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katherine-medina

Frontiers | Cerebrospinal Fluid Pressure-Related Features in Chronic Headache: A Prospe... - 0 views

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CSF-pressure HSR-2023 methods headaches

shared by katherine-medina on 01 Jun 23 - No Cached
  • magnetic resonance
  • magnetic resonance
    • katherine-medina
      katherine-medina on 01 Jun 23
       
      A non-invasive imaging software
  • A respondent to medical treatment (good outcome) was considered a subject who achieved a 50% or greater reduction in number of headache days per month.
  • ...14 more annotations...
  • The pressure transducer (Transducer kit, Edwards Lifesciences, Irvine, CA, USA) was attached to the hub of needle via a 10-cm long flexible tube without loss of CSF.
  • 93 had abnormal CSF pressure pulsations, with opening pressures ranging from 206 to 385 mm
  • . Group 1 comprised 55 patients, each with an opening pressure below 200 mm H2O
  • Group 2 comprised 56 patients, each with a slight elevation of CSF opening pressure (mean = 231.8
  • Group 3 included 37 patients, all with both elevated CSF opening pressure (mean = 282.2 mm H2O,
  • n Group 3, patients with severe abnormal pressure pulsations and mean pressure >250 mm H2O had the most severe headaches (highest scores on VAS and MIDAS) and associated symptoms (high frequency of: nocturnal headache, postural headache, photopsias, transient visual obscurations).
  • In Group 2, patients with less severe abnormal pressure pulsations and mean pressure >200 mm H2O, had less severe symptoms; in Group 1, patients who had no abnormal pressure pulsations and mean pressures below 200 mm H2O had primary chronic headache disorder (Figure 1).
  • . All of the subjects in the control group, all with opening pressures below 200 mm H2o and normal CSF pressure pulsations, had no headache.
    • katherine-medina
      katherine-medina on 01 Jun 23
       
      So essentially if the CSF pressure was too low the patient had chronic headache disorder, but if the patients had a higher level of pressure they would suffer from the most painful headaches. (This occurring as nocturnal headaches, postural headaches, and transient visual obstructions.
  • An improvement in the intensity of pain and frequency of headaches was observed following CSF removal in all patients with ICH
  • 69 (74%) out 93 patients achieved ≥50% reduction in headache days.
  • Our results provide evidence that nocturnal and postural headache, and abnormal pressure pulsations are the most common pressure-related features of isolated high CSF pressure in patients with chronic headache
  • o explain this mimicry, we hypothesize that abnormal pulsations in CSF pressure may trigger the same mechanism that cause the pain in a primary headache attack. The mimicry thereby emerges as a variation of pre-existing primary headache; as such, it could be considered a triggered headache rather than a secondary or primary one.
  • The pathogenesis of these abnormal pulsations in CSF pressure (B waves and plateau waves) may be clarified by reference to the theory that CSF pressure is derived from the circulation of cerebral blood and cerebrospinal fluid
    • katherine-medina
      katherine-medina on 01 Jun 23
       
      Hmmm... I had no idea that there is a theory that states that CSF pressure is derived from the circulation of blood. (I might wanna look into the further)
  • This suggests that CSF pressure assessment by measuring the height of the fluid column in the manometer line connected to a spinal puncture needle may be misleading in the case of headache sufferers.
  • katherine-medina on 01 Jun 23
     
    A good study to look at when looking at possible causes of headaches, and more information about CSF.
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