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Matti Narkia

Cancer Journal: Latest cancer research Link between cancer and dietary restriction | ec... - 0 views

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    A signalling pathway that influences how sensitive cancer cells are to the beneficial effects of dietary restriction is described in this week's Nature. Dietary restriction - eating less calories while maintaining essential vitamins and minerals - can extend lifespan, and reduce cancer incidence and growth. But some types of cancer cell are more sensitive to the anti-growth effects of dietary restriction than others, Nada Kalaany and David Sabatini report. The effect hinges on the activity of the phosphatidylinositol-3-kinase (PI3K) pathway. If the pathway is active, dietary restriction has no effect on cancer cells. However, if the pathway is inactive, tumours are sensitive to dietary restriction.
Matti Narkia

Sloan-Kettering - Garlic - 0 views

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    Derived from the bulb or clove of the plant. Garlic is used as a spice and to treat hyperlipidemia, hypertension, atherosclerosis, cancer, and infections. Processing can have a substantial effect on the chemical content in garlic; the volatile oil components are sensitive to heat and certain enzymes are acid-labile. Several oral garlic formulations are available, and clinical studies have addressed a variety of the proposed claims. Placebo-controlled trials on the cholesterol lowering effect of garlic yielded mixed results (16) (17) (18) (21) (22) (26). Studies evaluating the antithrombotic effects repeatedly have shown modest reduction in platelet aggregation, but varying levels of fibrinolytic activity. Research shows mixed effects with regard to reductions in blood glucose, blood pressure, or risk of cardiovascular disease (23). Frequently reported adverse events include bad breath, headache, fatigue, GI upset, diarrhea, sweating, and possible hypoglycemia (9). Because garlic is known to decrease platelet aggregation and potentially elevate the INR, it should not be used with anticoagulants or in patients with platelet dysfunction (15). Garlic appears to induce cytochrome p450 3A4 and may enhance metabolism of many medications (e.g. cyclosporin and saquinavir) (12). An analysis of several case-control studies in Europe suggests an inverse association between garlic consumption and risk of common cancers (25).
odiedog garfield

The Harmful Side Effects of DES - 0 views

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    DES side effects questions answered concerning birth defects, infertility, miscarriages and breast cancer.
Matti Narkia

Addition of milk prevents vascular protective effects of tea. - Eur Heart J. 2007 Jan;2... - 0 views

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    Addition of milk prevents vascular protective effects of tea. Lorenz M, Jochmann N, von Krosigk A, Martus P, Baumann G, Stangl K, Stangl V. Eur Heart J. 2007 Jan;28(2):219-23. Epub 2007 Jan 9. PMID: 17213230 doi:10.1093/eurheartj/ehl442 In conclusion, milk may counteract the favourable health effects of tea on vascular function. The finding that the tea-induced improvement of vascular function in humans is completely attenuated after addition of milk may have broad implications on the mode of tea preparation and consumption. In addition, it indicates that caution is warranted in the design of studies involving nutritional flavonoids.
Matti Narkia

Scientists hail the first effective treatment for skin cancer victims - Hea... - 0 views

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    Scientists have developed the first "personalised" drug shown to be effective against advanced melanoma, the deadliest type of skin cancer which is on the rise in Britain. Warnings about the risks of melanoma were heightened this weekend as the fine weather drew thousands to sunbathe outdoors, putting them at increased risk. "Binge tanning", where sunbathers allow their skin to burn in their eagerness to get a tan, is a key cause of the cancer. Melanoma, which starts as a blemish or change to a mole on the skin, is treatable in its early stages but once it has spread to other organs such as the lungs and liver there are no treatment options. Patients with melanoma that has spread usually die within months
Matti Narkia

Biochemical effects of consumption of eggs containing omega-3 polyunsaturated fatty aci... - 0 views

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    Biochemical effects of consumption of eggs containing omega-3 polyunsaturated fatty acids. Ohman M, Akerfeldt T, Nilsson I, Rosen C, Hansson LO, Carlsson M, Larsson A. Ups J Med Sci. 2008;113(3):315-23. PMID: 18991244 Addition of one regular egg per day to the normal diet had no negative impact on blood lipids or inflammation markers. Consumption of omega-3 enriched eggs resulted in higher levels of ApoA1, lower ApoB/ApoA1 ratio and lower plasma glucose. These effects have been associated in previous studies with a reduced risk for cardiovascular mortality and diabetes.
avivajazz  jazzaviva

Lupus (Systemic Lupus Erythematosus) | A Google Knol by David Daikh, MD, PhD at UCSF - 0 views

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    Treatment of most forms of SLE involves suppression of the immune system, as summarized in Table I. The most commonly used immunosuppressive drugs for moderately severe lupus are the corticosteroids, such as prednisone. These agents effectively suppress disease activity for most patients, but they also have many undesirable side effects.
Matti Narkia

New data on link between cancer and nutrition discussed at European symposium - 0 views

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    European experts in cancer and nutrition are meeting in Zurich, Switzerland late this month to discuss cutting-edge research in one of the most important and fiercely debated topics in cancer prevention: the link between diet and cancer. There is growing evidence that many cancers may be prevented through healthy lifestyle, including a nutritionally balanced diet. In addition, nutritional problems can also have a negative impact on cancer management and the lives of patients. Other presentations will include new data on topics such as: Childhood nutrition and later breast cancer risk The anti-tumour effects of green tea Malnutrition and patient distress in cancer Possible anti-tumour effects of soy extracts in mice Estrogens in beef and cancer risk
Matti Narkia

Vitamin K help for diabetes? - 0 views

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    The vitamin K dependant protein osteocalcin may have a positive effect on reducing obesity and diabetes, suggests a new study with mice.\nResearchers writing in the journal Cells studied the effect bone cells have in energy regulation, and found that osteocalcin plays a key role in regulating insulin activity.
Matti Narkia

Vitamin D and Vitamin K Team Up to Lower CVD Risk - Part I - 0 views

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    Strong correlations have been noted between cardiovascular diseases and low bone density / osteoporosis-connections so strong that the presence of one type of pathology is considered a likely predictor of the other. This potentially causal relationship has led to the hypothesis that these conditions share core mechanisms. Recent advances in our understanding of the complimentary roles played by vitamin D3 and vitamin K2 in vascular and bone health provide support for this hypothesis, along with insight into key metabolic dysfunctions underlying cardiovascular disease and osteoporosis. Part I of this review summarizes current research linking vitamin D deficiency to cardiovascular disease, the physiological mechanisms underlying vitamin D's cardiovascular effects, and leading vitamin D researchers' recommendations for significantly higher supplemental doses of the pro-hormone. Part II reviews the vitamin K connection to cardiovascular disease; the ways in which vitamin D and vitamin K pair up to prevent inflammation, vascular calcification and osteoporosis; and the necessity of providing vitamin K along with vitamin D to preclude adverse effects associated with hypervitaminosis D, which include vascular and other soft tissue calcification.
Matti Narkia

EFSA sets lower tolerable intake level for cadmium in food - 0 views

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    The European Food Safety Authority's Panel on contaminants in the food chain has set a reduced tolerable weekly intake (TWI)[1] for cadmium of 2.5 micrograms per kilogram of body weight (µg/kg bw), based on an analysis of new data. The TWI is the level at which adverse effects are not expected. Average dietary exposure to cadmium for adults across Europe is around this level. Some population groups - vegetarians, children, smokers and people living in highly contaminated areas - can have a higher level of exposure up to twice the TWI. However, the Panel concluded that even for these groups the risk of adverse effects would be very low. The Panel concluded that current exposure to cadmium at the level of the population should be reduced.
Matti Narkia

Fish Oil Consumption and Reduction of Arterial Disease -- Vanschoonbeek et al. 133 (3):... - 0 views

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    Here we propose that the beneficial effect of (n-3) PUFA diet is related to down-regulation of the mutually positive interactions of platelet activation and coagulation. In addition, we consider the possibility that the dietary effect on hemostatic and lipid factors involves transcription regulation of multiple genes, perhaps in a subject-dependent manner. Fish oil consumption and reduction of arterial disease. Vanschoonbeek K, de Maat MP, Heemskerk JW. J Nutr. 2003 Mar;133(3):657-60. Review. PMID: 12612132
Matti Narkia

Omega fatty acid balance can alter immunity and gene expression - 0 views

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    Floyd Chilton and colleagues wanted to examine whether theses fatty acids might have other effects, and developed a dietary intervention strategy in which 27 healthy humans were fed a controlled diet mimicking the w6/w3 ratios of early humans over 5 weeks. They then looked at the gene levels of immune signals and cytokines (protein immune messengers), that impact autoimmunity and allergy in blood cells and found that many key signaling genes that promote inflammation were markedly reduced compared to a normal diet, including a signaling gene for a protein called PI3K, a critical early step in autoimmune and allergic inflammation responses. This study demonstrates, for the first time in humans, that large changes in gene expression are likely an important mechanism by which these omega fatty acids exert their potent clinical effects
Dr. John Bureau DC

Face Protection Effective In Preventing The Spread Of Influenza, Study Suggests - 0 views

  • ScienceDaily (May 22, 2009) — A new article in the journal Risk Analysis assessed various ways in which aerosol transmission of the flu, a central mode of diffusion which involves breathing droplets in the air, can be reduced. Results show that face protection is a key infection control measure for influenza and can thus affect how people should try to protect themselves from the swine flu. See also: Health & Medicine Cold and Flu Influenza Bird Flu Plants & Animals Bird Flu Research Virology Developmental Biology Reference Flu vaccine Influenza pandemic Transmission (medicine) Avian flu Lawrence M. Wein, Ph.D., and Michael P. Atkinson of Stanford University constructed a mathematical model of aerosol transmission of the flu to explore infection control measures in the home. Their model predicted that the use of face protection including N95 respirators (these fit tight around the face and are often worn by construction workers) and surgical masks (these fit looser around the face and are often worn by dental hygienists) are effective in preventing the flu. The filters in surgical masks keep out 98 percent of the virus. Also, only 30 percent of the benefits of the respirators and masks are achieved if they are used only after an infected person develops symptoms. "Our research aids in the understanding of the efficacy of infection control measures for influenza, and provides a framework about the routes of transmission," the authors conclude. This timely article has the potential to impact current efforts and recommendations to control the so-called swine flu by international, national and local governments in perspective. This study is published in the journal Risk Analysis.
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    for more articles, see blog: drjohndc.tumblr.com
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    ScienceDaily (May 22, 2009) - A new article in the journal Risk Analysis assessed various ways in which aerosol transmission of the flu, a central mode of diffusion which involves breathing droplets in the air, can be reduced. Results show that face protection is a key infection control measure for influenza and can thus affect how people should try to protect themselves from the swine flu. Lawrence M. Wein, Ph.D., and Michael P. Atkinson of Stanford University constructed a mathematical model of aerosol transmission of the flu to explore infection control measures in the home. Their model predicted that the use of face protection including N95 respirators (these fit tight around the face and are often worn by construction workers) and surgical masks (these fit looser around the face and are often worn by dental hygienists) are effective in preventing the flu. The filters in surgical masks keep out 98 percent of the virus. Also, only 30 percent of the benefits of the respirators and masks are achieved if they are used only after an infected person develops symptoms. "Our research aids in the understanding of the efficacy of infection control measures for influenza, and provides a framework about the routes of transmission," the authors conclude. This timely article has the potential to impact current efforts and recommendations to control the so-called swine flu by international, national and local governments in perspective. This study is published in the journal Risk Analysis.
Dr. John Bureau DC

Childhood Secondhand Smoke Effects Persist - 0 views

  • SAN DIEGO, May 20 -- The effects of exposure to secondhand smoke in childhood may persist for decades, a researcher said here. In a large cohort of nonsmokers, early signs of emphysema were noticeable on CT scans among those who had lived with one or more smokers in childhood, according to Gina Lovasi, Ph.D., of Columbia University. Those signs -- a significant increase in the number of "air-like spaces" -- were not accompanied by any clinical symptoms, Dr. Lovasi said at the annual meeting of the American Thoracic Society.
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    SAN DIEGO, May 20 -- The effects of exposure to secondhand smoke in childhood may persist for decades, a researcher said here. In a large cohort of nonsmokers, early signs of emphysema were noticeable on CT scans among those who had lived with one or more smokers in childhood, according to Gina Lovasi, Ph.D., of Columbia University. Those signs -- a significant increase in the number of "air-like spaces" -- were not accompanied by any clinical symptoms, Dr. Lovasi said at the annual meeting of the American Thoracic Society.
Dr. John Bureau DC

Medical News: AAN: Epilepsy Drug Not Effective for Chronic Headache - in Meeting Covera... - 0 views

  • SEATTLE, April 30 -- The epilepsy drug levetiracetam (Keppra) does not appear to be effective for prevention of chronic daily headache, researchers said here. Action Points  Explain that the epilepsy drug levetiracetam did not significantly increase the headache-free rate for patients with chronic daily headache compared with placebo.Note, however, that there was a significant reduction in disability and reduced pain severity in the treatment group, and the findings show that there is a subpopulation of chronic daily headache patients for whom levetiracetam remains a therapeutic option.Note that this study was published as an abstract and presented orally at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal. Levetiracetam drug achieved a 3.9% increase in headache-free performance over placebo, but the trend did not reach statistical significance, Roy Beran, M.D., of the University of New South Wales, and colleagues reported at the American Academy of Neurology meeting.
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    SEATTLE, April 30 -- The epilepsy drug levetiracetam (Keppra) does not appear to be effective for prevention of chronic daily headache, researchers said here. Levetiracetam drug achieved a 3.9% increase in headache-free performance over placebo, but the trend did not reach statistical significance, Roy Beran, M.D., of the University of New South Wales, and colleagues reported at the American Academy of Neurology meeting.
Matti Narkia

Enriched eggs as a source of N-3 polyunsaturated fatty acids for humans. - Poult Sci. 2... - 0 views

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    Enriched eggs as a source of N-3 polyunsaturated fatty acids for humans. Lewis NM, Seburg S, Flanagan NL. Poult Sci. 2000 Jul;79(7):971-4. Review. PMID: 10901195 Plasma triglycerides (TG) are decreased by addition of n-3 PUFA-enriched eggs to the diet. N-3 PUFA may influence LDL particle size, causing a shift toward a less atherogenic particle. Blood platelet aggregation is significantly decreased in participants consuming n-3 PUFA-enriched eggs. Overall results of studies to date demonstrate positive effects and no negative effects from consumption of n-3-enriched eggs. Three n-3 PUFA-enriched eggs provide approximately the same amount of n-3 PUFA as one meal with fish. It is recommended that n-3 PUFA-enriched eggs be used as one source of n-3 PUFA to increase individual consumption to meet the current Canadian recommendations
Matti Narkia

Eating mushrooms may boost immune system (ASU Research) - 0 views

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    Edible mushrooms are a versatile functional food and have been touted as a way to preserve youth, longevity and overall health for centuries. Now nutrition researchers from Arizona State University and Pennsylvania State University are finding that they may even help boost the immune system and reduce inflammation, especially in the colon. Keith R. Martin, ASU assistant professor in nutrition, along with his Penn State colleagues, experimented with various types of mushrooms, from the more common white button to the exotic like shiitake and oyster, to see what sort of effect they had on the immune system. Their paper was published in late February in BMC Immunology, a peer reviewed online journal. "We found that the white button mushroom seemed to be the most effective in boosting the immune system, which is good because they are the most affordable," said Martin.
Matti Narkia

Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of actio... - 0 views

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    Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. Volvert ML, Seyen S, Piette M, Evrard B, Gangolf M, Plumier JC, Bettendorff L. BMC Pharmacol. 2008 Jun 12;8:10. PMID: 18549472 doi:10.1186/1471-2210-8-10 Conclusion Our results show that, though benfotiamine strongly increases thiamine levels in blood and liver, it has no significant effect in the brain. This would explain why beneficial effects of benfotiamine have only been observed in peripheral tissues, while sulbutiamine, a lipid-soluble thiamine disulfide derivative, that increases thiamine derivatives in the brain as well as in cultured cells, acts as a central nervous system drug. We propose that benfotiamine only penetrates the cells after dephosphorylation by intestinal alkaline phosphatases. It then enters the bloodstream as S-benzoylthiamine that is converted to thiamine in erythrocytes and in the liver. Benfotiamine, an S-acyl derivative practically insoluble in organic solvents, should therefore be differentiated from truly lipid-soluble thiamine disulfide derivatives (allithiamine and the synthetic sulbutiamine and fursultiamine) with a different mechanism of absorption and different pharmacological properties.
Matti Narkia

Omega-3 Kills Cancer Cells - 0 views

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    ScienceDaily (Apr. 5, 2009) - Docosahexanoic acid (DHA), an omega-3 fatty acid found in fish oils, has been shown to reduce the size of tumours and enhance the positive effects of the chemotherapy drug cisplatin, while limiting its harmful side effects. The rat experiments provide some support for the plethora of health benefits often ascribed to omega-3 acids.
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