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Matti Narkia

DHA reduces tumor growth - Life Extension Update - 0 views

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    Mice injected with cancer cells experienced significantly elevated levels of C-reactive protein, white blood cells, and lipid peroxidation compared with control mice. These levels were reduced in animals that received cisplatin and/or DHA. While treatment with 125 mg/kg DHA inhibited tumor growth by 38 percent compared to untreated animals, 250 mg/kg suppressed tumor growth by 79 percent, which was a greater effect than that of cisplatin alone (which was associated with a 55 percent reduction). The combination of DHA and cisplatin resulted in an 81 percent inhibition of growth, while reducing elevated white blood cell levels (leukocytosis) to normal levels. Treatment with the higher dose of DHA alone was associated with a similar reduction in white blood cells, which, when elevated, are associated with tumor growth. A strong relationship was observed between tumor growth and white blood cell levels as well as C-reactive protein levels. In another experiment with rats treated with cisplatin, the addition of 250 mg/kg DHA prevented lethal kidney toxicity in 88 percent of the animals that received it, while none of the rats that received cisplatin alone survived.
Matti Narkia

Chemopreventive and renal protective effects for docosahexaenoic acid (DHA): implicatio... - 0 views

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    Chemopreventive and renal protective effects for docosahexaenoic acid (DHA): implications of CRP and lipid peroxides. Elmesery ME, Algayyar MM, Salem HA, Darweish MM, El-Mowafy AM. Cell Div. 2009 Apr 2;4(1):6. [Epub ahead of print] PMID: 19341447 doi:10.1186/1747-1028-4-6
Matti Narkia

n-3 Fatty acids, cancer and cachexia: a systematic review of the literature - 0 views

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    Our findings suggest that administration of n-3 FA (EPA and DHA) in doses of at least 1.5 g/day for a prolonged period of time to patients with advanced cancer is associated with an improvement in clinical, biological and QoL parameters. N-3 fatty acids, cancer and cachexia: a systematic review of the literature. Colomer R, Moreno-Nogueira JM, García-Luna PP, García-Peris P, García-de-Lorenzo A, Zarazaga A, Quecedo L, del Llano J, Usán L, Casimiro C. Br J Nutr. 2007 May;97(5):823-31. Review. PMID: 17408522 doi:10.1017/S000711450765795X
Matti Narkia

Omega-3 Kills Cancer Cells - 0 views

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    ScienceDaily (Apr. 5, 2009) - Docosahexanoic acid (DHA), an omega-3 fatty acid found in fish oils, has been shown to reduce the size of tumours and enhance the positive effects of the chemotherapy drug cisplatin, while limiting its harmful side effects. The rat experiments provide some support for the plethora of health benefits often ascribed to omega-3 acids.
Matti Narkia

Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease - ... - 0 views

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    Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. Sijben JW, Calder PC. Proc Nutr Soc. 2007 May;66(2):237-59. Review. PMID: 17466105 doi:10.1017/S0029665107005472
Matti Narkia

Nutrient Intake and Immune Function of Elderly Subjects - J Am Diet Assoc. 2008 Dec - 0 views

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    Nutrient intake and immune function of elderly subjects. Wardwell L, Chapman-Novakofski K, Herrel S, Woods J. J Am Diet Assoc. 2008 Dec;108(12):2005-12. PMID: 19027403 doi:10.1016/j.jada.2008.09.003
Matti Narkia

What can we expect from omega-3 fatty acids? - Cleveland Clinic Journal of Medicine - 0 views

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    What can we expect from omega-3 fatty acids? Chan EJ, Cho L. Cleve Clin J Med. 2009 Apr;76(4):245-51. PMID: 19339640 doi: 10.3949/ccjm.76a.08042
Matti Narkia

Fatty acid facts, part III: Cardiovascular disease, or, a fish diet is noy fishy. - [Dr... - 0 views

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    Fatty acid facts, part III: Cardiovascular disease, or, a fish diet is noy fishy. Pauwels EK, Kostkiewicz M. Drug News Perspect. 2008 Dec;21(10):552-61. PMID: 19221636
Matti Narkia

Sham vs. Wham: The Health Insider: Omega 3 In the News Again - Lower Advanced Prostate ... - 0 views

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    new (March 24th) report in Clinical Cancer Research, a journal of the American Association for Cancer Research, shows that Omega-3 fatty acids appear protective against advanced prostate cancer. Dr. John S. Witte, Ph.D., professor of epidemiology and biostatistics at the University of California San Francisco, says that previous research has shown protection against prostate cancer, but that this is one of the first studies to show protection against advanced prostate cancer.
Matti Narkia

Dietary Omega-3 Fatty Acids, Cyclooxygenase-2 Genetic Variation, and Aggressive Prostat... - 0 views

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    Dietary Omega-3 Fatty Acids, Cyclooxygenase-2 Genetic Variation, and Aggressive Prostate Cancer Risk. Fradet V, Cheng I, Casey G, Witte JS. Clin Cancer Res. 2009 Mar 24. [Epub ahead of print] PMID: 19318492 DOI: 10.1158/1078-0432.CCR-08-2503
Matti Narkia

Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver d... - 0 views

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    CONCLUSION: Our results indicate that n-3 PUFA from seal oils is safe and efficacious for patients with NAFLD associated with hyperlipidemia and can improve their total symptom scores, ALT, serum lipid levels and normalization of ultrasonographic evidence. Further study is needed to confirm these results. Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia. Zhu FS, Liu S, Chen XM, Huang ZG, Zhang DW. World J Gastroenterol. 2008 Nov 7;14(41):6395-400. PMID: 19009658
Matti Narkia

Enriched eggs as a source of N-3 polyunsaturated fatty acids for humans. - Poult Sci. 2... - 0 views

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    Enriched eggs as a source of N-3 polyunsaturated fatty acids for humans. Lewis NM, Seburg S, Flanagan NL. Poult Sci. 2000 Jul;79(7):971-4. Review. PMID: 10901195 Plasma triglycerides (TG) are decreased by addition of n-3 PUFA-enriched eggs to the diet. N-3 PUFA may influence LDL particle size, causing a shift toward a less atherogenic particle. Blood platelet aggregation is significantly decreased in participants consuming n-3 PUFA-enriched eggs. Overall results of studies to date demonstrate positive effects and no negative effects from consumption of n-3-enriched eggs. Three n-3 PUFA-enriched eggs provide approximately the same amount of n-3 PUFA as one meal with fish. It is recommended that n-3 PUFA-enriched eggs be used as one source of n-3 PUFA to increase individual consumption to meet the current Canadian recommendations
Matti Narkia

Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human... - 0 views

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    Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells. Habbel P, Weylandt KH, Lichopoj K, Nowak J, Purschke M, Wang JD, He CW, Baumgart DC, Kang JX. World J Gastroenterol. 2009 Mar 7;15(9):1079-84. PMID: 19266600
Matti Narkia

Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow veloc... - 0 views

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    Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals. Oe H, Hozumi T, Murata E, Matsuura H, Negishi K, Matsumura Y, Iwata S, Ogawa K, Sugioka K, Takemoto Y, Shimada K, Yoshiyama M, Ishikura Y, Kiso Y, Yoshikawa J. Heart. 2008 Mar;94(3):316-21. Epub 2007 Jun 25. PMID: 17591648 doi:10.1136/hrt.2006.113159
Matti Narkia

Nutritional intervention with omega-3 Fatty acids in a case of malignant fibrous histio... - 0 views

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    Nutritional intervention with omega-3 Fatty acids in a case of malignant fibrous histiocytoma of the lungs. Pardini RS, Wilson D, Schiff S, Bajo SA, Pierce R. Nutr Cancer. 2005;52(2):121-9. PMID: 16201843
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