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lincolnt

Structure and function of bacteriophage T4 - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC4275845

HSR Phages biology science Bacteria structure T4 head tail tailfiber

shared by lincolnt on 30 May 23 - No Cached
Sean Nash liked it
  • The 194 MDa mature head encapsidates 172 kbp dsDNA, representing 102% of the unique genome [24,25]. The head is first assembled as an empty capsid that is subsequently packaged with DNA by an ATP-dependent packaging machine. This machine binds to the same special pentameric vertex that is later occupied by the phage tail. The head is prolate, meaning that it has two icosahedral ends and a cylindrical mid-section.
katherine-medina

In Vitro and In Vivo Evaluation of the Effectiveness and Safety of Amygdalin as a Cance... - 0 views

www.ncbi.nlm.nih.gov/...PMC9697812

potential research idea HSR-2023 rat-experiments Amygdalin cancer-fighting Natural-remides

shared by katherine-medina on 11 Jun 23 - No Cached
Sean Nash liked it
  • ]. Approximately 80% of all medications approved by the FDA in the last three decades have been derived from natural sources
  • Transdermal drug delivery is a promising route for cancer treatment compared with the oral route due to its low side effects and improved efficacy and selectivity
  • All ALN formulations containing DDP exhibited a higher percent of EE and smaller particle size and PDI than those that did not have DDP at the molar ratio investigated.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      If I am to do my research project over the affects of amygdalin patches on cancer, I will need to keep this section of text in mind.
  • ...9 more annotations...
  • The optimum ALN gel formulation reduced mean relative carcinoma volume (MCV) at a higher rate (p < 0.05) compared with free amygdalin solution and free tamoxifene suspension.
  • that the optimum ALN gel formulation reduced mean relative carcinoma volume (MCV) compared with the DMBA control.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      reduced carcinoma in comparison to control group
  • . The value of the zeta potential indicated a negative surface charge, which is considered advantageous for transdermal drug delivery and for electrostatic stabilization due to the electrostatic repulsions between vesicles
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      Good to note.
  • 3. Materials and Methods3.1. MaterialsAmygdalin was attained from Nature’s Only Choice Company (Tbilisi, GA, USA). Sigma Aldrich (Agitech Company, Cairo, Egypt) provided Tween 60, Span 60, cholesterol, 7, 12-dimethylbenz[a] anthracene (DMBA), triethanolamine, and dihexadecyl phosphate. Carbopol 934, methanol, acetone, and chloroform were attained from Corner-Lab Company (Cairo, Egypt).
  • Histological examination of the oral tamoxifen suspension treated group (Figure 7C) revealed the presence of hyperkeratosis and acanthosis in the surface epithelium of the epidermis with signs of a diffuse inflammatory response and edema in the dermis and sub-cutaneous tissue.
  • Histological examination of the optimum ALN gel treated group (Figure 7F) showed clearly healed skin with normal covering epithelium and marked improvement in all signs of the epidermis and dermis that were better than those of the oral amygdalin solution. These results confirmed the effectiveness of amygdalin loaded niosomes gel as a cancer therapy in vivo.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      Cool, so they tested and confirmed that ALN gel does work to treat cancer of the skin.
  • Histological examination of the optimum ALN gel-treated group (Figure 8B) showed clearly healed skin with normal covering epithelium.
  • The group treated with plain niosomes gel showed MCV nearly similar to that of the DMBA control group.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      SO the niosome gel doesn't do much.
  • The optimum ALN gel enhanced the permeation of amygdalin into deep skin layers and showed significant anti-tumor activity compared with oral tamoxifen.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      I think that Amygdalen could be one of my research topics for this upcoming year.
  • katherine-medina on 11 Jun 23
     
    A really cool study that showed that Amygdalin in a gel form can prove to be very sucsessful at healing tumors from the epidermis.
katherine-medina

https://assets.researchsquare.com/files/rs-2962278/v1/95a4813e-7c91-423d-8608-d3e697f79... - 0 views

assets.researchsquare.com/...c91-423d-8608-d3e697f797f4.pdf

MRSA stilbene polyphenols antibiotics HSR-2023 Research-idea pigeon-peas

shared by katherine-medina on 27 Jun 23 - No Cached
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      A. Besides, the results implied that these stilbenes effectively inhibited the levels of adhesion and virulence genes and downregulate the production of -hemolysin. This study showed that stilbenes from pigeon pea have anti-Staphylococcus potential, and they also inhibited bacterial proliferation, biofilm formation, and key gene expressions related to adhesion and virulence of MRSA.
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      "Over the past few years, bacterial biofilm has aroused wide attention. And the biofilm can be called sessile microbial community where cells are attached to the surface or to other cells and can embed themselves in a protective extracellular polymeric matrix." This is a pretty interesting piece of information.
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      Moreover, as an ethnological herb, pigeon pea is adopted in traditional medicine for its treatments of diabetes (Al-Saeedi and Hossain 2015; Talukdar 2013), hepatic-disorder (Ghosh et al. 2006), necrosis of femoral head (Luo et al. 2009), measles (Nwodo Page 4/20 et al. 2011) and osteoporosis HUH that is really interesting considering the amount of pigeon peas I have had in arroz con gondules.
  • ...3 more annotations...
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      Additionally, the epidermis was the external barrier of the body and thus HaCaT (human keratinocyte) was used to investigate the cytotoxicity of these stilbenes. As a result, these compounds had no discernible harmful effects on HaCaT at concentrations of 1/4 of their MIC, and their IC50 on HaCaT were 9.58 ± 0.22, 12.76 ± 0.31, 18.38 ± 0.41 µg/mL, respectively. Hence, the maximum concentrations of these stilbenes were set at 1/4 MIC in the follow-up research It is quite remarkable that pigeon peas are that effective.
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      The growth cures suggested that 1 MIC and 1/2 MIC of these compounds had remarkable inhibitory effects on the MRSA growth. Wow
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      It is incredibly important that the article states this, "However, current researches barely reveal the anti-MRSA biofilm ability of stilbenes from pigeon pea." This makes me want to learn more and more about how pigeon pea polyphenols work mostly because it is a very unexplored area of biochemistry.
  • katherine-medina on 27 Jun 23
     
    This article is about three different stilbenes in pigeon peas that were found to fight against MRSA.
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