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Sean Nash

Creating an ocean of data with the help of underwater robots | Dropbox Blog - 0 views

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    (not all scientific analysis must be done using data YOU have collected!)
Sean Nash

Health Effects from Swimming Training in Chlorinated Pools and the Corresponding Metabo... - 4 views

  • Numerous epidemiological publications have associated the chlorination of pools with dysfunctions of the respiratory system and with some other diseases
  • Therefore, the health effects from swimming in chlorinated pools and the corresponding stress reactions in organisms are unclear. In this study, we show that although the growth and behaviors of experimental rats were not affected, their health, training effects and metabolic profiles were significantly affected by a 12-week swimming training program in chlorinated water identical to that of public pools.
    • katherine-medina
       
      This may prove to be a concerning fact that myself and others on the swim team swim rather consistently.
  • The epidemiological evidence for adverse health effects from swimming in chlorinated water primarily originate from studies concerning respiratory function and asthma, althoughVillanueva et al. reported a significant increased risk of bladder cancer for swimmers compared with nonswimmers [5].
    • katherine-medina
       
      Kinda scary to think about the fact that swimming could be hurting my lungs.
    • Sean Nash
       
      OK... this is all a very rare and interesting topic to me. I've never considered it. Of course, in thinking a bout this as a HS research topic, the fact that it centers around humans... is a feasibility issue. However, what sort of invertebrate models could we use in place? Would we be able to detect DBPs?
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  • Interestingly, the eyes and skin are the organs that are more directly affected than the lungs by the irritants in chlorinated water; instead of chlorination, training intensity, training frequency and choking on water may be the primary factors for lung damage induced by swimming.
  • he water for the EG was purified using a water purifier and then disinfected using calcium hypochlorite, similar to public swimming pools, whereas the water for the CG was only purified, not chlorinate
  • Therefore, the health effects from swimming in chlorinated pools and the corresponding stress reactions occurring in our bodies are unclear
  • In fact, similar symptoms, red and swollen eyes, dried skin and nasal mucosal congestion, always appear after humans swim in a chlorinated pool; however, the long-term (12 weeks) and high-frequency (5 days a week) of the experimental swimming training caused even worse symptoms in these experimental rats.
  • however, some unusual appearance changes appeared in the EG rats.
    • katherine-medina
       
      EG rats had the exposure of a public level of chlorine.
  • First, the skin around their eyes became increasingly red with the development of the experiment, and in the ending period of the experiment, bloodstains could be observed in the rims of most rats’ eyes.
    • katherine-medina
       
      Wow.
  • Third, their fur became increasingly dry and lackluster, and significant signs of hair loss were observed during the last month.
    • katherine-medina
       
      This doesn't sound good.
  • These results indicated that the fur, respiratory tracts and eyes of the EG rats were severely affected by chlorinated water, although their growth was essentially unaffected. According to our observations, the daily behaviors and sizes of the EG rats were normal, and their final body weights were even slightly heavier than those weights of the control group. Nevertheless, dried and lackluster fur, hair removal, bloody noses and eyes did occur in the EG rats and not to the CG rats.
  • A meta-analysis performed by Goodman et al. demonstrated that the association between asthma and swimming could only be confirmed among competitive swimmers and could not be confirmed among non-competitive swimmers
    • katherine-medina
       
      SO competitive swimmers are the ones with an association of asthma and pool water.
  • Additionally, an interesting phenomenon was observed by comparing the development of the bloody noses and bloody eyes. The bloody noses commonly appeared in the third and in the fourth week; however, approximately two weeks later, this symptom gradually disappeared. The significantly bloody eyes commonly appeared in the ending period of the experiment; however, this problem was becoming worse during the study, and no signs of improvement appeared. The bloody noses appeared first, suggesting that respiratory tracts may be more vulnerable to the irritants from the chlorinated water than eyes; the gradually disappearing symptom suggests that respiratory tracts may have some adaptability to chlorinated water possibly because of the protection from nasal mucous. In contrast, without the mucosal protection, the bloody eyes were becoming increasingly significant during the entire experiment, although this symptom appeared later than the bloody noses.
  • Hippurate is an inhibitor of glucose utilization in the muscle and in the kidneys, an inhibitor of glucose utilization in the kidneys and in the liver, a modulator of fatty acid metabolism, and a stimulator of ammoniagenesis
  • Three rats from the EG were found liver damage, indicating that the positive rate reached 18 percen
  • or instance, Tumasonis et al. reported that a significantly increased incidence of hepatic neoplastic nodules in female rats and a significantly increased incidence of hepatic adenofibrosis in both male and female rats were induced by the chronic ingestion of chloroform [15].
  • Representative hematoxylin and eosin staining (H&E, 400×) of liver sections.
    • katherine-medina
       
      The liver literally changed between the two groups.
  • . We suppose that the primary differences between the competitive swimmers and non-competitive swimmers are training intensity and frequency, not the pool water.
    • katherine-medina
       
      An interesting theory, but I wonder if it has been proved.
  • The first three principal components (PCs) explain 57.3% of the total variance of the raw data and are sufficient to present the differences between the EG and the CG
  • In Fig. 3, we can see that the majority of the differences between the EG and the CG are explained by PC 1 and PC 3.
  • which suggests that the 12-week swimming training in chlorinated water induced a significant change in the metabolic profiles of the experimental group rats.
  • As an antioxidant, taurine can directly scavenge hypochlorous acid (HClO) and prevents changes in membrane permeability due to oxidative impairment
  • The duration period from the entry into water until the rats reached exhaustion was significantly shorter for the EG rats compared with the CG rats (29.74±11.50 vs. 39.15±9.85 minutes, p<0.05)
    • katherine-medina
       
      Rats in chlorine swam ten minutes less on average.
  • Chlorine is a necessary element for our bodies, and nontoxic.
    • katherine-medina
       
      I did not know that.
  • In summary, the 12-week swimming training in chlorinated pool water did induce some disease symptoms, an impairment of training effects and a significant change in the metabolic profiles, although the growth and behaviors of the experimental animals were not affected
  • Thus, the eyes and skin might be the organs that require greater attention for permanent damage.
  • Symptoms found in the liver and lung sections indicate that the liver is most likely the most possible target organ of DBPs, and training intensity, training frequency and water choking may be the primary factors for lung damage induced by swimming, instead of chlorination. The result of the swimming capacity test showed that training effects were significant affected by chlorinated water through perturbing the TCA cycle and oxidative phosphorylation.
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    A really cool article about how chlorine can affect the bodies of mice. (An article I will never be able to forget about due to it being similar to my situation.)
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    A really cool article about how chlorine can affect the bodies of mice. (An article I will never be able to forget about due to it being similar to my situation.)
Sean Nash

Satellite Monitoring of Biodiversity Moves Within Reach | Current Science Daily - 2 views

  • Data for the study came from the National Ecological Observatory Network (NEON). The network uses standardized methods to collect biodiversity and Earth observation data across the United States which are then made publicly available. NEON imaging spectrometer data collected from research flights have a pixel size of 1x1 meter.
    • Sean Nash
       
      I wonder if any of the imagery they have is: 1. Accessible by us, and 2. Available for our area. If so, it might be as simple as doing plant diversity surveys to look for ground truth in our area (young forests & grasslands) between what is REALLY on the ground here, vs. what the satellite imagery shows.
  • Biodiversity monitoring from space possible via satellite
  • The reflectance of plants is determined by their chemical, anatomical and morphological characteristics, which are important for interactions among plants and with their environment. “Plants with similar traits, as well as closely related species, therefore tend to have similar reflectance spectra,” explains Schweiger.
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  • Spectral diversity calculated in forests with closed canopies and large individual trees matched plant diversity determined on the ground better than spectral diversity calculated in open landscapes dominated by small herbaceous plants and grasses.
Sean Nash

Low-dose radiation from A-bombs elongated lifespan and reduced cancer mortality relativ... - 1 views

  • individuals
    • Sean Nash
       
      These "individuals" could just as easily be plants of lower invertebrates (as model organisms at this level). This is fascinating to me. There is no doubt that we would be limited in our ability to work with ionizing radiation, but that's not to say a project couldn't be developed along these lines. I never cease to be amazed at what a motivated student can resourcefully come up with when their passion for a particular line of research is so high.
Sean Nash

"I Wonder...": Reconnecting with Our Natural Curiosity - YouTube - 0 views

  • Reconnecting with Our Natural Curiosity
    • Sean Nash
       
      This is Caitlyn with the Society for Science (the group that sponsors the ISEF & RTS. I saw her give this talk in person last October. she gives some really good suggestions for reconnecting to the curiosity and wonder of your childhood. It is THIS skill that separates the typical student from the creative mind of a scientist. Will YOU try out any of her suggestions??
katherine-medina

Increased 3-O-sulfated heparan sulfate in Alzheimer's disease brain is associated with ... - 1 views

  • Genetic factors contribute substantially to the pathological process of AD as demonstrated by the fact that the genetic heritability in AD is in the range of between 60 and 80% (10).
  • however, whether the variants alter the level of 3-OST-1 enzyme activity to change the structure of HS remains unknown
    • katherine-medina
       
      Good to note what exactly the article remains unsure about
  • The synthesis of additional 13C-labeled calibrants to cover these three reported 3-O-sulfated tetrasaccharides will be the subject for future study.
    • katherine-medina
       
      LOOK INTO THIS PART CAYSE THEY ARE SAYING THAT THEY ARE NOT FULLY SURE
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  • the elevation of total HS and the percentage of the 3-O-sulfated domain in HS.
  • HS and tau revealed that the sugar mainly interacts with the proline-rich region 2, a repeat domain 2 in tau protein
  • Further analysis of the distribution of 3-O-sulfated HS from different areas of AD brains will be of interest and the subject for a subsequent study.
  • Experimental design
    • katherine-medina
       
      READ THIS IF THIS TOPIC COMES BACK UP AGAIN
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    A interesting study about a sulfate that suggests that Alzheimer's is genetic
katherine-medina

Plants | Free Full-Text | Expression of a Stilbene Synthase Gene from the Vitis labrusc... - 0 views

  • Stilbenes are found in plants of different families, but the best studied stilbene is resveratrol (3,5,4′-trihydroxystilbene) isolated from grape plants.
  • Resveratrol synthesis in transgenic plants did not always render them fully resistant to one or another pathogen.
  • The aim of our investigation was to isolate a VlvSTS stilbene synthase gene from the hybrid grape V. labrusca x V. vinifera L. and obtain transgenic tobacco plants overexpressing the gene to study their resistance to a number of bacterial and fungal pathogens, among them bacteria as E. carotovora and fungi as B. cinerea, F. oxysporum, F. sporotrichioides, F. culmorum.
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  • by PCR. F
    • katherine-medina
       
      PCR is a method with which scientists are able to amplify a gene
  • Based on the results of the VlvSTS gene transcription analysis, seven transgenic tobacco lines were selected for further experiments.
  • Expression of the VlvSTS gene in tobacco plants led to a significant increase in the pollen grain size, but with a tendency to a decrease in the total number of pollen grains per anther
    • katherine-medina
       
      Too much of that gene leads to a decrease of fertility.
  • In all tests with E. carotovora bacteria, transgenic plants expressing the VlvSTS gene demonstrated a significantly higher resistance versus control plants
    • katherine-medina
       
      interesting
  • The leaf involvement was significantly smaller in transgenic plants expressing the VlvSTS gene.
  • Overexpression of the VlvSTS gene reduced the corolla pigmentation in transgenic plants.
    • katherine-medina
       
      Why did the overexpression of that gene reduce the corolla pgmentation.
  • binary vector
    • katherine-medina
       
      like a DNA transfer
  • showed a significant fertility reduction,
  • For the first time it was shown that plants expressing the VlvSTS gene had enhanced resistance to the bacterial pathogen E. carotovora subsp. carotovora B15.
    • katherine-medina
       
      Interesting that it took this long for it to be shown that this specific stilbene can fight against certain pathogens.
  • Interestingly, resistance correlated with the expression level of the stilbene synthase gene. In plants with a higher gene expression (L10 and L23), the area of Erwinia-caused leaf damage was in a range from 0 to 40% respect to the control, while the leaves of line L24 were affected up to 60–100%.
  • hile in transgenic lines, the lysis areas were significantly smaller, probably due to the synthesis of the phytoalexin resveratrol.
  • Some studies showed that Arabidopsis plants transformed with wild grape stilbene synthase genes responded to a pathogen attack by activating genes responsible for the synthesis of signaling molecules such as salicylic and jasmonic acids (SA and JA, respectively) [
  • Our data show a decrease in the total flavonoid content in the flower petals but not in the leaves of plants upon expression of the VlvSTS gene.
    • katherine-medina
       
      That seems rather odd.
  • We were the first to show that transgenic tobacco plants carrying the VlvSTS gene had a significantly larger pollen grain size and a smaller number of pollen grains per anther. At the same time, the number of fertile pollen grains decreased, especially in the plant line with the highest expression of the VlvSTS gene.
  • For example, in apple plants with the grape stilbene synthase gene Vst1 under its own promoter, the expression of the gene had no effect on pollen development
  • The study showed that the expression of a VlvSTS stilbene syntase gene in tobacco transgenic plants increases their resistance to bacterial pathogen E. carotovora. There was a significant reduction of disease symptoms after infection of leaves by grey mould fungus B. cinerea, but not to Fusarium fungi. We were the first to show that transgenic tobacco plants carrying the VlvSTS gene had a significantly larger pollen grain size and a smaller number of pollen grains per anther. The number of fertile pollen grains decreased, especially in the plant line with the highest expression of the VlvSTS gene. These changes resulted in a decreased weight of seed bolls in the transgenic tobacco lines.
    • katherine-medina
       
      Overall, this article is one that I may come back to depending on what path I go down when searching to develop a research topic further.
Isabella Tungjaroenkul

Anténor Firmin challenged anthropology's racist roots 150 years ago - 1 views

  • “This is hardly surprising since most of the early [Black] pioneers of anthropology have only recently been brought to light.”
    • Isabella Tungjaroenkul
       
      Sadly not surprising. There are many amazing discoveries that are overlooked and even forgotten because they were performed or written by women or non-white people.
  • It did not take long for Firmin to question his membership in a group openly hostile to people who looked like him. Faced with such a tough environment, Firmin remained silent at meetings.
Sean Nash

How patient-led research could speed up medical innovation - 0 views

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    This makes me think of my Mom and her struggle with migranes. She would benefit from a simple iOS app that helps her track symptoms & potential triggers in a way that could easily be shared with her doctor.
Sean Nash

Airplane Noise Exposure May Increase Risk of Chronic Disease | SPH - 0 views

  • “Prior research has shown that aircraft noise can elevate stress responses and disturb sleep, but there has been mixed evidence of any links with body mass index,” says study lead and corresponding author Matthew Bozigar, assistant professor of epidemiology at OSU and a former postdoctoral associate at SPH. “We were surprised to see a fairly robust link between aircraft noise and higher body mass index among women across the US.”
    • Sean Nash
       
      Again, this reminds me of the UCSD juncos and the increased stressors they must endure to live in an urban environment. However, we must remember that just because their emerging population in and around the UCSD campus is successful, it comes with a cost of shorter lifespans, increased mortality, etc. Very interesting stuff.
  • These new findings underscore the role of the environment on one’s risk of chronic disease.
  • Junenette Peters, associate professor of environmental health, and colleagues examined airplane noise exposure and self-reported BMI and other individual characteristics among nearly 75,000 participants living around 90 of the major US airports
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  • The team examined aircraft noise levels every five years from 1995 to 2010, using a day-night estimate (DNL) that captures the average noise level over a 24-hour period and applies a 10 dB adjustment for aircraft noise occurring at night, when background noise is low.
  • Although the team acknowledges that BMI is a suboptimal metric, the independent and strong association between more aircraft noise exposure and higher BMI that they observed is notable.
  • “We can only hypothesize about why we saw these regional variations, but one reason may relate to the era of regional development, building characteristics, and climate which may affect factors such as housing age, design, and level of insulation,” says Peters. “Regional differences in temperature and humidity may influence behaviors such as window opening, so perhaps study participants living in the West were more exposed to aircraft noise due to open windows or housing type, which allowed more noise to penetrate.”
  • Previous data suggest that Black, Hispanic, and low-income populations are disproportionately exposed to aircraft noise. The participants in the NHS study groups were primarily White and of mid-level socioeconomic status. 
  • “We need to study the potential health impacts of environmental injustices in transportation noise exposures alongside other environmental drivers of poor health outcomes” Bozigar says. “There is a lot more to figure out, but this study adds evidence to a growing body of literature that noise negatively impacts health.”
Sean Nash

Race car drivers tend to blink at the same places in each lap - 4 views

  • The world goes dark for about one-fifth of a second every time you blink, a fraction of an instant that’s hardly noticeable to most people. But for a Formula One race car driver traveling up to 354 kilometers per hour, that one-fifth means almost 20 meters of lost vision
  • People are often thought to blink at random intervals, but researchers found that wasn’t the case for three Formula drivers.
  • the drivers tended to blink at the same parts of the course during each lap, cognitive neuroscientist Ryota Nishizono and colleagues report in the May 19 iScience
    • Sean Nash
       
      Interesting. So, do we do the same thing while driving around town? Could you design a method to record eye blinks as people drive known routes around town? We could simultaneously use the Arduino Science Journal app on the iPhone to also correlate physical data in a moving car like acceleration/deceleration, motion in X, Y, Z directions, etc. I wonder if we could find a correlation in everyday driving that could help from a safety perspective?
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  • He was surprised to find almost no literature on blinking behavior in active humans even though under extreme conditions like motor racing or cycling
    • Sean Nash
       
      OK, now this SCREAMS: "potential research idea."
  • Nishizono and colleagues mounted eye trackers on the helmets of three drivers and had them drive three Formula circuits
  • Where the drivers blinked was surprisingly predictable, the team found. The drivers had a shared pattern of blinking that had a strong connection with acceleration, such that drivers tended not to blink while changing speed or direction — like while on a curve in the track — but did blink while on relatively safer straightaways.
    • Sean Nash
       
      What sort of implications does this have for driving in key, known, busy interchanges in KC? Could we potentially provide data to show certain stretches of highway need more signage, etc? That could have civil engineering implications.
  • “We think of blinking as this nothing behavior,” he says, “but it’s not just wiping the eyes. Blinking is a part of our visual system.”
  • Nishizono next wants to explore what processes in the brain allow or inhibit blinking in a given moment, he says, and is also interested in how blinking behavior varies among the general population.
    • Sean Nash
       
      While the "brain" part might move beyond our feasibility, the potential of finding real correlations to driving patterns or routes is a completely different spin-off and one that could have really practical suggestive applications for city planners, etc.
Sean Nash

Large Data Sets - Society for Science - 1 views

  • Locate a data set that interests you, see how others students have used large data sets in their research, and learn about current scientific studies fueled by big data.
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    Another really solid pathway into project development is the examination and study of already existing large data sets. I have seen excellent projects that didn't even require students to generate their own data. Instead, they utilize already existing data to answer questions others may not have posed before in relation to that data set. At the very least, becoming familiar with these lines of research can help you discover a line of research that is most compelling to you!
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