently considered, and then look for spots where simple changes can be made. Second thing: go back to the ISEF categories in Engineering and check out how those projects look at the national level. Just go get a feel. Engineering is a bit different from typical "hypothesis testing" seen in most natural sciences. Very cool, but different. Give it a look.
ryleighnyp

The night gardeners: Immune cells rewire, repair brain while we sleep -- ScienceDaily - 0 views

www.sciencedaily.com/...191021111835.htm

HSR HSR-2023 Sleep

shared by ryleighnyp on 06 Jun 23 - No Cached
  • implications for brain plasticity, diseases like autism spectrum disorders, schizophrenia, and dementia, which arise when the brain's networks are not maintained properly, and the ability of the brain to fight off infection and repair the damage following a stroke or other traumatic injury.
  • implications for brain plasticity, diseases like autism spectrum disorders, schizophrenia, and dementia, which arise when the brain's networks are not maintained properly, and the ability of the brain to fight off infection and repair the damage following a stroke or other traumatic injury.
    • ryleighnyp
      ryleighnyp on 06 Jun 23
       
      It would be interesting to look deeper into these process and the mechanism behind maintenance of the brain.
  • This research shows that the signals in our brain that modulate the sleep and awake state also act as a switch that turns the immune system off and on."
  • ...2 more annotations...
  • plasticity, the ongoing process by which the complex networks and connections between neurons are wired and rewired during development and to support learning, memory, cognition, and motor function.
    • ryleighnyp
      ryleighnyp on 06 Jun 23
       
      I think it would be cool to look into the difference between this function in people's brains with and without learning disabilities.
  • high levels of norepinephrine, the microglia became inactive and were unable to respond to local injuries and pulled back from their role in rewiring brain networks.
katherine-medina

The chemical composition and antioxidant properties of common dandelion leaves compared... - 1 views

cdnsciencepub.com/...cjps-2016-0409

Dandelions environmental antioxidants HSR-2023 botany

shared by katherine-medina on 06 Jun 23 - No Cached
  • sea buckthorn leaves exhibited a significantly higher level of antioxidant activity as measured by ABTS
  • . Dandelion leaves were richer in tocopherols, thiamine, riboflavin, and niacin while the sea buckthorn leaves contained higher levels of l-ascorbic acid.
  • aw dandelion are partly related to the antioxidant properties of some of its components;
    • katherine-medina
      katherine-medina on 06 Jun 23
       
      Why haven't they done more studies on this specific part about dandelions?
  • ...5 more annotations...
  • The present study will also be helpful with regard to the standardization of bioactive content in plant materials.
    • katherine-medina
      katherine-medina on 06 Jun 23
       
      Cool, cool, although I was hopping that their goal was something slightly different.
  • polyphenols: flavonoids, isoflavones, anthocyanins, and catechins
  • Sea buckthorn
  • Plants contain small amounts of lead, which may significantly increase when exposed to lead contamination in the soil and air; however, lead was not detected in the examined leaves of dandelion and sea buckthorn.
    • katherine-medina
      katherine-medina on 06 Jun 23
       
      Did not know that.
  • neutralize ABTS
    • katherine-medina
      katherine-medina on 06 Jun 23
       
      So essentially the higher the antioxidant concentration the more the color of the ABTS changes.
  • katherine-medina on 06 Jun 23
     
    This article helped me understand a few of the different antioxidants that dandelions, and sea buckthorn.
Xander Kleiber

Energy-efficient computing | MIT Energy Initiative - 2 views

energy.mit.edu/...energy-efficient-computing

potential research idea computer science engineering HSR HSR-2023

shared by Xander Kleiber on 05 Jun 23 - No Cached
Sean Nash liked it
  • 1’s are literally thrown away, and that wasted energy is dissipated as heat.
    • Xander Kleiber
      Xander Kleiber on 05 Jun 23
       
      In logic gates specifically, because there are cases where a 1 goes in and a 0 can come out, that 1 (directly represented by electrical voltage) gets wasted in the computation and is released as heat.
  • the inputs are 1-0 and 0-1, and the output is 1-0. That setup is wasteful: An incoming 1 is lost during the computation. The researchers solve that problem by retaining the extra inputs as “garbage bits” that carry useless information (see the bottom example). The 1-0 order doesn’t matter, but now the number of 1’s is preserved after the computation.
    • Xander Kleiber
      Xander Kleiber on 05 Jun 23
       
      Seems like a great way to solve the issue. However, I don't see anywhere else in the article any sort of actual circuit design/implementation of said solution...
  • On the energy front, the goal is to conserve all information—not just the 1’s but the 0’s as well. Their approach is based on “reversible computing,” an idea first proposed in the 1970s.
    • Xander Kleiber
      Xander Kleiber on 05 Jun 23
       
      Expanded upon later.
  • ...1 more annotation...
  • “If you can play everything backwards, then no energy has escaped during your computation,” says Demaine.
    • Xander Kleiber
      Xander Kleiber on 05 Jun 23
       
      So in reversible computing, if an algorithm can be reversed, that means no information (and therefore no 1's, or measures of voltage) are wasted, resulting in an even lower production of waste.
  • Xander Kleiber on 05 Jun 23
     
    Overall, this seems like a decent course of study. After all, mentioned throughout the article is something called "Landauer's limit," which is a limit to the efficiency of computing devices using the current, wasteful methods. Also mentioned briefly in the article is that we are continually getting much closer to this limit. This makes it a timely issue, along with the fact that not many people have elaborated on its implications or tried implementing it.
  • Sean Nash on 06 Jun 23
     
    This is really interesting... though I'm sure I would benefit from a back-and-forth conversation to make sure I'm understanding what I think I am.
katherine-medina

Sci-Hub | Dandelion Root and Lemongrass Extracts Induce Apoptosis, Enhance Chemotherape... - 1 views

sci-hub.ru/...31391857

Cancer-fighting dandelions potential research idea environmental HSR-2023

shared by katherine-medina on 04 Jun 23 - No Cached
    • katherine-medina
      katherine-medina on 04 Jun 23
       
      They found cancer cell-fighting properties in the dandelion root, lemon grass, long pepper, and hibiscus extract. (I should probably look into what makes these plants prone to killing cancer cells.)
    • katherine-medina
      katherine-medina on 04 Jun 23
       
      In order to further understand how these complex extracts exhibit their anticancer efects, the mechanism of apoptotic induction should be investigated. In order to determine if apoptosis is induced through oxidative stress, N-acetylcysteine (NAC) is used
    • katherine-medina
      katherine-medina on 04 Jun 23
       
      Okay, so they made sure to have a control group of cancer cells, then a group of healthy cells that are being experimented on with the liquid, then they had the cancer-ridden cells.
  • ...1 more annotation...
    • katherine-medina
      katherine-medina on 04 Jun 23
       
      s. Tus, we have shown for the frst time that these NHPs can be used as adjuvants to chemotherapies and potentially enhance their effect.
  • katherine-medina on 04 Jun 23
     
    I will likely come back to this if I so choose to look into how dandelion roots fight cancer.
  • Sean Nash on 04 Jun 23
     
    Yes. Another approach is often... once (if) you can find a suggested mechanism of action... you can often pivot with that action into looking for similar effects in other areas (doesn't have to be human or mammal cancer cells). That area isn't a no-go, but it does present feasibility issues to be tackled. If you can find a suggested mechanism, then you can think more widely about how else could you look to see if that effect can be leveraged in other areas. That is often how you can move toward an easily feasible model organism to test that effect on. Keep up the good work!
Sean Nash

Mysterious Underwater Acoustic World of British Ponds Revealed in New Study | Current S... - 3 views

currentsciencedaily.com/...sh-ponds-revealed-in-new-study

hydrophone sound survey pond potential research idea biology physics computer science environmental science HSR HSR-2023

shared by Sean Nash on 04 Jun 23 - No Cached
  • The previously hidden and diverse underwater acoustic world in British ponds has been revealed by a team of researchers at the University of Bristol.
    • Sean Nash
      Sean Nash on 04 Jun 23
       
      So... my immediate thought is: How cool would it be to do this here? One thing we DO have: PONDS. See if this *sounds* interesting. Get it? ;)
  • Acoustic monitoring has been shown to effectively survey birds and monkeys in rainforests, and marine mammals in the oceans. However, freshwater environments have remained largely unexplored despite their diverse soundscapes.
    • Sean Nash
      Sean Nash on 04 Jun 23
       
      BOOM. Again, "relatively unexplored" is super exciting verbiage to me. Acoustics. Hydrophones. Is this feasible? Is the equipment affordable? If not, could we borrow one? Dig into it. What are the possibilities?
  • analysis of the audio files revealed clear daily acoustic activity cycles in each pond
    • Sean Nash
      Sean Nash on 04 Jun 23
       
      Aside from the exploratory surveys you would do just to see "what's out there" and assess what we CAN learn from listening to a pond, you could make it experimental by comparing ponds you've assessed the health of by other means. In other words, do acoustic comparisons between two ponds correlate with what you find by doing a macroinvertebrate sampling? I really LIKE the possibilities in this one!
  • ...3 more annotations...
  • Typically, a nocturnal chorus is made by aquatic insects that compete to attract mates by producing strange scratching sounds as they rub their genitals against their abdomens. During the daytime, however, aquatic plants dominate the underwater orchestra with rhythmic whining and ticking sounds produced as tiny oxygen bubbles are released by plants respiring in the hot sun.
  • Using this acoustic method, the presence of species, and a determination of ecological health, can be inferred simply by listening to the natural world without disturbing the environment or harming the plants and animals within it.
    • Sean Nash
      Sean Nash on 04 Jun 23
       
      Here is the obvious value proposition if you could work this out.
  • Publication: Jack A. Greenhalgh, et al., Diel variation in insect-dominated temperate pond soundscapes and guidelines for survey design, Freshwater Biology (2023). DOI: 10.1111/fwb.14092.
    • Sean Nash
      Sean Nash on 04 Jun 23
       
      BEST THING YET: Here is the FULL TEXT of the actual research paper!
katherine-medina

Nowcasting lightning occurrence from commonly available meteorological parameters using... - 0 views

www.nature.com/...s41612-019-0098-0

weather lightning AI-prediction HSR-2023 meteorology environmental

shared by katherine-medina on 03 Jun 23 - No Cached
  • They hypothesized that the mesoscale environment indirectly influences CG lightning polarity by directly controlling the storm structure, dynamics, and microphysics, which in turn control storm electrification and ground flash polarity.
  • he lightning forecast is made 30–45 min before rainfall occurs
    • katherine-medina
      katherine-medina on 03 Jun 23
       
      I guess that would make sense considering the fact that the electricity in the air before a storm is active.
  • katherine-medina on 03 Jun 23
     
    An article about how AI can now predict where lightning will occur
izzy kelly

Further link identified between autoimmunity and schizophrenia -- ScienceDaily - 0 views

www.sciencedaily.com/...230531150109.htm

HSR science HSR-2023 questions brain

shared by izzy kelly on 02 Jun 23 - No Cached
  • Synaptic adhesion proteins are specialized proteins that bind to create physical connections between brain cells
  • utoantibodies against the synaptic protein neurexin 1α,
  • neurexin 1α can cause schizophrenia-related changes, at least in mice,
  • ...2 more annotations...
  • which is expressed by one cell in the synapse and binds to proteins known as neuroligins on the other cell in the synapse,
  • autoantibodies is important for improving symptom control
  • izzy kelly on 02 Jun 23
     
    autoantibodies that target neurexin 1a could possibly play a role in the development of schizophrenia. possible treatment with identifying autoantibodies
katherine-medina

Frontiers | Cerebrospinal Fluid Pressure-Related Features in Chronic Headache: A Prospe... - 0 views

www.frontiersin.org/...full

CSF-pressure HSR-2023 methods headaches

shared by katherine-medina on 01 Jun 23 - No Cached
  • magnetic resonance
  • magnetic resonance
    • katherine-medina
      katherine-medina on 01 Jun 23
       
      A non-invasive imaging software
  • A respondent to medical treatment (good outcome) was considered a subject who achieved a 50% or greater reduction in number of headache days per month.
  • ...14 more annotations...
  • The pressure transducer (Transducer kit, Edwards Lifesciences, Irvine, CA, USA) was attached to the hub of needle via a 10-cm long flexible tube without loss of CSF.
  • 93 had abnormal CSF pressure pulsations, with opening pressures ranging from 206 to 385 mm
  • . Group 1 comprised 55 patients, each with an opening pressure below 200 mm H2O
  • Group 2 comprised 56 patients, each with a slight elevation of CSF opening pressure (mean = 231.8
  • Group 3 included 37 patients, all with both elevated CSF opening pressure (mean = 282.2 mm H2O,
  • n Group 3, patients with severe abnormal pressure pulsations and mean pressure >250 mm H2O had the most severe headaches (highest scores on VAS and MIDAS) and associated symptoms (high frequency of: nocturnal headache, postural headache, photopsias, transient visual obscurations).
  • In Group 2, patients with less severe abnormal pressure pulsations and mean pressure >200 mm H2O, had less severe symptoms; in Group 1, patients who had no abnormal pressure pulsations and mean pressures below 200 mm H2O had primary chronic headache disorder (Figure 1).
  • . All of the subjects in the control group, all with opening pressures below 200 mm H2o and normal CSF pressure pulsations, had no headache.
    • katherine-medina
      katherine-medina on 01 Jun 23
       
      So essentially if the CSF pressure was too low the patient had chronic headache disorder, but if the patients had a higher level of pressure they would suffer from the most painful headaches. (This occurring as nocturnal headaches, postural headaches, and transient visual obstructions.
  • An improvement in the intensity of pain and frequency of headaches was observed following CSF removal in all patients with ICH
  • 69 (74%) out 93 patients achieved ≥50% reduction in headache days.
  • Our results provide evidence that nocturnal and postural headache, and abnormal pressure pulsations are the most common pressure-related features of isolated high CSF pressure in patients with chronic headache
  • o explain this mimicry, we hypothesize that abnormal pulsations in CSF pressure may trigger the same mechanism that cause the pain in a primary headache attack. The mimicry thereby emerges as a variation of pre-existing primary headache; as such, it could be considered a triggered headache rather than a secondary or primary one.
  • The pathogenesis of these abnormal pulsations in CSF pressure (B waves and plateau waves) may be clarified by reference to the theory that CSF pressure is derived from the circulation of cerebral blood and cerebrospinal fluid
    • katherine-medina
      katherine-medina on 01 Jun 23
       
      Hmmm... I had no idea that there is a theory that states that CSF pressure is derived from the circulation of blood. (I might wanna look into the further)
  • This suggests that CSF pressure assessment by measuring the height of the fluid column in the manometer line connected to a spinal puncture needle may be misleading in the case of headache sufferers.
  • katherine-medina on 01 Jun 23
     
    A good study to look at when looking at possible causes of headaches, and more information about CSF.
katherine-medina

Sci-Hub | Amyloid-β as a Blood Biomarker for Alzheimer's Disease: A Review of... - 0 views

sci-hub.ru/...31868667

blood-plasma biomarkers Alzheimer's-disease potential research idea HSR-2023

shared by katherine-medina on 31 May 23 - No Cached
    • katherine-medina
      katherine-medina on 31 May 23
       
      So seeing as if scientists have mostly studied AB40-42, and 38 why don't they look at the other peptides under the name of AB.
    • katherine-medina
      katherine-medina on 31 May 23
       
      I shall take note of this excerpt of the passage for future reference, "The discrep- 104 ancy between these two ultrasensitive assays may 105 be due to the different principle and design that 106 IMR assay could inhibit the oligomerization of A42 107 by the iron-chelating effect of magnetic Fe3O4 108 nanoparticles."
    • katherine-medina
      katherine-medina on 31 May 23
       
      Important to see that they are figuring out that, "that there is a blood-brain transportation mechanism 261 for A and indicated that plasma A may be able to 262 reflect the brain A condition."
  • ...1 more annotation...
    • katherine-medina
      katherine-medina on 31 May 23
       
      Maybe I could look into the blood plasma levels AB1-40 and make it into a sort of predictor that could show if somehow may in future years live with some sort of Alzeheimer's Dementia.
  • katherine-medina on 31 May 23
     
    A good look at what scientist have found about the presence of Amyloid B in the blood as a biomarker for Alzheimer's disease
lincolnt

Structure and function of bacteriophage T4 - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC4275845

HSR Phages biology science Bacteria structure T4 head tail tailfiber

shared by lincolnt on 30 May 23 - No Cached
Sean Nash liked it
  • The 194 MDa mature head encapsidates 172 kbp dsDNA, representing 102% of the unique genome [24,25]. The head is first assembled as an empty capsid that is subsequently packaged with DNA by an ATP-dependent packaging machine. This machine binds to the same special pentameric vertex that is later occupied by the phage tail. The head is prolate, meaning that it has two icosahedral ends and a cylindrical mid-section.
Hannah Herrera

Can investigators use household dust as a forensic tool? -- ScienceDaily - 1 views

www.sciencedaily.com/...230403162459.htm

lab potential research idea questions stem cells biology chemistry

shared by Hannah Herrera on 30 May 23 - No Cached
Sean Nash liked it
  • we don't know how long an individual has to stay in a household before they leave DNA traces in household dust."
Hannah Herrera

Growing blood stem cells in the lab to save lives -- ScienceDaily - 0 views

www.sciencedaily.com/...230524181957.htm

lab potential research idea questions stem cells biology chemistry

shared by Hannah Herrera on 30 May 23 - No Cached
  • Hematopoietic stem cells
  • bone marrow is damaged and no longer able to produce healthy blood cells
  • Though cytokines were once believed to be indispensable for ex vivo HSC growth, the research team hypothesized other new approaches as suitable alternatives.
  • ...2 more annotations...
  • ompound called UM171,
  • specific polymer, improved the results by supporting long-term HSC expansion.
katherine-medina

Cerebrospinal Fluid (CSF) Exchange with Artificial CSF Enriched with Mesenchymal Stem C... - 2 views

www.ncbi.nlm.nih.gov/...PMC6480705

CSF-experiments mice stem-cells potential research idea HSR-2023

shared by katherine-medina on 29 May 23 - No Cached
  • Moreover, toxicity of the CSF from patients affected by neurodegenerative diseases has been reported
  • Moreover, toxicity of the CSF from patients affected by neurodegenerative diseases has been reported
    • katherine-medina
      katherine-medina on 29 May 23
       
      Good to note.
  • A beneficial effect was also demonstrated under Aβ neurotoxicity in PC12 cells
  • ...21 more annotations...
  • n humans, it was reported that filtration of the CSF was beneficial in Guillain-Barré syndrome [
    • katherine-medina
      katherine-medina on 29 May 23
       
      interesting that filtering the liquid can help people.
  • . MSCs produce a variety of neurogenic, neuroprotective, and immunomodulatory agents [15,16,17,18,19,20,21], and have been shown to induce beneficial effects when transplanted in EAE-mice [22,23,24,25], stroke [26,27], traumatic brain injury [28], Parkinson’s disease [29], schizophrenia, and autism [30,31] as well as increased neurogenesis in adult mice
  • Moreover, no studies using biologically enriched-aCSF for exchanging the CSF have been published.
    • katherine-medina
      katherine-medina on 29 May 23
       
      That makes me want to search hard for studies that do involve the transfer, however I would have to figure out a way to create an experiment around this base idea of artificial CSF.
  • Artifical cerebrospinal fluid (aCSF) enriched with secretions of mesenchymal stem cells (MSCs) increases cell viability of PC12 and SH-SY5Y neuronal cell lines
  • While secretions of 2 days growing 10 or 100 K/mL MSCs in aCSF did not show an increase in PC12 cell viability
    • katherine-medina
      katherine-medina on 29 May 23
       
      HMMM.... that is utterly fascinating the fact that after 2 days there seemed to be no change amongst the cell viability for both the 10 and 100 ml aCSF.
  • etions of 5 days growing MSCs in aCSF did show a significant increase in the PC12 cell viability relative to unenriched-aCSF treated cells
  • The principle of CSF exchange is similar to plasma exchange by plasmapheresis, which is in use for the treatment of autoimmune disorders
    • katherine-medina
      katherine-medina on 29 May 23
       
      Did not know that it was similar to plasmapheresis.
  • a significant increase in cell viability was noticed in the enriched-aCSF (
  • A similar trend of increased cell viability by enriched-aCSF treatment was noticed in SH-SY5Y cells exposed to H2O2, but without reaching a statistical significance
  • while cell viability was reduced under Aβ, a significant increase in cell viability was noted in the enriched-aCSF treated cells
  • significantly suppressed in spleen lymphocytes treated with the enriched-aCSF compared to lymphocytes treated with (unenriched-) aCSF
    • katherine-medina
      katherine-medina on 29 May 23
       
      This limiting of the lymphocytes is most likely a good thing under the guise of this paper because the suppression of lymphocytes likely helps with certain autoimmune disorders.
  • These results show that the “in/out” enriched-aCSF therapy was the most effective one, affecting both time of onset (EAE-control mice develop the disease at day 10 while the treated mice at day 14 post induction) and disease progression
  • Prolonged amelioration of EAE clinical symptoms during prolonged CSF exchange therapy: (in/out) enriched-aCSF protocol was more effective than (in) enriched-aCSF and (in/out) aCSF.
  • A trend of less demyelination in the LFB staining in the (in/out) enriched-aCSF treated- mice relative to the EAE-control mic
  • Our results show that elimination of endogenous CSF, and its replacement with MSC secretions enriched-aCSF ((in/out)-enriched-aCSF), delayed EAE onset and reduced the clinical score with indications of reduced axonal damage and demyelination.
  • in vitro and in vivo, has shown that MSCs can promote survival and axonal myelination in sensory dorsal root ganglia neurons and may be effective in non-inflammatory models of demyelination [
  • MSCs transplantation alone has been applied and tested with strong indications of beneficial effects in animal models of MS [22,23,24,25], stroke [26,27], traumatic brain injury [28], PD [29], schizophrenia, and autism
  • showing that local (intraventricular) transplantation of MSCs is more effective than intravenous administration
  • The feasibility of CSF exchange therapy reported here in the EAE model might possibly be applied to other neurodegenerative diseases of the CNS.
  • our approach of CSF exchange therapy could be beneficial for fully developed neurological diseases through a repeated application of the proposed CSF exchange protocol
    • katherine-medina
      katherine-medina on 29 May 23
       
      A good thing to recognize and note for future reference.
  • 5. Conclusions
  • katherine-medina on 29 May 23
     
    This is a more recent study about the effects of artificial CSF infused with MSC in mice.
« First ‹ Previous 121 - 140 of 164 Next › Last »
Showing 20▼ items per page