Prostate tumor growth and recurrence can be modulated by the omega-6:omega-3 ratio in diet: athymic mouse xenograft model simulating radical prostatectomy.
Kelavkar UP, Hutzley J, Dhir R, Kim P, Allen KG, McHugh K.
Neoplasia. 2006 Feb;8(2):112-24.
PMID: 16611404
Biochemical effects of consumption of eggs containing omega-3 polyunsaturated fatty acids.
Ohman M, Akerfeldt T, Nilsson I, Rosen C, Hansson LO, Carlsson M, Larsson A.
Ups J Med Sci. 2008;113(3):315-23.
PMID: 18991244
Addition of one regular egg per day to the normal diet had no negative impact on blood lipids or inflammation markers. Consumption of omega-3 enriched eggs resulted in higher levels of ApoA1, lower ApoB/ApoA1 ratio and lower plasma glucose. These effects have been associated in previous studies with a reduced risk for cardiovascular mortality and diabetes.
Floyd Chilton and colleagues wanted to examine whether theses fatty acids might have other effects, and developed a dietary intervention strategy in which 27 healthy humans were fed a controlled diet mimicking the w6/w3 ratios of early humans over 5 weeks. They then looked at the gene levels of immune signals and cytokines (protein immune messengers), that impact autoimmunity and allergy in blood cells and found that many key signaling genes that promote inflammation were markedly reduced compared to a normal diet, including a signaling gene for a protein called PI3K, a critical early step in autoimmune and allergic inflammation responses.
This study demonstrates, for the first time in humans, that large changes in gene expression are likely an important mechanism by which these omega fatty acids exert their potent clinical effects
ScienceDaily (Apr. 5, 2009) - Docosahexanoic acid (DHA), an omega-3 fatty acid found in fish oils, has been shown to reduce the size of tumours and enhance the positive effects of the chemotherapy drug cisplatin, while limiting its harmful side effects. The rat experiments provide some support for the plethora of health benefits often ascribed to omega-3 acids.
Opposing effects of n-6 and n-3 polyunsaturated fatty acids on
pancreatic cancer growth.
Funahashi H, Satake M, Hasan S, Sawai H, Newman RA, Reber HA,
Hines OJ, Eibl G.
Pancreas. 2008 May;36(4):353-62.
PMID: 18437081 10.1097/MPA.0b013e31815ccc44
Enriched eggs as a source of N-3 polyunsaturated fatty acids for humans.
Lewis NM, Seburg S, Flanagan NL.
Poult Sci. 2000 Jul;79(7):971-4. Review.
PMID: 10901195
Plasma triglycerides (TG) are decreased by addition of n-3 PUFA-enriched eggs to the diet. N-3 PUFA may influence LDL particle size, causing a shift toward a less atherogenic particle. Blood platelet aggregation is significantly decreased in participants consuming n-3 PUFA-enriched eggs. Overall results of studies to date demonstrate positive effects and no negative effects from consumption of n-3-enriched eggs. Three n-3 PUFA-enriched eggs provide approximately the same amount of n-3 PUFA as one meal with fish. It is recommended that n-3 PUFA-enriched eggs be used as one source of n-3 PUFA to increase individual consumption to meet the current Canadian recommendations
new (March 24th) report in Clinical Cancer Research, a journal of the American Association for Cancer Research, shows that Omega-3 fatty acids appear protective against advanced prostate cancer.
Dr. John S. Witte, Ph.D., professor of epidemiology and biostatistics at the University of California San Francisco, says that previous research has shown protection against prostate cancer, but that this is one of the first studies to show protection against advanced prostate cancer.
Omega-3 fatty acids: a comprehensive review of their role in health and disease.
Yashodhara BM, Umakanth S, Pappachan JM, Bhat SK, Kamath R, Choo BH.
Postgrad Med J. 2009 Feb;85(1000):84-90.
PMID: 19329703
doi:10.1136/pgmj.2008.073338
ScienceDaily (Apr. 10, 2009) - New research from Trinity College Dublin published in this month's Annals of Surgery points to a potentially significant advance in the treatment of patients undergoing major cancer surgery. The study was carried out by the oesophageal research group at Trinity College Dublin and St James's Hospital. A randomised controlled trial showed omega-3 fatty acids given as part of an oral nutritional supplement resulted in the preservation of muscle mass in patients undergoing surgery for oesopahageal cancer, a procedure normally associated with significant weight loss and quality of life issues.
Obesity-induced insulin resistance and hepatic steatosis are alleviated by {omega}-3 fatty acids: a role for resolvins and protectins.
González-Périz A, Horrillo R, Ferré N, Gronert K, Dong B, Morán-Salvador E, Titos E, Martínez-Clemente M, López-Parra M, Arroyo V, Clària J.
FASEB J. 2009 Feb 23. [Epub ahead of print]
PMID: 19211925
doi: 10.1096/fj.08-125674
Nutritional intervention with omega-3 Fatty acids in a case of
malignant fibrous histiocytoma of the lungs.
Pardini RS, Wilson D, Schiff S, Bajo SA, Pierce R.
Nutr Cancer. 2005;52(2):121-9.
PMID: 16201843
A Systemic Review of the Roles of n-3 Fatty Acids in Health and Disease.
Riediger ND, Othman RA, Suh M, Moghadasian MH.
J Am Diet Assoc. 2009 Apr;109(4):668-79.
PMID: 19328262
doi:10.1016/j.jada.2008.12.022