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Sean Nash

Large Data Sets - Society for Science - 1 views

www.societyforscience.org/...large-data-sets

resources HSRTC SFS research data sets society SCI-I projectdevelopment questioning statistical analysis HSR-2023 HSR science

shared by Sean Nash on 23 Jun 23 - No Cached
  • Locate a data set that interests you, see how others students have used large data sets in their research, and learn about current scientific studies fueled by big data.
  • Sean Nash on 23 Jun 23
     
    Another really solid pathway into project development is the examination and study of already existing large data sets. I have seen excellent projects that didn't even require students to generate their own data. Instead, they utilize already existing data to answer questions others may not have posed before in relation to that data set. At the very least, becoming familiar with these lines of research can help you discover a line of research that is most compelling to you!
ryleighnyp

Electrical grounding technique may improve health outcomes of NICU babies -- ScienceDaily - 2 views

www.sciencedaily.com/...170803120627.htm

HSR HSR-2023 potential research idea

shared by ryleighnyp on 07 Jun 23 - No Cached
Sean Nash liked it
  • "What we can conclude is that a baby's autonomic nervous system is able to sense the electrical environment and it seems as though a baby is more relaxed when grounded,"
  • redesigning incubators to ground babies and cancel out the electrical field
  • ryleighnyp on 07 Jun 23
     
    I think a possible research idea could be redesigning NICU incubators to allow for less electromagnet interference with the babies with the use of grounding.
  • Sean Nash on 07 Jun 23
     
    Interesting, for sure. Two things... the actual measurements they made on children (skin tests, etc.) are a no-go for us. I'm not sure what our model system could be for checking the electrical outputs of whatever design changes were made. We would need to know a lot more about the current setup in NICUs. There is no doubt a lot of design in how things are currently set up. Essentially: why things are set up the way they are right now? You would have to know every variable currently considered, and then look for spots where simple changes can be made. Second thing: go back to the ISEF categories in Engineering and check out how those projects look at the national level. Just go get a feel. Engineering is a bit different from typical "hypothesis testing" seen in most natural sciences. Very cool, but different. Give it a look.
Sean Nash

Learning in Plants: Lessons from Mimosa pudica - 4 views

www.frontiersin.org/...full

Mimosa learning plants botany research SCI-I science student lab potential research idea biology HSR HSR-2023

shared by Sean Nash on 23 Jun 23 - No Cached
  • there is a lack of observational data on the behavior of plants
  • Observational research allows the researcher to establish baseline activity and response levels of the subject
  • Perhaps the first study of learning in plants was a habituation experiment reported by Pfeffer (1873) using the sensitive plant Mimosa. In this experiment, repeated mechanical stimulation of leaflets led to a decrease in sensitivity
  • ...12 more annotations...
  • the question naturally arises as to whether Mimosa can discriminate between stimuli. This was answered in the affirmative by Holmes and Gruenberg (1965) whose experimental design included a drop of water and finger touch as stimuli
  • the results suggest that Mimosa can discriminate between stimuli
  • Thomas performed an experiment on classical conditioning in Mimosa that took advantage of the finding that, under field conditions, the leaflets of Mimosa slowly drop as dusk approaches and slowly rise at dawn (personal communication). In the experiment, the CS was turning on the light in the growth chamber and the US was touching selected leaflets. Thomas found that leaflets in the paired condition showed conditioning compared to a light only or alternating stimulation condition. This finding should be replicated with controls for pseudoconditioning.
  • Given the importance of the Gagliano et al. (2014) experiment and the failure to replicate some previous experimental results it is critical that the Gagliano et al. (2014) results be repeated by an independent laboratory.
  • In addition to Mimosa, habituation has been found in the carnivorous plant Drosera (sundew
  • Applewhite (1975) cites an experiment by Darwin reportedly showing habituation in the passion flower (Passiflora gracilis). During this experiment, when Darwin mechanically stimulated the passion flower tendrils, the tendrils no longer responded after 54 h of training.
  • Abramson et al. (2002) investigated the use of bioelectrical potentials as a method to explore plant behavior.
  • In an interesting article, Karpinski and Szechynska-Hebda (2010) discuss the intellect of plants from memory to intelligence. By studying recall, the researcher investigates a host of independent variables and that are solidly anchored to a set of dependent variables. This study focused on recall at the cellular level rather than as an externally observable behavior. The discussion of plant learning at various levels, from cellular to organismal and from different scientific fields is exactly what is advocated for in this article
  • There is also interest from behavioral scientists seeking to determine whether the similarities and differences in learning found among invertebrates and vertebrates could also be found in plants (Warden et al., 1940; Applewhite, 1975; Abramson et al., 2002; Guiguet, 2013).
  • The majority of early plant studies used the Sensitive plant (M. pudica). Mimosa has much to recommend it for learning studies. They are easy to maintain, much is known about its natural history, and they have a visible leaf closure response to external stimuli. However, there are drawbacks in the use of Mimosa, for example, it takes about 15 min for a leaf to recover (Holmes and Gruenberg, 1965) and not much is known about its genome in contrast to model species such as Arabidopsis thaliana whose entire genome is known.
  • In the following section we will focus on methods to develop studies utilizing habituation, sensitization, and classical conditioning techniques. Instrumental and operant conditioning will not be covered because at this time there are no Mimosa studies in these areas; although one can envision a situation where the opening and closing of a leaf can be detected electronically. Once detected, the response would produce a consequence such as an airpuff or changes in light intensity.
    • Sean Nash
      Sean Nash on 23 Jun 23
       
      The remainder of this comprehensive article is to outline the main lines of research in this area:
  • Learning in Plants: Lessons from Mimosa pudica
    • Sean Nash
      Sean Nash on 23 Jun 23
       
      This well-compiled article does a really nice job of outlining the history of study regarding plant behavior. It also suggests model organisms for study. Mimosa is a favorite of mine as their response is VERY rapid and quite visible for a plant! There are all sorts of feasible project ideas that could arise from this area of research.
Sean Nash

E-learning courses - GrowNextGen - 2 views

grownextgen.org/elearning

agriculture food foodscience courses SCI-I topicselection resources learning research ideas environmental science botany biology HSR HSR-2023

shared by Sean Nash on 23 Jun 23 - No Cached
  • These self-guided digital resources allow students to work independently. Pre- and posttests can be used to check knowledge gains.
    • Sean Nash
      Sean Nash on 23 Jun 23
       
      An interesting set of open online courses to take your learning to the next level in some area... These might be interesting early on in the problem-finding phase, but also once a topic is chosen... you need to get up to speed in an area of science much more quickly than in traditional teacher-led courses. Perhaps one of these can help you build early background expertise in some area?
katherine-medina

https://assets.researchsquare.com/files/rs-2962278/v1/95a4813e-7c91-423d-8608-d3e697f79... - 0 views

assets.researchsquare.com/...c91-423d-8608-d3e697f797f4.pdf

MRSA stilbene polyphenols antibiotics HSR-2023 Research-idea pigeon-peas

shared by katherine-medina on 27 Jun 23 - No Cached
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      A. Besides, the results implied that these stilbenes effectively inhibited the levels of adhesion and virulence genes and downregulate the production of -hemolysin. This study showed that stilbenes from pigeon pea have anti-Staphylococcus potential, and they also inhibited bacterial proliferation, biofilm formation, and key gene expressions related to adhesion and virulence of MRSA.
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      "Over the past few years, bacterial biofilm has aroused wide attention. And the biofilm can be called sessile microbial community where cells are attached to the surface or to other cells and can embed themselves in a protective extracellular polymeric matrix." This is a pretty interesting piece of information.
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      Moreover, as an ethnological herb, pigeon pea is adopted in traditional medicine for its treatments of diabetes (Al-Saeedi and Hossain 2015; Talukdar 2013), hepatic-disorder (Ghosh et al. 2006), necrosis of femoral head (Luo et al. 2009), measles (Nwodo Page 4/20 et al. 2011) and osteoporosis HUH that is really interesting considering the amount of pigeon peas I have had in arroz con gondules.
  • ...3 more annotations...
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      Additionally, the epidermis was the external barrier of the body and thus HaCaT (human keratinocyte) was used to investigate the cytotoxicity of these stilbenes. As a result, these compounds had no discernible harmful effects on HaCaT at concentrations of 1/4 of their MIC, and their IC50 on HaCaT were 9.58 ± 0.22, 12.76 ± 0.31, 18.38 ± 0.41 µg/mL, respectively. Hence, the maximum concentrations of these stilbenes were set at 1/4 MIC in the follow-up research It is quite remarkable that pigeon peas are that effective.
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      The growth cures suggested that 1 MIC and 1/2 MIC of these compounds had remarkable inhibitory effects on the MRSA growth. Wow
    • katherine-medina
      katherine-medina on 27 Jun 23
       
      It is incredibly important that the article states this, "However, current researches barely reveal the anti-MRSA biofilm ability of stilbenes from pigeon pea." This makes me want to learn more and more about how pigeon pea polyphenols work mostly because it is a very unexplored area of biochemistry.
  • katherine-medina on 27 Jun 23
     
    This article is about three different stilbenes in pigeon peas that were found to fight against MRSA.
katherine-medina

Marine Drugs | Free Full-Text | Microalgae Photo-Protectants and Related Bio-Carriers L... - 0 views

www.mdpi.com/487

shared by katherine-medina on 14 Sep 23 - No Cached
Sean Nash liked it
  • This review focuses on the use of these microalgae compounds obtained by UV stimulation and takes advantage of their natural UV-resistant characteristics to potentially apply them as an alternative for UV protection products.
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      Can I put this on a plant in order to mitigate heat damage?
  • pproximately 90–99% of the solar UV radiation energy that reaches the Earth’s surface is UV-A
  • whereas only 1–10% is UV-B [4]. Both UV-A and UV-B are responsible for one of the biggest concerns related to UV radiation, which is skin cancer
  • ...28 more annotations...
  • The mechanisms leading to skin damage are not fully understood and may derive from the generation of ROS and subsequent lipid peroxidation
  • To prevent photodamage, organisms have evolved to provide biochemical and physical defenses to UV by synthesizing robust bioactive compounds
  • Some algae species synthesize substances with chemical structures that can absorb UV radiation as well as inhibit actions on melanin synthesis
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      Which algaes
  • Microalgae can produce organic metabolites, such as sporopollenin, scytonemin, and MAAs to mention a few, and these metabolites have the purpose to protect the microalgae from UV radiation while allowing visible radiation involved in photosynthesis to pass through
  • two marine microalgae Pavlova lutheri, currently known as Diacronema lutheri, and Odontella aurita
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      After I get through the other ones I will get to you my pretty
  • UV-Resistant Microalgae
  • Marine organisms, including eukaryotic microalgae and cyanobacteria, during evolution, have developed physiological and biochemical traits for defense and/or tolerance to UV rays
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      Come back to this part
  • This research also mentioned the Antarctic microalgae Chaetoceros dichaeta, Phaeocystis antarctica, and Polarella glacialis, these were subjected to acclimation to photosynthetically active radiation (PAR) and showed resistance to UV-B rays.
  • It was found that the tolerant species contained substantial amounts of acetolysis-resistant residue
  • So far, several species, e.g., Coelastrella rubescens, Coelastrella terestris, Enallax coelastroides, Scotiella chlorelloidea, Ankistrodesmus spiralis, Chlorella minutissima, Chlorella sorokiniana, and Pseudococcomyxa sp. have been reported as rich sources of MAAs
  • They are abundant in various aquatic and terrestrial environments and are known for being eco-sustainable compounds since they are the outcome of the evolution of algae. Unlike their synthetic counterparts used unconventional sunscreens, there are no possibilities for pollution caused by them [22]. Thus, algal metabolites shape the safety and sustainability profiles of commercial sunscreens [22].
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      How long can the algae last on the skin or leaf of a plant
  • The results obtained point out different resistance and defense mechanisms of the four microalgae in response to UV-B irradiance and suggest that the strain of Nostoc sp. tested is the most suitable for surviving under the high UV irradiation [33]
  • Certain microalgae produce organic metabolites, such as sporopollenin, scytonemin, and MAAs as well as other UV-absorbing substances to counteract the harmful effects of UV radiation and protect themselves while allowing visible radiation involved in photosynthesis to pass through
  • The best known photoprotective response in marine organisms is the production or accumulation of UV-absorbing compounds, including MAAs as the most common compounds with such properties, but there are also others, such as scytonemin, carotenoids, alganean, and various secondary metabolites
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      photoprootective means protecting the skin
  • f low molecular weight, commonly found in marine environments. These compounds have absorption maxima in the UV region between 310 and 360 nm, they can dissipate radiation as heat without producing ROS. Under fixed light, MAA biosynthesis seems the most effective photoprotective mechanism
  • For these reasons, they potentially can prevent UV-induced skin damage
  • It was reported that species of microalgae that were highly tolerant to UV radiation had substantial amounts of sporopollenin. This compound functions as an antimicrobial agent, confers rigidness to the cell wall, and may further protect from UV rays by increasing the optical density, whereas species containing little or no sporopollenin were highly UV radiation susceptible
  • However, the potential of microalgae as topical photoprotectants has not been fully exploited, since there are not a lot of studies regarding this application.
  • Other reports determine that scytonemin is suspected to be synthesized from metabolites of aromatic amino acid biosynthesis
    • katherine-medina
      katherine-medina on 14 Sep 23
       
      No set decision on how it is created
  • Alginate is a
  • ydration
  • However, some microalgae have a great ability to overcome or counteract different stresses such as intense solar UV radiation, this has been happening over the years and with the evolution of microalgae, some examples of defense and/or tolerance mechanisms are: DNA repair, synthesis of antioxidants, and enzymatic/non-enzymatic compounds, such as MAAs and scytonemin to counteract the harmful effects of UV radiation
  • Scytonemin is a yellow-brown lipid soluble sheath pigment that absorbs maximally in the UV-A and UV-C regions, but with some absorbance in the UV-B region. It has an in vivo absorption maximum of 370 nm.
  • tigate UV damage induced.
  • photosensitizers, their antioxidant
  • V
  • ed.
  • t
  • katherine-medina on 14 Sep 23
     
    A recent article showing the potential use of microalgae as a sunscreen.
  • Sean Nash on 14 Sep 23
     
    Yes..... let's chat this one out!
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