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Sean Nash

Race car drivers tend to blink at the same places in each lap - 4 views

www.sciencenews.org/...ula-one-race-car-drivers-blink

ArduinoScienceJournal app driving blinking vision research potential research idea biology engineering HSR HSR-2023 science statistical analysis car auto safety civilengineering blink

shared by Sean Nash on 25 May 23 - No Cached
izzy kelly liked it
  • The world goes dark for about one-fifth of a second every time you blink, a fraction of an instant that’s hardly noticeable to most people. But for a Formula One race car driver traveling up to 354 kilometers per hour, that one-fifth means almost 20 meters of lost vision
  • People are often thought to blink at random intervals, but researchers found that wasn’t the case for three Formula drivers.
  • the drivers tended to blink at the same parts of the course during each lap, cognitive neuroscientist Ryota Nishizono and colleagues report in the May 19 iScience
    • Sean Nash
      Sean Nash on 25 May 23
       
      Interesting. So, do we do the same thing while driving around town? Could you design a method to record eye blinks as people drive known routes around town? We could simultaneously use the Arduino Science Journal app on the iPhone to also correlate physical data in a moving car like acceleration/deceleration, motion in X, Y, Z directions, etc. I wonder if we could find a correlation in everyday driving that could help from a safety perspective?
  • ...5 more annotations...
  • He was surprised to find almost no literature on blinking behavior in active humans even though under extreme conditions like motor racing or cycling
    • Sean Nash
      Sean Nash on 25 May 23
       
      OK, now this SCREAMS: "potential research idea."
  • Nishizono and colleagues mounted eye trackers on the helmets of three drivers and had them drive three Formula circuits
  • Where the drivers blinked was surprisingly predictable, the team found. The drivers had a shared pattern of blinking that had a strong connection with acceleration, such that drivers tended not to blink while changing speed or direction — like while on a curve in the track — but did blink while on relatively safer straightaways.
    • Sean Nash
      Sean Nash on 25 May 23
       
      What sort of implications does this have for driving in key, known, busy interchanges in KC? Could we potentially provide data to show certain stretches of highway need more signage, etc? That could have civil engineering implications.
  • “We think of blinking as this nothing behavior,” he says, “but it’s not just wiping the eyes. Blinking is a part of our visual system.”
  • Nishizono next wants to explore what processes in the brain allow or inhibit blinking in a given moment, he says, and is also interested in how blinking behavior varies among the general population.
    • Sean Nash
      Sean Nash on 25 May 23
       
      While the "brain" part might move beyond our feasibility, the potential of finding real correlations to driving patterns or routes is a completely different spin-off and one that could have really practical suggestive applications for city planners, etc.
katherine-medina

In Vitro and In Vivo Evaluation of the Effectiveness and Safety of Amygdalin as a Cance... - 0 views

www.ncbi.nlm.nih.gov/...PMC9697812

potential research idea HSR-2023 rat-experiments Amygdalin cancer-fighting Natural-remides

shared by katherine-medina on 11 Jun 23 - No Cached
Sean Nash liked it
  • ]. Approximately 80% of all medications approved by the FDA in the last three decades have been derived from natural sources
  • Transdermal drug delivery is a promising route for cancer treatment compared with the oral route due to its low side effects and improved efficacy and selectivity
  • All ALN formulations containing DDP exhibited a higher percent of EE and smaller particle size and PDI than those that did not have DDP at the molar ratio investigated.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      If I am to do my research project over the affects of amygdalin patches on cancer, I will need to keep this section of text in mind.
  • ...9 more annotations...
  • The optimum ALN gel formulation reduced mean relative carcinoma volume (MCV) at a higher rate (p < 0.05) compared with free amygdalin solution and free tamoxifene suspension.
  • that the optimum ALN gel formulation reduced mean relative carcinoma volume (MCV) compared with the DMBA control.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      reduced carcinoma in comparison to control group
  • . The value of the zeta potential indicated a negative surface charge, which is considered advantageous for transdermal drug delivery and for electrostatic stabilization due to the electrostatic repulsions between vesicles
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      Good to note.
  • 3. Materials and Methods3.1. MaterialsAmygdalin was attained from Nature’s Only Choice Company (Tbilisi, GA, USA). Sigma Aldrich (Agitech Company, Cairo, Egypt) provided Tween 60, Span 60, cholesterol, 7, 12-dimethylbenz[a] anthracene (DMBA), triethanolamine, and dihexadecyl phosphate. Carbopol 934, methanol, acetone, and chloroform were attained from Corner-Lab Company (Cairo, Egypt).
  • Histological examination of the oral tamoxifen suspension treated group (Figure 7C) revealed the presence of hyperkeratosis and acanthosis in the surface epithelium of the epidermis with signs of a diffuse inflammatory response and edema in the dermis and sub-cutaneous tissue.
  • Histological examination of the optimum ALN gel treated group (Figure 7F) showed clearly healed skin with normal covering epithelium and marked improvement in all signs of the epidermis and dermis that were better than those of the oral amygdalin solution. These results confirmed the effectiveness of amygdalin loaded niosomes gel as a cancer therapy in vivo.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      Cool, so they tested and confirmed that ALN gel does work to treat cancer of the skin.
  • Histological examination of the optimum ALN gel-treated group (Figure 8B) showed clearly healed skin with normal covering epithelium.
  • The group treated with plain niosomes gel showed MCV nearly similar to that of the DMBA control group.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      SO the niosome gel doesn't do much.
  • The optimum ALN gel enhanced the permeation of amygdalin into deep skin layers and showed significant anti-tumor activity compared with oral tamoxifen.
    • katherine-medina
      katherine-medina on 11 Jun 23
       
      I think that Amygdalen could be one of my research topics for this upcoming year.
  • katherine-medina on 11 Jun 23
     
    A really cool study that showed that Amygdalin in a gel form can prove to be very sucsessful at healing tumors from the epidermis.
katherine-medina

Marine Drugs | Free Full-Text | Microalgae Photo-Protectants and Related Bio-Carriers L... - 0 views

www.mdpi.com/487

shared by katherine-medina on 14 Sep 23 - No Cached
Sean Nash liked it
  • This review focuses on the use of these microalgae compounds obtained by UV stimulation and takes advantage of their natural UV-resistant characteristics to potentially apply them as an alternative for UV protection products.
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      Can I put this on a plant in order to mitigate heat damage?
  • pproximately 90–99% of the solar UV radiation energy that reaches the Earth’s surface is UV-A
  • whereas only 1–10% is UV-B [4]. Both UV-A and UV-B are responsible for one of the biggest concerns related to UV radiation, which is skin cancer
  • ...28 more annotations...
  • The mechanisms leading to skin damage are not fully understood and may derive from the generation of ROS and subsequent lipid peroxidation
  • To prevent photodamage, organisms have evolved to provide biochemical and physical defenses to UV by synthesizing robust bioactive compounds
  • Some algae species synthesize substances with chemical structures that can absorb UV radiation as well as inhibit actions on melanin synthesis
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      Which algaes
  • Microalgae can produce organic metabolites, such as sporopollenin, scytonemin, and MAAs to mention a few, and these metabolites have the purpose to protect the microalgae from UV radiation while allowing visible radiation involved in photosynthesis to pass through
  • two marine microalgae Pavlova lutheri, currently known as Diacronema lutheri, and Odontella aurita
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      After I get through the other ones I will get to you my pretty
  • UV-Resistant Microalgae
  • Marine organisms, including eukaryotic microalgae and cyanobacteria, during evolution, have developed physiological and biochemical traits for defense and/or tolerance to UV rays
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      Come back to this part
  • This research also mentioned the Antarctic microalgae Chaetoceros dichaeta, Phaeocystis antarctica, and Polarella glacialis, these were subjected to acclimation to photosynthetically active radiation (PAR) and showed resistance to UV-B rays.
  • It was found that the tolerant species contained substantial amounts of acetolysis-resistant residue
  • So far, several species, e.g., Coelastrella rubescens, Coelastrella terestris, Enallax coelastroides, Scotiella chlorelloidea, Ankistrodesmus spiralis, Chlorella minutissima, Chlorella sorokiniana, and Pseudococcomyxa sp. have been reported as rich sources of MAAs
  • They are abundant in various aquatic and terrestrial environments and are known for being eco-sustainable compounds since they are the outcome of the evolution of algae. Unlike their synthetic counterparts used unconventional sunscreens, there are no possibilities for pollution caused by them [22]. Thus, algal metabolites shape the safety and sustainability profiles of commercial sunscreens [22].
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      How long can the algae last on the skin or leaf of a plant
  • The results obtained point out different resistance and defense mechanisms of the four microalgae in response to UV-B irradiance and suggest that the strain of Nostoc sp. tested is the most suitable for surviving under the high UV irradiation [33]
  • Certain microalgae produce organic metabolites, such as sporopollenin, scytonemin, and MAAs as well as other UV-absorbing substances to counteract the harmful effects of UV radiation and protect themselves while allowing visible radiation involved in photosynthesis to pass through
  • The best known photoprotective response in marine organisms is the production or accumulation of UV-absorbing compounds, including MAAs as the most common compounds with such properties, but there are also others, such as scytonemin, carotenoids, alganean, and various secondary metabolites
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      photoprootective means protecting the skin
  • f low molecular weight, commonly found in marine environments. These compounds have absorption maxima in the UV region between 310 and 360 nm, they can dissipate radiation as heat without producing ROS. Under fixed light, MAA biosynthesis seems the most effective photoprotective mechanism
  • For these reasons, they potentially can prevent UV-induced skin damage
  • It was reported that species of microalgae that were highly tolerant to UV radiation had substantial amounts of sporopollenin. This compound functions as an antimicrobial agent, confers rigidness to the cell wall, and may further protect from UV rays by increasing the optical density, whereas species containing little or no sporopollenin were highly UV radiation susceptible
  • However, the potential of microalgae as topical photoprotectants has not been fully exploited, since there are not a lot of studies regarding this application.
  • Other reports determine that scytonemin is suspected to be synthesized from metabolites of aromatic amino acid biosynthesis
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      No set decision on how it is created
  • Alginate is a
  • ydration
  • However, some microalgae have a great ability to overcome or counteract different stresses such as intense solar UV radiation, this has been happening over the years and with the evolution of microalgae, some examples of defense and/or tolerance mechanisms are: DNA repair, synthesis of antioxidants, and enzymatic/non-enzymatic compounds, such as MAAs and scytonemin to counteract the harmful effects of UV radiation
  • Scytonemin is a yellow-brown lipid soluble sheath pigment that absorbs maximally in the UV-A and UV-C regions, but with some absorbance in the UV-B region. It has an in vivo absorption maximum of 370 nm.
  • tigate UV damage induced.
  • photosensitizers, their antioxidant
  • V
  • ed.
  • t
  • katherine-medina on 14 Sep 23
     
    A recent article showing the potential use of microalgae as a sunscreen.
  • Sean Nash on 14 Sep 23
     
    Yes..... let's chat this one out!
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