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Matti Narkia

Definition of white button mushroom extract - National Cancer Institute Drug Dictionary - 0 views

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    A heat-stable extract of white button mushrooms (Agaricus bisporus) with potential chemopreventive and immunomodulating activities. Phytochemicals, such as polysaccharides and especially beta-D-glucans found in the white button mushroom extract, bind to and inhibit the activity of aromatase, an enzyme responsible for the conversion of androgens to estrogens and which is often upregulated in breast cancer cells. The consequent decrease in estrogen production may result in the suppression of estrogen-dependent cellular proliferation. In addition, this extract may promote dendritic cell (DC) maturation, increase interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) production, and may enhance natural killer (NK) cell activity, thus amplifying both innate and T cell-mediated immune responses against cancer cells. Check for active clinical trials or closed clinical trials using this agent.
Matti Narkia

VitaminK2.org - 0 views

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    Vitamin K has been known as the coagulation vitamin, because of its role in the blood-clotting process. However, research over the last few decades has shown that the role of K Vitamins - and natural Vitamin K2, the menaquinones, in particular - has been greatly expanded. Of note, K Vitamins activity outside the liver is required for calcium utilization, the key factor in maintaining both bone and cardiovascular health.\n\nVitamin K2 helps to activate vitamin K-dependent proteins responsible for healthy tissues. In bone, it activates osteocalcin, a protein required to bind calcium to the mineral matrix, thus strengthening the skeleton. In circulation, Vitamin K2 participates in carboxylation of Matrix Gla Protein (MGP), the most potent inhibitor of arterial calcification known, lowering the risk of vascular damage.
Matti Narkia

Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disea... - 0 views

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    Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Kidd P. Altern Med Rev. 2003 Aug;8(3):223-46. Review. PMID: 12946237 Th1 pathways typically produce activation of cytotoxic T lymphocytes (Tc), NK cells, macrophages, and monocytes, all of which can attack cancer cells and generally defend against tumors. 55 IFN-gamma and other Th1 cytokines are typically lower in advanced cancer patients, while the Th2 marker IL-4 can be higher or unchanged.56 Nodules of non-small cell lung cancer freshly removed from patients expressed a marked imbalance toward Th2, as did biopsy samples from basal cell carcinoma.57 In prostate cancer patients IL-2 was low (Th1) and IL-10 high.58 IL-10 is a confirmed Th1-suppressive cytokine, and heightened IL-10 is a common factor in cancer.55 IL-10 has a variety of suppressive effects that include inhibiting Th1 cytokine production, down-regulating APC and NK cell function, and lowering overall T-cell proliferation.57 Especially under the influence of IL-4 (Th2), tumor cells apparently up-regulate IL-10 that suppresses nearby killer cells. Tumor-derived IL-10 has been documented in lymphoma, ovarian carcinoma, melanoma, neuroblastoma, and renal cell and colon carcinoma.57 IL-12 is another cytokine that can be up-regulated by Th1 activity and inhibited by Th2.59 A low IL-12/IL-10 ratio was found in cervical cancer patients.55 Recent clinical studies suggest elevated IL-10 is predictive of a poor prognosis. 57 With both IL-4 and IL-10 being proven inhibitors of Th1 and promoters of Th2 activity, the recognized capability of cancerous tissue to suppress immunity is readily rationalized.
Matti Narkia

Fish oil feeding alters liver gene expressions to defend against PPARalpha activation ... - 0 views

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    These data indicate that fish oil feeding downregulated the endogenous PPAR-activation system and increased antioxidant gene expressions to protect against ROS excess Fish oil feeding alters liver gene expressions to defend against PPARalpha activation and ROS production. Takahashi M, Tsuboyama-Kasaoka N, Nakatani T, Ishii M, Tsutsumi S, Aburatani H, Ezaki O. Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G338-48. PMID: 11804856
Matti Narkia

Active Hexose Correlated Compound shown to enhances immune system by increasing product... - 0 views

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    A recently published study in Nutrition and Cancer (60(5), 643-651) by researchers at Kansai Medical University in Osaka, Japan has shown that AHCC (Active Hexose Correlated Compound) enhances immune function by increasing the number of dendritic cells (DCs). DCs are a key part of the immune system responsible for presenting foreign substances to other immune system cells. The study was conducted in a double-blind randomized fashion where twenty-one healthy subjects received a placebo or AHCC at 3.0 g/day for 4 weeks. Blood samples were obtained and measured at baseline and at 4 weeks. The number of circulating types of DCs was measured which included CD 11c+ DCs (myeloid DC population; DC1) and CD11c- DCs (lymphoid DC population; DC2). Other parameters measured included mixed-leukocyte reaction (MLR), natural killer (NK) cell activity, the proliferative response of T lymphocytes toward mitogen (phytohemagglutinin [PHA]) and cytokine production of interleukin (IL)-2, IL-4, IL-6, IL-10, interferon gamma-gamma, and (alpha)-tumor necrosis factor.
Matti Narkia

Active Hexose Correlated Compound - Wikipedia, the free encyclopedia - 0 views

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    Active Hexose Correlated Compound (AHCC) is an alpha-glucan rich nutritional supplement produced from the mycelia of shiitake (Lentinula edodes) of the basidiomycete family of mushrooms, and should not be confused or used as a drug or medicine.[1][2] AHCC was originally designed to lower high-blood pressure. However, researchers at Tokyo University found AHCC's influence upon the innate immune system highly beneficial and published the results in 1992, though not in the commonly indexed scientific literature. In this study, researchers found that AHCC significantly increased natural killer (NK) cell activity in cancer patients, and also enhanced the effects of killer T-cells, and cytokines (interferon, IL-12, TNF-alpha
Matti Narkia

Ursolic acid - Wikipedia, the free encyclopedia - 0 views

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    Ursolic acid is a pentacyclic triterpene acid, used in cosmetics,[2] that is also capable of inhibiting various types of cancer cells by inhibiting the STAT3 activation pathway[3][4] and human fibrosarcoma cells by reducing the expression of matrix metalloproteinase-9 by acting through the glucocorticoid receptor. Ursolic acid is present in many plants, including apples, basil, bilberries, cranberries, elder flower, peppermint, rosemary, lavender, oregano, thyme, hawthorn, prunes. Apple peels contain high quantity of ursolic acid and related compounds which are responsible for the anti-cancer activity of apple. Ursolic acid can also serve as a starting material for synthesis of more potent bioactive derivatives, such as anti-tumor agents
Matti Narkia

Cancer Journal: Latest cancer research Link between cancer and dietary restriction | ec... - 0 views

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    A signalling pathway that influences how sensitive cancer cells are to the beneficial effects of dietary restriction is described in this week's Nature. Dietary restriction - eating less calories while maintaining essential vitamins and minerals - can extend lifespan, and reduce cancer incidence and growth. But some types of cancer cell are more sensitive to the anti-growth effects of dietary restriction than others, Nada Kalaany and David Sabatini report. The effect hinges on the activity of the phosphatidylinositol-3-kinase (PI3K) pathway. If the pathway is active, dietary restriction has no effect on cancer cells. However, if the pathway is inactive, tumours are sensitive to dietary restriction.
Matti Narkia

Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tub... - 0 views

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    Liu PT, Stenger S, Tang DH, Modlin RL. \nCutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on the Induction of Cathelicidin.\nJ Immunol. 2007 Aug 15;179(4):2060-3.\nPMID: 17675463 [PubMed - in pr
Matti Narkia

In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagi... - 0 views

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    In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D. J Nutr Biochem. 2005 Jun;16(6):360-7. PMID: 15936648
Matti Narkia

Vitamin D - Linus Pauling Institute at Oregon State University - 0 views

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    Vitamin D is a fat-soluble vitamin that is essential for maintaining normal calcium metabolism (1). Vitamin D3 (cholecalciferol) can be synthesized by humans in the skin upon exposure to ultraviolet-B (UVB) radiation from sunlight, or it can be obtained from the diet. Plants synthesize ergosterol, which is converted to vitamin D2 (ergocalciferol) by ultraviolet light. Vitamin D2 is less active in birds than vitamin D3 and may also be less active in humans (2). When exposure to UVB radiation is insufficient for the synthesis of adequate amounts of vitamin D3 in the skin, adequate intake of vitamin D from the diet is essential for health.
Matti Narkia

White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell ... - 0 views

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    White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation. Grube BJ, Eng ET, Kao YC, Kwon A, Chen S. J Nutr. 2001 Dec;131(12):3288-93. PMID: 11739882
Matti Narkia

Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus)... - 0 views

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    Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus). Chen S, Oh SR, Phung S, Hur G, Ye JJ, Kwok SL, Shrode GE, Belury M, Adams LS, Williams D. Cancer Res. 2006 Dec 15;66(24):12026-34. PMID: 17178902 doi: 10.1158/0008-5472.CAN-06-2206
Matti Narkia

Sloan-Kettering - AHCC - 0 views

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    A proprietary extract prepared from co-cultured mycelia of several species of Basidiomycete mushrooms, including shiitake (Lentinus edodes), active hexose correlated compound (AHCC) is extracted from mushrooms using hot water following an enzyme pretreatment, but specific mushroom source and preparation details have not been fully disclosed. Patients use this to prevent and treat cancer. Animal studies suggest that AHCC has antioxidant effects and may protect against disorders induced by oxidative stress (1) and may also enhance resistance against bacterial (2) (7)and viral infections (3). In healthy humans, AHCC increased dendritic cell number and function (4) In vitro and animal studies show that AHCC exhibits some anticancer activities, but the results of these studies are vague
Matti Narkia

Phospholipase A(2) activation as a therapeutic approach for cognitive enhancement in ea... - 0 views

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    Phospholipase A(2) activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease. Schaeffer EL, Forlenza OV, Gattaz WF. Psychopharmacology (Berl). 2009 Jan;202(1-3):37-51. Epub 2008 Oct 14. PMID: 18853146 DOI: 10.1007/s00213-008-1351-0
Matti Narkia

Dietary supplementation with white button mushroom enhances natural killer cell activit... - 0 views

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    Dietary supplementation with white button mushroom enhances natural killer cell activity in C57BL/6 mice. Wu D, Pae M, Ren Z, Guo Z, Smith D, Meydani SN. J Nutr. 2007 Jun;137(6):1472-7. PMID: 17513409
Matti Narkia

Inhibition of platelet phospholipase A2 activity by catuaba extract suggests antiinflam... - 0 views

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    Inhibition of platelet phospholipase A2 activity by catuaba extract suggests antiinflammatory properties. Barbosa NR, Fischmann L, Talib LL, Gattaz WF. Phytother Res. 2004 Nov;18(11):942-4. PMID: 15597313 DOI: 10.1002/ptr.1579
Matti Narkia

Fish Oil Consumption and Reduction of Arterial Disease -- Vanschoonbeek et al. 133 (3):... - 0 views

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    Here we propose that the beneficial effect of (n-3) PUFA diet is related to down-regulation of the mutually positive interactions of platelet activation and coagulation. In addition, we consider the possibility that the dietary effect on hemostatic and lipid factors involves transcription regulation of multiple genes, perhaps in a subject-dependent manner. Fish oil consumption and reduction of arterial disease. Vanschoonbeek K, de Maat MP, Heemskerk JW. J Nutr. 2003 Mar;133(3):657-60. Review. PMID: 12612132
Matti Narkia

Supplementation with active hexose correlated compound increases survival following inf... - 0 views

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    Supplementation with active hexose correlated compound increases survival following infectious challenge in mice. Ritz BW. Nutr Rev. 2008 Sep;66(9):526-31. Review. PMID: 18752476 DOI: 10.1111/j.1753-4887.2008.00085.x
Matti Narkia

Oral administration of active hexose correlated compound enhances host resistance to We... - 0 views

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    Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. Wang S, Welte T, Fang H, Chang GJ, Born WK, O'Brien RL, Sun B, Fujii H, Kosuna K, Wang T. J Nutr. 2009 Mar;139(3):598-602. Epub 2009 Jan 13. PMID: 19141700 doi:10.3945/jn.108.100297
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